scholarly journals Early-onset Postirradiation Sarcoma of the Head and Neck: Report of Three Cases

2002 ◽  
Vol 81 (6) ◽  
pp. 402-406 ◽  
Author(s):  
Michael M. Johns ◽  
Adriane P. Concus ◽  
Ted F. Beals ◽  
Theodoras N. Teknos
Keyword(s):  
Electron Microscopy ◽  
Radiation Therapy ◽  
Soft Tissue ◽  
Head And Neck ◽  
Early Onset ◽  
Soft Tissue Sarcomas ◽  
Suspicious Lesion ◽  
Original Tumor ◽  
Epithelial Lesions ◽  
Postirradiation Sarcoma

Postirradiation sarcomas of the head and neck are rare. When they do occur, most appear at least 10 years following radiation therapy. We report three cases of early-onset (1, 2, and 7 yr) postirradiation sarcoma. Physicians who care for previously irradiated patients should consider the possibility of a postirradiation sarcoma whenever they see a suspicious lesion, regardless of the amount of time that has passed since radiation therapy was administered. The original pathology should be reexamined to ensure that the original tumor was diagnosed correctly. Electron microscopy can be useful in differentiating sarcomatous-appearing epithelial lesions from true soft-tissue sarcomas, and thus can be helpful in guiding therapy.

scholarly journals Radiation therapy and conservative surgery for soft tissue sarcomas of the extremities, torso and head and neck

1992 ◽  
Vol 3 ◽  
pp. S97-S101 ◽  
Author(s):  
A. De Paoli ◽  
G. Bertola ◽  
G. Boz ◽  
F. Gherlinzoni ◽  
S. Frustaci ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Head And Neck ◽  
Soft Tissue Sarcomas ◽  
Conservative Surgery

scholarly journals Head and Neck Soft Tissue Sarcomas Treated with Radiation Therapy

Rare Tumors ◽  
2016 ◽  
Vol 8 (2) ◽  
pp. 60-65 ◽  
Author(s):  
Lucas K. Vitzthum ◽  
Lindsay C. Brown ◽  
Jessica W. Rooney ◽  
Robert L. Foote
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Head And Neck ◽  
Soft Tissue Sarcomas

Fibrosacroma of the vocal fold: a late complication of radiotherapy

1994 ◽  
Vol 108 (11) ◽  
pp. 993-994 ◽  
Author(s):  
B. Nageris ◽  
J. Elidan ◽  
Y. Sherman
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Ionizing Radiation ◽  
Head And Neck ◽  
Vocal Fold ◽  
Rare Case ◽  
Late Complication ◽  
Soft Tissue Sarcomas ◽  
Glottic Carcinoma ◽  
Carcinogenic Effect

AbstractThe carcinogenic effect of ionizing radiation is a well known phenomenon. However, the induction of malignancies following irradiation for head and neck cancers is quite rare (Steeves and Vataini, 1982). Most reported cases are osteogenic sarcomas with soft tissue sarcomas encountered less often.We report a rare case of fibrosarcoma of the larynx, following radiation therapy for glottic carcinoma.

Functional and psychosocial effects of multimodality limb-sparing therapy in patients with soft tissue sarcomas.

1989 ◽  
Vol 7 (9) ◽  
pp. 1217-1228 ◽  
Author(s):  
A E Chang ◽  
S M Steinberg ◽  
M Culnane ◽  
M H Lampert ◽  
A J Reggia ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Sexual Activity ◽  
Standardized Test ◽  
Soft Tissue Sarcomas ◽  
High Grade ◽  
Postoperative Radiation ◽  
Limb Function ◽  
Postoperative Radiation Therapy ◽  
Global Quality Of Life

We have documented functional and psychosocial changes in patients with extremity soft tissue sarcomas who have undergone multimodality limb-sparing treatments. In 88 patients, parameters related to economic status, sexual activity, pain, limb function, and global quality of life (QOL) were recorded prior to surgery and every 6 months postoperatively. Changes from the preoperative assessment for every parameter were analyzed in each patient. Six months after surgery, there was a decrease in employment status, sexual activity, and in limb function in a significant number of patients. At 12 months, these decreases were still evident. Despite these changes, global QOL measured by a standardized test showed at least some improvement in a significant proportion of patients at 12 months. These findings highlight the difficulty in defining QOL. It could not be ascertained if radiation therapy and/or chemotherapy were causative factors in specific changes because of the small numbers of patients in each subgroup. However, among 60 patients with high-grade sarcomas, significant wound problems developed in 10 of 33 who received postoperative radiation therapy in combination with adjuvant doxorubicin and cyclophosphamide chemotherapy compared with one of 27 patients who received adjuvant chemotherapy alone (P = .016). Also, among high-grade sarcoma patients with 12-month follow-up, six of 19 patients who received radiation therapy and chemotherapy developed joint contractures compared with zero of 15 patients who received chemotherapy alone (P less than .04). The combination of postoperative radiation therapy and chemotherapy appeared to be associated with significantly more tissue-related injury in patients with high-grade sarcomas compared with chemotherapy alone.

OC-0087: Preoperative Hypofractionated Radiation Therapy for Soft Tissue Sarcomas of Extremity and Trunk

2020 ◽  
Vol 152 ◽  
pp. S40
Author(s):  
F. Navarria ◽  
A. Lauretta ◽  
E. Palazzari ◽  
R. Innocente ◽  
M. Gigante ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Hypofractionated Radiation Therapy ◽  
Hypofractionated Radiation

Soft tissue sarcomas of the head and neck: outcome and prognostic factors

2000 ◽  
Vol 5 (4) ◽  
pp. 269-275
Author(s):  
T. Shouman ◽  
M. Gameel ◽  
A. Attia ◽  
S. A. El-Aziz ◽  
N. Mohamed
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Head And Neck ◽  
Soft Tissue Sarcomas

Flap Reconstruction of Sarcoma Defects in the Setting of Neoadjuvant and Adjuvant Radiation

2018 ◽  
Vol 35 (04) ◽  
pp. 287-293 ◽  
Author(s):  
Rohini Kadle ◽  
Catherine Motosko ◽  
George Zakhem ◽  
John Stranix ◽  
Timothy Rapp ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Radiation Treatment ◽  
Soft Tissue Sarcomas ◽  
Adjuvant Radiation ◽  
Complication Rates ◽  
Flap Reconstruction ◽  
Fasciocutaneous Flaps ◽  
Musculoskeletal Tumor Society

Background Limb-sparing treatment of extremity soft tissue sarcomas requires wide resections and radiation therapy. The resulting complex composite defects necessitate reconstructions using either muscle or fasciocutaneous flaps, often in irradiated wound beds. Methods A retrospective chart review was performed of all limb-sparing soft tissue sarcoma resections requiring immediate flap reconstruction from 2012 through 2016. Results Forty-four patients with 51 flaps were identified: 25 fasciocutaneous and 26 muscle-based flaps. Mean defect size, radiation treatment, and follow-up length were similar between groups. More often, muscle-based flaps were performed in younger patients and in the lower extremity. Seventeen flaps were exposed to neoadjuvant radiation, 12 to adjuvant radiation, 5 to both, and 17 to no radiation therapy. Regardless of radiation treatment, complication rates were comparable, with 28% in fasciocutaneous and 31% in muscle-based groups (p < 0.775). Muscle-based flaps performed within 6 weeks of undergoing radiotherapy were less likely to result in complications than those performed after greater than 6 weeks (p < 0.048). At time of follow-up, Musculoskeletal Tumor Society scores for fasciocutaneous and muscle-based reconstructions, with or without radiation, showed no significant differences between groups (mean [SD]: 91% [8%] vs. 89% [13%]). Conclusion The similar complication rates and functional outcomes in this study support the safety and efficacy of both fasciocutaneous flaps and muscle-based flaps in reconstructing limb-sparing sarcoma resection defects, with or without radiotherapy.

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