scholarly journals Platelet-Rich Plasma Myringoplasty: A New Office Procedure for the Repair of Small Tympanic Membrane Perforations

2017 ◽  
Vol 96 (8) ◽  
pp. 312-326 ◽  
Author(s):  
Mohammad Waheed El-Anwar ◽  
Ismail Elnashar ◽  
Yaser Ahmad Foad
Keyword(s):  
Tympanic Membrane ◽  
Platelet Rich Plasma ◽  
Invasive Procedure ◽  
Minimally Invasive Procedure ◽  
Office Procedure ◽  
Taste Disturbance ◽  
Tympanic Membrane Perforations ◽  
Single Piece ◽  
Study Population ◽  
A Prospective Study

We conducted a prospective study to assess the effectiveness of a platelet-rich plasma hourglass graft in the repair of small tympanic membrane perforations as an office-based procedure. Our study population was made up of 25 patients—10 men and 15 women, aged 19 to 45 years (mean: 30.4 ± 7.2)—who each underwent repair of one eardrum. After administration of topical anesthesia, a single piece of platelet-rich plasma approximately double the size of the perforation was obtained from each patient's intravenous blood sample. After the margin of the perforation was freshened, the platelet-rich plasma was placed in an hourglass configuration, with equal portions lying medial and lateral to the perforation. Successful perforation repair was achieved in 21 of the 25 ears (84%). No patient developed an infection, hearing impairment, tinnitus, vertigo, bleeding, taste disturbance, or hyperkeratosis. We conclude that office-based platelet-rich plasma myringoplasty is a safe and effective minimally invasive procedure that is suitable for repairing small tympanic membrane perforations.

scholarly journals The Minimally Invasive Effect of Breast Approach Endoscopic Thyroidectomy: An Expert's Experience

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Wei Zhang ◽  
Zhi-guo Jiang ◽  
Dao-zhen Jiang ◽  
Xiang-min Zheng ◽  
Hong-liang Shen ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Endoscopic Thyroidectomy ◽  
Invasive Procedure ◽  
Minimally Invasive Procedure ◽  
Analog Scale ◽  
Time Points ◽  
Conventional Thyroidectomy ◽  
Objective Evidence ◽  
Study Population ◽  
Group Serum

We evaluated the invasiveness of breast approach endoscopic thyroidectomy (BAET) carried out by surgeon very experienced in this procedure. Twenty-four patients who underwent BAET and 19 patients who underwent conventional thyroidectomy were the study population. Postoperative pain was assessed by a visual analog scale (VAS). The values 2, 12, and 24 h after surgery were significantly lower in the BAET group than those in the conventional group. Serum IL-6 and CRP levels were measured by an ELISA preoperatively and at 2, 12, 24 and 48 h after operation. Their values increased significantly after both procedures when compared to preoperative levels with significant differences between the two groups detected at the 24-hour and 48-hour time points. Subjective and objective evidence supported the notion that BAET could become a minimally invasive procedure if the surgeon gained sufficient experience.

scholarly journals Mastoid Reconstruction With Platelet-Rich Plasma and Bone Pate After Canal Wall Down Mastoidectomy: A Preliminary Report

2019 ◽  
pp. 014556131987978 ◽  
Author(s):  
Sherif M. Askar ◽  
Ibrahim M. Saber ◽  
Mohammad Omar
Keyword(s):  
Tympanic Membrane ◽  
Cortical Bone ◽  
Platelet Rich Plasma ◽  
Case Series ◽  
Stressful Events ◽  
Mastoid Cavity ◽  
Canal Wall ◽  
Tympanic Membrane Perforations ◽  
Canal Wall Down ◽  
Canal Wall Down Mastoidectomy

Objectives: Mastoid reconstruction principle had been described to overcome problems of chronic discharging cavity. Different materials were used; nonbiologic materials seem to be less preferred. Platelet-rich plasma (PRP) could promote the regeneration of mineralized tissues. In this work, the authors present a simple and easy technique for mastoid reconstruction with PRP and cortical bone pate. Methods: The study design is a case series. Patients had mastoid reconstruction after canal wall down mastoidectomy using PRP and cortical bone pate. Results: This study included 21 patients: 9 males, and 12 females. Sixteen patients had left side disease. All surgical procedures were conducted smoothly within 90 to 135 minutes with no stressful events had been reported. At 12 to 16 months of follow-up, external canal stenosis and mastoid fistulas were not reported. Good healing of the tympanic membrane was seen in 18 patients. No radiological signs suggestive of recurrence were detected and the reconstructed mastoid cavity was smooth and well aerated. Residual tympanic membrane perforations were detected in 3 patients. Conclusion: Autologous materials (PRP and bone pate pate) after canal wall down mastoidectomy appear to be a reliable and effective choice for mastoid reconstruction.

Composite chondro-perichondrial clip myringoplasty: our experience

2016 ◽  
Vol 2 (4) ◽  
pp. 249
Author(s):  
Shrikrishna B. H. ◽  
Jyothi A. C.
Keyword(s):  
Prospective Study ◽  
Success Rate ◽  
Tympanic Membrane ◽  
Canal Wall ◽  
Inclusion Criteria ◽  
Temporalis Fascia ◽  
Tympanic Membrane Perforations ◽  
Complete Closure ◽  
External Canal ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">There are several studies on the efficacy of the commonly used temporalis fascia for myringoplasty where the temporalis fascia is placed by underlay method after incising external canal wall skin. This study was conducted assess the success rate and efficacy of use of a composite chondro-perichondrial graft in a combined overlay-underlay fashion where the external canal wall is not incised. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A prospective study was conducted where 30 cases of non-marginal perforation of tympanic membrane were properly selected based on the inclusion criteria. All the 30 cases underwent myringoplasty using composite chondro-perichondrial graft harvested from tragal cartilage and placed in a combined overlay-underlay fashion.  </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">There was complete closure of the perforation in 27 of the total 30 cases. Also there was reduction in the air-bone gap post-operatively in all the 27 cases with complete closure of the tympanic membrane perforations. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Composite chondro-perichondrial clip myringoplasty is an effective method of closing non-marginal perforations of the tympanic membrane.</span></p>

Platelet-rich plasma improves healing of tympanic membrane perforations: experimental study

2008 ◽  
Vol 123 (5) ◽  
pp. 482-487 ◽  
Author(s):  
E Erkilet ◽  
M Koyuncu ◽  
S Atmaca ◽  
M Yarim
Keyword(s):  
Tympanic Membrane ◽  
Histopathological Examination ◽  
Platelet Rich Plasma ◽  
Healing Time ◽  
Tympanic Membrane Perforation ◽  
Control Group ◽  
Tympanic Membrane Perforations ◽  
Significant Difference ◽  
Membrane Perforation ◽  
Tympanic Membranes

AbstractObjective:The aim of this study was to investigate the effect of local application of platelet-rich plasma to perforated rat tympanic membranes, in terms of healing time and histopathological outcome.Methods:Eighty-eight tympanic membranes of 44 rats were given a standard 3 mm perforation, and platelet-rich plasma was applied to the right tympanic membrane perforations. The left tympanic membranes were left to heal spontaneously, as controls. The 44 rats were divided into two groups. In group one, comprising 20 rats, daily otomicroscopic examination of the tympanic membrane perforations was performed. The 24 rats in group two were subdivided into four subgroups of six rats each; these subgroups were sacrificed sequentially on days three, seven, 14 and 28 for histopathological examination, regardless of tympanic membrane healing stage.Results:In group one, the mean tympanic membrane healing times for tympanic membrane perforations receiving platelet-rich plasma and controls were respectively 10.2 ± 2.1 and 13.0 ± 2.9 days (mean ± standard deviation). This difference was statistically significant (p < 0.001). In group two, histopathological evaluation of tympanic membrane perforation healing at days three, seven, 14 and 28 did not reveal any statistically significant difference, individually or within the four groups as a whole.Conclusion:These findings suggest that earlier healing of tympanic membrane perforations occurred in the platelet-rich plasma group compared with the control group. These findings suggest that platelet-rich plasma is effective in accelerating tympanic membrane perforation healing, and that it may be effective in human subjects, particularly as it is an autologous material.

Platelet-Rich Plasma Fat Graft versus Cartilage Perichondrium for Repair of Medium-Size Tympanic Membrane Perforations

2018 ◽  
Vol 160 (1) ◽  
pp. 116-121 ◽  
Author(s):  
Mahmoud Fawzy Mandour ◽  
Mohamed Nasser Elsheikh ◽  
Mohamed Fathy Khalil
Keyword(s):  
Tympanic Membrane ◽  
Platelet Rich Plasma ◽  
Neck Surgery ◽  
Tympanic Membrane Perforation ◽  
Fat Graft ◽  
Controlled Study ◽  
Medium Size ◽  
Tympanic Membrane Perforations ◽  
Group 2 ◽  
Group 1

Objectives To compare clinical and audiologic outcomes among patients who underwent myringoplasty with fat graft enriched with platelet-rich plasma and cartilage perichondrium graft. Study Design Prospective randomized controlled study. Setting Department of Otolaryngology–Head and Neck Surgery, Tanta University, Egypt. Subjects and Methods The study comprised 50 patients who had tympanic membrane perforation of medium size (25%-50% of its surface area) without evidence of active otitis media or ossicular abnormalities and who had surgery between December 2016 and December 2017. Patients randomly underwent myringoplasty with fat graft enriched with platelet-rich plasma (group 1) or cartilage perichondrium graft (group 2). Results Twenty-five patients were included in each group. Rates of successful closure at 3-month follow-up were 88% (group 1) and 92% (group 2). The mean overall improvement in pure tone average was 18.08 dB (95% CI, 16.9-19.25) for group 1 and 18.24 dB (95% CI, 16.94-19.53) for group 2. Conclusion Fat graft enriched with platelet-rich plasma can be recommended as an alternative choice for first-line treatment of medium-size central perforations of the tympanic membrane, with healing and hearing results comparable to those of conventional cartilage perichondrium myringoplasty.

scholarly journals Efficacy of Platelet-Rich Plasma on Fat Grafts in the Repair of Tympanic Membrane Perforations: An Experimental Study

2018 ◽  
pp. 58-62 ◽  
Author(s):  
Mehmet Akif Aksoy ◽  
◽  
Mustafa Fuat Acikalin ◽  
Melek Kezban Gurbuz ◽  
Erkan Niyazi Ozudogru ◽  
...  
Keyword(s):  
Experimental Study ◽  
Tympanic Membrane ◽  
Platelet Rich Plasma ◽  
Fat Grafts ◽  
Tympanic Membrane Perforations

scholarly journals Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

2017 ◽  
Vol 13 (2) ◽  
pp. 195-199 ◽  
Author(s):  
Selmin Karatayli Ozgursoy ◽  
M. Emin Tunckasik ◽  
Fatma Tunckasik ◽  
Egemen Akincioglu ◽  
Handan Dogan ◽  
...  
Keyword(s):  
Tympanic Membrane ◽  
Platelet Rich Plasma ◽  
Tympanic Membrane Perforations

An observational study of the management of traumatic tympanic membrane perforations

2002 ◽  
Vol 116 (3) ◽  
pp. 181-184 ◽  
Author(s):  
J. E. O. Amadasun
Keyword(s):  
Observational Study ◽  
Prospective Study ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforation ◽  
Control Group ◽  
Tympanic Membrane Perforations ◽  
Membrane Perforation ◽  
A Prospective Study

Controversies of how best to treat fresh tympanic membrane perforations have always existed. While some otolaryngologists prefer the paper patch method, others prefer modified myringoplasty. A prospective study is needed to investigate the most effective and least expensive management of this common ear trauma.This study examined prospectively, in three sections, a group of patients with a cellophane patch (n = 6), another group with a gentamicin ointment seal (n = 15) and a control group (n = 9) with a gentamicin plug placed at the distal end of the external auditory cavity. Successful healing of the traumatic tympanic membrane perforations was achieved in 50 per cent of the cellophane seal group, 86.7 per cent of the gentamicin ointment seal group and 77.8 per cent of the control group. This study shows that the management of a fresh tympanic membrane perforation should be limited to cleaning the traumatized ear and preventing infection.

scholarly journals A Comparison of the Autologous Platelet-Rich Plasma Gel Fat Graft Myringoplasty and the Fat Graft Myringoplasty for the Closure of Different Sizes of Tympanic Membrane Perforations

2020 ◽  
Vol 99 (5) ◽  
pp. 331-336 ◽  
Author(s):  
Tolga Ersözlü ◽  
Erdogan Gultekin
Keyword(s):  
Success Rate ◽  
Tympanic Membrane ◽  
Platelet Rich Plasma ◽  
Chronic Otitis Media ◽  
Fat Graft ◽  
Tympanic Membrane Perforations ◽  
Group A ◽  
Autologous Platelet Rich Plasma ◽  
Group B ◽  
Autologous Platelet

Objective: We aimed to evaluate the effect of autologous platelet-rich plasma gel (PRPG) on fat graft myringoplasty (FGM) in tympanic membrane perforations caused by chronic otitis media. Methods: This retrospective study involved 63 patients who underwent operations between 2015 and 2018. Fat graft myringoplasty was performed with the transcanal approach with and without the use of PRPG in the surgical field. The patients were classified into 2 groups: group A, which included 32 patients who underwent FGM with the use of autologous PRPG, and group B, which included 31 patients who underwent FGM alone. Tympanic membrane perforations were divided into 2 groups: small perforations (1-2 mm) in a single quadrant and large perforations (2-4 mm) in at least 2 quadrants. Results: Both groups were statistically matched regarding age and sex. The mean postoperative follow-up was 11.6 and 12.1 months for groups A and B, respectively. Four months postoperatively, the success rate of the graft in group A (100%) was significantly higher than that in group B (83.8%; P = .03). The preoperative and postoperative median air–bone gaps of the groups were similar ( P = .653 and P = .198, respectively). No worsening of the air–bone gap was noted postoperatively in either group. Conclusions: This study demonstrated that autologous PRPG application during FGM allows for a higher success rate than FGM alone. Furthermore, the use of PRPG with FGM for large perforations increases the success rate. Further studies are needed to investigate the PRPG healing effect on other tympanic membrane perforation closure techniques.

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