scholarly journals The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma

2019 ◽  
Vol 98 (8) ◽  
pp. 504-509 ◽  
Author(s):  
Jungirl Seok ◽  
Se Jin Hyun ◽  
Woo-Jin Jeong ◽  
Soon-Hyun Ahn ◽  
Hyojin Kim ◽  
...  
Keyword(s):  
Lymph Node ◽  
Pleomorphic Adenoma ◽  
Clinical Features ◽  
Regional Lymph Node ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Apparent Diffusion Coefficient Value ◽  
Lymph Node Enlargement ◽  
The Difference

Carcinoma ex pleomorphic adenoma (CXPA) arises from the primary or recurrent benign pleomorphic adenoma. The purpose of this study was to evaluate the clinical features that could be referenced in the differentiation. The medical records of 221 patients with pleomorphic adenoma and 15 patients with CXPA were retrospectively reviewed. Clinical characteristics, computed tomography and magnetic resonance imaging findings, and surgical pathology were analyzed. Patients with CXPA were older (55.1 vs 42.3; P < .01). Carcinoma ex pleomorphic adenoma was observed at higher rates in the minor salivary glands (24.9% vs 2.7%) and higher incidence of regional lymph node enlargement ( P = .04). While all CXPA showed a low-to-intermediate mean apparent diffusion coefficient value (ADC), most of pleomorphic adenoma had an intermediate-to-high ( P = .01). From this study, the following features should be considered as the clinical features of CXPA: (1) old age; (2) minor salivary gland tumor; (3) regional lymph node enlargement (>5 mm); and (4) low ADC findings.

scholarly journals Carcinoma ex Pleomorphic Adenoma in the Parapharyngeal Space

2013 ◽  
Vol 28 (1) ◽  
pp. 24-27
Author(s):  
Sudipta Pal ◽  
Sampurna Pati ◽  
Somnath Saha ◽  
Vedula Padmini Saha
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Parapharyngeal Space ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Gland Tumor ◽  
Mandibular Swing ◽  
Operative Recovery

Objective: To present a case of carcinoma ex pleomorphic adenoma in the parapharyngeal space and discuss its management.   Methods: Design:            Case Report Setting:           Tertiary Government Teaching Hospital Subjects:         One   Results:  A 40-year-old male patient with dysphagia for three months and a left-sided mucosa-covered oropharyngeal mass was found to have a prestyloid parapharyngeal lesion on CT Scans. Fine Needle Aspiration Cytology (FNAC) revealed a pleomorphic adenoma. With a past history of parapharyngeal pleomorphic adenoma excised transorally three years before, the present mass was excised by mandibular swing approach. Post-operative recovery was uneventful, but the final histopathological report was carcinoma ex pleomorphic adenoma.   Conclusion: Malignant transformation should be suspected in recurrent salivary tumors in the parapharyngeal space. Provided there was truly no pre-existing malignant focus in the originally-excised tumor, and that early recurrence was not due to inadequate initial excision, this patient had a rare condition where the same tumor underwent malignant transformation within 3 years only. To the best of our knowledge, such an early transformation to malignancy of a minor salivary gland tumor of the parapharyngeal space has not been reported in the English literature.   Keywords: carcinoma ex pleomorphic adenoma, pleomorphic adenoma, carcinoma,  parapharyngeal space, malignant, transformation, minor salivary gland tumor,  mandibular swing

scholarly journals A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis

2015 ◽  
Vol 16 (7) ◽  
pp. 603-606
Author(s):  
Felipe Perozzo Daltoe ◽  
Liliane Janete Grando ◽  
Maria Inês Meurer ◽  
Elena Riet Correa Rivero ◽  
Filipe Modolo
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Rare Case ◽  
Periodic Acid ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Immunohistochemical Analysis ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Periodic Acid Schiff

ABSTRACT Mucoepidermoid carcinoma ex pleomorphic adenoma (MCxPA) is a rare salivary gland tumor predominantly found in major salivary glands. A case of MCxPA involving the soft tissue and bone of the retromolar region of a 26-year-old man is presented. The histopathological features revealed a neoplasm with predominance of pleomorphic adenoma (PA) elements, and presence of mucoepidermoid carcinoma malignant epithelial cells in several areas. Histochemical and immunohistochemical studies were positive for periodic acid Schiff, alcian blue, cytokeratins 7, 13, 14, and 19, Bcl-2, c-erbB-2, FGF-2 and maspin in the malignant areas. The patient underwent a partial resection of the left side of the mandible with neck dissection and MCxPA diagnosis was confirmed. How to cite this article Daltoe FP, Grando LJ, Meurer MI, Rivero ERC, Modolo F. A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis. J Contemp Dent Pract 2015;16(7):603-606.

scholarly journals Myoepithelial Cell-Rich Pleormorphic Adenoma of Minor Salivary Gland of Parapharyngeal Space

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Digvijay Singh Rawat ◽  
Divij Sonkhya ◽  
Nishi Sonkhya ◽  
Shubha Gupta
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Myoepithelial Cell ◽  
Parapharyngeal Space ◽  
Histopathological Examination ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Neck Tumors ◽  
S 100 ◽  
Fibrous Tumor

Parapharyngeal space tumors are rare and constitute only 0.5–1.0% of head and neck tumors. Minor salivary gland tumor is still rare in parapharyngeal space. We are reporting a case of pleomorphic adenoma of minor salivary gland of parapharyngeal space. A 42-year-old female presented with a history of mass in the oropharynx for 3 years. She presented with “hot potato voice” and dysphagia. CECT and MRI were done, showing large parapharyngeal space tumor. FNAC was suspicious for tumor of nerve cell origin. Tumor was excised using “paramedian mandibulotomy with mandibular swing approach”. Histopathological examination was inconclusive, suggesting possibility of extraskeletal myxoid chondrosarcoma, solitary fibrous tumor, neurogenic tumor. On immunohistochemistry, tumor was positive for cytokeratin, EMA (dim), S-100, and P 63 and negative for SMA thus proving the case as myoepithelial cell-rich pleomorphic adenoma.

scholarly journals Relevance of Regional Lymph Node Invasion in Radical Hepatectomy and Lymphadenectomy for Alveolar Echinococcosis: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Xianwei Yang ◽  
Tao Wang ◽  
Shu Shen ◽  
Wentao Wang
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Alveolar Echinococcosis ◽  
Regional Lymph Node ◽  
Regional Lymph Nodes ◽  
Node Number ◽  
Lymph Node Enlargement ◽  
Group A ◽  
Group B ◽  
Node Diameter

Abstract Background Hepatic Alveolar echinococcosis (AE) is also known as worm cancer, parasitic cancer, and it often invades the regional lymph nodes of the liver. The present study was to investigate the clinical value of radical hepatectomy and lymphadenectomy in AE patients. Methods Our study enrolled consecutive AE patients who underwent radical hepatectomy with removal the regional lymph nodes between January 2009 and April 2019. Patients with inflammatory lymph node enlargement was included in group A, and patients with AE lymph node invasion were included in group B. The clinical characteristics, survival and recurrence rates were compared.Results A total of 103 patients were enrolled group A, and 24 in group B. Preoperative computed tomography showed that the lymph node positivity rate in group B was 70.8% while that in group A was 43.7% (p=0.017). The lymph node diameter was 1.8±0.9 cm in group A vs 2.5±1.1 cm in group B (p=0.004), and the lymph node number (p=0.035) and lymph node location (p=0.001). A total of 10 patients (7.9%) had recurrent lesions, and 6 patients (4.7%) died (P>0.05). Conclusions lymph node diameter, number, and distance from the liver were important characteristics for describing lymph node invasion. There was no difference in the long-term efficacy of lymphadenectomy between patients with lymph node enlargement and those with invasion.

Carcinoma Ex Pleomorphic Adenoma of Upper Lip: An Unusual Presentation

2010 ◽  
Vol 1 (2) ◽  
pp. 121-124
Author(s):  
Devarshi Nandi ◽  
S Shivaprasad ◽  
L Ashok ◽  
BR Ahmed Mujib
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Benign Tumor ◽  
Minor Salivary Gland ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Rare Tumor ◽  
Upper Lip ◽  
Salivary Gland Carcinomas ◽  
Salivary Gland Malignancy

ABSTRACT Carcinoma ex-pleomorphic adenoma is a rare salivary gland malignancy, usually derived from a long-standing or recurrent benign tumor, the pleomorphic adenoma.1 This rare tumor comprises less than 4% of salivary gland neoplasms and 11.6% of salivary gland carcinomas. They mostly involve the “major” salivary glands1 and their occurrence in the minor salivary gland is considered rare, especially in the upper lip. So far there is only one report of CXPA occurring in the upper lip in the literature.13 Hereby, we present a case of carcinoma ex-pleomorphic adenoma in a 52-year-old woman who reported to our department with a painful swelling on the upper lip which was diagnosed and treated successfully.

scholarly journals Pleomorphic Adenoma Arising from Heterotropic Salivary Gland Tumor in a Supraclavicular Lymph Node

2008 ◽  
Vol 23 (2) ◽  
pp. 35-37 ◽  
Author(s):  
Grace Naomi B. Galvan ◽  
Ma. Delhia A. De Leon ◽  
Romulus A. Instrella ◽  
Nixon S. See
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Lymph Node ◽  
Pleomorphic Adenoma ◽  
Cancer Metastasis ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Supraclavicular Lymph Node ◽  
Rare Location

Objectives: To present a case of pleomorphic adenoma arising from heterotopic salivary gland tissue in a supraclavicular lymph node. Design: Case report Setting: Tertiary government hospital Patient:  One   Result: A 38-year-old female consulted with a six month history of an enlarging right supraclavicular mass. Fine needle aspiration biopsy was negative for malignant cells. No primary tumor could be demonstrated elsewhere. Excision biopsy was performed and final histopathology revealed pleomorphic adenoma surrounded by a normal lymph node. Atypical tumor cells and mitoses were not found. Conclusion: Criteria were met for diagnosing heterotopic salivary gland in a supraclavicular lymph node which subsequently developed into pleomorphic adenoma The rare location of the lesion as well as the unusual histopathological result of pleomorphic adenoma arising from a lymph node merited submission of this case report. Key words:  heteroplasia, heterotopic, cancer, metastasis, tumor

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