Minor Salivary Gland Carcinoma ex Pleomorphic Adenoma

AbstractThis paper reviews 22 cases of minor salivary gland carcinoma of the oral cavity or oropharynx which were treated at Kurume University Hospital between 1976 and 2005. Minor salivary gland carcinoma was observed in eight of 362 patients with cancer of the oral cavity (2 per cent), and in 14 of 275 patients with cancer of the oropharynx (5 per cent). The five-year and 10-year survival rates of patients with oropharyngeal minor salivary gland carcinoma were 90 per cent. No statistically significant difference was observed between survival rates for oropharyngeal minor salivary gland carcinoma and for oropharyngeal squamous cell carcinoma (p = 0.06). The five- and 10-year survival rates of patients with oral cavity minor salivary gland carcinoma were 75 and 37 per cent, respectively. No statistically significant difference was observed between survival rates for oral cavity minor salivary gland carcinoma and oral cavity squamous cell carcinoma.Patients' survival results correlated well with the clinical stage of their lesions. A significant difference in survival was observed, comparing stage IV with stages I, II and III (p = 0.04). In contrast, no significant relationship was found between either survival and tumour type or survival and treatment. Adjuvant therapy is recommended for patients with grade III adenoid cystic carcinoma with perineural infiltration or intravascular infiltration.

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P41. Carcinoma ex pleomorphic adenoma in a minor salivary gland of the upper lip

Oral Oncology ◽

10.1016/j.oraloncology.2011.06.284 ◽

2011 ◽

Vol 47 ◽

pp. S87

Author(s):

Z.J. McNamara ◽

M.D. Batstone ◽

C.S. Farah

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Minor Salivary Gland ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Upper Lip ◽

A Minor

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Metachronous Manifestation of Carcinoma Ex Pleomorphic Adenoma in a Buccal Minor Salivary Gland and the Contralateral Parotid Gland: A Case Report and Review of the Literature

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2011.12.016 ◽

2012 ◽

Vol 70 (11) ◽

pp. 2701-2712 ◽

Cited By ~ 3

Author(s):

Kazuo Sano ◽

Shuichi Fujita ◽

Joji Sekine ◽

Masataka Uehara ◽

Noriyuki Sakihama ◽

...

Keyword(s):

Salivary Gland ◽

Case Report ◽

Parotid Gland ◽

Pleomorphic Adenoma ◽

Minor Salivary Gland ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Review Of The Literature

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Carcinoma ex Pleomorphic Adenoma in the Parapharyngeal Space

Philippine Journal of Otolaryngology Head and Neck Surgery ◽

10.32412/pjohns.v28i1.499 ◽

2013 ◽

Vol 28 (1) ◽

pp. 24-27

Author(s):

Sudipta Pal ◽

Sampurna Pati ◽

Somnath Saha ◽

Vedula Padmini Saha

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Malignant Transformation ◽

Parapharyngeal Space ◽

Minor Salivary Gland ◽

Salivary Gland Tumor ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Gland Tumor ◽

Mandibular Swing ◽

Operative Recovery

Objective: To present a case of carcinoma ex pleomorphic adenoma in the parapharyngeal space and discuss its management. Methods: Design: Case Report Setting: Tertiary Government Teaching Hospital Subjects: One Results: A 40-year-old male patient with dysphagia for three months and a left-sided mucosa-covered oropharyngeal mass was found to have a prestyloid parapharyngeal lesion on CT Scans. Fine Needle Aspiration Cytology (FNAC) revealed a pleomorphic adenoma. With a past history of parapharyngeal pleomorphic adenoma excised transorally three years before, the present mass was excised by mandibular swing approach. Post-operative recovery was uneventful, but the final histopathological report was carcinoma ex pleomorphic adenoma. Conclusion: Malignant transformation should be suspected in recurrent salivary tumors in the parapharyngeal space. Provided there was truly no pre-existing malignant focus in the originally-excised tumor, and that early recurrence was not due to inadequate initial excision, this patient had a rare condition where the same tumor underwent malignant transformation within 3 years only. To the best of our knowledge, such an early transformation to malignancy of a minor salivary gland tumor of the parapharyngeal space has not been reported in the English literature. Keywords: carcinoma ex pleomorphic adenoma, pleomorphic adenoma, carcinoma, parapharyngeal space, malignant, transformation, minor salivary gland tumor, mandibular swing

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A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1728 ◽

2015 ◽

Vol 16 (7) ◽

pp. 603-606

Author(s):

Felipe Perozzo Daltoe ◽

Liliane Janete Grando ◽

Maria Inês Meurer ◽

Elena Riet Correa Rivero ◽

Filipe Modolo

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Rare Case ◽

Periodic Acid ◽

Minor Salivary Gland ◽

Salivary Gland Tumor ◽

Immunohistochemical Analysis ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Periodic Acid Schiff

ABSTRACT Mucoepidermoid carcinoma ex pleomorphic adenoma (MCxPA) is a rare salivary gland tumor predominantly found in major salivary glands. A case of MCxPA involving the soft tissue and bone of the retromolar region of a 26-year-old man is presented. The histopathological features revealed a neoplasm with predominance of pleomorphic adenoma (PA) elements, and presence of mucoepidermoid carcinoma malignant epithelial cells in several areas. Histochemical and immunohistochemical studies were positive for periodic acid Schiff, alcian blue, cytokeratins 7, 13, 14, and 19, Bcl-2, c-erbB-2, FGF-2 and maspin in the malignant areas. The patient underwent a partial resection of the left side of the mandible with neck dissection and MCxPA diagnosis was confirmed. How to cite this article Daltoe FP, Grando LJ, Meurer MI, Rivero ERC, Modolo F. A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis. J Contemp Dent Pract 2015;16(7):603-606.

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Prediction of Minor Salivary Gland Carcinoma: A Novel Nomogram and Risk Classification System for Overall Survival and Cancer-Specific Survival

Otolaryngology ◽

10.1177/0194599820938323 ◽

2020 ◽

pp. 019459982093832

Author(s):

Ling-feng lan ◽

Chen-kai Gao ◽

Chao-wu Ma

Keyword(s):

Overall Survival ◽

Salivary Gland ◽

Minor Salivary Gland ◽

Proportional Hazard ◽

Seer Database ◽

Concordance Index ◽

Salivary Gland Carcinoma ◽

Cancer Specific Survival ◽

Cox Proportional Hazard ◽

Gland Carcinoma

Objective Minor salivary gland carcinoma (MiSGC) is rare, and the understanding of this disease is insufficient. This study aimed to identify independent risk factors and develop a nomogram for evaluating the overall survival (OS) and cancer-specific survival (CSS) of patients with MiSGC. Study Design Retrospective cohort study. Setting SEER database (Surveillance, Epidemiology, and End Results). Subjects and Methods We collected data from patients diagnosed with MiSGC between 2004 and 2015 from the SEER database. According to patient registration, all patients were randomly allocated to training sets and validation sets (2:1). Then, Kaplan-Meier product limit curves and Cox proportional hazard regressions were performed to estimate the prognostic effect of variables. Nomograms based on Cox proportional hazard regressions were established to estimate 3- and 5-year OS and CSS. Finally, the nomogram was developed by the training set, and validation was performed with the concordance index, calibration curves, and decision curve analyses. Results In total, 1787 MiSGC cases were registered in SEER. The concordance index for internal validation of OS and CSS prediction was 0.842 and 0.816; that of external validation was 0.871 and 0.831. The calibration plots showed good consistency between nomogram prediction and actual survival. The decision curve analysis showed substantial net benefits of the new predictive model. Conclusions We constructed nomograms and a corresponding risk classification system predicting the OS and CSS of patients with MiSGC. These tools can generate simple-to-use clinical risk grouping and determine the relationship between adjuvant therapy and active surveillance.

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