scholarly journals Eosinophilic Angiocentric Fibrosis Invading the Nasal Septum: A Case Report and Review of Literature

2020 ◽  
pp. 014556132096426
Author(s):  
Seung Cheol Han ◽  
Jeong Hwan Park ◽  
Seung No Hong
Keyword(s):  
Progressive Disease ◽  
Inflammatory Cell ◽  
Recent Literature ◽  
Upper Respiratory Tract ◽  
Review Of Literature ◽  
Soft Tissue Swelling ◽  
Submucosal Mass ◽  
Upper Respiratory ◽  
Unclear Etiology ◽  
Eosinophilic Angiocentric Fibrosis

Eosinophilic angiocentric fibrosis (EAF) is a rare and slowly progressive disease, which usually involves the sino-nasal structures and upper respiratory tract. It is a fibroinflammatory lesion with an unclear etiology. Recent literature suggests a relation to rheumatic or immunological disorders. Therefore, immunophenotypic workup is critical when suspected. We report a case of a 32-year-old man complaining of nasal obstruction lasting more than 2 years. Nasal endoscopy and computed tomography showed a deviated septum with bilateral soft tissue swelling. During the septoturbinoplasty, a submucosal mass with severe adhesion was observed beneath the septal flap. The mass was completely removed. Dense stromal fibrosis with eosinophil-rich inflammatory cell infiltration was found on histologic examination and the patient was diagnosed with EAF. In addition, we reviewed the pathologic diagnostic criteria, differential diagnosis, and management of EAF.

scholarly journals Fluindione and cefixime induced cutaneous bleeding manifestations –A case report and review of literature

2018 ◽  
Vol 8 (3) ◽  
pp. 24
Author(s):  
Nishanthi Anandabaskar ◽  
Nalinidevi Jayabalan ◽  
Mohanasundaram Jayaraman ◽  
Meher Ali Rajamohammad
Keyword(s):  
Drug Interaction ◽  
Oral Anticoagulant Therapy ◽  
Lower Limbs ◽  
Upper Respiratory Tract ◽  
Review Of Literature ◽  
Oral Vitamin ◽  
Periodic Monitoring ◽  
Life Threatening ◽  
Upper Respiratory ◽  
Rheumatic Heart

Fluindione an oral vitamin K antagonist is associated with various hemorrhagic and immunoallergic effects. This drug is also prone to produce various drug interactions, which if not taken into consideration while prescribing, might lead to increased incidence of adverse drug reactions for the patients. We report a case of drug interaction between fluindione and cefixime leading to cutaneous bleeding manifestations and raised PT-INR. Our patient was a 59 year old lady, a known case of rheumatic heart disease and mitral valve replacement, on tablet fluindione 20 mg for past 11 years. She was prescribed tablet cefixime 200 mg two times a day for three days for treatment of upper respiratory tract infection, following which she developed cutaneous bleeding manifestations like ecchymosis and purpura in left upper and lower limbs. She also had a rise in PT-INR level to 4.2, predisposing the patient to life threatening bleeding manifestations. Hence, caution is warranted while prescribing antibiotics to patients on oral anticoagulant therapy. Antibiotics that do not cause drug interaction with the anticoagulants must be selected in these patients. Also, periodic monitoring of PT INR in patients on anticoagulants especially when a new drug is co-prescribed is essential to curb the hazards of potential adverse drug interaction.

scholarly journals Inflammatory Cell Infiltration of Adrenals in COVID-19

2020 ◽  
Vol 52 (09) ◽  
pp. 639-641 ◽  
Author(s):  
Vsevolod A. Zinserling ◽  
Natalya Yu. Semenova ◽  
Alexander G. Markov ◽  
Oksana V. Rybalchenko ◽  
Jun Wang ◽  
...  
Keyword(s):  
Inflammatory Cell ◽  
Adrenal Glands ◽  
Virus Entry ◽  
Upper Respiratory Tract ◽  
Angiotensin Converting Enzyme 2 ◽  
Cd8 T Lymphocytes ◽  
The World ◽  
Upper Respiratory ◽  
Perivascular Infiltration

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November–December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Interestingly, ACE2 is expressed not only in the respiratory system, but also in the other organs and systems including adrenal glands. Here we provide the first description of the pathomorphological changes in adrenal glands in patients with severe COVID-19 characterized by perivascular infiltration of CD3+ and CD8+ T-lymphocytes. Due to the central role of the adrenals in the stress response of the organism, this finding is of potential clinical relevance, because infection with the SARS-CoV-2 virus might critically impair adrenal function under pathophysiological conditions.

scholarly journals Haemophilus influenzae Pyomyositis in a Patient with Diabetic Ketoacidosis: A Unique Case and Review of Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Kamolyut Lapumnuaypol ◽  
Sanna Fatima ◽  
Pradhum Ram ◽  
Gemlyn George ◽  
Antoinette Climaco
Keyword(s):  
Haemophilus Influenzae ◽  
Respiratory Tract Infections ◽  
Upper Respiratory Tract Infections ◽  
Soft Tissue Infections ◽  
Upper Respiratory Tract ◽  
Review Of Literature ◽  
Unique Case ◽  
Negative Bacillus ◽  
Upper Respiratory ◽  
Tract Infections

Haemophilus influenzae is a Gram-negative bacillus commonly known to cause upper respiratory tract infections. Skin and soft tissue infections are very uncommon. Of these, the majority were associated with necrotizing fasciitis requiring emergent debridement. We report a case of pyomyositis caused by Haemophilus influenzae in an adult with diabetes.

scholarly journals Nasal fibrosis: long-term follow up of four cases of eosinophilic angiocentric fibrosis

2005 ◽  
Vol 119 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Santdeep Paun ◽  
Valerie J Lund ◽  
Andrew Gallimore
Keyword(s):  
Soft Tissues ◽  
Disease Process ◽  
Upper Respiratory Tract ◽  
Comprehensive Review ◽  
Long Term Follow Up ◽  
Upper Respiratory ◽  
Facial Soft Tissues ◽  
Eosinophilic Angiocentric Fibrosis

Eosinophilic angiocentric fibrosis is a rare, benign cause of submucosal thickening and fibrosis within the upper respiratory tract. It predominantly affects the nose although cases have been reported in the subglottis. We describe four cases of the disease centred around the nasal cavity, with widespread infiltration of the facial soft tissues and orbit in three of the four patients. Each underwent long term follow up. Multiple surgical resections were required with two of our patients and, to date, medical therapy has been of limited help. The disease process, with its clinical and characteristic histopathological findings, is described. We also discuss the management of the disease following a comprehensive review of, and comparison with, the few prior reported cases.

scholarly journals Vasculitis - Wegener’s granulomatosis in pulmonary practice

2013 ◽  
Vol 66 (suppl. 1) ◽  
pp. 93-100
Author(s):  
Dragana Jovanovic ◽  
Ruza Stevic ◽  
Natalija Samardzic ◽  
Marina Roksandic-Milenkovic ◽  
Marta Velinovic ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Antinuclear Antibodies ◽  
Early Stage ◽  
Clinical Manifestations ◽  
Upper Respiratory Tract ◽  
Review Of Literature ◽  
American College Of Rheumatology ◽  
Granulomatous Vasculitis ◽  
The Mean ◽  
Upper Respiratory

Introduction and Review of Literature. Diagnosis of Wegener?s granulomatosis in the early stage is difficult because nonspecific symptoms of the disease mimic other disorders. Our Experience. A retrospective review of case records of 37 patients with Wegener?s granulomatosis referred to the Institute for Lung Diseases in Belgrade to be diagnosed and treated over a 15-year period was carried out. There were 37 patients (20 males and 17 females), ranging in age from 18 to 73 years (mean age 46.2 years). The mean period from the onset of first symptoms to diagnosis of Wegener?s granulomatosis was 4.59?6.15 months. The American College of Rheumatology criteria were fulfilled in all patients. Twenty-five of 37 patients had evidence of systemic, generalized form of Wegener?s granulomatosis and a limited involvement of the upper and lower respiratory system occurred in 12 cases. The frequency of different system involvement expressed in percents was as follows: the upper respiratory tract 64.8%, the lower respiratory tract 100%, the kidneys 67.5%, the musculoskeletal system 40.5%, the skin 27.2%, the eyes 8.1%, the nervous system in two patients. Anti-neutrophil cytoplasmic antibodies test was positive in 32 (6.5%) patients, and negative in 5 (13.5%). All patients were antinuclear antibodies negative. Histological evidence of granulomatous vasculitis was obtained in 34 (91.9%), whereas in three patients the diagnosis was based on clinical manifestations and positive c-anti-neutrophil cytoplasmic antibodies test.

Eosinophilic angiocentric fibrosis

2003 ◽  
Vol 117 (5) ◽  
pp. 410-413 ◽  
Author(s):  
Abtin Tabaee ◽  
Mani H. Zadeh ◽  
Maria Proytcheva ◽  
Anthony LaBruna
Keyword(s):  
Respiratory Tract ◽  
Rare Disorder ◽  
Upper Respiratory Tract ◽  
Unknown Aetiology ◽  
Histological Findings ◽  
Upper Respiratory ◽  
Eosinophilic Angiocentric Fibrosis

Eosinophilic angiocentric fibrosis of the upper respiratory tract is a rare disorder of unknown aetiology. Despite characteristic histological findings, the aetiology and management of this lesion remain unclear. We describe a case of nasal eosinophilic angiocentric fibrosis and discuss possible demographic and aetiological patterns.

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