Unusual Cervical Lymph Node Metastasis of Papillary Urothelial Carcinoma

Papillary urothelial carcinoma is aggressive and characterized by frequent metastasis to distant sites at an early stage. Papillary urothelial carcinoma of the urinary bladder usually metastasizes to the local lymph nodes, liver, lungs, bone, and mediastinum. Urogenital tract carcinoma of the head and neck metastasis is uncommon and rarely reported to the cervical lymph nodes. We present a case of cervical lymph node metastasis of papillary urothelial carcinoma of the urinary bladder.

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Transitional cell carcinoma of urinary bladder with cervical lymph node metastasis: a case report and review of literature

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20190130 ◽

2019 ◽

Vol 6 (1) ◽

pp. 194

Author(s):

Ramya V. ◽

Sahayaraj J.

Keyword(s):

Bladder Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Urinary Bladder ◽

Lymph Nodes ◽

Cervical Lymph Node ◽

Cervical Lymph Node Metastasis ◽

Regional Lymph Nodes ◽

Cervical Lymph Nodes ◽

Node Metastasis

Bladder cancer usually spreads via the lymphatic and hematogenous routes, the common sites of metastases of urinary bladder cancers being the regional lymph nodes, liver, lung, bone, peritoneum, pleura, kidney, adrenal gland and intestines. Metastasis to non-regional lymph nodes especially cervical lymph nodes is extremely rare presentation. Metastasis to head and neck region is associated with poor prognosis and low survival rate. Here-in we report a case of cervical lymph node metastasis in patient with muscle invasive bladder cancer.

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Maxillary Verrucous Carcinoma Coincident With Cervical Lymph Node Metastasis of Colon Adenocarcinoma

International Surgery ◽

10.9738/cc107.1 ◽

2012 ◽

Vol 97 (3) ◽

pp. 270-274

Author(s):

Hatsumi Yano Kato ◽

Hiroaki Ishibashi ◽

Yoshiki Nariai ◽

Katsumi Hideshima ◽

Michael Vieth ◽

...

Keyword(s):

Colon Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Nodes ◽

Cervical Lymph Node ◽

Verrucous Carcinoma ◽

Colon Adenocarcinoma ◽

Cervical Lymph Node Metastasis ◽

Cervical Lymph Nodes ◽

Node Metastasis

Abstract Cervical lymph node metastasis is an extremely rare event in oral verrucous carcinoma. Isolated cervical lymph node metastasis of colon cancer is also rare. This article describes a case of maxillary verrucous carcinoma accompanied by colon adenocarcinoma that metastasized to a cervical lymph node in a 69-year-old Japanese woman. During preoperative evaluation for maxillary verrucous carcinoma, enlarged cervical lymph nodes and colon cancer were suspected by positron emission tomography. Colonoscopy with biopsies confirmed primary colon adenocarcinoma. Left radical neck dissection, partial maxillectomy, and full-thickness skin graft to the mucosa of the upper lip were performed before treatment of colon adenocarcinoma. Cervical lymph nodes showed metastasis from colon adenocarcinoma, and right hemicolectomy was performed. This is the first case report of synchronous oral verrucous carcinoma and colon adenocarcinoma with cervical lymph node metastasis.

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Microwave Ablation for Papillary Thyroid Cancer With Cervical Lymph Node Metastasis

10.21203/rs.3.rs-111310/v1 ◽

2020 ◽

Author(s):

Zhen-Long Zhao ◽

Ying Wei ◽

Xiao-Jing Cao ◽

Li-Li Peng ◽

Yan Li ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Nodes ◽

Cervical Lymph Node ◽

Microwave Ablation ◽

Cervical Lymph Node Metastasis ◽

Thyroid Function Tests ◽

Cervical Lymph Nodes ◽

Node Metastasis

Abstract Background: To evaluate the feasibility and safety of microwave ablation (MWA) for PTC with metastatic cervical lymph nodes who are ineligible for or refuse surgery. Materials and Methods: Twenty patients of unifocal PTC with metastatic cervical lymph nodes from three hospitals were enrolled in this study, and MWAs were performed. Contrast-enhanced ultrasound was used to evaluate the extent of ablation. The volume of the ablated area and thyroid hormones were measured. Results: PTC nodules in 9 patients completely disappeared at the end of follow-up. Compared with the volume before ablation, the mean volume reduction ratio of ablated lesions was 0.414 ± 0.700 (range: -1.92-0.95) at postoperative 6 months. The patients' thyroid function tests were normal at the end of follow-up. New lymph node metastasis was found in one patient during follow-up visits and she underwent a second MWA procedure. For the other patients, no new PTC nodule, local recurrence or cervical lymph node metastasis were suspected on ultrasound by the end of follow-up. No distant metastasis was encountered during the follow up. None of the patients developed hypocalcemia, permanent hoarseness or skin burns. Conclusions: MWA is a minimal invasive and safe method in treating PTC with cervical lymph node metastasis.

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Cervical lymph node metastasis from transitional cell carcinoma of urinary bladder: Case report and review of literature

Journal of Solid Tumors ◽

10.5430/jst.v2n3p59 ◽

2012 ◽

Vol 2 (3) ◽

Cited By ~ 1

Author(s):

Mutahir A Tunio ◽

Mushabbab Asiri ◽

Yasir Bayoumi ◽

Shoaib Ahmad ◽

Mohsin Fareed

Keyword(s):

Case Report ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Urinary Bladder ◽

Transitional Cell Carcinoma ◽

Cervical Lymph Node ◽

Transitional Cell ◽

Cervical Lymph Node Metastasis ◽

Review Of Literature ◽

Node Metastasis

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Risk factors of the suprasternal lymph node metastasis in papillary thyroid carcinoma with clinical lateral cervical lymph node metastasis

10.21203/rs.3.rs-17663/v1 ◽

2020 ◽

Author(s):

Hyun-Keun Kwon ◽

Yong-Il Cheon ◽

Sung-Chan Shin ◽

Eui-Suk Sung ◽

Jin-Choon Lee ◽

...

Keyword(s):

Risk Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Nodes ◽

Cervical Lymph Node ◽

Cervical Lymph Node Metastasis ◽

Nodal Metastasis ◽

Papillary Thyroid ◽

Inferior Pole ◽

Node Metastasis

Abstract Background: Metastatic lymph nodes are occasionally found in the suprasternal lymph nodes in patients with papillary thyroid cancer (PTC), but there are few studies on these lymph nodes. Therefore, we investigated the frequency and risk factors of suprasternal lymph node metastasis in PTC patients with lateral cervical lymph node metastasis.Methods: A total of 85 patients with cN1b PTC underwent total thyroidectomy with elective lateral neck dissection including the suprasternal lymph nodes. We analyzed the correlation between suprasternal lymph node metastasis and sex, age, tumor characteristics, and cervical lymph node metastasis status.Results: Eleven patients (12.9%) had pathological suprasternal lymph node metastasis. Suprasternal lymph node metastasis was associated with tumors located in the inferior pole and level IV lymph node metastasis.Conclusion: In cN1b PTC patients, especially those with inferior pole tumors and level IV nodal metastasis, the suprasternal lymph node should be routinely dissected.

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Prediction model for cervical lymph node metastasis using CT characteristics in patients with head and neck squamous cell carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e17547 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e17547-e17547

Author(s):

Young Jun Choi ◽

Mi Sun Chung ◽

Jeong Hyun Lee

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Nodes ◽

Head And Neck ◽

Cervical Lymph Node ◽

Cervical Lymph Node Metastasis ◽

Diameter Ratio ◽

Short Axis ◽

Cystic Change ◽

Node Metastasis

e17547 Background: Lymph node metastasis is a major prognostic determinant for patients with head and neck squamous cell cancer (HNSCC). This study aimed to construct a predictive model using CT characteristics of lymph node and tumor for patients with HNSCC to stratify the risk of lymph node metastasis. Methods: The study population was obtained from historical cohort of 472 cervical lymph nodes from 191 patients with HNSCC in a tertiary referral hospital. We analyzed preoperative CT images of lymph nodes according to diameter, ratio of long-to-short axis diameter, necrosis or cystic change, conglomeration, infiltration to adjacent soft tissue, and laterality (ipsilateral vs contralateral) and analyzed T stage. Reference standard was surgical pathologic results. Multivariate logistic regression analysis was performed to predict whether nodules were diagnosed as metastasis or benign. Results: CT features of lymph nodes, including minimal axial diameter, ratio of long-to-short axis diameter, necrosis or cystic change, and T stage were selected as predictors for lymph nodes metastasis. A 10-point risk scoring system was developed, and the risk of malignancy ranged from 7.3% to 99.8%, which was positively associated with increases in risk scores. The areas under the receiver operating characteristic curve of the development and validation sets were 0.886 and 0.879, respectively. Conclusions: We have devised a simple predictive model using the CT characteristics of lymph nodes and tumor for HNSCC to stratify the risk of cervical lymph node metastasis. [Table: see text]

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Primary Evaluation of Appling HMGA2 in the Diagnosis of Thyroid Carcinoma

10.21203/rs.3.rs-531082/v1 ◽

2021 ◽

Author(s):

Jian Shen ◽

Yi Li ◽

Qiong Wu ◽

Yilun Liu ◽

Anqi Jin ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Nodes ◽

Cervical Lymph Node ◽

Thyroid Nodules ◽

Cervical Lymph Node Metastasis ◽

Expression Level ◽

Papillary Thyroid ◽

Node Metastasis ◽

Hmga2 Protein

Abstract Background Molecular marker is on the hot spot for thyroid tumor research in the recent years. The purpose of this study is try to clarify the value of HMGA2 for differential diagnosis between benign and malignant thyroid nodules in order to further assessing the risk of simultaneous cervical lymph nodes metastasis. Methods With a total of 125 thyroid samples, including 85 papillary thyroid carcinomas, 20 follicular thyroid adenomas and 20 normal thyroid tissue were retrospectively analyzed, and we compare expression level of HMGA2 protein among these three groups in this study. PTC group was then subdivided according to the number of metastasis lymph nodes in order to explore the possibility of using HMGA2 protein to predict invasion of lymph nodes in PTC. We also compare the efficiency of BRAFV600E mutation and HMGA2 expression level in the prediagnosis of cervical lymph node metastasis during the experiment. Results Expression rate of HMGA2 protein in PTC was measured at 100%, which has significant statistical differences with HMGA2 in FTA and NT (P < 0.05). Moreover, there was no significant correlation between expression level of HMGA2 and the size of PTC; whether it accompanied by Hashimoto's thyroiditis; high expression level of HMGA2 could be more sensitive in the prediagnosis of cervical lymph node metastasis than BRAFV600E mutation. Conclusion ①HMGA2 protein can be used as a molecular marker for differential diagnosis of benign and malignant thyroid nodules. ②The expression level of HMGA2 protein is correlated with cervical lymph node metastasis in papillary thyroid carcinoma, performing an auxiliary value for clinical decision.

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2108 Cases of Thyroid Cancer: Cervical Lymph Node Dissection or Not

10.21203/rs.3.rs-133510/v1 ◽

2021 ◽

Author(s):

Lin Han ◽

Zhen Wu ◽

Wenlei Li ◽

Yingxue Li ◽

Jinglin Ma ◽

...

Keyword(s):

Thyroid Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Nodes ◽

Lymph Node Dissection ◽

Cervical Lymph Node ◽

Tumor Diameter ◽

Node Dissection ◽

Cervical Lymph Nodes ◽

Node Metastasis

Abstract Based thyroid cancer data from patients treated in Liaocheng People’s Hospital from 2015 to 2018, with Chinese national and regional characteristics, in this study we addressed the controversy of which initial thyroid surgical mode, lobectomy or total thyroidectomy, is most effective. Clinical and pathological data from 2108 patients with thyroid cancer, who were initially diagnosed and treated surgically, were collected from the Department of Thyroid Surgery. The overall metastasis rate of all patients was 57.23%.With the increase of tumor diameter, the metastasis of cervical lymph nodes ranged from 22.54–73.33%, which showed positive correlation.49.32% of patients had lymph node metastasis in the lateral cervical region.When the diameter of the tumor reached T1c level, the metastasis of the cervical lymph nodes was 56.91%, and the number of metastatic cases above T1c level accounted for 69.96% of the total metastatic cases. It is recommended that initial treatment should comprise at least total thyroidectomy + central lymph node dissection in China, to avoid the risks associated with secondary surgery and effects on patient quality of life.When the tumor diameter exceeds 1 cm, the risk of cervical lymph node metastasis is high, we recommended the lateral lymph node dissection.

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