scholarly journals Intranodal Angiomyomatous Hamartoma in a Cynomolgus Monkey

2018 ◽  
Vol 47 (2) ◽  
pp. 190-195 ◽  
Author(s):  
Catherine Thirion-Delalande ◽  
Frédéric Gervais ◽  
Bernard Palate ◽  
Roy Forster ◽  
André Almeida Schenka
Keyword(s):  
Lymph Node ◽  
Cynomolgus Monkey ◽  
Animal Species ◽  
Partial Replacement ◽  
Axillary Lymph ◽  
Human Beings ◽  
Short Term ◽  
Rare Lesion ◽  
The Right ◽  
Toxicological Significance

We describe here an angiomyomatous hamartoma in the right axillary lymph node of a three-year-old male cynomolgus monkey ( Macaca fascicularis), used as a control subject in a short-term toxicity study. This is a very rare lesion that has been reported almost exclusively in inguinal lymph nodes, and to date only in human beings. In the present case, light microscopy revealed partial replacement of the lymph node parenchyma by a disorganized, irregular vascular network, sparsely distributed smooth muscle cells, and a fibro-adipocytic stroma. This was considered to be fortuitous given the age of the animal, with no clinical or toxicological significance. To the best of our knowledge, this is the first report of an intranodal angiomyomatous hamartoma in a nonhuman animal species.

scholarly journals Chyle Leak after Right Axillary Lymph Node Dissection in a Patient with Breast Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Ankita Sarawagi ◽  
Jessica Maxwell
Keyword(s):  
Lymph Node ◽  
Axillary Lymph Node Dissection ◽  
Lymph Node Dissection ◽  
Axillary Lymph Node ◽  
Ductal Carcinoma ◽  
Tissue Expander ◽  
Axillary Lymph ◽  
Node Dissection ◽  
Chyle Leak ◽  
The Right

Background. A female patient was diagnosed with a right-sided chyle leak following right skin sparing mastectomy, axillary lymph node dissection, and immediate tissue expander placement in the setting of invasive ductal carcinoma status post neoadjuvant chemotherapy. Summary. Our patient underwent a level I and II right axillary lymph node dissection followed by an axillary drain placement. On the first postoperative day, a change from serosanguinous to milky fluid in this drain was noted. The patient was diagnosed with a chyle leak based on the milky appearance and elevated triglyceride levels in the fluid. While chyle leaks are rare after an axillary dissection and even rarer to present on the right side, it is a complication of which breast surgeons should be aware. The cause of this complication is thought to be due to injury of the main thoracic duct, its branches, the subclavian duct, or its tributaries. Management is usually conservative; however, awareness of this potential complication even on the right side is of the utmost importance Conclusion. Chyle leaks are an uncommon complication of axillary node dissections and even rarer for them to present on the right side. It can be diagnosed by monitoring the drainage for changes in appearance and volume and by conducting supporting laboratory tests. Conservative management is generally suggested.

Volume-controlled vs no/short-term drainage after axillary lymph node dissection in breast cancer surgery: A meta-analysis

The Breast ◽  
2009 ◽  
Vol 18 (2) ◽  
pp. 109-114 ◽  
Author(s):  
R.A. Droeser ◽  
D.M. Frey ◽  
D. Oertli ◽  
D. Kopelman ◽  
M.J. Baas-Vrancken Peeters ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Axillary Lymph Node Dissection ◽  
Axillary Lymph Node ◽  
Meta Analysis ◽  
Breast Cancer Surgery ◽  
Axillary Lymph ◽  
Node Dissection ◽  
Short Term ◽  
Volume Controlled

Possibility to Use the Radiopharmaceutical Based on the Gamma-Aluminum Oxide Labeled with 99mTc to Identify Sentinel Lymph Nodes in the Experiment

2015 ◽  
Vol 1084 ◽  
pp. 443-446 ◽  
Author(s):  
Vladimir Chernov ◽  
Anna Titskaya ◽  
Ivan Sinilkin ◽  
Roman Zelchan ◽  
Natalya V. Varlamova
Keyword(s):  
Experimental Study ◽  
Lymph Node ◽  
Aluminum Oxide ◽  
Lymph Nodes ◽  
Axillary Lymph Node ◽  
Subcutaneous Injection ◽  
Sentinel Lymph Nodes ◽  
Male Rats ◽  
Axillary Lymph ◽  
The Right

Studying the possibility of using the radiopharmaceutical to identify sentinel lymph nodes were carried out on male rats. The preparation was injected subcutaneously in the I interfinger space of the right forelimb. Radiometry of rats’ organs showed that the studied preparation was actively accumulated in the axillary lymph node after subcutaneous injection. The experimental study of the pharmacokinetics of radiopharmaceutical based on gamma-oxide aluminum labeled with 99mTc showed that the analyzed RPP can be successfully used for lymphoscintigraphy and visualization of sentinel node starting with the 15th minute and up to the 24th hour after subcutaneous injection.

scholarly journals Case report: association between lymph node tuberculosis and breast cancer

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
Marina Fontes Medeiros ◽  
Gustavo Lanza de Melo ◽  
Thássia Mariz de Melo ◽  
Rachel Saraiva Teatini Selim de Sales ◽  
Janaina Cotta Rodrigues Ferreira
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Pulmonary Nodules ◽  
Southeastern Brazil ◽  
Tuberculous Lymphadenitis ◽  
Axillary Lymph ◽  
Safety Margins ◽  
Lymph Node Tuberculosis ◽  
The Right

Introduction: Lymph node tuberculosis is the most common extra-lung presentation of tuberculosis, responsible for 43% of peripheral lymphadenopathies in developing countries. The coexistence between lymph node tuberculosis and breast cancer is rare, ranging from 0.1% to 4.9%.Objective: To present a case of axillary lymph node tuberculosis due to its rare association with breast cancer. Methods: We have investigated the case of a 48-year-old woman from Congonhas, Minas Gerais, Southeastern Brazil, who presented a palpable nodule in the junction of the right upper quadrants with two years of progression, category 4B of the Breast Imaging Reporting and Data System (BI-RADS) on mammography and ultrasound, with core needle biopsy compatible with benignancy. No axillary lymphadenopathy was identified. Case report: The patient underwent resection of the right breast nodule with safety margins due to disagreement between biopsy and imaging tests. Anatomopathological examination was consistent with luminal B invasive ductal carcinoma, measuring 1.6 cm. The patient was submitted to sentinel lymph node biopsy using patent blue in the right axilla. Anatomopathological analysis revealed tuberculous lymphadenitis. Chest computed tomography showed pulmonary nodules. The patient received adjuvant radiotherapy and tamoxifen, as well as antituberculous antibiotics, with regression of pulmonary nodules. The final staging was pT1cN0M0- IA. Discussion: Most cases of coexistence between these diseases involve tuberculous lymphadenitis with or without neoplastic lymph node involvement. Some reports indicate that the involvement by tuberculosis does not prevent neoplastic proliferation. Before starting chemotherapy, tuberculosis must be treated to avoid the immunosuppressive effect that can cause a spread of tuberculosis. Conclusion: Despite the rare coexistence of these diseases, we should not rule out this possibility, especially in endemic tuberculosis areas. Also, an accurate diagnosis prevents incorrect staging and can spare the patient from a more aggressive treatment.

Passive and specific targeting of lymph nodes: the influence of the administration route

2015 ◽  
Vol 7 (2) ◽  
Author(s):  
Marion Pitorre ◽  
Guillaume Bastiat ◽  
Elodie Marie dit Chatel ◽  
Jean-Pierre Benoit
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Injection Site ◽  
Lymph Flow ◽  
Axillary Lymph Nodes ◽  
Optimal Size ◽  
Axillary Lymph ◽  
Left And Right ◽  
The Right ◽  
Weak Accumulation

AbstractPatients diagnosed with an advanced-stage cancer present a dismal prognosis due to the presence of metastases. From the primary tumor, the cancer cells are disseminated via lymphatic circulation; metastases develop initially in lymph nodes. Therefore, the targeting of lymph nodes needs to be improved in the design of future chemotherapy, and one way to ensure this targeting is by using the subcutaneous (SC) route. Using lipid nanocapsules (LNCs) (40 nm and fluorescently-labeled with DiD) as nanocarriers, a correlation between the SC injection site (behind the neck, the right and left flanks, and above the tail) for LNC administration and specific lymph node accumulation (left and right cervical, axillary and inguinal lymph nodes) was achieved for Sprague-Dawley rats. The pharmacokinetic and biodistribution profiles confirmed the absence of LNCs in systemic circulation after SC administration due to the optimal size of the LNCs. With appropriate SC administration, LNCs can accumulate in specific lymph nodes, whereas IV administration led to a weak accumulation of LNCs in all lymph nodes. Specific accumulation followed the lymph flow: bottom-up from the lower to upper limbs and top down from the head, with two lymph circulation partitions: right upper limb and the rest. Administration above the tail presented high inguinal and axillary lymph node accumulation whereas weak accumulation was observed after administration behind the neck. LNCs administered in the left flank only accumulated in the left inguinal and axillary lymph nodes, whereas left and right inguinal and axillary lymph nodes presented accumulation after administration in the right flank. Cervical lymph nodes, in the opposite direction of lymph flow, were never targeted after SC administration, whatever the injection site.

scholarly journals Prevention of Breast Cancer-Related Lymphedema Using the Lymphatic Microsurgical Preventive Healing Approach: A Case Report

2021 ◽  
Author(s):  
Min Suk Park ◽  
Jin A Yoon ◽  
Jae Woo Lee ◽  
Joo Hyoung Kim
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Axillary Lymph Node Dissection ◽  
Lymph Node Dissection ◽  
Axillary Lymph Node ◽  
Axillary Lymph ◽  
Axillary Vein ◽  
Node Dissection ◽  
Breast Cancer Related Lymphedema ◽  
The Right

Breast cancer-related lymphedema is a major complication of breast cancer surgery. The lymphatic microsurgical preventive healing approach, a surgical technique that can prevent breast cancer-related lymphedema, creates a lymphovenous bypass between the damaged axillary lymphatics during axillary lymph node dissection and the axillary vein. We report a case using the unilateral lymphatic microsurgical preventive healing approach in a patient with bilateral breast cancer. A 58-year-old woman diagnosed with bilateral invasive ductal carcinoma underwent a bilateral nipple-sparing mastectomy. The lymphatic microsurgical preventive healing approach was performed on the left side after axillary lymph node dissection; the lymphatic microsurgical preventive healing approach was not performed after axillary sentinel lymph node biopsy on the right side. Six months after the surgery, MD Anderson Cancer Center stage 2 lymphedema was observed in the lymphography images of the right arm, where the lymphatic microsurgical preventive healing approach had not been performed.

scholarly journals Active Herpes Zoster Mimicking Worsening of Axillary Lymph Node Metastases of Breast Cancer after Chemotherapy on 18F-Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1085
Author(s):  
Tomoyuki Fujioka ◽  
Kota Yokoyama ◽  
Mio Mori ◽  
Yuka Yashima ◽  
Emi Yamaga ◽  
...  
Keyword(s):  
Lymph Node ◽  
Herpes Zoster ◽  
Axillary Lymph Node ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Node Metastasis ◽  
Positron Emission ◽  
Pet Ct ◽  
The Right ◽  
Pet Ct Scan

A woman in her 60s presented to our hospital with a left breast mass that was diagnosed as breast cancer. 18F-Fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) revealed intense, hot uptake in the cancerous mass and left axillary lymph node metastasis. After chemotherapy, another PET/CT scan was performed. Although the mass and left axillary lymph nodes shrank and FDG uptake decreased, enlarged lymph nodes with high FDG uptake appeared in the right axilla. The patient had a painful vesicular eruption on the front to the back of the right upper hemithorax, which was diagnosed as active herpes zoster. Active herpes zoster mimics a worsening axillary lymph node metastasis on the PET/CT scan.

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