Evidence of Maxillary Sinus Inflammation in Seasonal Allergic Rhinitis

2012 ◽  
Vol 146 (6) ◽  
pp. 880-886 ◽  
Author(s):  
Fuad M. Baroody ◽  
Samantha M. Mucha ◽  
Marcy deTineo ◽  
Robert M. Naclerio
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Maxillary Sinus ◽  
Medical Center ◽  
Academic Medical Center ◽  
Allergic Inflammation ◽  
Prospective Longitudinal Study ◽  
Academic Medical ◽  
Prospective Longitudinal

Objective. Allergic rhinitis has been frequently associated with both acute and chronic sinusitis. Previous studies have shown an influx of eosinophils into the maxillary sinus after nasal challenge with allergen. The objective of this study was to determine, in humans, if the development of seasonal allergic inflammation, secondary to natural allergen exposure, leads to similar inflammation within the maxillary sinus. Study Design. Prospective, longitudinal study. Setting. Academic medical center and research laboratory. Subjects and Methods. Eighteen subjects were evaluated in and out of the ragweed allergy season using subjective measures (nasal symptoms, quality of life), nasal secretory response to methacholine challenge, and evaluation of biomarkers in nasal and sinus lavages. Results. The subjects became symptomatic during the season and reported worse quality of life and increased nasal reactivity to methacholine. The total number of eosinophils obtained by nasal lavage during the season (median= 35,691) was significantly higher compared with out of season (median = 2811, P ≤ .02). Similarly, there were significantly more eosinophils, albeit to a lesser magnitude, in the maxillary sinus during the season (median = 4248) compared with the out-of-season samples (median = 370, P ≤ .02). Conclusion. The authors provide evidence that natural exposure to pollen during an individual’s allergy season leads to both nasal and sinus inflammation, strengthening the association between allergic rhinitis and sinusitis. The mechanism of this inflammatory response needs to be elucidated.

Acitretin

2016 ◽  
Vol 21 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Marcus G. Tan ◽  
Neil H. Shear ◽  
Scott Walsh ◽  
Raed Alhusayen
Keyword(s):  
Quality Of Life ◽  
Partial Response ◽  
Inflammatory Disease ◽  
Hidradenitis Suppurativa ◽  
Medical Center ◽  
Academic Medical Center ◽  
Case Series ◽  
Global Scale ◽  
Academic Medical

Background: Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory disease of the pilosebaceous follicle that severely affects patients’ quality of life and can be challenging for clinicians to manage. A few case series have reported on the efficacy of acitretin monotherapy in the treatment of intractable HS. Objective: To assess the efficacy of acitretin for the treatment of intractable HS. Methods: A retrospective review was conducted involving all patients with HS who received acitretin between January 2011 and January 2015 in a tertiary academic medical center. All patients with HS who received acitretin, either as a monotherapy or as an adjuvant to other systemic medications, were included, and clinical response was assessed using the physician global scale. Results: Fourteen patients with HS (mean age 48 years [range 32-64 years]; 9 [64%] were men) received acitretin. Most patients (86%) had Hurley stage II or III disease. All patients had failed other standard systemic medications prior to initiating acitretin. Six patients (43%) received acitretin monotherapy, and 8 patients (57%) received acitretin as an adjuvant to other standard systemic medications. None of the patients who received acitretin monotherapy exhibited clinical improvements. Clinical improvements were observed in 7 of the 8 (87.5%) patients who received acitretin as an adjuvant to other systemic medications, with 3 patients (37.5%) exhibiting partial response and 4 patients (50%) exhibiting good response. Conclusions and Relevance: Acitretin monotherapy was ineffective for the treatment of intractable HS. Acitretin may be effective when used as an adjuvant to other systemic medications.

144: A Prospective Longitudinal Study of Quality of Life Following Radical Perineal Prostatectomy

2004 ◽  
Vol 171 (4S) ◽  
pp. 38-38
Author(s):  
Benjamin K. Yang ◽  
Matthew D. Young ◽  
Brian Calingaert ◽  
Johannes Vieweg ◽  
Brian C. Murphy ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Longitudinal Study ◽  
Prospective Longitudinal Study ◽  
Perineal Prostatectomy ◽  
Prospective Longitudinal

scholarly journals Quality of life of critically ill patients in a developing country: a prospective longitudinal study

2016 ◽  
Vol 28 (10) ◽  
pp. 2915-2920
Author(s):  
José Marcelo e Souza Mafra ◽  
Janete Maria da Silva ◽  
Leda Tomiko Yamada da Silveira ◽  
Carolina Fu ◽  
Clarice Tanaka
Keyword(s):  
Quality Of Life ◽  
Longitudinal Study ◽  
Developing Country ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

scholarly journals Inpatient Hospice Palliative Care Unit and Palliative Consultation Service Enhance Comprehensive Quality of Life Outcomes in Terminally Ill Cancer Patients: A Prospective Longitudinal Study

2021 ◽  
Vol 18 (17) ◽  
pp. 8992
Author(s):  
Li-Fang Chang ◽  
Li-Fen Wu ◽  
Chi-Kang Lin ◽  
Ching-Liang Ho ◽  
Yu-Chun Hung ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Hospice Care ◽  
Terminally Ill ◽  
Consultation Service ◽  
Prospective Longitudinal Study ◽  
Terminally Ill Cancer Patients ◽  
Prospective Longitudinal ◽  
Hospice Palliative Care

This study aimed to explore the effectiveness of an inpatient hospice palliative care unit (PCU) and palliative consultation service (PCS) on comprehensive quality of life outcome (CoQoLo) among terminally ill cancer patients. This was a prospective longitudinal study. Terminally ill cancer patients who met the inclusion criteria and received PCU or PCS in a northern Taiwanese medical center were recruited. The CoQoLo Inventory was used to measure CoQoLo level pre- and seven days following hospice care between August 2018 and October 2019. A total of 90 patients completed the study. No significant differences were found in CoQoLo levels between the PCU and PCS groups pre- and seven days following care. However, the CoQoLo level of patients significantly improved seven days following care in both PCU and PCS groups, compared with pre-hospice care. Patients’ age, religious belief, marital status, closeness with family, palliative prognostic index (PPI), and symptom severity were significant concerning CoQoLo levels after adjusting for patients’ baseline characteristics. PCU and PCS showed no difference in CoQoLo levels, but both of them can improve CoQoLo among terminally ill cancer patients. These patients could receive PCU or PCS to achieve a good CoQoLo at the end-of-life stage.

scholarly journals The problem with treating sinusitis against the background of allergic rhinitis

2019 ◽  
pp. 110-114
Author(s):  
A. I. Kryukov ◽  
A. B. Turovsky ◽  
I. G. Kolbanova ◽  
Yu. V. Luchsheva ◽  
K. M. Musaev ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Allergic Inflammation ◽  
Histamine Receptor ◽  
Receptor Blocker ◽  
Basic Principles ◽  
Financial Costs ◽  
Health Burden ◽  
Histamine Antagonist

Both allergic rhinitis (AR) and sinusitis are widespread diseases that significantly worsen the patient’s quality of life, lead to significant financial costs and are associated with a huge health burden. When treating any AS, it is necessary to follow three basic principles: address the cause of the disease; eradicate the pathogen; restore drainage of sinuses, aerate and restore CO. The efficacy and speed in the treatment of sinusitis, which arose against the background of allergic inflammation, are comparable to those in the use of oral GCS (Ib level, persuasion scale A). The H1-histamine receptor blocker and competitive histamine antagonist ebastine is one of the most effective and safe latest-generation antihistamine.

scholarly journals Comprehensive quality of discharge summaries at an academic medical center

2013 ◽  
Vol 8 (8) ◽  
pp. 436-443 ◽  
Author(s):  
Leora I. Horwitz ◽  
Grace Y. Jenq ◽  
Ursula C. Brewster ◽  
Christine Chen ◽  
Sandhya Kanade ◽  
...  
Keyword(s):  
Medical Center ◽  
Academic Medical Center ◽  
Academic Medical ◽  
Discharge Summaries
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