Preservation of Viscoelastic Properties of Rabbit Vocal Folds after Implantation of Hyaluronic Acid-Based Biomaterials

2012 ◽  
Vol 147 (3) ◽  
pp. 515-521 ◽  
Author(s):  
Jeong-Seok Choi ◽  
Nahn Ju Kim ◽  
Sarah Klemuk ◽  
Yun Ho Jang ◽  
In Suh Park ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Viscoelastic Properties ◽  
Vocal Folds

Histologic Characterization of Rat Vocal Fold Scarring

2005 ◽  
Vol 114 (3) ◽  
pp. 183-191 ◽  
Author(s):  
Tomoko Tateya ◽  
Jin Ho Sohn ◽  
Ichiro Tateya ◽  
Diane M. Bless
Keyword(s):  
Hyaluronic Acid ◽  
Vocal Fold ◽  
Type I Collagen ◽  
Collagen Type ◽  
Control Level ◽  
Vocal Folds ◽  
Collagen Type I ◽  
Type I ◽  
Type Iii ◽  
Blue Stain

This study aimed to clarify the characteristics of rat vocal fold scarring by examining the alteration of key components in the extracellular matrix: hyaluronic acid, collagen, and fibronectin. Under monitoring with a 1.9-mm-diameter telescope, unilateral vocal fold stripping was performed, and larynges were harvested at 2, 4, 8, and 12 weeks after operation. The vocal folds were histologically analyzed with Alcian blue stain, trichrome stain, and immunofluorescence of collagen type I, collagen type III, and fibronectin. The scarred vocal folds showed less hyaluronic acid and more collagen types I and III than did the controls at all time points. Type III was stable for 12 weeks, while type I declined until 8 weeks and thereafter remained unchanged. Fibronectin increased for 4 weeks and then decreased; it was close to the control level at 8 and 12 weeks. These results suggest that the tissue remodeling process in scarred vocal folds slows down around 2 months after wounding.

scholarly journals Analysis of hyaluronic acid concentration in rat vocal folds during estral and gravidic puerperal cycles

2009 ◽  
Vol 75 (5) ◽  
pp. 654-659
Author(s):  
José Eduardo de Sá Pedroso ◽  
Osíris Camponês do Brasil ◽  
João Roberto Maciel Martins ◽  
Helena Bociane Nader ◽  
Manuel de Jesus Simões
Keyword(s):  
Hyaluronic Acid ◽  
Acid Concentration ◽  
Vocal Folds

scholarly journals The Efficacy and Safety of Hyaluronic Acid Microinjection for Skin Rejuvenation in Vietnam

2019 ◽  
Vol 7 (2) ◽  
pp. 234-236 ◽  
Author(s):  
Hao Nguyen Trong ◽  
Thao Vu Thi Phuong ◽  
Thuong Van Nguyen ◽  
Ha Vu Thai ◽  
Nghi Dinh Huu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Viscoelastic Properties ◽  
Rating Scale ◽  
Modern Society ◽  
Efficacy And Safety ◽  
Skin Rejuvenation ◽  
Severity Rating ◽  
Significant Clinical Improvement ◽  
The Face ◽  
The Aesthetic

BACKGROUND: Aging is an increasing concern of modern society, particularly facial ageing. In recent years, the microinjection technique has increasingly been emphasised as a skin rejuvenation strategy. Hyaluronic acid (HA) plays an important role in the hydration of the extracellular space and can thus improve skin hydration, firmness and viscoelastic properties. AIM: To evaluate the efficacy and safety of HA microinjection in skin rejuvenation. METHODS: We enrolled thirty participants underwent three sessions of HA microinjection involving multiple injections in the face or back of the hands at 2-week intervals. The aesthetic outcomes were assessed at baseline and after 2, 4 and 8 weeks. Clinical evaluation was based on the Global Aesthetic Improvement Scale (GAIS) and the Wrinkle Severity Rating Scale (WSRS). RESULTS: Evaluation of photographs from 2, 4 and 8 weeks revealed significant clinical improvement in the brightness, texture and wrinkling of the skin. Analysis of the GAIS and WSRS scores revealed statistically significant results after 2 months. CONCLUSION: Most of the participants felt satisfied with the treatment (93.3%).

scholarly journals Hyaluronic Acid Based Hydrogels for Regenerative Medicine Applications

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Assunta Borzacchiello ◽  
Luisa Russo ◽  
Birgitte M. Malle ◽  
Khadija Schwach-Abdellaoui ◽  
Luigi Ambrosio
Keyword(s):  
Hyaluronic Acid ◽  
Viscoelastic Properties ◽  
Structural Parameters ◽  
Weight Ratio ◽  
Rheological Behaviour ◽  
Biological Properties ◽  
Cross Linking ◽  
In Vitro Tests ◽  
The Cross

Hyaluronic acid (HA) hydrogels, obtained by cross-linking HA molecules with divinyl sulfone (DVS) based on a simple, reproducible, and safe process that does not employ any organic solvents, were developed. Owing to an innovative preparation method the resulting homogeneous hydrogels do not contain any detectable residual cross-linking agent and are easier to inject through a fine needle. HA hydrogels were characterized in terms of degradation and biological properties, viscoelasticity, injectability, and network structural parameters. They exhibit a rheological behaviour typical of strong gels and show improved viscoelastic properties by increasing HA concentration and decreasing HA/DVS weight ratio. Furthermore, it was demonstrated that processes such as sterilization and extrusion through clinical needles do not imply significant alteration of viscoelastic properties. Both SANS and rheological tests indicated that the cross-links appear to compact the network, resulting in a reduction of the mesh size by increasing the cross-linker amount. In vitro degradation tests of the HA hydrogels demonstrated that these new hydrogels show a good stability against enzymatic degradation, which increases by increasing HA concentration and decreasing HA/DVS weight ratio. Finally, the hydrogels show a good biocompatibility confirmed by in vitro tests.

Viscoelastic properties modulation of a novel autocrosslinked hyaluronic acid polymer

1996 ◽  
Vol 7 (11) ◽  
pp. 695-698 ◽  
Author(s):  
M. Mensitieri ◽  
L. Ambrosio ◽  
L. Nicolais ◽  
D. Bellini ◽  
M. O'Regan
Keyword(s):  
Hyaluronic Acid ◽  
Viscoelastic Properties

scholarly journals Effects of Dehydration on the Viscoelastic Properties of Vocal Folds in Large Deformations

2012 ◽  
Vol 26 (6) ◽  
pp. 688-697 ◽  
Author(s):  
Amir K. Miri ◽  
François Barthelat ◽  
Luc Mongeau
Keyword(s):  
Viscoelastic Properties ◽  
Large Deformations ◽  
Vocal Folds

Concentration of Hyaluronic Acid in Human Vocal Folds in Young and Old Subjects

2011 ◽  
Vol 145 (6) ◽  
pp. 981-986 ◽  
Author(s):  
Gustavo Polacow Korn ◽  
João Roberto Maciel Martins ◽  
Sung Woo Park ◽  
Aline Mendes ◽  
Elsa Yoko Kobayashi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Age Groups ◽  
Vocal Folds ◽  
Neck Surgery ◽  
Elderly Subjects ◽  
Enzyme Linked Immunosorbent Assay ◽  
Women Subjects ◽  
Younger Women ◽  
Young Subjects ◽  
Surgery Department

Objective. To compare and evaluate concentrations of hyaluronic acid (HA) in normal vocal folds of both young and elderly people of both sexes. Study Design. Experimental study. Setting. The research was carried out at the ENT, Head and Neck Surgery Department and the Pharmacology Institute of São Paulo Federal University. Subjects and Methods. Enzyme-linked immunosorbent assay plates coated with biotin-conjugated binding protein and streptavidin-europium conjugate were sequentially incubated with samples from the middle portion of the cover, vocal ligament, and vocal muscle of 19 young and 20 elderly subjects of both sexes. After the release of europium in an enhancement solution, final fluorescence was measured using a fluorometer. Results. Statistically significant comparisons: (1) all subject groups combined exhibited a higher HA concentration in the cover and ligament compared with the muscle samples; (2) women subjects had a significantly lower HA concentration in muscle compared with the ligament, and male subjects showed significantly lower HA in muscle compared with the cover; and (3) both genders of young subjects showed a higher HA concentration in ligament samples compared with the muscle. Conclusion. HA concentrations are higher in the cover and ligament compared with the muscle in both genders and age groups, and there is a higher HA concentration in ligament compared with the muscle of young subjects of both genders. HA levels in the cover samples of younger women showed great variability that may relate to ovarian hormone levels, reflecting different phases of the menstrual cycle.

scholarly journals Cervids with different vocal behavior demonstrate different viscoelastic properties of their vocal folds

2009 ◽  
Vol 271 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Tobias Riede ◽  
Susan Lingle ◽  
Eric J. Hunter ◽  
Ingo R. Titze
Keyword(s):  
Viscoelastic Properties ◽  
Vocal Folds ◽  
Vocal Behavior
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