Response to “Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts”

2021 ◽  
Vol 165 (4) ◽  
pp. 606-606
Author(s):  
Enrique Salmerón-González ◽  
Elena García-Vilariño ◽  
Ignacio Llópez-Carratalá ◽  
Diego Collado-Martin ◽  
José María Perolada-Valmaña ◽  
...  
Keyword(s):  
Vocal Folds ◽  
Autologous Fat ◽  
Fat Grafts

In Reference to “Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts”

2021 ◽  
Vol 165 (4) ◽  
pp. 605-605
Author(s):  
Giovanna Cantarella ◽  
Riccardo F. Mazzola
Keyword(s):  
Vocal Folds ◽  
Autologous Fat ◽  
Fat Grafts

Long-term Survival of Autologous Fat Grafts into the Vocal Folds

2014 ◽  
Vol 151 (1_suppl) ◽  
pp. P72-P73
Author(s):  
Guillermo Campos ◽  
Natalia Mantilla ◽  
Sonia Bermudez
Keyword(s):  
Vocal Folds ◽  
Term Survival ◽  
Long Term Survival ◽  
Autologous Fat ◽  
Fat Grafts

Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts

2020 ◽  
Vol 163 (6) ◽  
pp. 1226-1231
Author(s):  
Enrique Salmerón-González ◽  
Elena García-Vilariño ◽  
Ignacio Llópez-Carratalá ◽  
Diego Collado-Martin ◽  
José María Perolada-Valmaña ◽  
...  
Keyword(s):  
Tumor Resection ◽  
Vocal Folds ◽  
Complication Rates ◽  
Injection Laryngoplasty ◽  
Glottic Insufficiency ◽  
Time Jitter ◽  
Autologous Fat ◽  
Maximum Phonation Time ◽  
Fat Grafts ◽  
The Voice

Objective To review the results of a series of patients with glottic insufficiency caused by scarred vocal folds who underwent injection laryngoplasty with centrifuged and emulsified autologous fat. Study Design Prospective cohort. Setting Single center, tertiary institution. Subjects and Methods Examination of the medical records of 21 patients operated on through injection laryngoplasty with fat grafts for the treatment of dysphonia was performed. All patients were operated on between January of 2015 and September of 2019. The voice variables measured were the GRABS (Grade, Roughness, Breathiness, Asthenia, Strain) scale, the Voice Handicap Index–10 (VHI-10), maximum phonation time, jitter, shimmer, and harmonic/noise ratio before surgery and 8 months later. Results Twenty-six injection laryngoplasties were performed in 21 patients during the reviewed period. Seventeen were men, and 4 were women. Mean age was 57.2 (range, 18-80) years. Mean (SD) follow-up time was 20.7 (9.3) months. Etiology of dysphonia was scarring after tumor resection in 17 patients and sulcus vocalis in 4. Five patients received an additional injection laryngoplasty. Statistically significant improvements were observed in all the parameters evaluated ( P < .05). Conclusions Injection laryngoplasty with fat grafts processed through centrifugation and emulsification is an effective technique for the treatment of dysphonia caused by glottic insufficiency related to scarred vocal folds, with minimal complication rates.

Targeted Protection of Donor Graft Vasculature Using a Phosphodiesterase Inhibitor Increases Survival and Predictability of Autologous Fat Grafts

2015 ◽  
Vol 135 (2) ◽  
pp. 488-499 ◽  
Author(s):  
Marc A. Soares ◽  
Obinna C. Ezeamuzie ◽  
Maria J. Ham ◽  
April M. Duckworth ◽  
Piul S. Rabbani ◽  
...  
Keyword(s):  
Phosphodiesterase Inhibitor ◽  
Autologous Fat ◽  
Fat Grafts ◽  
Donor Graft

Autologous Fat Transplantation

1997 ◽  
Vol 14 (4) ◽  
pp. 433-443 ◽  
Author(s):  
Melvin A. Shiffman
Keyword(s):  
Preliminary Analysis ◽  
Personal Communication ◽  
Review Of The Literature ◽  
Fat Transplantation ◽  
Experimental Procedure ◽  
Autologous Fat ◽  
Fat Grafts ◽  
Autologous Fat Transplantation ◽  
Practicing Physicians ◽  
Attention To Detail

A preliminary analysis of the methods that have been used and the results achieved since fat grafts were first used in 1889 is presented. Descriptions of the techniques used by several practicing physicians were collected by personal communication and a review of the literature and are recorded in this paper. Although the process of fat transplantation has not been standardized, it can no longer be considered an experimental procedure as enough surgeons have shown that there can be consistently good results. Failures and complications are not the result of the theory that fat cannot be transplanted, but the result of errors in technique and not adequate attention to detail.

Use of Autologous Fat Grafts for the Endoscopic Reconstruction of Skull Base Defects: Indications, Outcomes, and Complications

2018 ◽  
Vol 32 (4) ◽  
pp. 310-317 ◽  
Author(s):  
Kent Lam ◽  
Amber U. Luong ◽  
William C. Yao ◽  
Martin J. Citardi
Keyword(s):  
Skull Base ◽  
Tertiary Care ◽  
Anterior Skull Base ◽  
Fat Graft ◽  
Skull Base Reconstruction ◽  
Autologous Fat ◽  
Fat Grafts ◽  
Autologous Fat Graft ◽  
Skull Base Defects ◽  
Csf Leaks

Background The use of abdominal free fat is a traditional surgical method for the repair and reconstruction of the anterior skull base. Our objective is to assess the outcomes associated with the autologous fat graft to endoscopically repair anterior skull base defects at a single tertiary care center. Methods All patients, who underwent endoscopic skull base repair utilizing abdominal free fat from September 2009 to June 2016, were included for retrospective chart review. Evaluated outcome measurements included (1) the successful closure of preoperative and intraoperative cerebrospinal fluid (CSF) leaks and (2) complications at both donor and recipient graft sites during the postoperative periods. Four representative clinical cases have additionally been selected to highlight the common indications for which the fat graft may be effective in skull base reconstruction. Results Of the 27 patients who were identified for inclusion in this review, 25 (92.6%) demonstrated successful repair of preoperative or intraoperative CSF leaks following primary skull base repair. Two patients developed recurrent CSF leaks occurring about 1 week after their primary closures, and a secondary closure rate of 96.3% was achieved with use of fat grafts. Other complications included seroma and hematoma formation at the abdominal donor sites, each occurring in 1 patient. Conclusions The use of autologous fat remains a viable option for grafting material during endoscopic skull base reconstruction. Despite the wide variety of closure techniques in skull base surgery, autologous fat provides safe and easily accessible material to repair CSF leaks.

scholarly journals The Effect of Thymosin beta4 on the Survival of Autologous Fat Grafting: A Preliminary Study

2020 ◽  
Vol 40 (9) ◽  
pp. NP519-NP529
Author(s):  
Yaping Qu ◽  
Qian Wang ◽  
Su Fu ◽  
Xiaoshuang Guo ◽  
Jie Luan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adipose Tissue ◽  
Magnetic Resonance ◽  
Fat Grafting ◽  
Weight Retention ◽  
Resonance Imaging ◽  
Autologous Fat Grafting ◽  
Common Procedure ◽  
Autologous Fat ◽  
Fat Grafts

Abstract Background Autologous fat grafting is a common procedure to improve tissue deficiencies. However, the survival rate of fat grafting is unpredictable. Thymosin beta 4 (Tß4), a multifunctional peptide containing 43 amino acids, is effective in angiogenesis, inhibiting apoptosis and inflammation. Objectives The authors initially investigated the potential effect of Tß4 in fat grafting. Methods Adipose tissue premixed exogenous Tß4 were transplanted into rabbit ears. Rabbits were randomly assigned to 3 groups: group A, 5 μg/mL Tß4; group B, 10 μg/mL Tß4; and group C, phosphate-buffered saline buffer as a blank control. The fat grafts were subjected to magnetic resonance imaging at 2, 4, and 12 weeks in vivo. Each harvested graft was analyzed at 3 time points after transplantation. Results The fat grafts in the Tß4-treated groups showed better volume and weight retention, greater adipose tissue integrity, adipocyte viability, and angiogenesis. The results of dynamic contrast-enhanced magnetic resonance imaging also showed that the experimental groups increased microcirculation perfusion of the grafts. Conclusions The study proved that Tß4 could improve adipose tissue survival and neovascularization. It may be useful for fat grafting as a potential protective reagent.

Autologous Fat Grafts by Injection-Ten Years' Experience

1992 ◽  
Vol 9 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Gerald Johnson
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Augmentation ◽  
Recipient Site ◽  
Autologous Fat ◽  
Abdominal Skin ◽  
Fat Grafts ◽  
Microscopic Evaluation ◽  
Autologous Grafts ◽  
Fat Survival

The use of surgically excised/mechanically fragmented dermal fat grafts by injection led to the use of suction-aspirated fat for autologous grafts by injection. Efforts to scientifically evaluate the fat survival began with a microscopic evaluation of the integrity of the aspirated fat in a series of patients. The next study consisted of injection of dye-stained fat into the abdominal skin/fat followed by removal and microscopic evaluation of the grafts from 3 months to 1 year later. Also, different sized cannulas for removal and different sized needles for injection of fat were used, with the abdominal skin/fat used as the recipient site. Studies were also done to compare washing versus nonwashing of the fat. These studies and 10 years of clinical evaluation and follow-up has led us to conclude that fat, properly aspirated, properly prepared, and properly injected, is an excellent and permanent substance for soft tissue augmentation.

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