First Place — Resident Clinical Science Award 1994: Early Effects of Cerebellopontine Angle Compression on Rabbit Distortion-Product Otoacoustic Emissions: A Model for Monitoring Cochlear Function during Acoustic Neuroma Surgery

1994 ◽  
Vol 111 (4) ◽  
pp. 407-416 ◽  
Author(s):  
Michael P. Widick ◽  
Fred F. Telischi ◽  
Brenda L. Lonsbury-Martin ◽  
Barden B. Stagner
Keyword(s):  
Otoacoustic Emissions ◽  
Cerebellopontine Angle ◽  
Internal Auditory Canal ◽  
Otoacoustic Emission ◽  
Warning Signs ◽  
Distortion Product Otoacoustic Emissions ◽  
Surgical Removal ◽  
Distortion Product Otoacoustic Emission ◽  
Cochlear Function ◽  
Distortion Product

A rabbit model was developed to simulate the effects of Ischemia that may occur during surgical removal of tumors Involving the cerebellopontine angle or internal auditory canal. Specifically, the internal auditory artery was visualized through a posterior craniotomy and mechanically compressed for repetitive 1-minute intervals with a micromanipulator-controlled glass pipet terminating in a smooth bead. The 2f1-f2 distortion-product otoacoustic emissions were used to monitor the susceptibility of cochlear function to compressive effects. Distortion-product otoacoustic emissions were measured during discrete preblock, block, and postblock periods to determine the time course of distortion-product otoacoustic emission reduction and its return to baseline levels after rapid obstruction and resumption, respectively, of the cochlear vascular supply. Comparisons during these times indicated that preblock distortion-product otoacoustic emission levels were very stable, often varying by less than 1 dB. Additionally, distortion-product otoacoustic emissions were very sensitive to brief vascular occlusions in that, within approximately 25 seconds of blockage onset, emission levels at all frequencies decreased at rates of about − 1.5 dB/second. On alleviation of the occlusion, distortion-product otoacoustic emissions rapidly and completely returned to preblock levels with a delay of about 4 seconds and recovery slopes of about 10.5 dB/second. A notable finding in some animals was that early and reproducible variations in distortion-product otoacoustic emission levels occurred within 5 to 8 seconds of internal auditory artery compression. When present, these transitory changes on distortion-product otoacoustic emission levels acted as early warning signs for vascular compromise of cochlear function.

scholarly journals Emerging Distortion Product Otoacoustic Emission Techniques to Identify Preclinical Warning Signs of Basal Cochlear Dysfunction Due to Ototoxicity

2019 ◽  
Vol 9 (15) ◽  
pp. 3132 ◽  
Author(s):  
Gayla L. Poling ◽  
Brittany Vlosich ◽  
Laura E. Dreisbach
Keyword(s):  
Otoacoustic Emissions ◽  
Otoacoustic Emission ◽  
Warning Signs ◽  
Distortion Product Otoacoustic Emission ◽  
Cochlear Function ◽  
Distortion Product ◽  
Conventional Methods ◽  
The Stability ◽  
Monitoring Protocols ◽  
Hearing Damage

Hundreds of medications commonly prescribed for anticancer treatments and some infections are known to cause hearing damage, referred to as ototoxicity. Preventing or minimizing ototoxicity is critical in order to preserve quality of life for patients receiving treatment and to reduce the societal burden of hearing loss. Current clinical evaluations are restricted to a limited frequency range (≤8 kHz); however, this approach does not permit the earliest detection of ototoxicity, most likely to be observed at the highest frequencies (9–20 kHz). Distortion product otoacoustic emissions (DPOAEs) offer a noninvasive, objective approach to monitor cochlear health in those unable to respond via conventional methods. The current report analyzes different DPOAE paradigms used in patients undergoing chemotherapy treatments with various platinum derivatives. Individualized serial monitoring protocols were completed at the highest frequencies with measurable DPOAEs. This allowed the exploration of potential clinical translation opportunities for further quantification of the earliest signs of underlying cochlear damage, which may go undetected with conventional methods. Clinical practice has the potential to be enhanced by emerging DPOAE applications, including targeted monitoring protocols and high-frequency stimuli to assess cochlear function, especially at the highest frequencies, and advanced calibration techniques to ensure the stability of serial measurements.

The relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions

2017 ◽  
Vol 131 (11) ◽  
pp. 1017-1025 ◽  
Author(s):  
H Keppler ◽  
S Degeest ◽  
I Dhooge
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Otoacoustic Emission ◽  
Homeostatic Plasticity ◽  
Distortion Product Otoacoustic Emissions ◽  
Chronic Tinnitus ◽  
Distortion Product Otoacoustic Emission ◽  
Frequency Range ◽  
Distortion Product ◽  
The Relationship

AbstractObjectives:Chronic tinnitus is associated with reduced auditory input, which results in changes in the central auditory system. This study aimed to examine the relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. For audiometry, the parameters represented the edge frequency of hearing loss, the frequency of maximum hearing loss and the frequency range of hearing loss. For distortion product otoacoustic emissions, the parameters were the frequency of lowest distortion product otoacoustic emission amplitudes and the frequency range of reduced distortion product otoacoustic emissions.Method:Sixty-seven patients (45 males, 22 females) with subjective chronic tinnitus, aged 18 to 73 years, were included.Results:No correlation was found between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. However, tinnitus pitch fell mostly within the frequency range of hearing loss.Conclusion:The current study seems to confirm the relationship between tinnitus pitch and the frequency range of hearing loss, thus supporting the homeostatic plasticity model.

Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure

2015 ◽  
Vol 129 (12) ◽  
pp. 1174-1181 ◽  
Author(s):  
N Wooles ◽  
M Mulheran ◽  
P Bray ◽  
M Brewster ◽  
A R Banerjee
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Noise Exposure ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

AbstractObjective:To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupational noise exposure related auditory deficit.Methods:A retrospective review was conducted of pure tone audiometry and distortion product otoacoustic emission data obtained sequentially during mandatory screening of brickyard workers (n = 16). Individual pure tone audiometry thresholds were compared with distortion product otoacoustic emission amplitudes, and a correlation of these measurements was conducted.Results:Pure tone audiometry threshold elevation was identified in 13 out of 16 workers. When distortion product otoacoustic emission amplitudes were compared with pure tone audiometry thresholds at matched frequencies, no evidence of a robust relationship was apparent. Seven out of 16 workers had substantial distortion product otoacoustic emissions with elevated pure tone audiometry thresholds.Conclusion:No clinically relevant predictive relationship between distortion product otoacoustic emission amplitude and pure tone audiometry threshold was apparent. These results do not support the replacement of pure tone audiometry with distortion product otoacoustic emissions in screening. Distortion product otoacoustic emissions at frequencies associated with elevated pure tone audiometry thresholds are evidence of intact outer hair cell function, suggesting that sites distinct from these contribute to auditory deficit following ototrauma.

Effect of chronic suppurative otitis media on distortion product otoacoustic emission input–output functions in conventional and ultra-high frequencies

2019 ◽  
Vol 133 (11) ◽  
pp. 995-1004
Author(s):  
S I Kirubaharane ◽  
S Palani ◽  
A Alexander ◽  
A Sreenivasan
Keyword(s):  
Otitis Media ◽  
Otoacoustic Emissions ◽  
Otoacoustic Emission ◽  
Chronic Suppurative Otitis Media ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Clinical Group ◽  
Distortion Product Otoacoustic Emission ◽  
Suppurative Otitis Media ◽  
Distortion Product

AbstractBackgroundDetection and valid measurements of distortion product otoacoustic emissions are not influenced by cochlear status alone, but also by middle-ear status. There is a need to understand the use of ultra-high frequency distortion product otoacoustic emissions in cases of abnormal distortion product otoacoustic emission findings for conventional frequencies related to the middle-ear condition.MethodThe present study investigated distortion product otoacoustic emission input–output functions in conventional and ultra-high frequencies in: 37 adults with chronic suppurative otitis media (clinical group) and 37 adults with normal hearing sensitivity (control group).ResultsThere were significant reductions in distortion product otoacoustic emission amplitude and mean signal-to-noise ratio in the clinical group compared to the control group, especially for conventional frequencies.ConclusionThere was a significant reduction in the rate of ears with measurable distortion product otoacoustic emissions in the clinical group, especially for conventional frequencies. The effect of chronic suppurative otitis media was more pronounced in the conventional frequency range compared to the smaller effect seen in the ultra-high frequency range.

Distortion product otoacoustic emissions following stapedectomy versus stapedotomy

2009 ◽  
Vol 124 (1) ◽  
pp. 16-18
Author(s):  
L Migirov ◽  
M Wolf
Keyword(s):  
Otoacoustic Emissions ◽  
Surgical Techniques ◽  
Otoacoustic Emission ◽  
Normal Hearing ◽  
Stapes Surgery ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Gap Closure

AbstractObjectives:To evaluate distortion product otoacoustic emissions following stapes surgery in patients with otosclerosis, and to compare in this respect two surgical techniques used in our department.Method:This retrospective study included 17 stapedectomy and 23 stapedotomy patients aged 16–68 years who had been followed up for at least 12 months. Distortion product otoacoustic emission results at 2, 3, 4 and 5 kHz (i.e. =f2, with 2f1 − f2 = 0.6f2) were obtained pre-operatively and four weeks post-operatively. The control group included 13 volunteers aged 18–50 years with normal hearing and normal otoscopic findings.Results:Distortion product otoacoustic emissions were detected pre-operatively in 34.8 per cent of stapedotomy patients and 29.4 per cent of stapedectomy patients, and post-operatively in 91.3 per cent of stapedotomy patients and 88.2 per cent of stapedectomy patients. The differences between the stapedotomy and stapedectomy groups were statistically insignificant for each tested frequency, both pre- and post-operatively. The patients' post-operative distortion product otoacoustic emission amplitudes were less than those of normal hearing individuals, even in patients with complete air–bone gap closure and a significant improvement in hearing.Conclusion:Distortion product otoacoustic emissions were detected in most of our patients following successful stapes surgery, and appeared to be unaffected by the surgical technique or prosthesis used.

Effect of Acoustic Tumor Extension into the Internal Auditory Canal on Distortion-Product Otoacoustic Emissions

2002 ◽  
Vol 111 (10) ◽  
pp. 912-915 ◽  
Author(s):  
A. Onur Odabasi ◽  
Fred F. Telischi ◽  
Barden Stagner ◽  
Orlando Gomez-Marin ◽  
Glen Martin
Keyword(s):  
Otoacoustic Emissions ◽  
Internal Auditory Canal ◽  
Distortion Product Otoacoustic Emissions ◽  
Negative Effects ◽  
Cochlear Function ◽  
Tumor Extension ◽  
Distortion Product ◽  
Acoustic Neuromas ◽  
Tumor Involvement ◽  
Acoustic Tumor

We studied the effects on distortion-product otoacoustic emissions (DPOAEs) of internal auditory canal (IAC) extension of acoustic neuromas (ANs) with the hypothesis that cochlear patterns of DPOAEs would be more commonly observed when the IAC was completely filled with tumor because of direct tumor involvement of either the inner ear or its blood supply. In a retrospective analysis of 86 patients with surgically proven ANs, DPOAEs were classified as having cochlear or noncochlear patterns on the basis of comparisons with the behavioral pure tone thresholds. The results of behavioral audiometry and DPOAEs were compared with the extension of the tumor into the IAC, which was categorized as full or partial. Of the 86 patients, 58 had tumors with full IAC extension, and 28 had tumors with partial IAC involvement. Cochlear patterns of DPOAEs were found in 55.2% of the tumors in the full IAC group and in 71.4% of those in the partial IAC group (not statistically different). It was concluded that the extent of IAC involvement by ANs was not significantly related to the negative effects of the tumor on cochlear function as represented by DPOAEs.

scholarly journals Estimation of outer hair cells function in chronic bilateral tinnitus patients with normal hearing using distortion product otoacoustic emissions

2021 ◽  
Author(s):  
Aras Karimiani ◽  
Nematollah Rouhbakhsh ◽  
Farzaneh Zamiri Abdollahi ◽  
Shohreh Jalaie
Keyword(s):  
Hair Cells ◽  
Otoacoustic Emissions ◽  
Normal Hearing ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Distortion Product Otoacoustic Emission ◽  
Frequency Range ◽  
Cochlear Function ◽  
Distortion Product

Background and Aim: It is not clear if the measurement of distortion product otoacoustic emissions (DPOAE) at frequencies above 8 kHz adds any value in determining the differences in the cochlear function between patients with and without tinnitus. This study aimed to compare DPOAE in the frequency range of 0.5−10 kHz in patients with normal hearing with and without tinnitus. Methods: This comparative cross-sectional study was conducted on 20 individuals with tinnitus and normal hearing as a study group (SG) and a control group (CG) of 20 normal-hearing individuals without tinnitus. The DPOAE was measured with F1/F2 = 1.22 and intensities of F1 = 65 dB SPL and F2 =55 dB SPL in the frequency range of 0.5−10 kHz, moreover in the frequency of tinnitus in SG and corresponding frequency in CG. Results: DPOAE level at 10 kHz did not differ significantly between SG and CG (p = 0.491). However, the mean of overall DPOAE level, DPOAE level at the frequency of tinnitus, and F2 values of 2.5, 5, and 6.298 kHz were significantly lower in SG than CG (p < 0.05). Conclusion: Measurement of DPOAE at 10 kHz did not seem to add any value in determining the differences in the cochlear function between patients with and without tinnitus. However, decreased DPOAE levels at 2.5, 5, and 6.298 kHz which were observed among patients who have tinnitus and normal hearing, indicates some outer hair cells damage that was not detectable by conventional audiometry. Keywords: Tinnitus; normal hearing; outer hair cell; distortion product otoacoustic emission

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