Microcirculatory changes in venous disease

2013 ◽  
Vol 28 (1_suppl) ◽  
pp. 73-78 ◽  
Author(s):  
L C Huisman ◽  
C Den Bakker ◽  
C H A Wittens

Objective: The aim of this study was to investigate the feasibility to measure microcirculatory blood flow changes in patients with venous ulcers, by using the laser speckle imaging. Methods: Nine patients with a leg ulcer were measured with the laser speckle imager in a sitting position before and after mimicking venous hypertension, with the legs raised, by applying a blood pressure cuff and inflating it to 60 mmHg. Results: The results were inconclusive, due to the fact that a lot of practical problems interfered with the measurements, e.g. movement artefacts and inadequate wound visualisation. Conclusion: The additional value of laser speckle imaging in daily practice for wound care still remains an important question for further research. A reliable, reproducible microcirculation measurement in venous ulcers might predict venous ulcer healing and recurrence and therefore would be a valuable diagnostic tool in daily practice.

2017 ◽  
Vol 32 (10) ◽  
pp. 658-664 ◽  
Author(s):  
Timme MAJ van Vuuren ◽  
Carina Van Zandvoort ◽  
Suat Doganci ◽  
Ineke Zwiers ◽  
Arina J tenCate-Hoek ◽  
...  

Introduction Laser speckle imaging is used for noninvasive assessment of blood flow of cutaneous wounds. The aim of this study was to assess if laser speckle imaging can be used as a predictor of venous ulcer healing. Methods After generating the flux speckle images, three regions of interest (ROI) were identified to measure the flow. Sensitivity, specificity, negative predictive value, and positive predictive value for ulcer healing were calculated. Results In total, 17 limbs were included. A sensitivity of 92.3%, specificity of 75.0%, PPV of 80.0%, and NPV 75.0% were found in predicting wound healing based on laser speckle images. Mean flux values were lowest in the center (ROI I) and showed an increase at the wound edge (ROI II, p = 0.03). Conclusion Laser speckle imaging shows acceptable sensitivity and specificity rates in predicting venous ulcer healing. The wound edge proved to be the best probability for the prediction of wound healing.


2014 ◽  
Vol 39 (3) ◽  
pp. 678 ◽  
Author(s):  
J. C. Ramirez-San-Juan ◽  
R. Ramos-Garcia ◽  
G. Martinez-Niconoff ◽  
B. Choi

2021 ◽  
Author(s):  
Ilya Balmages ◽  
Janis Liepins ◽  
Dmitrijs Bliznuks ◽  
Stivens Zolins ◽  
Ilze Lihacova ◽  
...  

2019 ◽  
Vol 122 ◽  
pp. 52-59 ◽  
Author(s):  
AmirHessam Aminfar ◽  
Nami Davoodzadeh ◽  
Guillermo Aguilar ◽  
Marko Princevac

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
J. Buijs ◽  
J. van der Gucht ◽  
J. Sprakel

Abstract Laser speckle imaging is a powerful imaging technique that visualizes microscopic motion within turbid materials. At current two methods are widely used to analyze speckle data: one is fast but qualitative, the other quantitative but computationally expensive. We have developed a new processing algorithm based on the fast Fourier transform, which converts raw speckle patterns into maps of microscopic motion and is both fast and quantitative, providing a dynamnic spectrum of the material over a frequency range spanning several decades. In this article we show how to apply this algorithm and how to measure a diffusion coefficient with it. We show that this method is quantitative and several orders of magnitude faster than the existing quantitative method. Finally we harness the potential of this new approach by constructing a portable laser speckle imaging setup that performs quantitative data processing in real-time on a tablet.


Circulation ◽  
2005 ◽  
Vol 112 (6) ◽  
pp. 885-892 ◽  
Author(s):  
Seemantini K. Nadkarni ◽  
Brett E. Bouma ◽  
Tina Helg ◽  
Raymond Chan ◽  
Elkan Halpern ◽  
...  

2016 ◽  
Vol 22 (3) ◽  
pp. 307-318 ◽  
Author(s):  
Bernard Choi ◽  
Wenbin Tan ◽  
Wangcun Jia ◽  
Sean M. White ◽  
Wesley J. Moy ◽  
...  

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