Don’t Throw Your Heart Away: Increased Transparency of Donor Utilization Practices in Transplant Center Report Cards Alters How Center Performance Is Evaluated

2021 ◽  
pp. 0272989X2110389
Author(s):  
Alison E. Butler ◽  
Gretchen B. Chapman

Background Publicly available report cards for transplant centers emphasize posttransplant survival and obscure the fact that some centers reject many of the donor organs they are offered (reflecting a conservative donor acceptance strategy), while others accept a broader range of donor offers (reflecting an open donor acceptance strategy). Objective We assessed how the provision of salient information about donor acceptance practices and waitlist survival rates affected evaluation judgments of hospital report cards given by laypeople and medical trainees. Methods We tested 5 different report card formats across 4 online randomized experiments ( n1 = 1,003, n2 = 105, n3 = 123, n4 = 807) in the same hypothetical decision. The primary outcome variable was a binary choice between transplant hospitals (one with an open donor acceptance strategy and the other with a conservative donor acceptance strategy). Results Report cards featuring salient information about donor organ utilization rates (transplant outcomes categorized by quality of donor offers accepted) or overall survival rates (outcomes from both waitlist and transplanted patients) led lay participants (studies 1, 3, and 4) and medical trainees (study 2) to evaluate transplant centers with open donor acceptance strategies more favorably than centers with conservative strategies. Limitations Due to the nature of the decision, a hypothetical scenario was necessary for both ethical and practical reasons. Results may not generalize to transplant clinicians or patients faced with the decision of where to join the transplant waitlist. Conclusions These findings suggest that performance evaluations for transplant centers may vary significantly based not only on what outcome information is presented in report cards but also how the information is displayed.

JAMA Surgery ◽  
2014 ◽  
Vol 149 (2) ◽  
pp. 143 ◽  
Author(s):  
Justin B. Dimick ◽  
Samantha K. Hendren

2003 ◽  
Vol 28 (4) ◽  
pp. 353-368 ◽  
Author(s):  
Junni L. Zhang ◽  
Donald B. Rubin

The topic of “truncation by death” in randomized experiments arises in many fields, such as medicine, economics and education. Traditional approaches addressing this issue ignore the fact that the outcome after the truncation is neither “censored” nor “missing,” but should be treated as being defined on an extended sample space. Using an educational example to illustrate, we will outline here a formulation for tackling this issue, where we call the outcome “truncated by death” because there is no hidden value of the outcome variable masked by the truncating event. We first formulate the principal stratification ( Frangakis & Rubin, 2002 ) approach, and we then derive large sample bounds for causal effects within the principal strata, with or without various identification assumptions. Extensions are then briefly discussed.


Medical Care ◽  
2005 ◽  
Vol 43 (8) ◽  
pp. 801-809 ◽  
Author(s):  
Peter C. Austin ◽  
Jack V. Tu ◽  
David A. Alter ◽  
C David Naylor

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 6532-6532
Author(s):  
Jae Hong Park ◽  
Sean Devlin ◽  
Martin S. Tallman ◽  
Dan Douer

6532 Background: The cure rate of pediatric acute lymphoblastic leukemia (ALL) has increased over the last 4 decades to above 80%, compared to a much smaller improvement in adults aged < 60 years. However, outcome information on older ALL patients (age ≥ 60 years) is limited. Only a few clinical trials include the older patients, apply the same regimens developed for adults of all ages, and report a very poor outcome with no improvement over time. We therefore conducted a population-based survey of older ALL patients focusing on early death (ED) rates and changes in outcome over the last 30 years. Methods: Data from 9 population-based cancer registries that participate in the National Cancer Institute’s SEERprogram were used to identify patients aged 60 or older with a diagnosis of ALL. Survival rates at 1, 6, 12 and 24 months were estimated using actuarial methods for 4 calendar periods: 1980-1985, 1986-1992, 1993-1999, and 2000-2006. ED was defined as death occurring within one month of ALL diagnosis. Results: A total of 1066 ALL patients were identified. The ED rate significantly improved over the four study time periods from 20.2% in 1980-1985 to 13.2% in 2000-2006 (p=0.03). The overall survival (OS) at 6 months improved from 32.8% in 1980-1985 to 45.3% in 2000-2006, but at 24 months, only a modest difference in OS was noted across the time period (13.1% in 1980-85 vs. 17.5% in 2000-06). The median survival increased from 3 months to 6 months from the period 1980-1999 to 2000-2006. Conclusions: Although the long-term OS for patients aged 60 and over remains poor, there has been a slight improvement in early mortality and median OS from 1980s to the early 21st century. While the progress in reducing ED and increasing survival at 6 months is encouraging, and may be reflecting better supportive care measures, the limited improvement indicates poor tolerance and lack of efficacy of the toxic, long and complex chemotherapy regimens designed for younger adults. Therefore, future studies should be designed specifically for older ALL patients, focusing on novel, effective, but less toxic therapies, to further improve the short-term OS seen in the past decades and possibly a better overall outcome.


2005 ◽  
Vol 25 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Peter C. Austin ◽  
Geoffrey M. Anderson

2004 ◽  
Vol 148 (6) ◽  
pp. 1041-1046 ◽  
Author(s):  
Peter C. Austin ◽  
David A. Alter ◽  
Geoffrey M. Anderson ◽  
Jack V. Tu

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