Preparation methods prior to PET/CT scanning that decrease uptake of 18F-FDG by myocardium, brown adipose tissue, and skeletal muscle

2016 ◽  
Vol 58 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Dan Shao ◽  
Xu-Wei Tian ◽  
Qiang Gao ◽  
Chang-Hong Liang ◽  
Shu-Xia Wang
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Ct Scanning ◽  
High Fat ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Pet Ct ◽  
Low Carbohydrate ◽  
18F Fdg

Background The hypermetabolic environment of the myocardium, brown adipose tissue (BAT), and muscle will have an effect on the diagnostic accuracy of 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT). A low carbohydrate, high fat, and protein-permitted diet before PET/CT scanning can reduce the degree of 18F-FDG uptake by the myocardium, brown adipose tissue, and skeletal muscle. Purpose To determine the effect of a low carbohydrate, high fat and protein-permitted diet on 18F-FDG uptake by myocardium, BAT, and muscle during PET/CT. Material and Methods A total of 126 patients who adhered to two meals before PET/CT scanning (that were prepared using a low carbohydrate, high fat, and protein-permitted diet), i.e. the diet group, were compared with 126 patients who fasted for at least 12 h prior to scanning (i.e. the fasting group). The degree of 18F-FDG uptake within the myocardium, BAT, and muscle were stratified into four grades (range, 0–3) with 0 for negligible uptake, and 3 for intense uptake. Correlations between the diet and fasting groups with respect to degree of 18F-FDG uptake within the myocardium, BAT, and muscle were analyzed. Results The degree of 18F-FDG uptake within the myocardium, BAT, and muscle in the diet group was significantly lower compared with the 18F-FDG uptake within myocardium, BAT, and muscle in the fasting group ( P < 0.001, P = 0.001, P < 0.001). Conclusion A low carbohydrate/high fat diet before 18F-FDG injection can suppress uptake of 18F-FDG within the myocardium, BAT, and skeletal muscle.

Determinants of Physiologic 18F-FDG Uptake in Brown Adipose Tissue in Sequential PET/CT Examinations

2010 ◽  
Vol 13 (5) ◽  
pp. 1029-1035 ◽  
Author(s):  
Leonardo Pace ◽  
Emanuele Nicolai ◽  
Domenico D’Amico ◽  
Francesco Ibello ◽  
Anna Maria Della Morte ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg

Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging

2010 ◽  
Vol 41 (6) ◽  
pp. 759-768 ◽  
Author(s):  
Terence S. Hong ◽  
Amer Shammas ◽  
Martin Charron ◽  
Katherine A. Zukotynski ◽  
Laura A. Drubach ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Ct Imaging ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg

Preliminary PET/CT study of 18F-FDG uptake in cervical and supraclavicular brown adipose tissue

2008 ◽  
Vol 5 (5) ◽  
pp. 349-353
Author(s):  
Na Fang ◽  
Yanli Wang ◽  
Xinjian Cui ◽  
Lei Zeng ◽  
Lili Ma ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg

scholarly journals Sleep duration and quality are not associated with brown adipose tissue volume or activity—as determined by 18F-FDG uptake, in young, sedentary adults

SLEEP ◽  
2019 ◽  
Vol 42 (12) ◽  
Author(s):  
Francisco M Acosta ◽  
Guillermo Sanchez-Delgado ◽  
Borja Martinez-Tellez ◽  
Jairo H Migueles ◽  
Francisco J Amaro-Gahete ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Sleep Quality ◽  
Brown Adipose Tissue ◽  
Sleep Duration ◽  
Sleep Disturbances ◽  
Sleep Regulation ◽  
Clinical Trial Registration ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
18F Fdg

Abstract Study Objectives Short sleep duration and sleep disturbances have been related to obesity and metabolic disruption. However, the behavioral and physiological mechanisms linking sleep and alterations in energy balance and metabolism are incompletely understood. In rodents, sleep regulation is closely related to appropriate brown adipose tissue (BAT) thermogenic activity, but whether the same is true in humans has remained unknown. The present work examines whether sleep duration and quality are related to BAT volume and activity (measured by 18F-FDG) and BAT radiodensity in humans. Methods A total of 118 healthy adults (69% women, 21.9 ± 2.2 years, body mass index: 24.9 ± 4.7 kg/m2) participated in this cross-sectional study. Sleep duration and other sleep variables were measured using a wrist-worn accelerometer for seven consecutive days for 24 hours per day. The Pittsburgh Sleep Quality Index was used to assess sleep quality. All participants then underwent a personalized cold exposure to determine their BAT volume, activity, and radiodensity (a proxy of the intracellular triglyceride content), using static positron emission tomography combined with computed tomography (PET/CI) scan. Results Neither sleep duration nor quality was associated with BAT volume or activity (the latter represented by the mean and peak standardized 18F-FDG uptake values) or radiodensity (all p &gt; .1). The lack of association remained after adjusting the analyses for sex, date of PET/CT, and body composition. Conclusions Although experiments in rodent models indicate a strong relationship to exist between sleep regulation and BAT function, it seems that sleep duration and quality may not be directly related to the BAT variables examined in the present work. Clinical Trial Registration NCT02365129 (ClinicalTrials.gov).

scholarly journals The Relationship between Brown Adipose Tissue Activity and Neoplastic Status: an 18F-FDG PET/CT Study in the Tropics

2011 ◽  
Vol 10 (1) ◽  
pp. 238 ◽  
Author(s):  
Yung-Cheng Huang ◽  
Tai-Been Chen ◽  
Chien-Chin Hsu ◽  
Shau-Hsuan Li ◽  
Pei-Wen Wang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Brown Adipose Tissue Activity ◽  
Fdg Pet Ct ◽  
The Tropics ◽  
The Relationship

scholarly journals Brown adipose tissue volume and 18F-fluorodeoxyglucose uptake are not associated with energy intake in young human adults

2019 ◽  
Vol 111 (2) ◽  
pp. 329-339 ◽  
Author(s):  
Guillermo Sanchez-Delgado ◽  
Francisco M Acosta ◽  
Borja Martinez-Tellez ◽  
Graham Finlayson ◽  
Catherine Gibbons ◽  
...  
Keyword(s):  
Young Adults ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Energy Intake ◽  
Appetite Regulation ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Ad Libitum ◽  
18F Fdg ◽  
Meal Consumption

ABSTRACT Background Several studies have explored the role of human brown adipose tissue (BAT) in energy expenditure. However, the link between BAT and appetite regulation needs to be more rigorously examined. Objectives We aimed to investigate the associations of BAT volume and 18F-fluordeoxyglucose (18F-FDG) uptake after a personalized cold exposure with energy intake and appetite-related sensations in young healthy humans. Methods A total of 102 young adults (65 women; age: 22.08 ± 2.17 y; BMI: 25.05 ± 4.93 kg/m 2) took part in this cross-sectional study. BAT volume, BAT 18F-FDG uptake, and skeletal muscle 18F-FDG uptake were assessed by means of static 18F-FDG positron-emission tomography and computed tomography scans after a 2-h personalized exposure to cold. Energy intake was estimated via an objectively measured ad libitum meal and three nonconsecutive 24-h dietary recalls. Appetite-related sensations (i.e., hunger and fullness) were recorded by visual analog scales before and after a standardized breakfast (energy content = 50% of basal metabolic rate) and the ad libitum meal. Body composition was assessed by a whole-body DXA scan. Results BAT volume and 18F-FDG uptake were not associated with quantified ad libitum energy intake (all P &gt; 0.088), nor with habitual energy intake estimated from the 24-h dietary recalls (all P  &gt; 0.683). Lean mass was positively associated with both the energy intake from the ad libitum meal (β: 17.612, R2 = 0.213; P &lt; 0.001) and the habitual energy intake (β: 16.052, R2 = 0.123; P = 0.001). Neither the interaction BAT volume × time elapsed after meal consumption nor that of BAT 18F-FDG uptake × time elapsed after meal consumption had any significant influence on appetite-related sensations after breakfast or after meal consumption (all P &gt; 0.3). Conclusions Neither BAT volume, nor BAT 18F-FDG uptake after cold stimulation, are related to appetite regulation in young adults. These results suggest BAT plays no important role in the regulation of energy intake in humans. This trial was registered at clinicaltrials.gov as NCT02365129.

Pre-medication to block [18F]FDG uptake in the brown adipose tissue of pediatric and adolescent patients

2005 ◽  
Vol 35 (10) ◽  
pp. 984-990 ◽  
Author(s):  
Michael J. Gelfand ◽  
Sara M. O’Hara ◽  
Lois A. Curtwright ◽  
Joseph R. MacLean
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Adolescent Patients ◽  
18F Fdg
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