Efficiency of diffusion-weighted MRI for differentiating radiologically similar simple and type I hydatid cysts of the liver

2021 ◽  
pp. 028418512098813
Author(s):  
Ilyas Dundar ◽  
Mesut Ozgokce ◽  
Fatma Durmaz ◽  
Sercan Ozkacmaz ◽  
Saim Turkoglu ◽  
...  
Keyword(s):  
Treatment Options ◽  
Type I ◽  
Hydatid Cysts ◽  
Liver Cysts ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Mean Diameter ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Hepatic Lesions

Background Determining the nature of purely cystic hepatic lesions is essential because different kinds have different follow-ups, treatment options, and complications. Purpose To explore the potential of apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI) for the differentiation of type I hydatid cysts (HC) and simple liver cysts (SLC), which have similar radiological appearances. Material and Methods This single-center prospective study was conducted during 2016–2019. Round, homogenous, anechoic liver cysts >1 cm were classified according to at least two years of imaging follow-up, radiological features, serology, as well as puncture aspiration injection reaspiration procedure and pathology results. ADC values of 95 cysts (50 type I HCs and 45 SLCs) were calculated on DWI. The differences in ADC values were analyzed by independent t-test. Results Of 51 patients, 28 were female, 23 were male (mean age 32.07 ± 22.95 years; age range 5–82 years). Mean diameter of 45 SLCs was 2.59 ± 1.23 cm (range 1.2–7.6 cm) and ADCmean value was 3.03 ± 0.47 (range 2.64–5.85) while mean diameter of 50 type I HCs was 7.49 ± 2.95 cm (range 2.8–14 cm) and ADCmean value was 2.99 ± 0.29 (range 2.36–3.83). There was no statistically significant difference in ADC values between type I HCs and SLCs Conclusion Some studies report that ADC values of type I HCs are statistically significantly lower than those of SLCs. Others suggest no significant difference. In our study with a higher number of cases, using ADC parameters similar to those in previous studies, we did not find any statistically significant difference.

scholarly journals The Influence of Bowel Preparation on ADC Measurements: Comparison between Conventional DWI and DWIBS Sequences

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 394
Author(s):  
Ilze Apine ◽  
Monta Baduna ◽  
Reinis Pitura ◽  
Juris Pokrotnieks ◽  
Gaida Krumina
Keyword(s):  
Bowel Preparation ◽  
Diffusion Weighted Imaging ◽  
Mr Enterography ◽  
High Signal ◽  
Diffusion Weighted ◽  
Signal Suppression ◽  
Significant Difference ◽  
Before And After ◽  
Apparent Diffusion ◽  
Adc Values

Background and objectives: The aim of the study was to assess whether there were differences between apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI) and diffusion-weighted imaging with background body signal suppression (DWIBS) sequences in non-prepared and prepared bowels before and after preparation with an enteric hyperosmolar agent, to assess whether ADC measurements have the potential to avoid bowel preparation and whether ADC-DWIBS has advantages over ADC-DWI. Materials and Methods: 106 adult patients without evidence of inflammatory bowel disease (IBD) underwent magnetic resonance (MR) enterography before and after bowel preparation. ADC-DWI and ADC-DWIBS values were measured in the intestinal and colonic walls demonstrating high signal intensity (SI) at DWI tracking images of b = 800 s/mm2 before and after preparation. Results: There were significant difference (p < 0.0001) in both ADC-DWI and ADC-DWIBS results between non-prepared and prepared jejunum for DWI being 1.09 × 10−3 mm2/s and 1.76 × 10−3 mm2/s, respectively, and for DWIBS being 0.91 × 10−3 mm2/s and 1.75 × 10−3 mm2/s, respectively. Both ADC-DWI and DWIBS also showed significant difference between non-prepared and prepared colon (p < 0.0001), with DWI values 1.41 × 10−3 mm2/s and 2.13 × 10−3 mm2/s, and DWIBS—1.01 × 10−3 mm2/s and 2.04 × 10−3 mm2/s, respectively. No significant difference between ADC-DWI and ADC-DWIBS was found in prepared jejunum (p = 0.84) and prepared colon (p = 0.58), whereas a significant difference was found in non-prepared jejunum and non-prepared colon (p = 0.0001 in both samples). Conclusions: ADC between DWI and DWIBS does not differ in prepared bowel walls but demonstrates a difference in non-prepared bowel. ADC in non-prepared bowel is lower than in prepared bowel and possible overlap with the ADC range of IBD is possible in non-prepared bowel. ADC-DWIBS has no advantage over ADC-DWI in regard to IBD assessment.

scholarly journals Potentialities of Diffusion Weighted MRI in the Assessment of the Degree of Adjacent Intervertebral Disc Degeneration: Rigid Lumbosacral Stabilization and Total Intervertebral Disc Arthroplasty

2017 ◽  
pp. 18-24
Author(s):  
V. A. Byval’tsev ◽  
I. A. Stepanov ◽  
Yu. Ya. Pestryakov
Keyword(s):  
Intervertebral Disc ◽  
Postoperative Period ◽  
Intervertebral Discs ◽  
Early Postoperative Period ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Total Arthroplasty ◽  
Significant Difference ◽  
Apparent Diffusion ◽  
Adc Values

Purpose: to evaluate the condition of adjacent intervertebral discs (IVD) after single level rigid lumbosacral stabilization and total arthroplasty by calculating IVD height index and apparent diffusion coefficient (ADC).Patients and methods. The study included 117 patients (64 women and 53 men) after rigid lumbosacral stabilization or total arthroplasty of the degenerative IVD at L5–S1 level. Values of ADC and height of the adjacent IVD were assessed prior to surgery, at discharge and in 6, 12, 24 and 36 months after surgical intervention.Results. The value of the height of the adjacent IVD in patients after rigid stabilization in the early postoperative period averaged 0.58±0.046, in 6 months – 0.58±0.044 and 0.52±0.037 in 36 months after surgery. In patients after total arthroplasty it made up 0.59±0.041, 0.60±0.038 and 0.56±0.02, respectively. Comparison of the adjacent IVD height indices showed significant difference starting from the 12th observation months (p<0.05). In group of patients after rigid stabilization the value of ADC made up 1547.7±231.4 mm2/s in the early postoperative period, 1314.5±117.9 mm2/s in 6 months and 1189.3±117.9 mm2/s in 36 months after surgery. In patients after total arthroplasty it was 1539.7±228.9 mm2/s, 1477.3±245.1 mm2/s and 1334.5±217.6 mm2/s, respectively. Statistically significant difference in ADC values between 2 groups of patients was noted in 6 months after surgery and later (p<0.05).Conclusion. Diffusion weighted MRI with ADC calculation is a modern noninvasive diagnostic method for early stages of adjacent IVD degeneration. In contrast to rigid lumbosacral stabilization, total IVD arthroplasty enables to delay slightly the degeneration of segments adjacent to the operated level. 

scholarly journals Diagnostic value of Diffusion Weighted Imaging in assessment of malignant focal liver lesions

2009 ◽  
Vol 56 (4) ◽  
pp. 121-125 ◽  
Author(s):  
R.M. Maksimovic ◽  
M.S. Kratovac-Dunjic ◽  
G.B. Lilic ◽  
R.M. Milenkovic ◽  
D.M. Masulovic ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Diagnostic Value ◽  
Focal Liver Lesions ◽  
Cavernous Haemangioma ◽  
Liver Lesions ◽  
Secondary Tumors ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Adc Values ◽  
Hepatic Lesions

Introduction: The study was designed to determine if there was a difference between apparent diffusion coefficient (ADC) values using diffusion weighted imaging (DWI) MRI technique between different malignant focal liver lesions. Patients and methods: The study included 63 patients with focal hepatic lesions: fourteen patients (22.2%) with hepatocellular carcinoma (HCC), 16 patients (25.4%) with hepatic metastatic colorectal tumors, 17 patients (26.9%) with cavernous haemangioma and 16 patients (25.4%) with hepatic cysts. MRI was performed with 1.5T scanner, using EPI sequence with ADC values being determined for all lesions based on three b values. Results: ADC values were statistically different among the groups (F=70.7, p<0.01): HCC patients 1.11+0.29x10- 3 s/mm2, metastatic tumours 2.18+0.15x10-3 s/mm2, haemangioma 2.22+0.32x10-3 s/mm2, cysts 3.08+0.03 x10-3 s/mm2. Furthermore, there was statistically significant difference between benign lesions (haemangioma and cysts, 2.36+0.43x10-3 s/mm2), and malignant diseases (HCC and secondary tumors, 1.52+0.58x10-3 s/mm2), t=5,6, p<0.01. Conclusion: DWI technique could be helpful in defining the focal liver lesions.

scholarly journals Role of diffusion weighted MR imaging in diagnosis of acute pancreatitis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
K A A Sabry ◽  
O F Kamel ◽  
A Y Ahmed ◽  
H M Abuzeid
Keyword(s):  
Acute Pancreatitis ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Adc Value ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Normal Controls

Abstract Purpose to assess the role of Diffusion-weighted MRI in diagnosis of acute pancreatitis by measure the apparent diffusion coefficient (ADC) values detected by diffusion-weighted imaging (DWI) in acute pancreatitis and compare them with the control group Methods and Material sixteen patients with acute pancreatitis and sixteen normal controls underwent DWI with b values (0,200 & 800). Apparent diffusion coefficient (ADC) maps are generated from DWI and ADC values were calculated for pancreas and compared the results between the two groups Results The mean pancreatic ADC in the AP group (1.17 × 10(-3) mm(2)/s ± 0.2) was significantly lower than in the normal group (1.6 × 10(-3) mm(2)/s ± 0.32). There was no significant difference in mean ADCs between each of the pancreatic segments in the controls. A threshold ADC value of 1.38 × 10-3 mm(2)/s yielded a sensitivity of 93% and specificity of 87% for detecting acute pancreatitis. Pancreatic ADCs are significantly lower in patients with AP than normal controls. Conclusion MR diffusion imaging could be an important supportive tool in diagnosis of acute pancreatitis

scholarly journals Synthetic Apparent Diffusion Coefficient for High b-Value Diffusion-Weighted MRI in Prostate

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Prativa Sahoo ◽  
Russell C. Rockne ◽  
Alexander Jung ◽  
Pradeep K Gupta ◽  
Ram K. S. Rathore ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Contrast Ratio ◽  
Benign Lesions ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Malignant Lesions ◽  
Log Linear

Purpose. It has been reported that diffusion-weighted imaging (DWI) with ultrahigh b-value increases the diagnostic power of prostate cancer. DWI with higher b-values is challenging as it commonly suffers from low signal-to-noise ratio (SNR), distortion, and longer scan time. The aim of our study was to develop a technique for quantification of apparent diffusion coefficient (ADC) for higher b-values from lower b-value DW images. Materials and Methods. Fifteen patients (7 malignant and 8 benign) were included in this study retrospectively with the institutional ethical committee approval. All images were acquired at a 3T MR scanner. The ADC values were calculated using a monoexponential model. Synthetic ADC (sADC) for higher b-value was computed using a log-linear model. Contrast ratio (CR) between prostate lesion and normal tissue on synthetic DWI (sDWI) was computed and compared with original DWI and ADC images. Results. No significant difference was observed between actual ADC and sADC for b-2000 in all prostate lesions. However, CR increased significantly (p=0.002, paired t-test) in sDWI as compared to DWI. Malignant lesions showed significantly lower sADC as compared to benign lesions (p=0.0116, independent t-test). Mean (±standard deviation) of sADC of malignant lesions was 0.601 ± 0.06 and for benign lesions was 0.92 ± 0.09 (10−3 mm2/s). Discussion/Conclusion. Our initial investigation suggests that the ADC values corresponding to higher b-value can be computed using log-linear relationship derived from lower b-values (b ≤ 1000). Our method might help clinicians to decide the optimal b-value for prostate lesion identification.

scholarly journals Role of Quantitative Diffusion-Weighted Imaging in Differentiating Benign and Malignant Orbital Masses

2021 ◽  
Author(s):  
Preeti Mundhada ◽  
Sudarshan Rawat ◽  
Ullas Acharya ◽  
Dhananjay Raje
Keyword(s):  
Roc Curve ◽  
Diffusion Weighted Imaging ◽  
Care Hospital ◽  
Adc Value ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Orbital Masses ◽  
Adc Values ◽  
Orbital Lesions

Abstract Aim To determine the role of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) values in differentiating benign and malignant orbital masses. Materials and Methods After obtaining institutional ethical board approval and informed consent from all patients, an observational study was done for a period of 24 months in the radiology department of a tertiary care hospital in South India. Conventional magnetic resonance imaging and DWI using a 3T scanner was done for all patients with suspected orbital mass lesion. ADC value and clinicohistopathological correlation were studied for every patient. Chi-square test was used to compare the signal characteristics of DWI and ADC maps between benign and malignant lesions. A comparison of mean ADC values for benign and malignant masses was performed using Student’s t-test for independent samples. The cut-off value for ADC was obtained using the receiver operating characteristic (ROC) curve. Results Of 44 patients with orbital lesions, 70% were benign and 30% were malignant. There was a significant difference in the mean ADC values of benign and malignant orbital masses. Using ROC curve analysis, an optimal ADC threshold of 1.26 × 10−3 mm2/s was calculated for the prediction of malignancy with 100% sensitivity, 80.65% specificity, and 86.36% accuracy (95% confidence interval: 0.872, 1.00, p < 0.0001). Two ADC thresholds were used to characterize the orbital masses with more than 90% confidence. Conclusion Quantitative assessment of ADC is a useful noninvasive diagnostic tool for differentiating benign and malignant orbital masses. Malignant orbital lesions demonstrate significantly lower ADC values as compared with benign lesions.

scholarly journals The role of quantitative diffusion-weighted imaging in characterization of hypovascular liver lesions: A prospective comparison of intravoxel incoherent motion derived parameters and apparent diffusion coefficient

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247301
Author(s):  
Jelena Djokić Kovač ◽  
Marko Daković ◽  
Aleksandra Janković ◽  
Milica Mitrović ◽  
Vladimir Dugalić ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Liver Metastases ◽  
Diffusion Weighted Imaging ◽  
Intraclass Correlation ◽  
Intravoxel Incoherent Motion ◽  
Liver Lesions ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Apparent Diffusion

Background The utility of intravoxel incoherent motion (IVIM) related parameters in differentiation of hypovascular liver lesions is still unknown. Purpose The purpose of this study was to evaluate the value of IVIM related parameters in comparison to apparent diffusion coefficient (ADC) for differentiation among intrahepatic mass-forming cholangiocarcinoma (IMC), and hypovascular liver metastases (HLM). Methods Seventy-four prospectively enrolled patients (21 IMC, and 53 HLM) underwent 1.5T magnetic resonance examination with IVIM diffusion-weighted imaging using seven b values (0–800 s/mm2). Two independent readers performed quantitative analysis of IVIM-related parameters and ADC. Interobserver reliability was tested using a intraclass correlation coefficient. ADC, true diffusion coefficient (D), perfusion-related diffusion coefficient (D*), and perfusion fraction (ƒ) were compared among the lesions using Kruskal-Wallis H test. The diagnostic accuracy of each parameter was assessed by receiver operating characteristic (ROC) curve analysis. Results The interobserver agreement was good for ADC (0.802), and excellent for D, D*, and ƒ (0.911, 0.927, and 0.942, respectively). ADC, and D values were significantly different among IMC and HLM (both p < 0.05), while there was no significant difference among these lesions for ƒ and D* (p = 0.101, and p = 0.612, respectively). ROC analysis showed higher diagnostic performance of D in comparison to ADC (AUC = 0.879 vs 0.821). Conclusion IVIM-derived parameters in particular D, in addition to ADC, could help in differentiation between most common hypovascular malignant liver lesions, intrahepatic mass—forming cholangiocarcinoma and hypovascular liver metastases.

scholarly journals Prognostic value of diffusion-weighted MRI for post-cardiac arrest coma

Neurology ◽  
2020 ◽  
Vol 94 (16) ◽  
pp. e1684-e1692 ◽  
Author(s):  
Karen G. Hirsch ◽  
Nancy Fischbein ◽  
Michael Mlynash ◽  
Stephanie Kemp ◽  
Roland Bammer ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Brain Tissue ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Poor Outcome ◽  
Diffusion Weighted ◽  
Blinded Study ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Poor Outcomes

ObjectiveTo validate quantitative diffusion-weighted imaging (DWI) MRI thresholds that correlate with poor outcome in comatose cardiac arrest survivors, we conducted a clinician-blinded study and prospectively obtained MRIs from comatose patients after cardiac arrest.MethodsConsecutive comatose post-cardiac arrest adult patients were prospectively enrolled. MRIs obtained within 7 days after arrest were evaluated. The clinical team was blinded to the DWI MRI results and followed a prescribed prognostication algorithm. Apparent diffusion coefficient (ADC) values and thresholds differentiating good and poor outcome were analyzed. Poor outcome was defined as a Glasgow Outcome Scale score of ≤2 at 6 months after arrest.ResultsNinety-seven patients were included, and 75 patients (77%) had MRIs. In 51 patients with MRI completed by postarrest day 7, the prespecified threshold of >10% of brain tissue with an ADC <650 ×10−6 mm2/s was highly predictive for poor outcome with a sensitivity of 0.63 (95% confidence interval [CI] 0.42–0.80), a specificity of 0.96 (95% CI 0.77–0.998), and a positive predictive value (PPV) of 0.94 (95% CI 0.71–0.997). The mean whole-brain ADC was higher among patients with good outcomes. Receiver operating characteristic curve analysis showed that ADC <650 ×10−6 mm2/s had an area under the curve of 0.79 (95% CI 0.65–0.93, p < 0.001). Quantitative DWI MRI data improved prognostication of both good and poor outcomes.ConclusionsThis prospective, clinician-blinded study validates previous research showing that an ADC <650 ×10−6 mm2/s in >10% of brain tissue in an MRI obtained by postarrest day 7 is highly specific for poor outcome in comatose patients after cardiac arrest.

scholarly journals Differentiating Benign from Malignant Sinonasal Lesions: Feasibility of Diffusion Weighted MRI

2017 ◽  
Vol 21 (04) ◽  
pp. 358-365 ◽  
Author(s):  
Khaled El-Gerby ◽  
Mohammad El-Anwar
Keyword(s):  
Predictive Value ◽  
Quantitative Methods ◽  
Malignant Tumors ◽  
Adc Value ◽  
Diffusion Weighted ◽  
Tumor Tissues ◽  
Apparent Diffusion ◽  
Diagnostic Role ◽  
Adc Values ◽  
Histopathological Results

Introduction Appearance of nasal masses on routine CT and MRI are not pathognomonic. We utilized the apparent diffusion coefficient (ADC) value obtained from diffusion weighted image (DWI) to detect the differences in the microstructures of tumor and non-tumor tissues. Objective The objective of our study was to evaluate the diagnostic role of DWI and ADC values in differentiating between malignant and benign sinonasal lesions and its correlation with histopathological results as the reference standard. Methods Patients with nasal and / or paranasal mass underwent CT, MRI, and DWI before any surgical intervention. We used diagnostic sinonasal endoscopy and biopsy to confirm the diagnosis after MRI. Results When we used ADC value of (1.2 × 10–3 mm2/s) as a cut-off value for differentiating benign from malignant sinonasal lesions, we achieved 90% accuracy, 100% sensitivity, 88.4% specificity, 77.8% positive predictive value, and 100% negative predictive value. At this cut-off, benign lesions show statistically significant higher ADC value than malignant tumors. Conclusion DW MRI and ADC value calculation are promising quantitative methods helping to differentiate between malignant and benign sinonasal lesions. Thus, they are effective methods compared with other conventional methods with short imaging time thus it is recommended to be incorporated into routine evaluations.

scholarly journals Assessment of the percentage of apparent diffusion coefficient value changes as an early indicator of the response of colorectal hepatic metastases to chemotherapy

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Nada Gamal El-Husseiny ◽  
Sayed Mohamed Mehana ◽  
Sherif Farouk El Zawawy
Keyword(s):  
Colorectal Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Hepatic Metastasis ◽  
Percentage Increase ◽  
Early Assessment ◽  
Response To Chemotherapy ◽  
Significant Difference ◽  
Apparent Diffusion ◽  
Adc Values

Abstract Background Colorectal cancer is considered one of the most common causes of cancer-related deaths worldwide. We aim to evaluate the efficacy of DWI-MRI in predicting response to chemotherapy in this cohort. The study included 30 lesions in 20 biopsy proven-colorectal cancer patients with hepatic metastasis larger than 1 cm. All patients underwent both triphasic CT with intravenous contrast, pre-chemotherapy MRI (axial T2 and DW sequences) which was repeated 21 days following chemotherapy. A follow-up CT was done 2 months later. The response of the lesions was evaluated using the RESCIST criteria. On MRI, the lesions corresponding to the ones chosen on CT were identified and the apparent diffusion coefficient (ADC) values of pre- and post-chemotherapy images were recorded and correlated with the CT results. Results In the study, 17 (56.7%) of the lesions showed response to chemotherapy while 13 (43.3%) were non-responding. There was no significant difference in pretreatment ADC values between responding and non-responding lesions (p = 0.14). The mean percentage increase in ADC values in responding lesions was 42% compared to 18% in non-responding lesions (p < 0.001). Lesions that showed less than 18% increase were all found to be non-responsive Conclusion DWI-MRI has an emerging role in early assessment of early treatment response that can be detected before morphological response for patients with hepatic metastasis from colorectal cancer. Based on our study, the use of 25 % as the cutoff point of percent difference in ADC for detection of non-responding lesions proved to be successful only 21 days after the 1st chemotherapy cycle.

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