scholarly journals Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094794
Author(s):  
Jie Liu ◽  
Chunrong Li ◽  
Xiaoyang Zhou ◽  
Jian Sun ◽  
Meng Zhu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Web Of Science ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Gene Variants ◽  
Case Control Studies ◽  
The Relationship

Objective In recent years, a number of case–control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed. Methods Eligible studies concerning the DJ-1 g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case–control studies with 2890 cases and 3043 controls. Results This meta-analysis revealed that DJ-1 g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population. Conclusions Our meta-analysis suggests that DJ-1 gene variants are not associated with the risk of PD in the overall population.

scholarly journals Relationship between serum uric acid, all-cause mortality and cardiovascular mortality in peritoneal dialysis patients: systematic review and meta-analysis of cohort studies

BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e052274
Author(s):  
Xue Xue ◽  
Chun-Li Lu ◽  
Xin-Yan Jin ◽  
Xue-Han Liu ◽  
Min Yang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Uric Acid ◽  
Cohort Studies ◽  
Retrospective Cohort ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
All Cause Mortality ◽  
Retrospective Cohort Studies ◽  
The Relationship

ObjectivesTo analyse the relationship between serum uric acid (SUA), all-cause and cardiovascular (CV) mortality in peritoneal dialysis (PD) patients to inform clinical practice and future research.DesignA systematic review of observational studies.Data sourcesPubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure (CNKI), SinoMed, Chinese Science and Technology Journal Database (VIP) and Wan Fang databases were searched from their inception to January 2021 for cohort and case–control studies reporting SUA and mortality in patients with PD.MethodsThe Newcastle-Ottawa Quality Assessment Scale was used to appraise quality of cohort and case–control studies. Effect estimates were presented as HRs with 95% CIs in a meta-analysis using STATA V.16.0. Data not suitable for pooling were synthesised qualitatively.ResultsFourteen cohort studies with 24 022 patients were included. No case–control studies were identified. For prospective cohort studies, pooled results for the highest SUA category were significantly greater than the lowest for all-cause (one study; 1278participants; HR 1.79; 95% CI 1.17 to 2.75) and CV mortality (one study; 1278 participants; HR 2.63; 1.62–4.27). An increase of 1 mg/dL in SUA level was associated with a 16% increased risk of all-cause mortality (one study; 1278 participants; HR 1.16; 1.03–1.32) and 34% increased CV mortality risk (one study; 1278 participants; HR 1.34; 1.16–1.55). For retrospective cohort studies, the highest SUA category did not demonstrate an elevated all-cause (five studies; 4570 participants; HR 1.09; 0.70–1.70) or CV mortality (three studies; 3748 participants; HR 1.00; 0.44–2.31) compared with the lowest SUA category. Additionally, there was no increase in all-cause (eight studies; 11 541 participants; HR 0.94; 0.88–1.02) or CV mortality (three studies; 7427 participants; HR 0.90; 0.76–1.06) for every 1 mg/dL increase in SUA level.ConclusionsResults of prospective and retrospective cohort studies were inconsistent. Consequently, prospective, multicentre, long-term follow-up studies are required to confirm the relationship between SUA and mortality in patients with PD.

scholarly journals Association of Helicobacter pylori infection with diabetes mellitus: A Meta-analysis of Case Control Studies

2019 ◽  
Author(s):  
Kamyar Mansori ◽  
Yousef Moradi ◽  
Sara Naderpour ◽  
Roya Rashti ◽  
Ali Baradaran Moghaddam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Case Control Studies ◽  
Analysis Study ◽  
Geographical Regions ◽  
H Pylori

Abstract Background Results of previous studies were showed that the association between H. pylori infection and the risk of diabetes is still controversies. Therefore, this systematic review and meta-analysis study was designed and implemented aimed to determine the association between H. pylori infection and the risk of diabetes.Methods All case control articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to March 2019 without language limitations. Also, logarithm and standard error logarithm odds ratio (OR) were used for meta-analysis.Results A total of 41 studies were included in this meta-analysis. The range of association with odds ratio in case control studies which published between 1990 to 2019 was 0.21 to 6.08. The pooled estimate of the association between H. pylori infection with diabetes was 1.27 (95% CI 1.11 to 1.45, P = 0.0001, I 2 = 86.6%). The effect of H. pylori infection on diabetes mellitus, type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was higher than other population, but in the American, this was a protective relationship.Conclusion In conclusion, this systematic review & meta-analysis study suggested that H. pylori infection was associated with the risk of diabetes as compared to non- diabetes individual.

scholarly journals Association of ABO Polymorphisms and Pancreatic Cancer/ Cardiocerebrovascular Disease: a Meta-analysis.

2020 ◽  
Author(s):  
Yanxia Li ◽  
Luyang Liu ◽  
Yubei Huang ◽  
Hong Zheng ◽  
Lian Li
Keyword(s):  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Bias Assessment ◽  
Heterogeneity Test ◽  
Pancreatic Cancers ◽  
The Relationship ◽  
Eligible Case

Abstract Background: ABO gene polymorphisms have been reported to be associated with the risk of multiple cancers and cardiocerebrovascular disease s. However, the results remained controversial. In this study, we conducted a systematic review and meta-analysis to clarify the association between two SNPs (rs505922 and rs657152) in ABO gene and cancers/ cardiocerebrovascular disease s. Method: All eligible case-control studies come from PubMed, Embase and Web of Science up to Jan. 1, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the corresponding associations. Sensitivity analysis, publication bias assessment, and heterogeneity test were performed using STATA 12.0. Results : A total of nineteen articles involving twenty-two case-control populations were included according to inclusion and exclusion criteria. Twelve populations (20,820 cases and 27,837 controls) were used to evaluate the relationship between rs505922 and overall cancers and nine populations (22,275 cases and 71,549 controls) were included to assess the association between rs505922 and cardiocerebrovascular diseases. The results showed a significant association between the rs505922 polymorphism and cancers (CvsT: OR=1.13, 95%CI=1.05-1.22, P =0.001), and cardiocerebrovascular diseases (OR=1.36, 95%CI=1.19-1.57, P <0.001). Five populations (8,660 cases and 10,618 controls) were included to evaluate association between rs657152 and cancers and five populations (8,105 cases and 6,712 controls) were included to estimate the relationship between rs657152 and cardiocerebrovascular diseases. The result of meta-analysis reveals that rs657152 was significantly associated with cancers (OR=1.18, 95%CI=1.13-1.23, P <0.001) and cardiocerebrovascular diseases (OR=1.54, 95%CI=1.24-1.92, P <0.001). Conclusion: Our study suggested that ABO polymorphisms might serve as a risk factor of pancreatic cancers and cardiocerebrovascular diseases.

Mutations in GBA and risk of Parkinson’s disease: a meta-analysis based on 25 case-control studies

2013 ◽  
Vol 35 (8) ◽  
pp. 873-878 ◽  
Author(s):  
Xueye Mao ◽  
Tinghua Wang ◽  
Rong Peng ◽  
Xueli Chang ◽  
Nannan Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Impulse-Control Disorders in Parkinson’s Disease: A Meta-Analysis and Review of Case–Control Studies

2018 ◽  
Vol 9 ◽  
Author(s):  
Helge Molde ◽  
Yasaman Moussavi ◽  
Stine Therese Kopperud ◽  
Aleksander Hagen Erga ◽  
Anita Lill Hansen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Meta Analysis ◽  
Case Control ◽  
Impulse Control Disorders ◽  
Case Control Studies

The association between the LRRK2 G2385R variant and the risk of Parkinson’s disease: a meta-analysis based on 23 case–control studies

2014 ◽  
Vol 35 (10) ◽  
pp. 1495-1504 ◽  
Author(s):  
Cheng-long Xie ◽  
Jia-Lin Pan ◽  
Wen-Wen Wang ◽  
Yu Zhang ◽  
Su-fang Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Genetic Association betweenNFKBIAandNFKB1Gene Polymorphisms and the Susceptibility to Head and Neck Cancer: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Lin Li ◽  
Zhong-Ti Zhang
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Statistical Correlation ◽  
Case Control Studies ◽  
The Relationship

Background. The role of theNFKB1gene rs28362491 polymorphism andNFKBIAgene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively.Methods. PubMed, Embase, Web of Science, WanFang Data, and China National Knowledge databases were used to search for eligible articles. The relationship was evaluated by STATA 11.0.Results. Eight eligible articles were included in our study. Nine case-control studies from the eight included articles were correlated with rs28362491 polymorphism. Four articles were related to rs2233406 polymorphism. Overall, a significant correlation was observed between the rs28362491 polymorphism and a decreased risk of HNCs (OR=0.76,95%CI=0.60‐0.97for DD vs. II;OR=0.80,95%CI=0.68‐0.95for DD vs. DI+II). In subgroup analyses, the rs28362491 polymorphism was associated with the risk of nasopharyngeal carcinoma (NC), but not with oral cancer (OC). In addition, no statistical correlation was found between the polymorphism of rs2233406 and HNCs.Conclusion. rs28362491 polymorphism was significantly associated with the risk of HNCs, especially with NC. Additionally, our results showed that no association was discovered between rs2233406 polymorphism and HNCs.

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