Cardiorespiratory Function as Assessed by Exercise Testing in Patients with Non-Insulin-Dependent Diabetes Mellitus

1996 ◽  
Vol 24 (2) ◽  
pp. 209-213 ◽  
Author(s):  
J Katoh ◽  
Y Hara ◽  
M Kmvsu ◽  
J Miyaji ◽  
K Nabutaki
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Weight ◽  
Oxygen Uptake ◽  
Body Mass ◽  
Exercise Testing ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Cardiorespiratory Function ◽  
Insulin Dependent

Exercise testing was used to examine 19 cardiorespiratory diabetes mellitus patients, aged 32 – 68 years (body mass index, 27.8 ± 4.8 kg/m2), and 16 healthy volunteers, aged 23 – 57 years (body mass index, 22.7 ± 2.5 kg/m2). A graded cycling exercise test was done, monitoring gas exchange, ventilation and heart rate. Values were significantly higher in the non-insulin-dependent diabetes mellitus (NIDDM) patients than in the controls for fasting blood glucose ( P < 0.01), glycosylated haemoglobin ( P < 0.01), body weight ( P < 0.05) and body mass index ( P < 0.05). The exercise testing produced values that were significantly lower in the patients with NIDDM than in the controls for percentage oxygen uptake ( P < 0.05), maximum load ( P < 0.05), maximum metabolic equivalent ( P < 0.01) and maximum oxygen uptake per unit body weight ( P < 0.01). Ventilatory capacity and forced expiratory volume at 1 sec did not differ significantly in the two groups. These results suggest that general fitness is diminished due to reduced cardiorespiratory function in patients with NIDDM.

scholarly journals Leptin Synthesis Is Resistant to Acute Effects of Insulin in Insulin-Dependent Diabetes Mellitus Patients*

1997 ◽  
Vol 82 (2) ◽  
pp. 381-382 ◽  
Author(s):  
Juha A. Tuominen ◽  
Pertti Ebeling ◽  
Ulf-Håkan Stenman ◽  
Mark L. Heiman ◽  
Thomas W. Stephens ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Ob Gene ◽  
Insulin Dependent ◽  
Plasma Leptin

Abstract Insulin stimulates ob gene expression and increases serum leptin concentrations in mice and in noninsulin-dependent diabetes mellitus patients. Obese women have higher ob gene messenger ribonucleic acid levels than obese men, suggesting that sex hormones are involved in the regulation of leptin synthesis. We studied the relationship among leptin, insulin, and testosterone in 15 men with insulin-dependent diabetes mellitus (IDDM; age, 29 ± 2 yr; body mass index, 22.7 ± 0.5 kg/m2; body fat, 9.5 ± 1.0%; insulin dose, 44 ± 4 U/day; hemoglobin A1c, 8.1 ± 0.3%; diabetes duration, 12.7 ± 2.0 yr) and 15 healthy control subjects (age, 27 ± 1 yr; body mass index, 22.6 ± 0.4 kg/m2; body fat, 9.6 ± 0.5%) in the fasting state. In addition, the effect of a 4-h euglycemic hyperinsulinemia (∼600 pmol/L) on the plasma leptin concentration was determined. The fasting leptin concentration was negatively correlated to plasma testosterone (r = −0.55; P &lt; 0.05) in IDDM patients. The fasting plasma leptin level rose 25% in healthy subjects (from 1.0 ± 0.2 to 1.3 ± 0.3 ng/mL; P &lt; 0.05). The leptin levels were higher in IDDM subjects (P &lt; 0.01) and remained unchanged (2.7 ± 0.2 vs. 2.7 ± 0.2 ng/mL) during hyperinsulinemia. We reached the following conclusions. 1) In nonobese IDDM patients, leptin synthesis is resistant to the acute effect of insulin. 2) Serum testosterone may contribute to the regulation of leptin synthesis in IDDM patients.

Blood Pressure Response to Physical Exercise in Healthy Adolescents and Adolescents with Insulin-Dependent Diabetes Mellitus

1994 ◽  
Vol 86 (4) ◽  
pp. 425-432 ◽  
Author(s):  
H. Nordgren ◽  
U. Freyschuss ◽  
B. Persson
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Body Weight ◽  
Metabolic Control ◽  
Blood Pressure Response ◽  
Insulin Dependent Diabetes Mellitus ◽  
Pressure Response ◽  
Pressure Increase ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

1. Reference values for systolic blood pressure during exercise are provided for 88 healthy adolescents (12–22 years of age) of both sexes. Data were related to oxygen uptake, heart rate, blood lactate concentration, rate of perceived exertion, age, sex, body size and physcial fitness. 2. The same variables were measured in 55 adolescents of both sexes with insulin-dependent diabetes mellitus of about 12 years duration and were analysed with respect to the healthy control group, to degree of metabolic control and to late diabetic complications. 3. In healthy adolescents the pressure response was not related to sex or age. When compared with control subjects diabetic patients had a higher diastolic blood pressure at rest and a more marked blood pressure increase, 23 versus 19 mmHg W−1 kg−1 body weight, during exercise with no sex difference. The blood pressure rise was not related to metabolic control, glomerular hyperfiltration or physical fitness. 4. Prolonged exercise tests were no more informative regarding the blood pressure response to exercise than the stepwise increased load test. Analysing the blood pressure increase versus relative work load (W/kg body weight) during exercise reveals blood pressure differences otherwise not noted. A diabetic patient with blood pressure above the 97.5% confidence limit during exercise seems to have a higher risk of developing incipient nephropathy 5 years later.

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