An Analysis of 800 Breast Cancer Patients Relapsed after Radical Mastectomy

1976 ◽  
Vol 62 (1) ◽  
pp. 99-112 ◽  
Author(s):  
Sergio Di Pietro ◽  
Lucio Bertario ◽  
Giulio Cantù ◽  
Alberto Re
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Survival Rate ◽  
Soft Tissues ◽  
Regional Lymph Node ◽  
Radical Mastectomy ◽  
Lymph Node Involvement ◽  
Free Interval ◽  
Node Involvement ◽  
Visceral Metastases

The chronology of first recurrences, their topographic distribution and survival from mastectomy were retrospectively studied in a series of 800 mastectomized women with special reference to the relationship between these data and treatment delay, T N categories and free interval. Visceral metastases were more frequent in patients under 50 years, whereas local recurrences were more common in patients over 50. The average free interval was 26 months (over 5 years in 18% of cases) and seemed to be influenced little by the treament delay or by tumor size; it was shorter in patients under 50 years and shorter still in patients with lymph node involvement at operation. A similar correlation exists between these parameters and survival. The 5 year survival rate of the 800 cases with recurrence was 52%, which is quite different from the rate generally indicated for surgical cases, and much higher than the rate for the natural history of untreated breast cancer. The survival rate in cases with first metastases confined to the soft tissues is much higher than in those with bone and/or with visceral metastases. The survival after recurrence proves to be significantly influenced by the length of the free interval, but much more by the presence or absence of regional lymph node involvement, so that the lymph nodes status (N–- or N+) turns out to be a prognostic item of primary importance, even after the onset of recurrence.

scholarly journals Regional Lymph Node Involvement Among Patients With De Novo Metastatic Breast Cancer

2020 ◽  
Vol 3 (10) ◽  
pp. e2018790
Author(s):  
Almir Bitencourt ◽  
Carolina Rossi Saccarelli ◽  
Elizabeth A. Morris ◽  
Jessica Flynn ◽  
Zhigang Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
De Novo ◽  
Regional Lymph Node ◽  
Metastatic Breast ◽  
Lymph Node Involvement ◽  
Regional Lymph Node Involvement ◽  
Node Involvement

Breast cancer with extensive regional lymph node involvement: Toward optimizing local management.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1053-1053
Author(s):  
Lior Zvi Braunstein ◽  
Sigolene Galland ◽  
Saveli Goldberg ◽  
Betro T. Sadek ◽  
Mina Shenouda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Regional Lymph Node ◽  
Lymph Node Involvement ◽  
Local Management ◽  
Regional Lymph Node Involvement ◽  
Node Involvement

scholarly journals Evaluating the Effect of Axillary Lymph Node Involvement and Dissection in the Development of Post-Mastectomy Lymphedema

2019 ◽  
Vol 1 (1) ◽  
pp. 14-21
Author(s):  
Ahmed Abdulnabi ◽  
Issam Merdan
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Axillary Dissection ◽  
Disease Process ◽  
Radical Mastectomy ◽  
Lymph Node Involvement ◽  
Breast Cancer Surgery ◽  
Axillary Lymph ◽  
Node Involvement

Background: Lymphedema of the upper extremity is a serious consequence of breast cancer surgery. Postmastectomy lymphedema of the upper limb is usually related to many risk factors, like axillary surgery, radiotherapy, venous obstruction, obesity, and infection. In the current study, the objective was to identify the relationship between the extent of lymph node involvement and axillary dissection on the development of lymphedema. Patients and methods: One hundred and seventy patients managed by modified radical mastectomy with axillary dissection for mammary-invasive adenocarcinoma between January 2009 and December 2016 in Al-Fayhaa Teaching Hospital. The patients were divided into three groups according to the number of lymph nodes involvd, by pathology. The patients had been followed up for at least two years and assessed by standard lymphedema assessment, then categorized into three groups, according to the severity of lymphedema. Results: After the analysis of patient parameters, the highest age group was 36–45 years. More than 60% of the patients had 4–9 lymph nodes involved. Forty-one patients from the 170 developed lymphedema postoperatively. Forty patients had seroma and twenty-one patients had wound infection postoperatively. Conclusion: Post-mastectomy lymphedema is a sequelae of disease process related to the extent of lymph-node involvement and resection rather than operative fault. Key words: breast cancer, mastectomy, lymphedema.

A Russian nomogram for assessing the risk of metastatic regional lymph node involvement in patients with breast cancer

2020 ◽  
Vol 2_2020 ◽  
pp. 76-81
Author(s):  
Rodionov V.V. Rodionov ◽  
Kometova V.V. Kometova ◽  
Idrisova S.R. Idrisova ◽  
Savinov Yu.G. Savinov Yu ◽  
Balashov I.S. Balashov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Regional Lymph Node ◽  
Lymph Node Involvement ◽  
Regional Lymph Node Involvement ◽  
Node Involvement

scholarly journals Role of clinical and morphological data in prediction of regional lymph node involvement in early-stage breast cancer

2019 ◽  
Vol 15 (1) ◽  
pp. 29-34
Author(s):  
Yu. S. Shatova ◽  
L. N. Vashchenko ◽  
E. S. Bosenko ◽  
S. M. Bakulina ◽  
V. N. Kasyanenko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Primary Tumor ◽  
Regional Lymph Node ◽  
Lymph Node Involvement ◽  
Morphological Data ◽  
Significant Prognostic Factor ◽  
Axillary Lymph ◽  
Regional Lymph Node Involvement ◽  
Node Involvement

Objective:to evaluate the frequency of axillary lymph node metastasis (detected at routine pathomorphological examination) in order to determine the group of patients who do not require lymph node surgery.Materials and methods.We analyzed medical records of 485 patients with breast cancer and no signs (either clinical or instrumental) of regional lymph node involvement who underwent surgery at the first stage of their treatment.Results and conclusion.In patients with cN0 cancer, only the size of primary tumor ≤1 cm was found to be a significant factor indicating that regional lymph nodes are not involved (in addition to palpation, ultrasound, mammography, and spiral x-ray computed tomography of the chest). In patients with сТ1c cancer, the majority of standard immunohistochemical markers cannot yet be used as predictors of regional lymph node involvement. However, tumor differentiation grade G1 is rather an exclusion, which in combination with the size of the primary tumor сТ1c can also be considered as a significant prognostic factor.

Molecular genetic prognostic factors for metastatic regional lymph node involvement in breast cancer patients

2020 ◽  
Vol 3_2020 ◽  
pp. 141-147
Author(s):  
Dergunova Yu.A. Dergunova ◽  
Bozhenko V.K. Bozhenko ◽  
Podionov V.V. Podionov ◽  
Kometova V.V. Kometova ◽  
Makarova M.V. Makarova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Cancer Patients ◽  
Regional Lymph Node ◽  
Molecular Genetic ◽  
Lymph Node Involvement ◽  
Breast Cancer Patients ◽  
Regional Lymph Node Involvement ◽  
Node Involvement

scholarly journals Clinical profile of carcinoma breast cases at a tertiary care hospital

2017 ◽  
Vol 4 (3) ◽  
pp. 913 ◽  
Author(s):  
Arifa Almas
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Regional Lymph Node ◽  
Clinical Stage ◽  
Distant Metastases ◽  
Lymph Node Involvement ◽  
Breast Cancer Patients ◽  
Medical College ◽  
Regional Lymph Node Involvement ◽  
Node Involvement

Background: Breast carcinoma is a serious health problem and is among the major health issues in India. Also, it has a relatively early age presentation in this part of the world. Present study describes the features like age at presentation, clinical stage at presentation and incidence of regional lymph node involvement and distant metastases among the breast cancer patients at Government Medical College, Jabalpur in Madhya Pradesh, India.Methods: This hospital-based descriptive study was conducted at the Department of Surgery, Government Medical College, Jabalpur in Madhya Pradesh state of India. Fifty patients with a confirmed diagnosis of breast cancer were included in the study. The details like age at presentation, clinical stage at presentation and incidence of regional lymph node involvement and distant metastases among the breast cancer patients were described and tabulated.Results: Youngest patient of the series was aged 30 years whereas the oldest was aged 65 years. Maximum patients belonged to 41 to 50 years age group. Stage wise distribution of cases reflected that Stage III was the most common stage at presentation. Majority of the cases had lymph node involvement (90%). Liver metastasis was seen in 8 cases (16%), of which, 2 cases had ascites. There were 6 cases of lung metastasis, of which 2 cases had pleural effusion and remaining 4 cases showed solitary metastasis. 6 cases of osseous metastasis were observed, out of which, 2 cases had skull metastasis and 4 cases had spine involvement.Conclusions: It was found that the age group in majority of the patients was younger as compared to Western world and this finding is in line with data from India and other Asian regions. Also, there was a presentation at a later stage of disease in our study population.

Clinicostatistical Analysis of Rhinopharyngeal Neoplasms Treated by Radiotherapy from 1928 to 1963 (314 Cases)

1966 ◽  
Vol 52 (5) ◽  
pp. 375-391 ◽  
Author(s):  
Alberto Banfi ◽  
Giuseppe Carnevali ◽  
Gianfranco Coopmans De Yoldi ◽  
Ugo Felci ◽  
Adalgiso Guzzon
Keyword(s):  
Lymph Node ◽  
Survival Rate ◽  
Lymph Node Metastases ◽  
Regional Lymph Node ◽  
Lymph Node Involvement ◽  
Favourable Outcome ◽  
Node Involvement ◽  
Node Metastases ◽  
Epithelial Neoplasms ◽  
Base Of The Skull

Results obtained by radiotherapy in 314 cases of rhinopharyngeal neoplasms treated from 1928 to 1963 at the Institute of Radiology of the Medical School and at the National Cancer Institute are presented. The series of cases includes 61 epithelial neoplasms, 117 rhinopharyngiomas, 112 connective neoplasms and 24 cases non histologically proved. In 41.7 % of the cases regional lymph node invasion was the first sign of the disease. Regional lymph node involvement was present at the beginning of radiotherapy in 72.5 % of the cases. Sixty-eight cases, hospitalized from 1928 to 1945, were prevailingly treated with endocavitary radiumtherapy and by roentgentherapy. One hundred and sixty cases, hospitalized from 1946 to 1958, were treated by various procedures and, in the last years, almost exclusively by multiple small fields roentgentherapy and by convergent roentgentherapy. Most of the 80 cases treated from 1959 to 1963 were submitted to telecobalt therapy. In the connective neoplasms (lympho- and reticulosarcomas) the overall 3-year and 5-year survival rate has been 34.2 % and 28.5 % respectively. In particular, cases without regional lymph node invasion at the beginning of the treatment had a 5-year survival rate of 61.5 %, opposite to 15.4 % in patients with lymph node metastases. In the other histological forms (rhinopharyngiomas, epitheliomas and non ascertained cases) the overall 3-year survival was 28 %, and the 5-year survival 19.6 %. In patients showing no lymph node involvement at the beginning of the treatment the 5-year survival rate was 37.8 %, in those with unilateral invasion 15.8 %, and in those with bilateral lymph node metastases 5.8 %. In epithelial neoplasms, the 5-year survival was 12.5 % in patients who had, at the beginning of the treatment, neurological or radiological signs of metastases to the base of the skull, and 21.9 % in patients, without involvement of the base of the skull. A statistical analysis of the results obtained in the various periods showed a more favourable outcome in patients treated by telecobalt therapy, as demonstrated both by average life and 3-year and 5-year survival rates.

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