scholarly journals Histopathological pattern of malignancy in solitary thyroid nodule

2012 ◽  
Vol 18 (1) ◽  
pp. 5-10 ◽  
Author(s):  
SM Nazmul Huque ◽  
Mohammad Idrish Ali ◽  
Md Mahmudul Huq ◽  
Sk Nurul Fattah Rumi ◽  
Md Abdus Sattar ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Significant Proportion ◽  
Cervical Lymphadenopathy ◽  
Follicular Carcinoma ◽  
Neck Surgery ◽  
Anaplastic Carcinoma ◽  
Female Ratio ◽  
Significant Difference ◽  
Solitary Thyroid Nodule

Objective: To find out relative frequency and type of malignancy in solitary thyroid nodule (STN).Methods: This cross sectional study done in the Department of Otolaryngology Head & Neck Surgery, Dhaka Medical College Hospital (DMCH), Dhaka and Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during the period of July 2008 to June 2009. For this study, 118 patients who were admitted a case of solitary thyroid nodule for operation. Diagnosed the case by detailed history, clinical examination, investigations, analyzed data presented by various tables, graphs and figures. Total 118 patients were selected as per described criteria from the Department of otolaryngology and head-neck surgery DMCH & BSMMU, Dhaka from July 2008 to July 2009.Results: In this study of 118 patients of STN, majority of the patients were within 21-40 years age group with female predominance. In thyroid malignancy male and female ratio was 1:1.75. Among 118 cases of solitary thyroid nodule 22 cases were malignant. Out of 22 malignant cases, 16(73%) were papillary carcinoma, 4(18%) were follicular carcinoma and 2(9%) were anaplastic carcinoma. Thyroid swelling was the common presentation in all cases (100%), some patients also presented with other symptoms like cervical lymphadenopathy in 6 (5.08%) cases, dysphagia 2(1.69%) cases and hoarseness of voice 1(0.85%) case. Study showed very significant difference (p <0.01) between papillary and follicular carcinoma, highly significant difference (p<0.001) between papillary and anaplastic carcinoma. So, papillary carcinoma was more common among all thyroid malignancies in patients with solitary thyroid nodule.Conclusion: Significant proportion of solitary thyroid nodule (18.65%) was malignant. So, careful assessment of thyroid nodule is important for early diagnosis.DOI: http://dx.doi.org/10.3329/bjo.v18i1.10407Bangladesh J Otorhinolaryngol 2012; 18(1): 5-10

scholarly journals Frequency & pattern of malignancy in solitary thyroid nodule

1970 ◽  
Vol 15 (1) ◽  
pp. 1-5
Author(s):  
Md Rafiqul Islam ◽  
AFM Ekramuddaula ◽  
MS Alam ◽  
MS Kabir ◽  
Md Delwar Hossain ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Histopathological Examination ◽  
Malignant Lesion ◽  
Medullary Carcinoma ◽  
College Hospital ◽  
Frequency Pattern ◽  
Cross Sectional ◽  
Female Ratio ◽  
Solitary Thyroid Nodule

This cross sectional study done in the department of Banghabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital during the period of July 2005 to October 2007 to determine frequency & pattern of malignancy in solitary thyroid nodule. For this study, 118 patients who were diagnosed as a case of malignancy in solitary thyroid nodule by detailed history, clinical examination, thyroid hormone assay, ultrasonogram, thyroid scan, FNAC and histopathological examination, were collected. In this study majority of the patients were within 21-40 years of age. Frequency of solitary thyroid nodule is more in female with male female ratio 1: 2.11 Majority of the nodules were firm (72.03%), others were hard (16.95%) and cystic (11.02%). Malignant lesion was more common in hard nodule (70%). Most of the nodules were cold (66.10%) among them 25.6% cases were malignant, followed by warm (30.5%) and hot (3.3%). No malignancy was found in hot nodule. FNAC showed colloid nodule (44%), cellular follicular lesion (29.66%), papillary carcinoma (12.7%), colloid degeneration (4.2%) and medullary carcinoma (1.6%) Out of 118 patients, histopathologically non malignant were 96 (81.35%) and malignant were 22(18.65%). Among malignant cases, 16 (72.72%) cases were papillary carcinoma, 4 (18.18%) cases were follicular carcinoma and 2(9.1%) cases were medullary carcinoma. Key words: Solitary thyroid nodule, FNAC, Papillary carcinoma, Follicular carcinomaDOI: 10.3329/bjo.v15i1.4303 Bangladesh J of Otorhinolaryngology 2009; 15(1): 1-5

scholarly journals Histopathological Spectrum of Non-Neoplastic and Neoplastic Lesions of Thyroid: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (231) ◽  
Author(s):  
Dilasma Ghartimagar ◽  
Arnab Ghosh ◽  
Manish Kiran Shrestha ◽  
Sushma Thapa ◽  
Om Prakash Talwar
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Follicular Carcinoma ◽  
Cross Sectional Study ◽  
Anaplastic Carcinoma ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Neoplastic Lesions ◽  
Thyroid Lesions

Introduction: Thyroid gland lesions are the most common endocrine disorders encountered globally. Diseases of the thyroid gland present with either an alteration of hormone secretion or as an enlargement of the thyroid gland. The objective of the study is to find the frequency of different thyroid lesions. Methods: A descriptive cross-sectional study was conducted at Manipal Teaching Hospital, Pokhara from Jan 2005 to Jan 2020. Ethical approval was taken from the Institutional Review Committee (Ref: 330). Patients who had undergone thyroidectomy procedures for both non-neoplastic and neoplastic thyroid lesions were enrolled. Convenient sampling was done. IBM Statistical Package for Social Sciences version 21 and Microsoft Excel were used. Results: Out of 345 thyroidectomy specimens, 246 (71.3%) cases of non-neoplastic lesions, and 99 (28.69%) cases of neoplastic lesions were present. There were 54 males and 291 females with a male to female ratio of 1:5.4. The age ranged from 9 to 76 years with a mean age of 43.67 years. In non-neoplastic lesions, the predominant lesion was the colloid goiter with 205 (83.33%) cases followed by Grave’s disease and lymphocytic thyroiditis with 14 (5.69%) cases each. In neoplastic lesions, papillary carcinoma was the commonest lesion with 56 (56.56%) cases followed by follicular carcinoma with 14 (14.14%) cases and follicular adenoma with 13 (13.13%) cases. There were also 9 (9.09%) cases of anaplastic carcinoma in neoplastic lesions. Conclusions: Colloid goiter and papillary carcinoma was the most commonly encountered non-neoplastic and neoplastic lesion with a female predominance. Rare tumors like anaplastic carcinoma, papillary carcinoma, and follicular carcinoma with anaplastic transformation were also encountered.

scholarly journals Malignant Thyroid Lesions: A Histopathological Perspective

2019 ◽  
pp. 1-10
Author(s):  
Innocent Emmanuel ◽  
Mansur Aliyu Ramalan ◽  
Adam Ochigbo ◽  
Philip Akpa ◽  
Daniel Yakubu ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Carcinoma ◽  
Female Gender ◽  
Medullary Carcinoma ◽  
Anaplastic Carcinoma ◽  
Diagnostic Methods ◽  
University Teaching ◽  
Female Ratio ◽  
Thyroid Cancers ◽  
Age Range

Introduction: Thyroid cancer incidence is increasing globally. This increase has been attributed to improvement in diagnostic methods. This study has as its aim the analysis of the pattern of thyroid gland malignancies seen at the Jos University Teaching Hospital, Jos, Nigeria, between January 2008 and December 2018. Methodology: A descriptive retrospective study of consecutive cases of thyroid specimens analyzed at our center was done. Data was obtained from the Histopathology Department Records. The diagnosis of each case was confirmed by reviewing archival slides. Results: There were 70 cases of thyroid carcinomas during the period of the study. The histological types of thyroid cancers seen were: follicular carcinoma, papillary carcinoma, medullary carcinoma and anaplastic carcinoma, respectively accounting for 36(51.4%), 23(32.9%), 4(5.7%) and 7(8.6%) cases. There was only 1 case of follicular carcinoma in 2012, and non between 2013 and 2018. The male to female ratio was 1: 3.1. The mean age of thyroid carcinoma was 42.7 years, with an age range of 13-80 years. Conclusion: The histological pattern of thyroid cancers has changed over the last two decades in our environment with the erstwhile predominant follicular carcinoma receding to near disappearance. The papillary carcinoma histotype is currently overwhelmingly the commonest type diagnosed. The former is relatively commonly seen in the older age group, in a sharp contrast with the later. The female gender remains the most afflicted group.

scholarly journals Frequency of Malignancy in solitary Thyroid nodule and Multi-nodular Goitre

2015 ◽  
Vol 20 (2) ◽  
pp. 55-59 ◽  
Author(s):  
Md Abul Hossain ◽  
Md Zakaria Sarkar ◽  
Utpal Kumar Dutta ◽  
Md Abdul Karim ◽  
Md Zahedul Alam
Keyword(s):  
Thyroid Nodule ◽  
Relative Frequency ◽  
Follicular Adenoma ◽  
Anaplastic Carcinoma ◽  
Medical Attention ◽  
Cross Sectional ◽  
Female Ratio ◽  
Nodular Goitre ◽  
Number Of Patients ◽  
Solitary Thyroid Nodule

This cross sectional study with purposive sampling based on 50 cases of solitary thyroid nodule and multi-nodular goitre for operation in department of Otolaryngology and Head-Neck surgery of SSMC & Mitford Hospital, Dhaka and Dhaka Medical college, Dhaka during January 2009 to December 2009. Objectives of this study to find out relative frequency of malignancy in solitary thyroid nodule and multi-nodular goitre (by histopathology). Each case was studied by history taking, physical examination and relevant investigations. In this series, male to female ratio was 1:7. Mean age of the patients of nodular goitre was 36.5+12.33 years and the highest number of patients were found in age group 31-40 years. After operation, histopatholoical report analysis was done and found that nodular colloidal goitre was 52%, follicular adenoma was 24% and auto-immune thyroiditis was 6%. Among the malignancies papillary carcinoma was 66.66%, follicular carcinoma was 22.22% and anaplastic carcinoma was 11.11%. The relative frequency of malignancy in solitary thyroid nodule was 28% and in multi-nodular goitre was 8%. As there is a chance of malignancy is high so it should get serious medical attention DOI: http://dx.doi.org/10.3329/bjo.v20i2.22019 Bangladesh J Otorhinolaryngol; October 2014; 20(2): 55-59

scholarly journals Study of Pathological Variations of Solitary Thyroid Nodule

2019 ◽  
Vol 24 (2) ◽  
pp. 105-114
Author(s):  
Abdullah Al Mamun ◽  
Zahedul Alam ◽  
Mazharul Islam ◽  
Mashuque Mahamud ◽  
Mizanur Rahman ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Cervical Lymphadenopathy ◽  
Neck Surgery ◽  
Final Diagnosis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Nodular Goitre ◽  
Neoplastic Lesion ◽  
Malignant Case ◽  
Solitary Thyroid Nodule

Objective: To find out the incidence of malignancy in patient with solitary thyroid nodule. Methods: This cross-sectional study was carried out with 100 solitary thyroid nodular patients who admitted in Otolaryngology & Head-Neck Surgery Department of Sir Salimullah Medical College Mitford Hospital (SSMCMH) & Bangabondhu Sheikh Mujib Medical Univercity (BSMMU), Dhaka, from July 2012 to December 2013, where all patients were admitted throughout patient department. All patients were selected as per described criteria from the Department of Otolaryngology & Head-NeckSurgery,SSMCMH & BSMMU.Diagnosed the cases by detail history,clinical examination,investigations,analysed data presented by various tables,figures. Results: In this study mean age of the patients of solitary thyroid nodule was 35.613.54 years and the highest frequency (38%) was within 21-30 years of age with female predominance(78%).Thyroid swelling was the common presentation in all9100%) cases, some patients also presented with other symptoms like cervical lymphadenopathy 13(13%) cases, dysphagia 1(1%), dyspnoea 1(1%), hoarseness of voice 1(1%) case & no bone metastetic found.In this series of solitary thyroid nodules constituted 73% firm, 6% hard and 11% cystic. Malignancy was found more in firm nodule 13(72.22%).Isotopes scanning of the thyroid gland were done to see the functional status of the nodule. We found most 96(96%) of the nodules were cold & 4(4%) were warm nodule & no hot nodule found. In our study out of 96 cold nodular goiters we found 18(18.75 %) malignant & no malignant case found from rest of 4 warm cases. In our study, out of 89 solid nodule 72(80.89%) were benign & 17(19.10%) nodule were malignant and out of 11 cystic nodule 10(90.9%) were benign & 1 (9.1%) was malignant. In this study, most of the benign & malignant nodules were predominantly solid. Study showed the malignancy is significantly (p<0.001) more in solid than cystic solitary thyroid nodule. Final diagnosis in this study was on the basis of histopathological reports record. Out of 100 cases, 54 cases (54%) were proven as nodular goitre & 2 % were thyroiditis in non-neoplastic lesion & in neoplastic lesion we found 26(26%) Bangladesh J of Otorhinolaryngology; October 2018; 24(2): 105-114

Papillary and follicular thyroid carcinoma: the treatment results of 357 patients at the National Kyushu Cancer Centre of Japan

1996 ◽  
Vol 110 (7) ◽  
pp. 657-662 ◽  
Author(s):  
Kimimasa Yasumoto ◽  
Chisato Miyagi ◽  
Tadashi Nakashima ◽  
Hideo Baba ◽  
Yasaburoh Katsuta
Keyword(s):  
Prognostic Factors ◽  
Patient Survival ◽  
Follicular Thyroid Carcinoma ◽  
Follicular Carcinoma ◽  
Neck Surgery ◽  
Tumour Invasion ◽  
Patients Âgés ◽  
Cancer Centre ◽  
Extrathyroidal Invasion ◽  
Significant Difference

AbstractDuring the period from April 1974 to March 1993, 357 patients received surgical treatment for papillary and follicular carcinoma of the thyroid gland at the Department of Head and Neck Surgery of National Kyushu Cancer Centre, Japan. In this paper, we review the various clinico-pathological features of these patients and analyse their influence on patient survival. While the majority of the patients' ages ranged from the third through seventh decade, only the patients older than 40 years old died. In papillary carcinomas, there was a statistically significant difference in the survival rate between younger (less than 45 years old) and older (45 years of age or older) patients. The rate of patients who died of thyroid cancer also increased in the cases with extra-thyroidal tumour invasion, and metastasis to distant organs. A multivariate analysis also showed that the age, extrathyroidal invasion and distant metastasis are significant prognostic factors. However, sex, histology and lymph node metastasis were not prognostic factors for survival.

scholarly journals The Incidence of Thyroid Carcinoma in Multinodular Goiter: A Retrospective Study

2015 ◽  
Vol 10 (4) ◽  
pp. 18-21 ◽  
Author(s):  
D. Shrestha ◽  
S. Shrestha
Keyword(s):  
Retrospective Study ◽  
Multinodular Goiter ◽  
Nodular Goiter ◽  
Follicular Carcinoma ◽  
Neck Surgery ◽  
Anaplastic Carcinoma ◽  
Histopathological Analysis ◽  
Thyroid Lesion ◽  
Number Of Patients ◽  
Thyroid Malignancies

Background and Objective: To determine the incidence and the types of various thyroid malignancies in multi-nodular goiter.Material and methods: This is a retrospective study, conducted in Department of ENT and Head and Neck Surgery, National Academy of Medical Sciences Bir Hospital Kathmandu and Alka Hospital Pvt. Ltd Lalitpur. The study period was 3 years from 11 January 2011 to 10 January 2014. The study population consisted of 100 patients who were diagnosed as a multinodular thyroid nodule.Result: The highest frequency was 50 (50%) in 31-40 years. Among the total cases, 28 (28%) were males and 72(72%) females. Histopathological analysis showed that benign multi-nodular goiter was present in 87 (87%) cases, and malignant thyroid lesion in 13 (13%) cases. Among malignancies, papillary carcinoma was found as the commonest malignancy 11 (84.61%) cases followed by follicular carcinoma 1 (7.69%) case and anaplastic carcinoma 1(7.69%) case.Conclusion: The risk of malignancy in multinodular goiter should not be underestimated as significant number of patients with thyroid malignancies present with multinodular goiter.JCMS Nepal 2014; 10(4):18-21

Sonological evaluation of thyroid swellings

2021 ◽  
Vol 12 (2) ◽  
pp. 72-76
Author(s):  
Raghu G ◽  
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Clinical Diagnosis ◽  
Nodular Goiter ◽  
Anaplastic Carcinoma ◽  
Age Group ◽  
Thyroid Malignancy ◽  
Thyroid Lesion ◽  
Female Ratio ◽  
Male To Female

Background: Ultrasonography has become the procedure of choice for the initial evaluation of thyroid gland in many centers. It permits a quick evaluation of thyroid gland; its relationship with adjacent structure and an assessment of the main lymph node chains of the neck. The major advantage of ultrasound is the rapidity with which the images are obtained. In order to study the various typical and atypical sonological features of those lesions presenting as thyroid swellings, this study was undertaken. Aims and Objectives: To evaluate thyroid swelling with reference to-Ultrasonic appearance and characteristics of thyroid gland in its various disorders. Materials and Methods: In this series, during the period from September 2002 to September 2004, 65 cases of clinically suspected thyroid swellings were studied using real time ultrasound. The patients were referred from surgical and medical units of Victoria hospital, Bangalore. Results: 16.92% of patients were males and 83.08% females with male to female ratio of 1:4.9. Maximum number of cases was found in the age group 31-40 years (25 out of 65 cases i.e. 38.46%). Nodular goiter was found in 56.91% and 5 patients of thyroid malignancy of which 3 patients were papillary carcinoma, 1 was follicular carcinoma, and 1 patient was anaplastic carcinoma. The sonographic findings in clinical diagnosis of solitary thyroid nodule in 38 patients only 22 (i.e. 57.89%) of these were truly solitary on ultrasound examination. Of 27 patients referred with clinical diagnosis of multinodular disease, 6 patients had diffuse enlargement of the gland, 20 patients had multinodular involvement on ultrasonographic examination. Conclusions: Thyroid lesions were more common in females with male to female ratio of 1:4.9. Most frequently encountered thyroid lesion was nodular goiter and maximum incidence occurred in the age group of 31-40 years. 11 cases of adenoma and 5 cases of thyroid malignancy were found which included 3 cases of papillary carcinoma suggesting it as the commonest malignancy.

Anaplastic Carcinoma of the Thyroid Arising More Often from Follicular Carcinoma than Papillary Carcinoma

2007 ◽  
Vol 14 (10) ◽  
pp. 3011-3018 ◽  
Author(s):  
Hwei-Ming Wang ◽  
Yu-Wen Huang ◽  
Jen-Seng Huang ◽  
Cheng-Hsu Wang ◽  
Victor C. Kok ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Carcinoma ◽  
Anaplastic Carcinoma
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