Feline Anaplastic Giant Cell Adenocarcinoma of the Thyroid

An 8-year-old castrated, male, domestic short-haired cat had anaplastic giant cell adenocarcinoma in the thyroid gland. The cat had difficulty in breathing and swallowing because of a rapidly growing mass in the left thyroid region that partially enclosed the trachea and esophagus and had evidence of diffuse discrete interstitial pulmonary metastases. The neoplasm, which was locally invasive, was formed by groups of pleomorphic cells arranged in an endocrine-like pattern. The cells were round, spindle, fusiform or irregular; some were large and multinucleated with up to 50 nuclei. Metastases were in the lungs, pleura and regional lymph nodes. Microscopically, both thyroid glands were involved; areas of transition from a well differentiated papillary adenocarcinoma to an anaplastic form were seen.

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Intestinal carcinomas in two tamarins (Saguinus fuscicollis, Saguinus oedipus) of the German Primate Centre

Laboratory Animals ◽

10.1258/002367788780864538 ◽

1988 ◽

Vol 22 (2) ◽

pp. 144-147 ◽

Cited By ~ 15

Author(s):

M. Brack

Keyword(s):

Colon Cancer ◽

Lymph Nodes ◽

Lymphatic System ◽

Saguinus Oedipus ◽

Regional Lymph Nodes ◽

Ileocaecal Valve ◽

Saguinus Fuscicollis ◽

Well Differentiated

Two colonic mucoid adenocarcinomas in tamarins from the German Primate Centre are reported. A mucinous mucoid adenocarcinoma occurred in the ascending and transversal colon of a Saguinus oedipus male more than 8 years old, with metastases in the regional lymph nodes and the pancreas. The tumour corresponded to colon cancer in cotton-topped tamarins of other colonies. The second tumour, a well differentiated tubular mucoid adenocarcinoma, developed at the ileocaecal valve of a 14½ year old Saguinus fuscicollis male with metastases to the local lymphatic system.

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GIANT CELL GRANULOMATA IN REGIONAL LYMPH NODES OF CARCINOMA

Journal of Clinical Pathology ◽

10.1136/jcp.11.3.244 ◽

1958 ◽

Vol 11 (3) ◽

pp. 244-250 ◽

Cited By ~ 16

Author(s):

G. A. Gresham ◽

A. G. Ackerley

Keyword(s):

Lymph Nodes ◽

Giant Cell ◽

Regional Lymph Nodes

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An Unusual, Highly Aggressive, Anaplastic Carcinoma of the Nasal Cavity

Otolaryngology ◽

10.1177/019459988008800308 ◽

1980 ◽

Vol 88 (3) ◽

pp. 233-235

Author(s):

Marie Frankel ◽

Anand Chaudry ◽

Lorenzo Teruel

Keyword(s):

Lymph Nodes ◽

Nasal Cavity ◽

Pulmonary Metastases ◽

Anaplastic Carcinoma ◽

Initial Diagnosis ◽

Regional Lymph Nodes ◽

Local Recurrences

The case of a patient who had a rapidly growing anaplastic carcinoma of the nasal cavity is reported. The patient died from local recurrences, regional lymph nodes, and distant pulmonary metastases within seven months of the initial diagnosis.

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Lymph Nodal Merkel Cell Carcinoma; Primary or Metastatic Disease? A Clinical Case

Tumori Journal ◽

10.1177/030089160208800516 ◽

2002 ◽

Vol 88 (5) ◽

pp. 424-426 ◽

Cited By ~ 18

Author(s):

Giuseppe Fotia ◽

Roberto Barni ◽

Cristiana Bellan ◽

Alessandro Neri

Keyword(s):

Lymph Nodes ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Pulmonary Metastases ◽

Histopathological Examination ◽

Palliative Radiotherapy ◽

Merkel Cell ◽

Neoplastic Tissue ◽

Regional Lymph Nodes

We report a case of Merkel cell carcinoma (MCC) presenting in the lymph nodes in the absence of a primary cutaneous site. The MCC was treated by palliative radiotherapy, which controlled the disease locally. Eight months after diagnosis a mass appeared on the ipsilateral knee; histopathological examination of this lesion confirmed the diagnosis of MCC. The patient died two months later due to the development of pulmonary metastases. Interestingly, the neoplastic tissue was confined to the regional lymph nodes for several months before the primary site appeared. Primary lymph nodal MCC is rare and the diagnosis is difficult. In our opinion the only way to make a diagnosis of primary lymph nodal MCC is by appropriate clinical follow-up.

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Plexiform Vasculopathy in Feline Cervical Lymph Nodes

Veterinary Pathology ◽

10.1177/0300985817747949 ◽

2018 ◽

Vol 55 (3) ◽

pp. 453-456 ◽

Cited By ~ 2

Author(s):

Nicole Jungwirth ◽

Johannes Junginger ◽

Christoph Andrijczuk ◽

Wolfgang Baumgärtner ◽

Peter Wohlsein

Keyword(s):

Endothelial Cells ◽

Lymph Node ◽

Thyroid Gland ◽

Lymph Nodes ◽

Lymphoid Tissue ◽

Vascular Endothelial ◽

Cervical Lymph Nodes ◽

Vascular Neoplasms ◽

History Of ◽

Well Differentiated

Plexiform vasculopathy refers to an endothelial proliferative disorder affecting cervical or inguinal lymph nodes of cats. The cause of this disorder and the origin of the proliferating endothelial cells are still unknown. In 4 cats with a history of a slowly growing, well-demarcated, nonpainful mass adjacent to the thyroid gland, an enlarged dark brown to red lymph node was removed. Histologically, the lymph nodes showed severe loss of lymphoid tissue with accumulations of erythrocytes. In addition, networks of capillary structures with well-differentiated endothelial cells on a collagen-rich stroma were observed, consistent with benign plexiform vasculopathy. Immunohistochemistry revealed the expression of the vascular endothelial markers CD31 and factor VIII–related antigen. In addition, immunolabeling with a Prox-1 antibody indicated a lymphendothelial origin. With respect to our findings, a lymphendothelial origin has to be considered in cases of intranodal vascular neoplasms.

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20 Tumor Giant Cells in Regional Lymph Nodes of a Case of Recurrent Giant Cell Tumor of Bone

Clinical Orthopaedics and Related Research ◽

10.1097/00003086-196300300-00021 ◽

1963 ◽

Vol 30 (1) ◽

pp. 182???187 ◽

Cited By ~ 8

Author(s):

GLEB N. BUDZILOVICH ◽

GEORGE TRUCHLY ◽

SIGMUND L. WILENS

Keyword(s):

Lymph Nodes ◽

Giant Cell Tumor ◽

Giant Cell ◽

Giant Cells ◽

Cell Tumor ◽

Regional Lymph Nodes ◽

Recurrent Giant Cell Tumor

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Breast Cancer Clinical Regional Lymph Nodes TNM Finding v8

10.32388/akyy54 ◽

2020 ◽

Author(s):

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Regional Lymph Nodes

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Histological Study of Human Thyroid Gland Relative Proportion of Parenchyma and Stroma in Thyroid Glands of Bangladeshi People

Update Dental College Journal ◽

10.3329/updcj.v1i2.13981 ◽

2013 ◽

Vol 1 (2) ◽

pp. 17-20

Author(s):

Md Enayet Ullah ◽

Hasna Hena ◽

Rubina Qasim

Keyword(s):

Thyroid Gland ◽

Histological Study ◽

Relative Proportion ◽

Age Groups ◽

Human Thyroid ◽

Structural Units ◽

Thyroid Glands ◽

Group A ◽

Group B ◽

Connective Tissue Sheath

Deep cervical fascia forms a connective tissue sheath around the thyroid gland. Delicate trabeculae and septa penetrate the gland indistinctly dividing the gland into lobes and lobules which in turn composed of follicles.1,2,3 These follicles are structural units of thyroid gland which varies greatly in size and shape.4 The number of follicles varies in different age groups. The study was carried out to see the percentage of area occupied by follicles in the stained section of thyroid glands in different age groups. The collected samples were grouped as A (3.5 20yrs), B (21- 40yrs) & C (41 78yrs). Percentage of area occupied by follicles was (58.55±10.72) in group A, (63.79±12.35) in group B + (63.39±8.29) in group C.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13981 Update Dent. Coll. j. 2011: 1(2): 17-20

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INHIBITION OF THYROGLOBULIN BIOSYNTHESIS AND DEGRADATION BY EXCESS IODIDE. SYNERGISM WITH LITHIUM

Acta Endocrinologica ◽

10.1530/acta.0.0810495 ◽

1976 ◽

Vol 81 (2) ◽

pp. 495-506 ◽

Cited By ~ 9

Author(s):

A. Radvila ◽

R. Roost ◽

H. Bürgi ◽

H. Kohler ◽

H. Studer

Keyword(s):

Protein Synthesis ◽

Thyroid Gland ◽

Inhibitory Action ◽

Inhibit Protein Synthesis ◽

Thyrotrophic Hormone ◽

Thyroid Glands ◽

Pre Treatment ◽

Excess Iodide ◽

Kidney Liver

ABSTRACT Lithium and excess iodide inhibit the release of thyroid hormone from preformed stores. We thus tested the hypothesis that this was due to an inhibition of thyroglobulin breakdown. Rats were pre-treated with propylthiouracil (PTU) for 3 weeks in order to deplete their thyroids of thyroglobulin. While the PTU was continued, lithium chloride (0.25 mEq./100 g weight) or potassium iodide (3 mg per rat) were injected every 12 h for 3 days. Thereafter the thyroglobulin content in thyroid gland homogenates was measured. PTU pre-treatment lowered the thyroglobulin content from 4.21 to 0.22 mg/100 mg gland. Lithium caused a marked re-accumulation of thyroglobulin to 0.60 mg/100 mg within 3 days. While iodide alone had only a borderline effect, it markedly potentiated the action of lithium and a combination of the two drugs increased the thyroglobulin content to 1.04 mg/100 mg. Thyroxine was injected into similarly pre-treated animals to suppress secretion of thyrotrophic hormone. This markedly inhibited the proteolysis of thyroglobulin and 1.3 mg/100 mg gland accumulated after 3 days. Excess iodide, given in addition to thyroxine, decreased the amount of thyroglobulin accumulated to 0.75 mg/100 mg gland. To study whether this could be explained by an inhibitory action of iodide on thyroglobulin biosynthesis, thyroid glands from animals treated with excess iodide were incubated in vitro in the presence of 0.2 mm iodide for 3 h. Iodide decreased the incorporation of radioactive leucine into total thyroidal protein and into thyroglobulin by 25 and 35 % respectively. Iodide did not inhibit protein synthesis in the kidney, liver or muscle tissue. Thus, large doses of iodide selectively inhibit thyroglobulin biosynthesis.

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