Hemobartonella-like Parasites in Cynomolgus Monkeys (Macaca fascicularis)

1994 ◽  
Vol 31 (3) ◽  
pp. 301-307 ◽  
Author(s):  
J. E. Dillberger ◽  
D. E. Loudy ◽  
R. R. Adler ◽  
J. H. Gass
Keyword(s):  
Blood Cell ◽  
Adult Female ◽  
Red Blood Cell ◽  
Macaca Fascicularis ◽  
Latent Infections ◽  
Cynomolgus Monkeys ◽  
The Relationship ◽  
Research Studies

Red blood cell parasites were identified electron microscopically in five anemic adult female cynomolgus monkeys ( Macaca fascicularis), two of which died during anemic episodes. Organisms typically were 0.3–0.5-μm round, oval, or reniform bodies on the surface or within vacuoles of erythrocytes. Based on their size, location in the erythrocyte, and internal ultrastructural features, organisms were classified as Hemobartonella-like. The relationship between the organisms and the anemias in these monkeys was unclear. This report adds rickettsial erythrocyte infections to the list of latent infections that can complicate research studies with cynomolgus monkeys.

scholarly journals Effect of red blood cell transfusion on short-term outcomes in very low birth weight infants

2020 ◽  
Vol 63 (2) ◽  
pp. 56-62
Author(s):  
Eui Young Lee ◽  
Sung Shin Kim ◽  
Ga Young Park ◽  
Sun Hyang Lee
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Very Low Birth Weight ◽  
Short Term ◽  
Vlbw Infants ◽  
Early Onset Sepsis ◽  
The Relationship ◽  
Rbc Transfusion

Background: Red blood cell (RBC) transfusion improves cardiorespiratory status of preterm infants by increasing circulating hemoglobin, improving tissue oxygenation, and reducing cardiac output. However, RBC transfusion itself has also been suggested to negatively affect short-term outcomes such as intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), and necrotizing enterocolitis (NEC) in premature infants.Purpose: This study aimed to analyze the relationship between RBC transfusion and short-term outcomes in very low birth weight (VLBW) infants (birth weight, <1,500 g).Methods: We retrospectively reviewed the medical records of VLBW infants admitted to the Soonchunhyang University Bucheon Hospital between October 2010 and December 2017. Infants who died during hospitalization were excluded. The infants were divided into 2 groups according to RBC transfusion status. We investigated the relationship between RBC transfusion and short-term outcomes including BPD, ROP, NEC, and IVH.Results: Of the 250 enrolled VLBW infants, 109 (43.6%) underwent transfusion. Univariate analysis revealed that all shortterm outcomes except early-onset sepsis and patent ductus arteriosus were associated with RBC transfusion. In multivariate analysis adjusted for gestational age, birth weight and Apgar score at 1 minute, RBC transfusion was significantly correlated with BPD (odds ratio [OR], 5.42; <i>P</i><0.001) and NEC (OR, 3.40; <i>P</i>= 0.009).Conclusion: RBC transfusion is significantly associated with adverse clinical outcomes such as NEC and BPD in VLBW infants. Careful consideration of the patient’s clinical condition and appropriate guidelines is required before administration of RBC transfusions.

scholarly journals Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition

2020 ◽  
pp. neurintsurg-2020-016966
Author(s):  
Seán Fitzgerald ◽  
Rosanna Rossi ◽  
Oana Madalina Mereuta ◽  
Duaa Jabrah ◽  
Adaobi Okolo ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Formation Mechanisms ◽  
Large Artery ◽  
Cell Content ◽  
Stroke Etiology ◽  
Clot Burden ◽  
Similar Formation ◽  
The Relationship ◽  
Radiological Studies

BackgroundInitial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non-cardioembolic clots.ObjectiveTo report the relationship between stroke etiology, extracted clot area, and histological composition at each procedural pass.MethodsAs part of the multi-institutional RESTORE Registry, the Martius Scarlett Blue stained histological composition and extracted clot area of 612 per-pass clots retrieved from 441 patients during mechanical thrombectomy procedures were quantified. Correlations with clinical and procedural details were investigated.ResultsClot composition varied significantly with procedural passes; clots retrieved in earlier passes had higher red blood cell content (H4=11.644, p=0.020) and larger extracted clot area (H4=10.730, p=0.030). Later passes were associated with significantly higher fibrin (H4=12.935, p=0.012) and platelets/other (H4=15.977, p=0.003) content and smaller extracted clot area. Large artery atherosclerotic (LAA) clots were significantly larger in the extracted clot area and more red blood cell-rich than other etiologies in passes 1–3. Cardioembolic and cryptogenic clots had similar histological composition and extracted clot area across all procedural passes.ConclusionLAA clots are larger and associated with a large red blood cell-rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets/other content than LAA clots, making them stiffer clots. The per-pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms.

The Relationship Between Red Blood Cell Na/K-ATPase Activities and Diabetic Complications in Patients with Type 2 Diabetes Mellitus

Endocrine ◽  
2003 ◽  
Vol 21 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Bayram Koc ◽  
Vedat Erten ◽  
M. Ilker Yilmaz ◽  
Alper Sonmez ◽  
I. Hakki Kocar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Diabetic Complications ◽  
The Relationship

CONCENTRATIONS OF OESTRADIOL-17β AND PROGESTERONE IN THE PERIPHERAL PLASMA OF THE CYNOMOLGUS MONKEY (MACACA FASCICULARIS) IN RELATION TO THE LENGTH OF THE MENSTRUAL CYCLE AND ITS COMPONENT PHASES

1978 ◽  
Vol 79 (1) ◽  
pp. 1-7 ◽  
Author(s):  
A. A. SHAIKH ◽  
R. H. NAQVI ◽  
S. A. SHAIKH
Keyword(s):  
Menstrual Cycle ◽  
Cynomolgus Monkey ◽  
Luteal Phase ◽  
Cycle Length ◽  
Macaca Fascicularis ◽  
Phase Correlation ◽  
Cynomolgus Monkeys ◽  
Menstrual Cycles ◽  
Peripheral Plasma ◽  
The Relationship

Ninety-three female cynomolgus monkeys were monitored throughout 647 menstrual cycles; 93·2% of these cycles were 22–37 days long and were normally distributed, with a mean of 29·2 days. Menstrual bleeding generally lasted for 3–5 days and was not related to the length of the cycle. The levels of progesterone and oestradiol-17β in the plasma were measured during the menstrual cycle in 30 monkeys. The concentration of oestradiol-17β reached a mid-cycle peak on day 11 or 12 of the cycle. The interval between the beginning of the cycle and the oestrogen peak was constant; the interval between the oestrogen peak and the end of the cycle increased or decreased with the cycle length. The level of progesterone began to rise at about the time of the oestrogen peak and remained raised for longer periods as the length of the cycle increased. The length of the menstrual cycle, therefore, appeared to be determined by the duration of the increase in the level of progesterone or by the life of the corpus luteum in the luteal phase. The relationship between the lengths of the cycle and the luteal phase can be defined by the expression: cycle length = 12·6+0·96 × length of luteal phase (correlation coefficient = 0·875).

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