Postoperative Subchondral Bone Marrow Lesion Is Associated With Graft Extrusion After Lateral Meniscal Allograft Transplantation

2020 ◽  
Vol 48 (13) ◽  
pp. 3163-3169
Author(s):  
Ju-Ho Song ◽  
Seong-Il Bin ◽  
Jong-Min Kim ◽  
Bum-Sik Lee
Keyword(s):  
Bone Marrow ◽  
Regression Analysis ◽  
Lateral Compartment ◽  
Meniscal Allograft Transplantation ◽  
Chi Square ◽  
Postoperative Mri ◽  
Meniscal Allograft ◽  
Graft Extrusion ◽  
Mri Scans ◽  
Chi Square Analysis

Background: Adverse effects of graft extrusion after meniscal allograft transplantation (MAT) are difficult to assess and can be determined only in the long term using a simple radiograph. Recently, subchondral bone marrow lesions (BMLs) detected on magnetic resonance imaging (MRI) scans have been used to evaluate the outcomes or prognoses of various knee surgeries. However, whether subchondral BMLs on MRI scans reflect the effects of allograft extrusion remains unclear. Hypothesis: Subchondral BML in the lateral compartment of the knee joint on postoperative MRI scans would be associated with graft extrusion after lateral MAT. Study Design: Case-control study; Level of evidence, 3. Methods: Overall, 170 patients with lateral MAT between 2008 and 2013 were classified into extrusion (≥3 mm) and nonextrusion (<3 mm) groups based on findings on MRI scans obtained 3 to 6 months postoperatively. Subchondral BMLs in the lateral compartment were evaluated on the latest MRI scans. To exclude any bone marrow signal changes other than those caused by allograft extrusion, the latest MRI scans were compared with those obtained 3 to 6 months postoperatively. Only subchondral BMLs that occurred after that time point were counted. The association between allograft extrusion and subchondral BML was assessed using chi-square analysis. Logistic regression analysis was performed to control other related factors, including age, sex, body mass index, time from previous meniscectomy, alignment, and cartilage status at the time of MAT. Clinical outcomes according to subchondral BML were evaluated using the Lysholm score. Results: Of the 170 patients, 20 (11.8%) had subchondral BML on the latest MRI scans at a mean 53.6 ± 31.2 months postoperatively, with 14 and 6 patients in the extrusion and nonextrusion groups, respectively. Chi-square analysis showed a significant association between allograft extrusion and subchondral BMLs ( P = .025). Logistic regression analysis showed that extrusion and age were significant factors associated with subchondral BML ( P = .011 and .004, respectively). However, no differences were observed in the Lysholm scores in accordance with the subchondral BML ( P = .248). Conclusion: Subchondral BMLs on postoperative MRI scans were associated with graft extrusion after lateral MAT. However, there was no difference in clinical outcomes according to subchondral BML.

Delayed Rehabilitation After Lateral Meniscal Allograft Transplantation Can Reduce Graft Extrusion Compared With Standard Rehabilitation

2018 ◽  
Vol 46 (10) ◽  
pp. 2432-2440 ◽  
Author(s):  
Dhong Won Lee ◽  
Ji Hwan Lee ◽  
Du Han Kim ◽  
Jin Goo Kim
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Outcomes ◽  
Joint Space ◽  
Resonance Imaging ◽  
Meniscal Allograft Transplantation ◽  
Meniscal Allograft ◽  
Rehabilitation Protocols ◽  
Graft Extrusion ◽  
Outerbridge Grade ◽  
Group D

Background: Meniscal extrusion prevention would be important for restoring normal knee kinematics, even though the effect of graft extrusion after meniscal allograft transplantation (MAT) has not been clearly identified. Hypothesis: When compared with standard rehabilitation protocols, delayed rehabilitation after lateral MAT could reduce graft extrusion. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 53 patients who underwent lateral MAT with the keyhole technique from June 2011 to March 2015 were included. Graft extrusion and lateral compartment articular cartilage loss on magnetic resonance imaging, joint space width (JSW) on weightbearing radiographs, and clinical outcomes (including subjective scores and functional tests) of 25 patients who underwent standard rehabilitation (group S) after lateral MAT were compared with those of 28 patients who underwent delayed rehabilitation (group D), which included immobilization during the first 3 weeks and use of unloading braces for 9 weeks. Results: Mean ± SD follow-up times for groups S and D were 25.7 ± 6.4 and 24.5 ± 7.1 months, respectively. Although the postoperative clinical outcomes did not differ between the groups, graft extrusion (3.2 ± 1.5 mm vs 1.8 ± 1.6 mm) and relative percentage of extrusion (32.2% ± 14.6% vs 17.3% ± 16.6%) were greater in group S than in group D ( P < .001 for both). The percentage of patients with graft extrusion (≥3 mm) was 52% in group S and 21.4% in group D. JSWs on Rosenberg view decreased by 0.1 mm in group S but increased by 0.3 mm in group D ( P = .035). Kellgren-Lawrence grade and modified Outerbridge grade progressed by 44% and 44% among patients in group S and by 17.9% and 21.4% among patients in group D, respectively. There were significant correlations between the coronal graft extrusion and postoperative JSWs on full extension (–0.452) and Rosenberg (–0.410) views, Kellgren-Lawrence grade (0.727), and modified Outerbridge grade (0.732) on magnetic resonance imaging ( P < .001 for all). Conclusion: Compared with standard rehabilitation, delayed rehabilitation showed less coronal graft extrusion and joint space narrowing on weightbearing and reduced the progression of arthrosis, although the rehabilitation protocols showed no differences in clinical outcomes.

National trends in local excision and esophagectomy for cT1N0 esophageal cancer.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 62-62 ◽  
Author(s):  
Emily C. Sturm ◽  
Whitney Zahnd ◽  
John D. Mellinger ◽  
Sabha Ganai
Keyword(s):  
Esophageal Cancer ◽  
Regression Analysis ◽  
Local Excision ◽  
Clinical Characteristics ◽  
Cox Regression ◽  
Chi Square ◽  
Cox Regression Analysis ◽  
Significant Difference ◽  
Chi Square Analysis ◽  
Over Time

62 Background: Esophageal cancer management has evolved due to improvements in staging and treatment strategies. Endoscopic local excision presents an attractive option for definitive management of T1 cancers, avoiding the morbidity of esophagectomy. We hypothesized that for cT1N0 cancers, patients who underwent local excision would have lower survival compared to esophagectomy due to potential discordant staging. Methods: The National Cancer Database was queried for esophageal squamous cell carcinoma (SCC) and adenocarcinoma (AC) with AJCC T1N0 clinical stage who underwent local excision (n = 1625) or esophagectomy (n = 3255) between 1998 and 2012. Chi-square analysis was used to compare demographic and clinical characteristics by procedure. Chi-square trend analysis was performed to assess trends in procedure type over time. Cox Regression analysis was performed to assess survival by procedure controlling for demographic and clinical characteristics. Results: Between 1998 and 2012, the proportion of patients who underwent local excision increased from 12% to 50% for all patients (p < 0.001); from 17% to 40% for SCC patients (p < 0.001); and from 9% to 51% for AC patients (p < 0.001). Surgical procedure varied significantly by demographic, socioeconomic status, facility, and tumor-related factors. 65% of cT1N0 cancers had concordant clinical and pathological staging after esophagectomy, with 11% having positive nodal disease; 44% were concordant after local excision. While no significant difference was seen in unadjusted survival, adjusted Cox Regression analysis indicated worse survival after esophagectomy compared to local excision for all cases (HR 1.67; 95% CI, 1.40-2.00) and for ACs with concordant staging (HR 1.54; 95% CI, 1.11-2.14). Conclusions: Local excision for cT1N0 esophageal cancer has increased over time. Staging concordance for esophagectomy is seen in two-thirds of cases. Contrary to our hypothesis, patients undergoing local excision for T1N0 cancers have better overall survival than those undergoing esophagectomy, which may reflect early differences in mortality and/or selection bias. As this study was unable to distinguish T1a from T1b, further analysis is warranted.

scholarly journals Capsulodesis Versus Bone Trough Technique in Lateral Meniscal Allograft Transplantation: Graft Extrusion and Functional Results

2018 ◽  
Vol 34 (6) ◽  
pp. 1879-1888 ◽  
Author(s):  
Angel Masferrer-Pino ◽  
Joan C. Monllau ◽  
Maximiliano Ibáñez ◽  
Juan I. Erquicia ◽  
Xavier Pelfort ◽  
...  
Keyword(s):  
Functional Results ◽  
Meniscal Allograft Transplantation ◽  
Allograft Transplantation ◽  
Meniscal Allograft ◽  
Graft Extrusion

Determinants of Farmer’s Attitude to Plant Agro-forestry Trees in Kaduna State, Nigeria

2020 ◽  
pp. 155-166
Author(s):  
O. E. Olagunju ◽  
O. C. Ariyo ◽  
U. U. Emeghara ◽  
O. S. Olagunju ◽  
S. O. Olafemi
Keyword(s):  
Regression Analysis ◽  
Educational Level ◽  
Tree Planting ◽  
Years Of Experience ◽  
Chi Square ◽  
Nutrition Security ◽  
Food And Nutrition ◽  
The Mean ◽  
Chi Square Analysis ◽  
Agro Forestry

Agro-forestry trees enhance food and nutrition security, increase income and help solve land management problems. This study assessed the determinants of farmer’s attitude to plant agro-forestry trees in Giwa Local Government Area (LGA) of Kaduna State. Six (6) districts were purposively selected from the eight (8) districts in Giwa LGA. Two villages were randomly selected from each district to give a total of twelve (12) villages. Ten agroforestry farmers were selected from each village to make a total of 120 respondents. Data were collected using structured questionnaires. The data were analysed using descriptive statistics, inferential statistics - Chi- square and Pearson Product Moment Correlation (PPMC) and regression analysis. The results revealed that the mean age was 40.12 years. Chi-square analysis showed that age (χ2=18.487, P=0.001), educational level (χ2=9.656, P=0.04) were significant to farmersꞌ attitude. PPMC showed that income (r=0.181, p=0.049), membership in organization (r=0.214, P=0.02) were significant to farmersꞌ attitude. Regression analysis showed that years of experience (β=0.330, P=0.001) and constraints (β=0.246, P=0.11) were the determinants of farmers attitude. Farmers (59%) have unfavourable attitude towards tree planting. It was concluded that age group, educational level, income and membership in organization are very important and paramount in enhancing planting of agroforestry trees while years of experience and constraints faced by farmers were major determinants of famer’s attitude to planting agro-forestry trees.

scholarly journals Capsular fixation limits graft extrusion in lateral meniscal allograft transplantation

2019 ◽  
Vol 43 (11) ◽  
pp. 2549-2556 ◽  
Author(s):  
Angel Masferrer-Pino ◽  
Joan C. Monllau ◽  
Ferran Abat ◽  
Pablo E. Gelber
Keyword(s):  
Meniscal Allograft Transplantation ◽  
Allograft Transplantation ◽  
Meniscal Allograft ◽  
Graft Extrusion

scholarly journals Lycopene Rich Drink: Consumers Acceptance and Purchase Intention in Malaysia

2021 ◽  
Vol 11 (2) ◽  
pp. 204
Author(s):  
Rawaida Rusli ◽  
Siti 'Aisyah Baharudin ◽  
Nur Fazliana Md.Noh ◽  
Mohamad Nazim Anvarali ◽  
Hadijah Hassan
Keyword(s):  
Regression Analysis ◽  
Purchase Intention ◽  
Agricultural Research ◽  
Sociodemographic Factors ◽  
Additional Benefit ◽  
Research Development ◽  
Chi Square ◽  
Intent To Purchase ◽  
Functional Beverages ◽  
Chi Square Analysis

This study had been carried out to assess the level of acceptance and purchase intention towards new functional beverages developed by the Malaysia Agricultural Research Development Institute (MARDI). The Lycopene Rich Drink (LRD) had been assessed towards 400 respondents in 4 Zone in Malaysia which is Northern, Southern, Western, and Eastern using stratified sampling. The results revealed that the consumers had well accepted the LRD based on the highest mean score acceptance (mean=4.16) compared to the commercial (mean=3.15) beverages in the market. Taste and color are the most preferred attributes that influenced the purchase intention. The logistic regression analysis had predicted almost 95% of the respondents' intent to purchase. Marital status and number of households are the sociodemographic factors that show a significant relationship based on the Chi-Square analysis. The findings of this study are beneficial for the beverages industry players towards exploiting the opportunity of health additional benefit offered. 

Sign in / Sign up

Export Citation Format

Share Document