Metachronous bilateral testicular cancer: Case reports and review of literature

2019 ◽  
Vol 86 (4) ◽  
pp. 220-224
Author(s):  
Zhi-Yang Low ◽  
Angela Yan ◽  
Dhili Arul ◽  
Sudhanshu Chitale
Keyword(s):  
Literature Review ◽  
Testicular Cancer ◽  
Germ Cell ◽  
Case Reports ◽  
Favourable Outcome ◽  
Cancer Case ◽  
Review Of Literature ◽  
Metachronous Cancer ◽  
Contralateral Testis

Background:It is well recognised that men with unilateral testicular cancer may go on to develop metachronous cancer in the contralateral testis. Here, we present two cases of metachronous bilateral testicular cancer and a literature review.Clinical cases:In both cases, the second testicular cancer occurred several years after the initial cancer, and both cases were not screened for presence of contralateral germ cell neoplasia in situ upon the first diagnosis.Discussion:We also present a literature review on the need for screening biopsies of contralateral testis for germ cell neoplasia in situ and the risk factors which should encourage screening. Furthermore, we also explore the effect of chemotherapy on the incidence of contralateral testicular cancer and the effectiveness of radiotherapy in the treatment of germ cell neoplasia in situ.Conclusion:We believe that screening biopsies of the contralateral testis upon diagnosis of unilateral testicular cancer should be encouraged as it can lead to better management of the condition and a relatively favourable outcome on functional fronts.

scholarly journals Scrotal Involvement with Testicular Nonseminomatous Germ Cell Tumour

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
C. G. O’Leary ◽  
J. A. Allen ◽  
F. O’Brien ◽  
A. Tuthill ◽  
D. G. Power
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Complete Resolution ◽  
Case Reports ◽  
Traumatic Injury ◽  
Germ Cell Tumour ◽  
Ct Scanning ◽  
Tumour Markers ◽  
Cell Tumour ◽  
Cancer Case

A 37-year-old male presented with a traumatic injury to the scrotal region necessitating emergency surgery. Evacuation of a haematoma and bilateral orchidectomy were performed. A left sided nonseminomatous germ cell tumour (NSGCT), predominantly yolk sac, was identified. Microscopic margins were positive for tumour. Initial tumour markers revealed an AFP of 22,854 ng/mL, HCG of <1 mIU/mL, and LDH of 463 IU/L. Eight weeks after surgery, AFP levels remained elevated at 11,646 ng/mL. Computed tomography (CT) scanning demonstrated left inguinal adenopathy, 1.5 cm in max dimension. On review, extensive evidence of scrotal involvement was evident. His tumour was staged as stage IIIC, poor risk NSGCT. He was treated with 4 cycles of bleomycin, etoposide, and cisplatin over a 12-week period. His tumour markers normalised after 3 cycles. There was a marked improvement noted clinically. Follow-up CT scans demonstrated complete resolution of his tumour. He later underwent further surgery to remove a small amount of remaining spermatic cord. Histology revealed no malignant tissue. The patient suffered many complications including testosterone deficiency, osteopenia, infertility, and psychological distress.Discussion. A small proportion of testicular cancer may present in an atypical manner. The scrotum and testicle have markedly different embryonic origins and therefore a distinct anatomic separation. As a result the scrotum is not a typical site of spread of testicular cancer. Case reports have been described that were managed in a similar manner with good outcomes. Therefore, even with significant scrotal involvement, if timely and appropriate treatment is administered, complete resolution of the tumour may be achieved.

scholarly journals Erratum to “Paget´s disease of the male breast: An unusual case in a young man and literature review” [Current Problems in Cancer: Case Reports 1C (2020) 100019]

2021 ◽  
Vol 3 ◽  
pp. 100071
Author(s):  
Vanesa Rodríguez-Fernández ◽  
Lucía Cameselle-Cortizo ◽  
María José Lamas González ◽  
Gonzalo José De Castro Parga ◽  
Javier Valdés-Pons ◽  
...  
Keyword(s):  
Literature Review ◽  
Unusual Case ◽  
Case Reports ◽  
Male Breast ◽  
Cancer Case ◽  
Review Current

Impaired Testicular Function in Patients With Carcinoma-In-Situ of the Testis

1999 ◽  
Vol 17 (1) ◽  
pp. 173-173 ◽  
Author(s):  
Peter Meidahl Petersen ◽  
Aleksander Giwercman ◽  
Steen W. Hansen ◽  
Jørgen G. Berthelsen ◽  
Gedske Daugaard ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Leydig Cell ◽  
Carcinoma In Situ ◽  
Cell Function ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Testicular Dysfunction ◽  
Leydig Cell Function

PURPOSE: To elucidate the biologic association between germ cell neoplasia and testicular dysfunction, through investigation of Leydig cell function and semen quality in men with carcinoma-in-situ (CIS) of the testis. PATIENTS AND METHODS: We examined two groups of men, unilaterally orchidectomized for testicular cancer. Biopsy of the contralateral testis had showed CIS in a group of 24 patients and no evidence of CIS in the other group of 30 patients. Semen quality and serum levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were compared in these two groups of men after orchidectomy but before further treatment for testicular cancer. RESULTS: Significantly higher LH levels (median, 8.1 IU/L v 4.8 IU/L; P < .001) and generally lower testosterone levels (median, 12.5 nmol/L v 15.5 nmol/L; P = .13) were found in the CIS group. The proportion of patients with Leydig cell dysfunction was higher in the group of patients with CIS (11 of 24) than in the group of patients without (two of 30) (P = .01). Sperm concentration and total sperm count were significantly lower (P < .001) in patients with CIS (median, 0.03 × 106/mL and 0.10 × 106, respectively) than in patients without (median, 9.1 × 106/mL and 32 × 106, respectively), whereas the levels of FSH were significantly higher (P < .001) in the former group of men (median, 19.6 IU/L v 9.0 IU/L). CONCLUSION: Not only spermatogenesis but also Leydig cell function is impaired in testes with CIS. This impairment could be due to common factors in the pathogenesis of germ cell neoplasm and testicular dysfunction. Alternatively, CIS cells may have a negative impact on Leydig cell function.

Gastric Metastases From Testicular Cancer: Case Report and Review of Literature

2013 ◽  
Vol 45 (S1) ◽  
pp. 22-24 ◽  
Author(s):  
Salvatore Lauro ◽  
Riccardo Righini ◽  
Concetta Elisa Onesti ◽  
Eugenio Pucci ◽  
Alessandra Bramini ◽  
...  
Keyword(s):  
Case Report ◽  
Testicular Cancer ◽  
Cancer Case ◽  
Review Of Literature ◽  
Gastric Metastases

scholarly journals Screening for carcinoma in situ of the contralateral testis in patients with germinal testicular cancer.

BMJ ◽  
1982 ◽  
Vol 285 (6356) ◽  
pp. 1683-1686 ◽  
Author(s):  
J G Berthelsen ◽  
N E Skakkebaek ◽  
H von der Maase ◽  
B L Sorensen ◽  
P Mogensen
Keyword(s):  
Testicular Cancer ◽  
Carcinoma In Situ ◽  
Contralateral Testis

scholarly journals Synchronous metastatic seminoma and primary retroperitoneal ganglioneuroma: case report and literature review

2013 ◽  
Vol 5 (6) ◽  
pp. 109
Author(s):  
Jorg Michels ◽  
Nicholas Van der Westhuizen ◽  
Alison Ross
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Testicular Cancer ◽  
Germ Cell ◽  
Complete Response ◽  
Testicular Seminoma ◽  
Rare Tumours ◽  
Primary Retroperitoneal ◽  
Common Malignancy

Testicular cancer is the most common malignancy in young menwith seminomas comprising almost half of all germ cell tumours.Benign ganglioneuromas are rare tumours derived from the sympatheticnervous system. They usually occur in aldolescents andyoung adults and are predominantly located in the mediastinumand retroperitoneum. We report a case of a patient with synchronousmetastatic testicular seminoma with retroperitoneal lymphnode involvement and a benign retroperitoneal ganglioneuroma(RGN) which caused diagnostic and management challenges. Thepatient had a complete response following combination chemotherapyfor his seminoma and subsequently underwent completeresection of his ganglioneuroma.

Broviac catheter-related bacteraemias due to unusual pathogens in children with cancer: Case reports with literature review

1997 ◽  
Vol 34 (3) ◽  
pp. 215-218 ◽  
Author(s):  
E. Castagnola ◽  
M. Conte ◽  
P. Venzano ◽  
A. Garaventa ◽  
C. Viscoli ◽  
...  
Keyword(s):  
Literature Review ◽  
Case Reports ◽  
Cancer Case ◽  
Children With Cancer
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