Synchronous papillary endometrial and ovarian cancer in a 64-year-old woman

Obesity, nulliparity, and comparatively younger age may attribute a “hormonal field effect” which leads to the development of synchronous endometrioid cancers. The morphological unit consisting of the uterus, fallopian tubes, and ovary as part of the Mullerian system may explain the synchronous appearance of these malignancies. Synchronous endometrial and ovarian cancer (SEOC) is defined as the simultaneous presence of these dual cancers at the time of diagnosis as opposed to metachronous cancer where these two cancers are diagnosed at different chronologic time points. Synchronous malignancies in the female genital tract are very rare entities. Synchronous endometrial and ovarian tumors must be differentiated from either primary endometrium or ovarian tumors with metastasis. The landmark criteria for diagnosing such cases have been laid down by Ulbright and Roth.

LAPOROSCOPIC PELVIC EXENTERATION FOR TREATMENT OF PRIMARY MULTIPLE CANCER. CASE REPORT

This clinical case represents the experience of surgical treatment of a patient with multiple primary metachronous cancer: 1. Sigmoid cancer рТ4NxM0. Resection of sigmoid colon (16.12.2013). Three courses of adjuvant chemotherapy (XELOX). Recurrence (2015). Laparotomy, Colproctectomy with D3 paraaortic lymph dissection. Ileostomy (2015). One course of chemotherapy (XELOX). 2. Upper tract urothelial carcinoma (right ureter) pT2N0M0R0. Right nephroureterectomy with the resection of the bladder and right testicular cord, cystostomy (19.02.2015). Recurrence. Nephrostomy drainage of the left kidney. Adhesive disease. Rectovesical fistula. Taking into account the history and comorbid status of the patient, it was decided to perform laparoscopic supralevator pelvic exenteration, ureterectomy on the left. The duration of the operation was 280 minutes, intraoperative blood loss was 200 ml. The period of stay in intensive care is 24 hours, the patient was discharged on the 7th day after the operation, the resection margin was negative (R0). After 12 months, there is no data for the disease progressed.

Multiple Primary Advanced Metachronous Cancer of Abdominal Organs with Multifocal Obstructive Syndrome: a Clinical Case of Successful Complex Treatment

Impaired patency of the gastrointestinal and urinary tract, and bile ducts is one of the essential problems in oncological practice in patients with tumors of various localizations. Stenoses are one of the most severe complications of the course of tumor diseases.Obstruction is a polyetiological condition that can result from a primary tumor lesion and specific neoplastic processes of nearby organs and structures. Sometimes narrowing of the lumen of organs and ducts can occur as a result of reactive scar tissue changes along the periphery of tumors. In some cases stenosis manifests itself as a complication of certain stages of treatment (surgical, radiation).The development of stenoses of the large intestine, the pylorus, the bile and urinary tracts significantly reduces the quality of life of patients due to the increasing obstruction of the above structures. Elimination of this syndrome is the main aim of treatment, regardless of the presence of tumor or non-tumor complications that have arisen.

Metachronous Cancer Occurring after Endoscopic Resection of Superficial Esophageal Cancer

Esophageal cancer has a relatively high prevalence of local recurrence, which is associated with a poor prognosis. Superficial esophageal cancer has shown a metachronous recurrence rate of 2.6~35.8% with the cumulative overall 3-year and 5-year metachronous cancer incidence being 9.9~15.5% and 20.6~24.5%, respectively. In addition to recurrences in the remnant esophagus, second metachronous primary tumors have been reported to arise in 4.0~37.4% of esophageal cancer survivors. The second primary cancers arising after a diagnosis of esophageal cancer are most commonly detected in the head and neck area, followed by the lungs and stomach. The field cancerization theory explains the high prevalence of head and neck cancer among esophageal cancer patients. The reported risk factors for metachronous esophageal recurrences include scattered-type Lugol staining, circumferential endoscopic resection of the primary lesion, heavy alcohol use, smoking, inactive aldehyde dehydrogenase-2 genes, alcohol dehydrogenase-1B genes, and young age at diagnosis of the primary cancer. The risk factors for metachronous second primary tumors include heavy alcohol use, smoking, and a previous history of radiation therapy. Consequently, periodic follow-up endoscopy using narrow-band imaging is essential for the screening of metachronous esophageal cancers and second primary tumors after endoscopic resection for superficial esophageal cancer.

Ультразвуковое исследование с контрастным усилением в оценке результатов радиочастотной абляции опухоли единственной почки

Представлено клиническое наблюдение контроля процедуры радиочастотной абляции опухоли единственной почки с помо щью ультразвукового исследования с контрастным усилением. У пациента N., 49 лет, диагностирован первично-множественный метахронный рак. В 2010 г. проведена радикальная нефрэктомия правой почки (рак правой почки, рТ2N0M0, II стадия), в июне 2016 г. - радиочастотная абляция опухоли левой почки (рак левой почки, сТ1N0M0, I стадия). В сентябре 2016 г. (через 3 мес после радиочастотной абляции) проведено контрольное ультразвуковое исследование с контрастным усилением, которое продемонстрировало отсутствие контрастирования зоны абляции на протяжении артериальной и венозной фаз контрастирования паренхимы левой почки. В декабре 2016 г. (через 6 мес после радиочастотной абляции) данные ультразвукового исследования с контрастным усилением были подтверждены результатами компьютерной томографии с контрастированием. Представленное наблюдение демонстрирует возможности ультразвукового исследования с контраст ным усилением в качестве метода оценки результатов радиочастотной абляции опухолей почки, которое в перспективе можно рассматривать в качестве альтернативы компьютерной томографии с контрастированием и магнитно-резонансной томографии с контрастированием при невозможности выполнения этих методов. Ключевые слова: ультразвуковое исследование с контрастным усилением (КУУЗИ), радиочастотная абляция, опухоль почки, остаточная опухоль, первичномножественный рак, метахронный рак, contrast-enhanced ultrasound (CEUS), radiofrequency ablation, renal tumor, residual tumor, multiple primary cancers, metachronous cancer