New Side Effects in Prolonged Chlorpromazine Therapy

Three new side effects of prolonged chlorpromazine therapy have been described. Their pathogenesis has been discussed, and increased melanin production was found to be the cause of these manifestations of chlorpromazine melanosis. Skin pigmentation has produced an appearance which is cosmetically undesirable. Ocular deposits have caused visual impairment. Diffuse melanosis of internal organs has been accompanied by functional disturbance of the involved organs. A preliminary report on the therapy of these side effects has been presented.

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Su1505 Preliminary Report of a Prospective Study of Cryospray Ablation With Liquid Nitrogen Using Surgical Resection Specimens to Determine Treatment Effect, Depth of Injury and Side Effects

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2011.03.558 ◽

2011 ◽

Vol 73 (4) ◽

pp. AB286

Author(s):

Afonso C. Ribeiro ◽

Pablo A. Bejarano ◽

Lynne Sparling ◽

Dido Franceschi ◽

Bach Ardalan ◽

...

Keyword(s):

Side Effects ◽

Prospective Study ◽

Liquid Nitrogen ◽

Surgical Resection ◽

Treatment Effect ◽

Preliminary Report ◽

A Prospective Study

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Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report

Alcoholism Clinical and Experimental Research ◽

10.1111/acer.12177 ◽

2013 ◽

Vol 37 (11) ◽

pp. 1823-1826 ◽

Cited By ~ 22

Author(s):

Michael S. Irwig

Keyword(s):

Side Effects ◽

Alcohol Consumption ◽

Preliminary Report ◽

Sexual Side Effects

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The online behavior of pupils with visual impairment: A preliminary report

Disability and Health Journal ◽

10.1016/j.dhjo.2016.04.004 ◽

2016 ◽

Vol 9 (4) ◽

pp. 724-729 ◽

Cited By ~ 1

Author(s):

Magdalena Wrzesińska ◽

Klaudia Tabała ◽

Patryk Stecz

Keyword(s):

Visual Impairment ◽

Preliminary Report ◽

Online Behavior

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Simvastatin-induced changes in the leukocytic system of porcine bone marrow

Journal of Veterinary Research ◽

10.2478/jvetres-2018-0034 ◽

2018 ◽

Vol 62 (3) ◽

pp. 329-333 ◽

Cited By ~ 1

Author(s):

Anna Snarska ◽

Dominika Wysocka ◽

Liliana Rytel ◽

Sławomir Gonkowski ◽

Hanna Pawelec ◽

...

Keyword(s):

Bone Marrow ◽

Side Effects ◽

Oral Administration ◽

Cholesterol Level ◽

Muscle Weakness ◽

Metabolic Pathways ◽

Bone Marrow Cells ◽

Mammal Species ◽

Internal Organs ◽

Induced Changes

AbstractIntroductionSimvastatin is a substance which is commonly used as a medicine to reduce cholesterol level. Unfortunately, it shows numerous side effects. Simvastatin affects various internal organs, and among other detriments to health may cause persistent muscle weakness, osteolytic processes, headaches, and rashes. Until now knowledge of the influence of simvastatin on bone marrow cells has been rather scant and fragmentary.Material and MethodsDuring this experiment the numbers of all types of cells in the leukocytic system of porcine bone marrow were evaluated after 28 and 56 days of oral administration of simvastatin at a dose of 40 mg/day/animal.ResultsSimvastatin caused an increase in the number of all types of cells in the leukocytic system, and the most visible fluctuations concerned promyelocytes.ConclusionObservations obtained during the present study indicated that the results of the action of simvastatin on porcine bone marrow differ from those observed in other mammal species, including human. This may be due to various metabolic pathways within the bone marrow in the particular species, but the exact mechanisms of these actions are unknown at the present time.

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Walking biomechanics and energetics of individuals with a visual impairment: a preliminary report

Human Movement ◽

10.5114/hm.2019.85094 ◽

2019 ◽

Vol 20 (4) ◽

pp. 8-18

Author(s):

Hunter J. Bennett ◽

Kevin A. Valenzuela ◽

Kristina Fleenor ◽

Steven Morrison ◽

Justin A. Haegele

Keyword(s):

Visual Impairment ◽

Preliminary Report ◽

Walking Biomechanics

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Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH

Science Signaling ◽

10.1126/scisignal.aau7987 ◽

2018 ◽

Vol 11 (555) ◽

pp. eaau7987 ◽

Cited By ~ 2

Author(s):

Dalee Zhou ◽

Koji Ota ◽

Charlee Nardin ◽

Michelle Feldman ◽

Adam Widman ◽

...

Keyword(s):

Skin Cancer ◽

Skin Color ◽

Skin Pigmentation ◽

Melanin Production ◽

Melanocortin 1 Receptor ◽

New Class ◽

Camp Pathway ◽

Human Melanocytes ◽

Rate Limiting

The production of melanin increases skin pigmentation and reduces the risk of skin cancer. Melanin production depends on the pH of melanosomes, which are more acidic in lighter-skinned than in darker-skinned people. We showed that inhibition of soluble adenylyl cyclase (sAC) controlled pigmentation by increasing the pH of melanosomes both in cells and in vivo. Distinct from the canonical melanocortin 1 receptor (MC1R)–dependent cAMP pathway that controls pigmentation by altering gene expression, we found that inhibition of sAC increased pigmentation by increasing the activity of tyrosinase, the rate-limiting enzyme in melanin synthesis, which is more active at basic pH. We demonstrated that the effect of sAC activity on pH and melanin production in human melanocytes depended on the skin color of the donor. Last, we identified sAC inhibitors as a new class of drugs that increase melanosome pH and pigmentation in vivo, suggesting that pharmacologic inhibition of this pathway may affect skin cancer risk or pigmentation conditions.

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