Fatal Overdose with Amantadine

1986 ◽  
Vol 31 (8) ◽  
pp. 757-758 ◽  
Author(s):  
P.E. Cook ◽  
Stanley W. Dermer ◽  
Terry Mcgurk
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Adverse Reactions ◽  
Extrapyramidal Side Effects ◽  
Fatal Overdose ◽  
First Case

The authors describe the first case report in the psychiatric literature of death from an overdose of amantadine hydrochloride used to treat neuroleptic induced extrapyramidal side effects. The pharmacology, adverse reactions and risks of using amantadine are briefly reviewed.

OLANZAPINE INDUCED AMENORRHEA REVERSED BY SWITCHING TO ARIPIPRAZOLE- A RARE CASE REPORT

2021 ◽  
pp. 50-51
Author(s):  
Ankit Halder ◽  
Navna Panchami ◽  
Abhishek Das
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Rare Case ◽  
Atypical Antipsychotics ◽  
Extrapyramidal Side Effects ◽  
Rare Case Report

Due to less extrapyramidal side-effects ,atypical antipsychotics use in psychiatry has increased a lot. But it is associated with other metabolic and endocrine side effects. Olanzapine is one such antipsychotic that less likely to cause hyperprolactinemia which can present as amenorrhea in patients.Here we present a rare case of olanzapine induced amenorrhoea reversed by switching to Aripiprazole.

scholarly journals Extrapyramidal side effects and suicidal ideation under fluoxetine treatment: a case report

2010 ◽  
Vol 9 (1) ◽  
Author(s):  
Christos Christodoulou ◽  
Athanasia Papadopoulou ◽  
Emmanouil Rizos ◽  
Kalliopi Tournikioti ◽  
Xenia Gonda ◽  
...  
Keyword(s):  
Case Report ◽  
Suicidal Ideation ◽  
Side Effects ◽  
Extrapyramidal Side Effects ◽  
Fluoxetine Treatment

Accidental arterial catheterisation during a maxillary nerve block using a modified infraorbital approach in a dog

2020 ◽  
Vol 8 (2) ◽  
pp. e001097
Author(s):  
Paul Massimo Giannoni McCarthy ◽  
Arthur Yuk Kong Chau
Keyword(s):  
Case Report ◽  
Nerve Block ◽  
Local Anaesthetic ◽  
Adverse Reactions ◽  
Intravenous Catheter ◽  
Infraorbital Foramen ◽  
Maxillary Nerve ◽  
First Case ◽  
Maxillary Nerve Block ◽  
Oromaxillofacial Surgery

The maxillary nerve block (MNB) is a local anaesthetic technique used in dentistry and oromaxillofacial surgery, with recent popular use for minimising adverse reactions during rhinoscopy. A modified approach via the infraorbital foramen using an intravenous catheter has been recently described in the veterinary literature to minimise potential nerve block associated complications. This case report describes inadvertent arterial catheterisation using the aforementioned technique in a 5.4-kg, 9-year-old male neutered Maltese terrier cross that was presented for diagnostic workup of a chronic cough that had recently worsened. To the authors’ knowledge, this is the first case report of such a complication. It is recommended for veterinary practitioners to be aware of accidental arterial puncture and catheterisation whenever a modified infraorbital approach to the MNB is performed in order to facilitate rapid intervention and management.

Risperidone-Induced Neuroleptic Malignant Syndrome: A Case Report and Review

1996 ◽  
Vol 41 (1) ◽  
pp. 52-54 ◽  
Author(s):  
Gb Meterissian
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Neuroleptic Malignant Syndrome ◽  
Clinical Features ◽  
Prior History ◽  
Extrapyramidal Side Effects ◽  
Life Threatening ◽  
History Of ◽  
Life Threatening Complication ◽  
The One

Objectives: 1. To report the case of a 53-year-old patient who developed neuroleptic malignant syndrome (NMS) — a rare but potentially life-threatening complication of neuroleptic therapy — 4 days after treatment with risperidone was initiated. 2. To review previously reported cases of NMS associated with risperidone. Methods: A computerized search of several databases, including MEDLINE, was conducted to find all previously reported cases of NMS with risperidone. Results: Five reported cases of risperidone-induced NMS were found in the literature. All cases including the one reported here displayed typical clinical features of NMS and all 6 patients had a prior history of extrapyramidal side effects and/or NMS. Age and duration of exposure to risperidone did not seem to be of significance. Conclusions: These cases illustrate that clinicians should be on the lookout for risperidone-induced NMS.

scholarly journals Effectiveness of Factor XIII Infusion in Treatment of Refractory Ureteral Leakage after Kidney Transplantation

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Ryoichi Maenosono ◽  
Tomohisa Matsunaga ◽  
Hajime Hirano ◽  
Hayahito Nomi ◽  
Shunri Taniguchi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Kidney Transplantation ◽  
Case Report ◽  
Side Effects ◽  
Factor Xiii ◽  
Dizygotic Twin ◽  
First Case ◽  
Urological Complications ◽  
Plasma Factor ◽  
Urine Leakage

Despite the evolution of transplantation techniques, urological complications are common and result in loss of graft. We report the case of a 57-year-old man who developed continuous urine leakage despite pyeloureteral neoanastomosis and stenting after kidney transplantation from his dizygotic twin. Suspecting ureteral leakage, we performed pyeloureteral neoanastomosis using his native right ureter and a ureteral stent 5 days after the kidney transplant. However, urine leakage continued for several days. Because the plasma factor XIII level decreased to 48%, we administered factor XIII products (Fibrogammin P; CSL Behring, King of Prussia, PA) after the surgery. Although its utility and safety in patients with renal failure and/or transplantation are unclear, urine leakage stopped after the infusion of fibrogammin without any side effects. This is the first case report of the use of factor XIII for refractory urine leakage after kidney transplantation. Although further studies are needed, administration of factor XIII products could be one option for refractory urine leakage after transplantation.

scholarly journals HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia

2020 ◽  
Vol 21 (7) ◽  
pp. 2345 ◽  
Author(s):  
Mirko Grubor ◽  
Maja Zivkovic ◽  
Marina Sagud ◽  
Matea Nikolac Perkovic ◽  
Alma Mihaljevic-Peles ◽  
...  
Keyword(s):  
Side Effects ◽  
Gene Polymorphisms ◽  
Adverse Reactions ◽  
Dopaminergic System ◽  
Rating Scale ◽  
Extrapyramidal Side Effects ◽  
Microrna Regulation ◽  
Haloperidol Treatment ◽  
Symptom Rating ◽  
Serotonergic Modulation

Schizophrenia is a serious, chronic psychiatric disorder requiring lifelong treatment. Extrapyramidal side effects (EPS) are common adverse reactions to antipsychotic medications. In addition to the dopaminergic system, serotonergic mechanisms, including serotonin (5-HT) receptors, might be involved in EPS development. This study aimed to examine molecular associations of HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms with acute EPS in 229 male schizophrenia patients, following two weeks of haloperidol monotherapy. The Simpson–Angus Rating Scale for Extrapyramidal Side Effects (SAS), Barnes Akathisia Rating Scale (BARS) and Extrapyramidal Symptom Rating Scale (ESRS) were used to evaluate EPS severity. Genotyping was performed using real-time PCR, following extraction of blood DNA. Significant acute EPS appeared in 48.03% of schizophrenia patients. For the rs13212041 HTR1B gene polymorphism, affecting microRNA regulation of HTR1B gene expression, a higher frequency of TT carriers was found among haloperidol-treated patients with akathisia when compared to the group without akathisia symptoms. In comparison to C-allele carriers, patients carrying the TT genotype had higher akathisia severity, as determined by the SAS, BARS and ESRS scales. These molecular findings suggest potential involvement of 5-HT1B receptors in akathisia development following haloperidol treatment, as well as possible epigenetic mechanisms of serotonergic modulation associated with antipsychotic-induced EPS.

scholarly journals L-ASPARAGINASE INDUCED HYPOFIBRINOGENEMIA: A CASE REPORT

2017 ◽  
Vol 10 (5) ◽  
pp. 11 ◽  
Author(s):  
Balaji Ommurugan ◽  
Amita Priya ◽  
Navin Patil
Keyword(s):  
Adverse Effect ◽  
Case Report ◽  
T Cell ◽  
Side Effects ◽  
Adverse Reactions ◽  
Lymphoblastic Leukemia ◽  
Anticancer Therapy ◽  
Neurological Complications ◽  
Life Threatening

Anticancer therapy is always known to cause various side effects. L-asparaginase used in the treatment of adult T-cell lymphoblastic leukemia is anovel class of drug, an enzyme produced from plants as well as microorganisms except human. It is known to cause various adverse reactions including life-threatening neurological complications and thrombotic disorders. Hence, we report a case of hypofibrinogenemia associated with L-asparaginase in a patient treated for T-cell adult lymphoblastic leukemia.Keywords: L-asparaginase, Hypofibrinogenemia, Adverse effect, Leukemia.

scholarly journals BrightOcular® Cosmetic Iris Implant: A Spectrum from Tolerability to Severe Morbidity

2018 ◽  
Vol 9 (2) ◽  
pp. 395-400 ◽  
Author(s):  
Mona K. Koaik ◽  
Ahmad M. Mansour ◽  
Alain Saad ◽  
Samir G. Farah
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Safety Profile ◽  
Corneal Edema ◽  
Endothelial Keratoplasty ◽  
Descemet Membrane Endothelial Keratoplasty ◽  
Severe Morbidity ◽  
Ocular Side ◽  
First Case ◽  
Ocular Tolerability

Purpose: The BrightOcular® implants are the newest model of cosmetic iris devices that are currently advertised as safe. The previous generation known as NewColorIris® have had severe ocular side effects and were subsequently withdrawn from the market. There is little literature on the safety profile of BrightOcular® implants. Case Report: Herein we describe two cases with varying degrees of ocular tolerability. The first case had a normal ocular exam 1 year after implantation, whereas the second case had unilateral severe corneal edema requiring explantation of the iris device and Descemet membrane endothelial keratoplasty 9 months after bilateral implantation. Conclusions: These two cases attest to the unpredictability of the results of these cosmetic surgeries. Patients should be counseled about the vision-threatening complications of iris implants.

scholarly journals Over-The-Counter Oral Hygiene Products Misuse: A Case Report

2021 ◽  
Vol 14 (4) ◽  
pp. 1413-1416
Author(s):  
Ashwag Yagoub Aloyouny
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Side Effects ◽  
Oral Hygiene ◽  
English Literature ◽  
Signs And Symptoms ◽  
Dry Mouth ◽  
Over The Counter ◽  
First Case ◽  
Oral Condition

Oral hygiene products (OHP) are recommended to maintain the teeth and health of the oral cavity tissues by assisting in lowering the plaque level as well as the opportunistic flora. Oral hygiene products could cause oral health problems that may vary in severity. Due to the availability of over-the-counter (OTC) medications and lack of knowledge, customers may misuse these products. An oral hygiene product is a double-edged sword; a customer would develop side effects from it without even knowing or correlating the source. Many signs and symptoms may appear on the patients such as oral and perioral burning sensations, swelling, erythema, dysgeusia, and dysphagia. To our knowledge and based on the review of English literature through PubMed Midline, this is the first case report of misuse because of an over-the-counter oral hygiene product in which the patient used a mouthwash continuously and aggressively for 15 days without knowing of its side effects. This case report presents an eighty-two-year-old, male patient who complained of pain, burning, swollen, and dry mouth and lips. The author discussed the most common ingredients of oral mouthwashes. Some active ingredients may irritate the oral mucosa and lips. Also, the author discussed the possible differential diagnosis of painful, sensitive, burning, swollen, and dry mouth and lips. This report is intended as an overview of a rare and unusual oral condition associated with the misuse of OTC oral hygiene products. The findings of the present study necessitated the need for clear verbal and written instructions to be provided to the patients before recommending or prescribing any type of medication.

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