Protective effect of ascorbic acid and Ginkgo biloba against learning and memory deficits caused by fluoride

2013 ◽  
Vol 32 (1) ◽  
pp. 183-187 ◽  
Author(s):  
Raghu Jetti ◽  
CV Raghuveer ◽  
Rao C Mallikarjuna
Keyword(s):  
Ascorbic Acid ◽  
Protective Effect ◽  
Learning And Memory ◽  
Ginkgo Biloba ◽  
Memory Deficits ◽  
Learning And Memory Deficits

scholarly journals The ameliorative effect of ascorbic acid and Ginkgo biloba on learning and memory deficits associated with fluoride exposure

2013 ◽  
Vol 6 (4) ◽  
pp. 217-221 ◽  
Author(s):  
Jetti Raghu ◽  
Vasudeva C. Raghuveer ◽  
Mallikarjuna C. Rao ◽  
Nagabhooshana S. Somayaji ◽  
Prakash B. Babu
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Learning And Memory ◽  
Ginkgo Biloba ◽  
Soft Tissues ◽  
Memory Deficits ◽  
Ginkgo Biloba Extract ◽  
Fluoride Exposure ◽  
Ameliorative Effect ◽  
Learning And Memory Deficits

ABSTRACT Chronic exposure to fluoride causes dental and skeletal fluorosis. Fluoride exposure is also detrimental to soft tissues and organs. The present study aimed at evaluation of the effect of Ginkgo biloba and ascorbic acid on learning and memory deficits caused by fluoride exposure. Male Wistar rats were divided into five groups (n=6). Group 1 control. Groups 2 to 5 received 100 ppm of sodium fluoride over 30 days. Groups 3, 4 and 5 were further treated for 15 days receiving respectively 1% gum acacia solution, 100 mg/kg body weight ascorbic acid, and 100mg/kg body weight Ginkgo biloba extract. After 45 days, all animals were subjected to behavioural tests. The results showed that fluoride affected learning and memory. Fluoride causes oxidative stress and neurodegeneration, thereby affecting learning and memory. Ascorbic acid and Ginkgo biloba were found to augment the reversal of learning and memory deficits caused by fluoride ingestion

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