Synthesis and characterization of levan hydrogels and their use for resveratrol release

Considering the need for systematic studies on levan based hydrogels to widen their use in drug delivery systems and biomedical applications, this study is mainly focused on the synthesis and comprehensive characterization as well as drug release properties of hydrogels based on Halomonas levan (HL) and its chemical derivatives. For this, hydrolyzed and phosphonated HL derivatives were chemically synthesized and then cross-linked with 1,4-Butanediol diglycidyl ether (BDDE) and the obtained hydrogels were characterized in terms of their swelling, adhesivity, and rheological properties. Both native and phosphonated HL hydrogels retained their rigid gel like structure with increasing shear stress levels and tack test analysis showed superior adhesive properties of the phosphonated HL hydrogels. Moreover, hydrogels were loaded with resveratrol and entrapment and release studies as well as cell culture studies with human keratinocytes were performed. Biocompatible and adhesive features of the hydrogels confirmed their suitability for tissue engineering and drug delivery applications.

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Synthesis and characterization of MCM-48/hydroxyapatite composites for drug delivery: Ibuprofen incorporation, location and release studies

Materials Science and Engineering C ◽

10.1016/j.msec.2018.06.028 ◽

2018 ◽

Vol 91 ◽

pp. 734-742 ◽

Cited By ~ 18

Author(s):

Lukasz Pajchel ◽

Waclaw Kolodziejski

Keyword(s):

Drug Delivery ◽

Synthesis And Characterization ◽

Release Studies

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Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes II: effect of degradation on targeting activity

Biomaterials ◽

10.1016/j.biomaterials.2004.03.003 ◽

2005 ◽

Vol 26 (6) ◽

pp. 661-670 ◽

Cited By ~ 40

Author(s):

A.Omolola Eniola ◽

Daniel A Hammer

Keyword(s):

Drug Delivery ◽

Adhesive Properties ◽

Drug Delivery Vehicles ◽

Delivery Vehicles

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Characterization of phospholipid-encapsulated gold nanoparticles: a versatile platform to study drug delivery and cellular uptake mechanisms

Canadian Journal of Chemistry ◽

10.1139/cjc-2014-0280 ◽

2015 ◽

Vol 93 (2) ◽

pp. 265-271 ◽

Cited By ~ 5

Author(s):

Meijing Wang ◽

Nils O. Petersen

Keyword(s):

Drug Delivery ◽

Gold Nanoparticles ◽

Cellular Uptake ◽

Study Drug ◽

Cellular Systems ◽

Reaction Conditions ◽

Overall Stability ◽

Comprehensive Characterization ◽

Uptake Mechanisms

The data presented in this work aim to provide a comprehensive characterization of lipid-coated gold nanoparticles. We show that it is possible to envelop gold nanoparticles with a coating of lipids during the formation of the gold nanoparticles, that the gold in these lipid-coated gold nanoparticles is crystalline and the size and shape can be controlled by the reaction conditions (within limits), that the lipid coating corresponds to a thickness consistent with the formation of a bilayer, that the bilayer can include fluorescent probes that, while quenched, can be used to trace the fate of the gold nanoparticles in cellular systems, that their surface charge, and hence their overall stability in solution, is influenced by the lipid coating, and that while some lipid dyes may exchange among the particles, they are sufficiently stable to exchange to permit their use as tracers in cell studies. We believe this is the most comprehensive characterization of these systems to date.

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Nanoparticle albumin-bound mTHPC for photodynamic therapy: Preparation and comprehensive characterization of a promising drug delivery system

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2020.119347 ◽

2020 ◽

Vol 582 ◽

pp. 119347 ◽

Cited By ~ 1

Author(s):

Nora C. Stein ◽

Dennis Mulac ◽

Jörg Fabian ◽

Fabian C. Herrmann ◽

Klaus Langer

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Comprehensive Characterization

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Synthesis and characterization of new macromolecule systems for colon-specific drug delivery

e-Polymers ◽

10.1515/epoly.2007.7.1.314 ◽

2007 ◽

Vol 7 (1) ◽

Author(s):

M. Galehassadi ◽

M. Mahkam ◽

F. Hosseinzadeh

Keyword(s):

Drug Delivery ◽

In Vitro Release ◽

Network Polymers ◽

Release Studies ◽

Silyl Groups ◽

Silyl Derivatives ◽

Derivatives Of ◽

Vitro Release

AbstractNetwork polymers containing silyl groups were synthesized. Silyl derivatives of 2-hydroxyethylmethacrylate (HEMA), and methacrylic acid (MAA) were copolymerized with 1,2-bis(vinylphenyl)ethane (BVPE) and divinylbenzene (DVB) as cross-linking agents by radical polymerization using α,α′-azobis (isobutyronitrile) (AIBN) as initiator to produce network polymers. Then mesalasine (MZ) were loaded to these network polymers, and amount of drug entrapped was determined. In vitro release studies showed that drug delivery property was modified and showed considerable difference in swelling at pH 1 and 7.4. Incorporation of silyl groups in new macromolecule system modified network polymers for drug delivery. Monomers and polymers were characterized by spectroscopic methods.

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