Congenital Feline Hypothyroidism With Partially Erupted Adult Dentition in a 10-Month-Old Male Neutered Domestic Shorthair Cat: A Case Report

Congenital feline hypothyroidism was diagnosed in a 10-month-old kitten. The kitten appeared to have disproportionate dwarfism, with the clinical signs of incompletely erupted permanent dentition covered by thickened gingival tissue, short stature, a broad, flattened face, short neck, pendulous abdomen, kitten-like hair coat, and goiter. Hypothyroidism was confirmed with baseline T4, freeT4, and thyroid-stimulating hormone testing. The kitten was treated with thyroid hormone supplementation and monitored. The kitten appeared clinically like a normal healthy cat at 22 months of age on thyroid supplementation.

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Thyroid homeostasis in B6C3F1 mice upon sub-chronic exposure to trifluoroiodomethane (CF3I)

Toxicology and Industrial Health ◽

10.1177/07482337211019658 ◽

2021 ◽

pp. 074823372110196

Author(s):

Thomas A. Lewandowski ◽

Gensheng Wang ◽

Matthew D. Reed ◽

Andrew P. Gigliotti ◽

Joel M. Cohen ◽

...

Keyword(s):

Thyroid Hormone ◽

Health Effect ◽

Species Difference ◽

Recovery Period ◽

Clinical Signs ◽

Thyroid Stimulating Hormone ◽

Male Rats ◽

Whole Body ◽

Male Mice ◽

Fire Suppressant

Trifluoroiodomethane (CF3I) is a fire suppressant gas with potential for use in low global-warming refrigerant blends. Data from studies in rats suggest that the most sensitive health effect of CF3I is thyroid hormone perturbation, but the rat is a particularly sensitive species for disruption of thyroid homeostasis. Mice appear to be less sensitive than rats but still a conservative model with respect to humans. The purpose of this study was to test tolerance and thyroid response to CF3I in B6C3F1 male mice. Male mice were exposed to CF3I for 6 h per day, for 28 days, via whole body exposure at concentrations of 2500, 5000 and 10,000 ppm. A 16-day recovery period was included to evaluate reversibility. No adverse clinical signs were observed throughout the study, and body weights were unaffected by exposure. CF3I exposure had no effect on thyroid histology. An increase in relative thyroid weight was observed at 10,000 ppm on day 28 but not in a separate group of animals evaluated on day 29, and thyroid weight was not different from controls at 44 days. Slight and sporadic changes in serum triiodothyronine, thyroxine, and thyroid-stimulating hormone were observed but did not follow a consistent pattern with respect to timing, dose, or direction. Overall, exposure at up to 10,000 ppm (1.0%) of CF3I gas for 28 days produced no overt general toxicity and only transient, recoverable effects on thyroid weight and hormones at certain concentrations. On the basis of the effect of CF3I exposure on the thyroid, including evaluation of thyroid histopathology, the no observed adverse effect level for this study is 10,000 ppm. Considering the apparently greater toxicity reported in prior studies in male rats, our data suggest a species difference between rats and mice in terms of susceptibility to CF3I-induced thyroid hormone perturbation.

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Klippel Feil Syndrome: A Case Report

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v19i1.48810 ◽

2020 ◽

Vol 19 (1) ◽

pp. 78-81

Author(s):

Dhananjoy Das ◽

M A Chowdhury Arzu ◽

SM Zafar Hossain

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Case Report ◽

Head And Neck ◽

Short Stature ◽

Neurological Deficit ◽

Congenital Heart ◽

Good Prognosis ◽

Short Neck ◽

Clinical Triad

Klippel-Feil Syndrome (KFS) is a complex syndrome comprises of classical clinicaltriad of short neck, limitation of head and neck movements and low posteriorhairline. This syndrome is resulting from failure of the normal segmentation ofcervical vertebra.In this present case in addition to classical clinical triad we have found short stature,scoliosis at cervico- dorsal junction and sprengel deformity of the shoulder. Wedidn’t find any association of hearing impairment, congenital heart disease andrenal abnormalities. There was no any neurological deficit and normal schoolperformance.Patient with KFS usually have good prognosis if cardiopulmonary, genitourinary,auditory problems are identified and treated early. Chatt Maa Shi Hosp Med Coll J; Vol.19 (1); January 2020; Page 78-81

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Isolated Pulmonary Valvular Stenosis Noonan Syndrome A Case Report

University Heart Journal ◽

10.3329/uhj.v5i2.4564 ◽

1970 ◽

Vol 5 (2) ◽

pp. 91-93

Author(s):

Md Abu Siddique ◽

Md Mhurshid Ahmed ◽

Md Durul Hoda ◽

Yeshey Penjore ◽

Syed Ali Ahsan ◽

...

Keyword(s):

Case Report ◽

Short Stature ◽

Key Words ◽

Noonan Syndrome ◽

Autosomal Dominant ◽

Pulmonary Stenosis ◽

Bleeding Diathesis ◽

Short Neck ◽

Motor Delay ◽

Valvular Stenosis

Noonan syndrome is an autosomal dominant dysmorphic characterized by hypertelorism, a downward eyeslant, and low-set posteriorly rotated ears. Other features include short stature, a short neck with webbing or redundancy of skin, cardiac anomalies, epicanthic fold, deafness, motor delay, and a bleeding diathesis. In this case report a 20 years male presented with severe pulmonary stenosis with classical sketetal abnomalities. Key words: Autosomal dominant; pulmonary stenosis DOI: 10.3329/uhj.v5i2.4564 University Heart Journal Vol.5(2) July 2009 pp.91-93

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EVALUATION OF THE EFFICACY OF AYURVEDIC MEDICINES IN THE MANAGEMENT OF HYPOTHYROIDISM: A CASE REPORT

International Journal of Research in Ayurveda and Pharmacy ◽

10.7897/2277-4343.1105135 ◽

2020 ◽

Vol 11 (5) ◽

pp. 25-27

Author(s):

Pooja Sharma ◽

Nitin Sharma ◽

Divya Kajaria

Keyword(s):

Case Report ◽

Thyroid Hormone ◽

Menstrual Cycle ◽

Thyroid Hormones ◽

Female Patient ◽

Symptomatic Improvement ◽

Thyroid Stimulating Hormone ◽

Vital Role ◽

Stress And Strain ◽

Present Case Report

Hypothyroidism refers to deficiency of thyroid hormone caused due to various reasons. The global incidence of hypothyroidism is increasing alarmingly as people are exposed to more stress and strain. The synthesis and transport of thyroid hormones play a vital role in the normal physiology and functioning of thyroid hormones. The present case report was conducted to evaluate the efficacy of Ayurvedic medicines in the management of Hypothyroidism within time constrain. A 30 years old female patient was diagnosed as hypothyroidism in 2017 with the complaints of mild oedema over face, bowel irregular and weight increases. Other associated complaints were reduced appetite, lethargy, weakness, delayed menstrual cycle and headache. Arogyavardhini vati 1 tablet (in 100 mg), Kanchnar guggulu 2 tablet (in 250 mg), combination of Sudarshana Churna and Kalmegha Churna (each 3 gram), Mustakarishata 20 ml, with equal amount of water and Mahamanjishthadi kwatha 10 gram after food was administered twice a day for 15 days. The patient showed significant improvement in TSH (thyroid stimulating hormone) from 20.79 uIUmL/dl to 0.35 uIUmL. A symptomatic improvement was observed in irregular bowel, oedema over face, delayed menstruation, lethargy and reduced appetite was found. This case report highlights the potential of Ayurvedic management in hypothyroidism within the time constrain and provide the better pathway for this disease.

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Pathological study of Hepatic coccidiosis in naturally infected rabbits

Al-Qadisiyah Journal of Veterinary Medicine Sciences ◽

10.29079/vol11iss1art172 ◽

2012 ◽

Vol 11 (1) ◽

pp. 63 ◽

Cited By ~ 3

Author(s):

R. A.S AL- Naimi, O. H. Khalaf, S. Y. Tano And E. H. Al- Taee

Keyword(s):

Developmental Stages ◽

Clinical Signs ◽

Cell Aggregation ◽

Liver Parenchyma ◽

Histopathological Changes ◽

Pathological Study ◽

Hair Coat ◽

Pendulous Abdomen ◽

Eimeria Stiedae ◽

Hepatic Coccidiosis

Thirty young domesticated rabbits (age 2-2.5 mo) of sexes showed clinical signs of anorexia, debilitation, diarrhea, icterus, rough hair coat and pendulous abdomen with hepatomegaly. Fecal samples were collected for demonstrated the presence of oocysts. Postmortem examination revealed the presence of discrete yellowish-white nodules of 1mm to 2 cm size on the surface and throughout the parenchyma containing a thick creamy white fluid. The histopathological changes showed biliary hyperplasia with different developmental stages of Eimeria stiedae in the epithelial cells, cholangitis and peribiliary fibrosis with newly formed bile ductules, severe congestion, and dilation of central veins and sinusoids with disruption hemorrhagic areas. The hepatocytes showed degenerative changes to necrosis with areas of fibrosis and mononuclear cell aggregation, obstructive jaundice and a tendency to form oocyst granuloma. In conclusion hepatic coccidiosis lead to severe pathological changes both in bile ducts and liver parenchyma especially in young animals.

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Familial association of pseudohypoparathyroidism and psoriasis: case report

Sao Paulo Medical Journal ◽

10.1590/s1516-31802002000100007 ◽

2002 ◽

Vol 120 (1) ◽

pp. 23-27 ◽

Cited By ~ 4

Author(s):

Renan Magalhães Montenegro Junior ◽

Francisco José Albuquerque de Paula ◽

Norma Tiraboshi Foss ◽

Milton Cesar Foss

Keyword(s):

Mental Retardation ◽

Short Stature ◽

Soft Tissues ◽

White Male ◽

Elevated Serum ◽

Clinical Signs ◽

Ionized Calcium ◽

Total Calcium ◽

Short Neck ◽

History Of

CONTEXT: The association between psoriasis and hypoparathyroidism has been reported by several authors, and it has been suggested that abnormalities in calcium homeostasis may be involved in the development or exacerbation of psoriasis. However, so far there have only been two reports of pseudohypoparathyroidism associated with psoriasis. OBJECTIVE: To describe the familial occurrence of this association for the first time. CASE REPORTS: Two siblings with psoriasis associated with pseudohypoparathyroidism were presented. The first patient was a 24-year-old white male with disseminated erythrodermic pustular psoriasis that began 2 months before admission. He had had a history of mental retardation, recurrent otitis, seizures and arthralgia from the age of 11 years onwards. He presented the characteristic phenotype of Albright osteodystrophy: short stature, obesity, round facies, broad forehead, short neck and brachydactylia. He adopted a position of flexed limbs and showed proximal muscle weakness and a positive Trousseau sign. He had clinical signs of hypocalcemia (0.69 mmol/l ionized calcium and 3.2 mg/dl total calcium), hyperphosphatemia (6.6 mg/dl), hypomagnesemia (1.0 mEq/l), hypoalbuminemia (3.1 g/dl), normal serum intact PTH levels (45.1 pg/ml), primary hypothyroidism (13.2 mU/ml TSH, and 4.7 mg/dl total T4), hypergonadotrophic hypogonadism (116.0 ng/ml LH, 13.2 mU/ml FSH and 325.0 ng/dl testosterone), osteoporosis, and diffuse calcifications in soft tissues and in the central nervous system. The second case was a 14-year-old white girl with a history of psoriasis vulgaris from the age of five years onwards, and antecedents of mental retardation. She presented signs of Albright osteodystrophy (short stature, round facies, obesity, short neck, brachydactylia), hypocalcemia (ionized calcium of 1.08 mmol/l and total calcium of 6.7 mg/dl) hyperphosphatemia (9.4 mg/dl), elevated serum PTH levels (223.0 pg/ml), osteoporosis, and hypergonadotrophic hypogonadism (7.0 mU/ml LH, 9.3 mU/ml FSH and undetectable estradiol levels).

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