Determination of Serum Diclofenac by High-performance Liquid Chromatography by Electromechanical Detection
Keyword(s):
Diclofenac was isolated from plasma by double extraction with organic solvent. Chromatography was performed on Lichrosorb NH2 column with acetonitrile and perchloric acid (0.0025 mol/l; 35:65, v/v) as the mobile phase (flow rate 0.9 ml/min). The electrochemical detector was operated at +900 mV and sensitivity of 5-10 nA. The sensitivity of the method was 10 μg/1 and the coefficients of variation below 10% in the entire range of the concentration in a dose interval.
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1983 ◽
Vol 66
(3)
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pp. 606-609
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1990 ◽
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pp. 26-30
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1999 ◽
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pp. 770-772
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pp. 32-38
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1994 ◽
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pp. 569-574
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2021 ◽
Vol 66
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pp. 172-176