scholarly journals Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma

Tumor Biology ◽  
2017 ◽  
Vol 39 (10) ◽  
pp. 101042831772086 ◽  
Author(s):  
Young Mi Hong ◽  
Mong Cho ◽  
Ki Tae Yoon ◽  
Chong Woo Chu ◽  
Kwang Ho Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Early Recurrence ◽  
Curative Hepatectomy

scholarly journals Inflammatory indexes in preoperative blood routine to predict early recurrence of hepatocellular carcinoma after curative hepatectomy

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
YiFeng Wu ◽  
ChaoYong Tu ◽  
ChuXiao Shao
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Tumour Size ◽  
Area Under The Curve ◽  
Early Recurrence ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Lymphocyte Ratio ◽  
Inflammatory Index ◽  
Curative Hepatectomy

Abstract Background The inflammation indexes in blood routine play an essential role in evaluating the prognosis of patients with hepatocellular carcinoma, but the effect on early recurrence has not been clarified. The study aimed to investigate the risk factors of early recurrence (within 2 years) and recurrence-free survival after curative hepatectomy and explore the role of inflammatory indexes in predicting early recurrence. Methods The baseline data of 161 patients with hepatocellular carcinoma were analyzed retrospectively. The optimal cut-off value of the inflammatory index was determined according to the Youden index. Its predictive performance was compared by the area under the receiver operating characteristic curve. Logistic and Cox regression analyses were used to determine the risk factors of early recurrence and recurrence-free survival. Results The area under the curve of monocyte to lymphocyte ratio (MLR) for predicting early recurrence was 0.700, which was better than systemic inflammatory response index (SIRI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and systemic immune-inflammatory index (SII). MLR, tumour size, tumour differentiation and BCLC stage are all risk factors for early recurrence and recurrence-free survival of HCC. Combining the above four risk factors to construct a joint index, the area under the curve for predicting early recurrence was 0.829, which was better than single MLR, tumour size, tumour differentiation and BCLC stage. Furthermore, with the increase of risk factors, the recurrence-free survival of patients is worse. Conclusion The combination of MLR and clinical risk factors is helpful for clinicians to identify high-risk patients with early recurrence and carry out active postoperative adjuvant therapy to improve the prognosis of patients.

Risk factors and patterns of early recurrence after curative hepatectomy for hepatocellular carcinoma

2016 ◽  
Vol 25 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Fumitoshi Hirokawa ◽  
Michihiro Hayashi ◽  
Mitsuhiro Asakuma ◽  
Tetsunosuke Shimizu ◽  
Yoshihiro Inoue ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Early Recurrence ◽  
Curative Hepatectomy

scholarly journals TERT Mutations Correlated With the Prognosis of Patients With Hepatitis B-Related Hepatocellular Carcinoma Underwent Curative Hepatectomy

2021 ◽  
Author(s):  
Kangjian Song ◽  
Junyu Huo ◽  
Fu He ◽  
Qingwei Zhu ◽  
Liqun Wu
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Hepatitis B ◽  
Poor Prognosis ◽  
Early Recurrence ◽  
Single Factor ◽  
Risk Factors For Recurrence ◽  
Independent Risk Factors ◽  
Curative Hepatectomy

Abstract Background To explore the value of TERT mutations in predicting the early recurrence and prognosis of hepatitis B-related hepatocellular carcinoma (HCC) patients underwent curative hepatectomy.Methods A total of 81 patients with hepatitis B-related HCC were enrolled and all patients underwent curative hepatectomy. Associations were sought between TERT mutations and recurrence rate within 2 years after hepatectomy, time to progress (TTP) and overall survival (OS).Results TERT mutations (HR: 2.985, 95%CI: 1.158-7.692, p=0.024) and Barcelona clinic liver (BCLC) stage B (HR: 3.326, 95%CI: 1.019-10.856, p=0.046) were independent risk factors for recurrence within 2 years after hepatectomy. Patients with a TERT mutation had poor TTP (p=0.003) and OS (p=0.013) than others. TERT mutations (HR: 2.245, 95%CI: 1.185-4.252, p=0.013) and BCLC stage B (HR: 2.132, 95%CI: 1.082-4.198, p=0.029) were independent risk factors for poor TTP after curative hepatectomy. A predictive model based on TERT mutations and BCLC stage had better ability to predict early recurrence after hepatectomy of HCC patients than any single factor (AUC: 0.688 vs. 0.639, 0.688 vs. 0.607, respectively). Patients with both TERT mutations and BCLC stage B had poorer TTP and OS than others (p=0.001, p<0.001, respectively).Conclusion TERT mutations had ability to predict early recurrence and poor prognosis for hepatitis B-related HCC patients underwent curative hepatectomy.

scholarly journals Risk factors for very early recurrence of hepatocellular carcinoma: a retrospective review

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S83-S84
Author(s):  
R. Simon ◽  
K. Sasaki ◽  
Georgios A. Margonis ◽  
Jin He ◽  
L. Acevedo-Moreno ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Retrospective Review ◽  
Early Recurrence

Risk Factors for Early Recurrence of Single Lesion Hepatocellular Carcinoma After Curative Resection

2016 ◽  
Vol 40 (10) ◽  
pp. 2466-2471 ◽  
Author(s):  
Mitsugi Shimoda ◽  
Kazuma Tago ◽  
Takayuki Shiraki ◽  
Shozo Mori ◽  
Masato Kato ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Curative Resection ◽  
Early Recurrence ◽  
Single Lesion

Risk factors for early recurrence after curative hepatectomy for colorectal liver metastases

Surgery Today ◽  
2011 ◽  
Vol 41 (4) ◽  
pp. 526-532 ◽  
Author(s):  
Yo-ichi Yamashita ◽  
Eisuke Adachi ◽  
Yasushi Toh ◽  
Kippei Ohgaki ◽  
Osamu Ikeda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Early Recurrence ◽  
Curative Hepatectomy

Risk factors for early recurrence after surgical resection for hepatocellular carcinoma

2008 ◽  
Vol 14 (3) ◽  
pp. 371 ◽  
Author(s):  
Ui Jun Park ◽  
Yong Hoon Kim ◽  
Koo Jeong Kang ◽  
Tae Jin Lim
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Surgical Resection ◽  
Early Recurrence

Clinicopathological Risk Factors for Recurrence within One Year after Initial Hepatectomy for Hepatocellular Carcinoma

2011 ◽  
Vol 77 (5) ◽  
pp. 572-578 ◽  
Author(s):  
Michihiro Hayashi ◽  
Tetsunosuke Shimizu ◽  
Fumitoshi Hirokawa ◽  
Yoshihiro Inoue ◽  
Koji Komeda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
High Risk ◽  
Early Recurrence ◽  
Intrahepatic Metastasis ◽  
High Rate ◽  
Preoperative Imaging ◽  
Curative Intent ◽  
Initial Hepatectomy ◽  
Cancer Spread

Hepatocellular carcinoma (HCC) shows a high rate of recurrence after hepatectomy; predictive factors for early recurrence would help determine optimal therapeutic and management strategies. Among 163 patients with HCC undergoing hepatectomy with curative intent, 46 patients developed recurrence within 1 year. Clinicopathological data were retrospectively analyzed to identify predictive parameters for early recurrence. Survival rates in cases of recurrence within 1 year were worse than those of no recurrence within 1 year or recurrence after 1 year. Protein induced by vitamin K absence/antagonist II (PIVKA-II) greater than 150, positive fucosylated alpha-fetoprotein (L3-AFP), and deviancy from Milan criteria (MC) on preoperative imaging were associated with high risk of early recurrence and total number of these three risk factors predicted the survival. With multivariate analysis, 1) preoperatively, positive factors of two or more among three items of PIVKA-II, L3-AFP, and deviancy from MC; 2) and postoperatively, pathological cancer spread (microscopic vascular invasion and/or intrahepatic metastasis) both represented risks for early recurrence. A combination of three preoperative factors, PIVKA-II, L3-AFP, and MC status, in conjunction with the postoperative factor of cancer spread status represents a significant indicator for recurrence within 1 year. Improving the prognosis of patients with HCC would depend on how to adequately treat those at high risk of early recurrence.

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