scholarly journals Current Status of Histogenetic and Morphogenetic Concepts of Salivary Gland Tumorigenesis

1993 ◽  
Vol 4 (5) ◽  
pp. 639-677 ◽  
Author(s):  
Irving Dardick ◽  
Aileen P. Burford-Mason
Keyword(s):  
Salivary Gland ◽  
Acinar Cells ◽  
Neoplastic Transformation ◽  
Cell Types ◽  
Salivary Gland Tumors ◽  
Current Status ◽  
Normal Gland ◽  
Routine Diagnosis ◽  
Diagnosis And Classification

Because of their complexity and relative infrequency, salivary gland tumors commonly result in diagnostic problems. Histogenetic and morphogenetic concepts of tumorigenesis in these glands are reviewed and their relevance to routine diagnosis and classification of salivary gland tumors evaluated. Evidence is presented from animal and human studies that under steady-state and pathophysiological conditions, all cell types present in the normal gland, including acinar cells, are capable of rapidly entering the cell cycle and are, therefore, possible targets for neoplastic transformation.

scholarly journals Physiological and morphological evidence for coupling in mouse salivary gland acinar cells.

1978 ◽  
Vol 79 (1) ◽  
pp. 20-26 ◽  
Author(s):  
S B Kater ◽  
N J Galvin
Keyword(s):  
Salivary Gland ◽  
Lucifer Yellow ◽  
Electrical Coupling ◽  
Freeze Fracture ◽  
Acinar Cells ◽  
Cell Types ◽  
Morphological Evidence ◽  
Secretory Cells ◽  
Intercellular Exchange ◽  
Dc Current

Three experimental techniques were employed to examine coupling between acinar cells of the mouse salivary gland. Passage of DC current pulses via intracellular microelectrodes between neighboring cells showed that small ions could be directly passed from one cell to another. Intracellular iontophoresis of the dye Lucifer Yellow CH into a single cell indicated that small molecules could spread by means of intercellular cytoplasmic bridges througout an acinus and, occasionally, into cells of adjacent acini. Freeze-fracture replicas of acinar cell membranes indicated the presence of gap junctions which were correlated with both electrical and dye coupling experiments. Suggestions are made for the function of direct intercellular exchange in salivary secretory cells. The role of electrical coupling in coordination of the activity of different secretory cell types is discussed as one possible function.

Simple mucin-type carbohydrate antigens in major salivary glands.

1994 ◽  
Vol 42 (9) ◽  
pp. 1251-1259 ◽  
Author(s):  
M H Therkildsen ◽  
U Mandel ◽  
J Thorn ◽  
M Christensen ◽  
E Dabelsteen
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Acinar Cells ◽  
Salivary Gland Tumors ◽  
Basal Cells ◽  
T Antigens ◽  
Glycosylation Pattern ◽  
Carbohydrate Antigens ◽  
Major Salivary Glands ◽  
Duct Cells

Simple mucin-type carbohydrate antigens Tn, sialosyl-Tn and T are often markers of neoplastic transformation and have very limited expression in normal tissues. We performed an immunohistological study of simple mucin-type carbohydrate antigens, including H and A variants, with well-defined monoclonal antibodies (MAb) on frozen and paraffin-embedded normal salivary gland tissue from 22 parotid, 14 submandibular, six sublingual, and 13 labial glands to elucidate the simple mucin-type glycosylation pattern in relation to cyto- and histodifferentiation. The investigated carbohydrate structures were predominantly observed in the cell cytoplasm, most often in the supranuclear area, suggesting localization to the Golgi region, whereas ductal contents were unstained. Mucous acinar cells expressed Tn, sialosyl-Tn, and H and A antigens, regardless of glandular location. Serous acinar cells, on the other hand, expressed A, H, and inconstantly sialosyl-T, Tn, and sialosyl-Tn antigens in major salivary glands, whereas serous cells of minor (labial) salivary glands expressed H exclusively, Tn and sialosyl-T antigens inconstantly, but never sialosyl-Tn and A antigens. The difference may be related to a more simple cytodifferentiation of serous cells of minor (labial) salivary glands as compared with major salivary glands. Duct cells in major salivary glands expressed A, H, and inconstantly T, sialosyl-T, and Tn antigens, whereas minor (labial) salivary glands ducts exclusively expressed H, T and sialosyl-T antigens, differences that may be related to dissimilarities in the duct system. Myoepithelial cells and basal cells exclusively expressed T and sialosyl-T antigens, which may prove useful in studies of salivary gland tumors, since these cells are known to play a key role in the histological characteristics of some salivary gland tumors. The results indicate a similar glycosylation pattern in the different major salivary glands, whereas minor (labial) salivary gland differ slightly in serous and duct cells. The limited and exclusive intracellular expression of the immature Tn, sialosyl-Tn, and T antigens indicates that these structures may be of value as markers of salivary gland tumors.

The diagnosis and classification of mental disorders in French-speaking countries: background, current views and comparison with other nomenclatures

1982 ◽  
Vol 12 (3) ◽  
pp. 475-492 ◽  
Author(s):  
P. Pichot
Keyword(s):  
Mental Disorders ◽  
Detailed Account ◽  
Historical Background ◽  
Current Status ◽  
Background Current ◽  
French Speaking ◽  
Diagnosis And Classification

SYNOPSISA detailed account is given of the historical background and current status of the concepts of transitory delusional state (bouffée délirante) and chronic delusional state in French psychiatry. Their relations with other nosological systems are discussed.

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