Archaeology of disaster in Indonesia: where are we now?

Natural disasters are a phenomenon that shaped the Indonesian Archipelago. Earthquakes and volcanic activities have become periodic experiences in the lives of people in this region. The geographical characteristics of Indonesia which are located at the confluence of active plates and part of the global volcanic chain are natural factors that make these islands vulnerable to disasters. Cultural historical studies have recorded various phenomena of past natural disasters in the archipelago. Some have had minimal impact, but others have resulted in the loss of civilization. Although the issue has become the important part of the civilization and profile of Indonesia, the archaeological study of disasters has not well developed. The existing studies so far are still very partial with the fragmentary results. Characterized with this complex character, the study of archaeological disaster requires a multidisciplinary approach. This paper attempts to discuss the archaeology of disasters in Indonesia including the background, current conditions and the prospects of future development. Particularly in discussing the role of local wisdoms in dealing with disasters as part of the civilization of the archipelago.

Effects of an along-shelf current on the generation of internal tides near the critical latitude

The effects of along-shelf barotropic geostrophic currents on internal wave generation by the $K_1$ tide interacting with a shelf at near-critical latitudes are investigated. The horizontal shear of the background current results in a spatially varying effective Coriolis frequency which modifies the slope criticality and potentially creates blocking regions where freely propagating internal tides cannot exist. This paper is focused on the barotropic to baroclinic energy conversion rate, which is affected by a combination of three factors: slope criticality, size and location of the blocking region where the conversion rate is extremely small and the internal tide (IT) beam patterns. All of these are sensitive to the current parameters. In our parameter space, the current can increase the conversion rate up to 10 times.

Reagentless Sensing of Vancomycin Using an Indium Tin Oxide Electrode Grafted with Molecularly Imprinted Polymer including Ferrocenyl Group

Vancomycin (VCM) is a first-line antimicrobial agent against methicillin-resistant Staphylococcus aureus, a cause of nosocomial infections. Therapeutic drug monitoring is strongly recommended for VCM-based chemotherapy. The authors attempted to develop a simple VCM sensor based on molecularly imprinted polymer (MIP), which can be used with simple operations. Methacrylic acid (MAA), acrylamide, methylenebisacrylamide, and allylamine carboxypropionate-3-ferrocene (ACPF) were copolymerized in the presence of VCM and grafted from the surface of indium-tin oxide (ITO) to obtain MIP-coated electrodes. The MIP-grafted ITO electrode was used for differential pulse voltammetry (DPV) measurements in a buffer solution containing VCM or whole bovine blood. The obtained current depends on the VCM concentration with high linearity. The dynamic range covered the therapeutic range (20–40 μg/mL) of the VCM but was almost insensitive to teicoplanin, which has a similar structure to VCM. The ITO electrodes grafted by the same procedure except for omitting either VCM or APCF were not sensitive to VCM. The sensitivity of the MIP electrodes to VCM in whole blood and buffered saline, but the background current in blood was higher than that in saline. This high background current was also seen in the deproteinized plasma. Thus, the current is probably originated from the oxidation of low molecular weight reducing agents in the blood. The MIP-grafted ITO electrode using ACPF as a functional monomer would be a promising highly selective sensor for real-time monitoring of VCM with proper correction of the background current.

Mortality of Patients Infected by COVID-19 with and without Deep-Vein Thrombosis

Background: Current evidence points to a state of hypercoagulability (consequence of hyperinflammation) as an important pathogenic mechanism that contributes to the increase in mortality in cases of COVID-19. The aim of the present study was to investigate the influence of deep-vein thrombosis on mortality patient’s infected with SARS-CoV-2. Method: A clinical trial was conducted involving 200 consecutive patients with COVID-19—100 patients who were positive for deep-vein thrombosis (venous Doppler ultrasound) and 100 who were negative for deep-vein thrombosis at a public hospital. Results: The mortality rate was 67% in the group positive for DVT and 31% in the group negative for DVT. Conclusion: Deep-vein thrombosis is associated with an increase in mortality in patients with COVID-19 and failures can occur with conventional prophylaxis for deep-vein thrombosis.

Exclusive Breast Feeding: Infant Feeding Pattern and Practices among Mothers in Santa Fe, Romblon

This paper examines whether the profile of the respondents: age, number of living children, marital status, income status, employment status, educational background, current feeding practices, and level of knowledge on the importance of EBF has an effect in feeding among infants 0-6 months old. This is a descriptive study using a normative survey with a study population of 102 mothers from the Municipality of Santa Fe, Romblon upon informed consent was secured. The result as follows mothers, whose age ranges from 21 to 25 are the most prevailing, 39%, of the total respondents is practicing EBF. The more children the respondent had the higher the percentage of practicing EBF, 55% said that they are living with a partner, either married through church wedding, civil or in the state of cohabitation, lower-income mothers (45%) practice EBF more compared to other income class. Mothers without job practice EBF more (51%) exclusive breastfeeding are practiced more by elementary graduate mothers (63%), forty-four (44) mothers out of one hundred two (102) respondents are doing exclusive breastfeeding, at least 63% have revealed little knowledge on the importance of exclusive feeding.

Spontaneous clearance of vertically acquired hepatitis c infection: implications for testing and treatment

Background. Current guidelines recommend that infants born to women with hepatitis C (HCV) viremia are screened for HCV antibody at age 18 months, and if positive, referred for RNA testing at 3 years to confirm chronic infection. This policy is based in part on analyses suggesting 25%-40% of vertically acquired HCV infections clear spontaneously within 4-5 years. Methods. Data on 179 infants with RNA and/or anti-HCV evidence of vertically acquired viraemia (single PCR+) or confirmed infection (2 PCR+ or anti-HCV beyond 18 months) in three prospective European cohorts were investigated. Ages at clearance of viremia and confirmed infection were estimated taking account of interval censoring and delayed entry. We also investigated clearance in infants in whom RNA was not detectable until after 6 weeks. Results. Clearance rates decline rapidly over the first 6 months. An estimated 90.6% (95%CrI: 83.5-95.9) of viremia cleared by 5 years, most within 3 months, and 65.9% (50.1-81.6) of confirmed infection cleared by 5 years, at a median 12.4 (7.1-18.9) months. If treatment began at age 6 months, 18 months or 3 years, at least 59.0% (42.0-76.9), 39.7 (17.9-65.9), and 20.9 (4.6-44.8) of those treated would clear without treatment. In seven (6.6%) confirmed infections, RNA was not detectable until after 6 weeks, and in 2 (1.9%) not until after 6 months. However, all such cases subsequently cleared. Conclusions. Most viraemia clears within 3 months, and most confirmed infection by 3 years. Delaying treatment avoids but does not eliminate over-treatment and should be balanced against loss to follow-up.

JUVENILE JUSTICE METHODS: HISTORIC BACKGROUND, CURRENT SITUATION AND OPPORTUNITIES

В статье дан исторический экскурс внедрения ювенальных технологий в России. Исследованы различные аспекты правового регулирования уголовно-правовых отношений с участием несовершеннолетних, включая коллизии современного правосудия и пенитенциарной практики. С учетом анализа отечественного опыта, накопленного в ходе реализации ювенальных проектов, и зарубежных ювенальных практик сформулированы предложения по совершенствованию деятельности системы предупреждения преступности несовершеннолетних. The article provides a historical overview of the implementation of the juvenile justice methods in Russia. Different aspects of the legal regulation of criminal matters involving minors, especially in the light of the contradictions in contemporary justice and penitentiary practice, have been investigated. The author makes a proposal for improving the juvenile crime prevention system taking into account the domestic and foreign juvenile experience.

Determination of Atorvastatin with Voltammetric Sensors Based on Nanomaterials

This paper presents an accurate and fast electrochemical method for atorvastatin determination in pharmaceutical products. Two screen-printed sensors, one—carbon based (SPCE) and one based on carbon nanotubes and gold nanoparticles (AuNP-CNT/SPCE) were used during the electrochemical analyses. At all experimental stages, cyclic voltammetry was employed, both for the characterization of the sensors and their electrochemical behavior, and for quantitative determinations. AuNP-CNT/SPCE has showed an extended active area, higher intensity peaks, better reversibility and lower background current than the unmodified sensor. For atorvastatin quantification, a calibration curve has been developed within the 1.2–606.25 µM concentration range. A linearity relation between the current of the anodic peak and concentration has been obtained in the range 1.2–53.33 µMfor both sensors. With the AuNP-CNT/SPCE sensor, low values of limit of detection, LOD (1.92 × 10−7 M) and limit of quantification, LOQ (6.39 × 10−7 M) have been obtained, which demonstrates the feasibility of the method of determining atorvastatin from real samples. Atorvastatin amount has been successfully determined from pharmaceutical products using AuNP-CNT/SPCE. The results were similar to the manufacturer’s specifications regarding the dosage per tablet and to the concentrations obtained by applying the FTIR spectrometric method.