Elevations in Serum Transaminases and Alkaline Phosphatase Secondary to Papaverine Hydrochloride

1981 ◽  
Vol 15 (2) ◽  
pp. 127-129 ◽  
Author(s):  
Gail S. Geiger
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Function ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Liver Function Tests ◽  
Peripheral Vascular ◽  
Function Tests ◽  
Serum Transaminases ◽  
Elevated Liver Function Tests ◽  
Papaverine Hydrochloride

A case of papaverine-induced elevated liver function tests occurred in a 58-year-old female with peripheral vascular disease after she received papaverine hydrochloride 150 mg bid over a two- to three-week period. The patient presented with abnormal elevations in serum transaminases (SGOT and SGPT) and alkaline phosphatase. The papaverine was discontinued, and the elevated enzymes returned to normal within three weeks.

scholarly journals New insights into vitamin D regulation: is there a role for alkaline phosphatase?

2021 ◽  
Author(s):  
G. Bellastella ◽  
L. Scappaticcio ◽  
M. Longo ◽  
R. Carotenuto ◽  
C. Carbone ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Liver Function ◽  
Significant Negative Correlation ◽  
Liver Function Tests ◽  
Bone Alkaline Phosphatase ◽  
Gamma Glutamyl Transpeptidase ◽  
Function Tests ◽  
Group 2 ◽  
Group 1

Abstract Purpose The diagnosis of vitamin D deficiency is based on the determination of total plasma 25-hydroxyvitamin D (25-OHD) concentrations, but the regulation of vitamin D 25-hydroxylation is not a major consideration and very little information is available on this activity. To check what factors could interfere with the activity of vitamin D-25-hydroxylase and thus alter the 25-OHD concentrations, we looked for potential correlations between 25-OHD and results of liver function tests in healthy adults. Methods This single-centre study was retrospective and consisted of evaluating the correlations between 25-OHD and the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and bone alkaline phosphatase (BALP) in 349 healthy subjects aged from 18 to 65 years. In particular, in Group 1 (n = 119), we looked for correlations between 25OHD and all liver function tests and in Group 2 (n = 230) the correlation between 25OHD and BALP. Results In Group 1, we found no correlation between 25OHD and AST (r =  − 0.03; p = 0.8), ALT (r =  − 0.02; p = 0.91), GGT (r =  − 0.08; p = 0.68), direct bilirubin (r =  − 0.02; p = 0.89), indirect bilirubin (r =  − 0.24; p = 0.21), and total bilirubin (r =  − 0.24; p = 0.21) but one between 25OHD and ALP (r =  − 0.2; p = 0.007); in Group 2, we found a significant negative correlation between 25-OHD and BALP (r =  − 0.2; p = 0.0008). Conclusions The correlations that we found suggest that ALP and BALP might be involved in the regulation of vitamin D-25-hydroxylase activity, but further studies are mandatory to confirm our assumptions.

Case 4.25

2014 ◽  
pp. 234-235
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Liver Function ◽  
Pancreatic Duct ◽  
Liver Function Tests ◽  
Filling Defect ◽  
Distal Common Bile Duct ◽  
Biliary Dilatation ◽  
Function Tests ◽  
Elevated Liver Function Tests

64-year-old man with elevated liver function tests MIP image from 3D FRFSE MRCP (Figure 4.25.1) reveals a filling defect in the distal common bile duct, diffuse intrahepatic biliary dilatation, and mild dilatation of the pancreatic duct. Coronal oblique SSFSE images (Figure ...

Case 3.7

2014 ◽  
pp. 146-146
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Liver Function ◽  
Equilibrium Phase ◽  
Liver Function Tests ◽  
Quadrant Pain ◽  
Function Tests ◽  
Elevated Liver Function Tests ◽  
The Right

80-year-old man with right upper quadrant pain and elevated liver function tests; abdominal US performed at an outside institution showed a mass in the gallbladder Arterial (Figure 3.7.1), portal venous (Figure 3.7.2), and equilibrium phase (Figure 3.7.3) postgadolinium 3D SPGR images demonstrate a hyperenhancing mass within the gallbladder lumen. Note also the large heterogeneous mass seen in the upper pole of the right kidney....

Diagnostic Effectiveness of Biochemical Liver-Function Tests, as Evaluated by Discriminant Function Analysis

1977 ◽  
Vol 23 (4) ◽  
pp. 627-630 ◽  
Author(s):  
Paul Phillip Sher
Keyword(s):  
Alkaline Phosphatase ◽  
Lactate Dehydrogenase ◽  
Discriminant Analysis ◽  
Liver Function ◽  
Function Analysis ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Hepatic Disease ◽  
Stepwise Discriminant Analysis ◽  
Function Tests

Abstract I evaluated the diagnostic value of routinely ordered liver-function tests in 175 biopsy-proven cases of hepatic disease by use of stepwise discriminant analysis. The tests studied—total and "direct" bilirubin, alkaline phosphatase, lactate dehydrogenase, and aspartate aminotrans-ferase—correctly classified 45-73% of cases, depending on the homogeneity of the diagnostic groups. Aspartate aminotransferase and alkaline phosphatase were the best discriminators. When all tests were used in the most ho-mogeneous groups (tumors, cirrhosis, and hepatitis), there was a stepwise improvement in diagnostic accuracy from 51 to 73%.

scholarly journals Incidence and clinical significance of elevated liver function tests in cystic fibrosis clinical trials

2013 ◽  
Vol 34 (2) ◽  
pp. 232-238 ◽  
Author(s):  
Nicole Mayer-Hamblett ◽  
Margaret Kloster ◽  
Bonnie W. Ramsey ◽  
Michael R. Narkewicz ◽  
Lisa Saiman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Clinical Trials ◽  
Liver Function ◽  
Clinical Significance ◽  
Liver Function Tests ◽  
Function Tests ◽  
Elevated Liver Function Tests
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