An Intrahepatic Cholangiocarcinoma with Focal Rhabdoid Features and SMARCA4-Deficiency

2021 ◽  
pp. 106689692110701
Author(s):  
Hiroshi Minato ◽  
Akane Yoshikawa ◽  
Kazuyoshi Katayanagi ◽  
Hiroshi Kurumaya ◽  
Kaichiro Kato ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Genetic Heterogeneity ◽  
Staining Pattern ◽  
Case Reports ◽  
Immunohistochemical Analysis ◽  
Genetic Changes ◽  
Poorly Differentiated Adenocarcinoma ◽  
Poorly Differentiated ◽  
Avascular Tumor ◽  
Rhabdoid Features

Intrahepatic cholangiocarcinoma with rhabdoid morphology is rare, and only three case reports have been published to date, none of which discuss the genetic changes in the rhabdoid component. We present a case of intrahepatic cholangiocarcinoma with focal rhabdoid features and SMARCA4-deficiency detected using immunohistochemistry. A Japanese man in his 60s without viral hepatitis was diagnosed with an avascular tumor in the liver, measuring 4.4 cm in the greatest dimension. The tumor was mostly composed of moderately differentiated adenocarcinoma, focal poorly differentiated adenocarcinoma, and an undifferentiated rhabdoid component. Immunohistochemical analysis showed an inclusion-like staining pattern for keratin AE1/AE3 and vimentin in the rhabdoid component. BRG1/SMARCA4 was detected in the differentiated component but not in the poorly- and undifferentiated components. Our novel findings reflecting the morphological and genetic heterogeneity of intrahepatic cholangiocarcinoma and will aid the research on drugs targeting the aberrant SWItch/Sucrose NonFermentable complex.

scholarly journals A Case of Poorly Differentiated Adenocarcinoma with Signet Ring Cell Carcinoma of the Duodenal Bulb: A Case Report

2017 ◽  
Vol 102 (3-4) ◽  
pp. 141-144 ◽  
Author(s):  
Kosuke Hirano ◽  
Yukinori Yamagata ◽  
Teppei Tatsuoka ◽  
Yawara Kubota ◽  
Kazuyuki Saito ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Rare Case ◽  
Case Reports ◽  
Duodenal Bulb ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Poorly Differentiated Adenocarcinoma ◽  
Signet Ring ◽  
Poorly Differentiated ◽  
Ring Cell

Duodenal cancers are rare. Histopathologically, most duodenal cancers are adenocarcinoma. Signet ring cell carcinoma (SRCC) is a rare tumor more commonly found in the stomach than at other sites in the digestive tract. SRCC is extremely uncommon in the duodenum, with most of these tumors occurring in the ampulla. Until now, there are few case reports of duodenal cancers with SRCC. To accumulate case reports, we report a rare case of nonampullary duodenal bulb SRCC. A 74-year-old man was admitted to our hospital with melena. Esophagogastroduodenoscopy (EGD) showed a duodenal bulb ulcer. He was treated with a proton pump inhibitor. However, 1 month later, he was readmitted to our hospital with epigastric pain and nausea. A second EGD examination showed an ulcer at the duodenal bulb. Biopsies taken from the ulcer showed SRCC. Distal gastrectomy and duodenal bulb resection were performed. Histologic examination of the specimen showed a type 4 lesion located from the duodenal bulb to the pyloric antrum. The tumor was composed of poorly differentiated adenocarcinoma (por) with SRCC. The distal margin of the duodenal bulb was invaded with tumor. Therefore, pancreatoduodenectomy was performed. One year after the initial operation, he is alive and had no relapse. We described a rare case of por with SRCC of the duodenal bulb. It is important to bear in mind that an ulcer following an abnormal clinical course should be biopsied, and we have to select a suitable operation in cases of duodenal bulb cancer.

scholarly journals Primary Malignant Melanoma of the Rectum: Report of Two Cases

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Kodai Tomioka ◽  
Hitoshi Ojima ◽  
Makoto Sohda ◽  
Akiko Tanabe ◽  
Yasuyuki Fukai ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Systemic Treatment ◽  
Early Stage ◽  
Immunohistochemical Analysis ◽  
Pathological Examination ◽  
Anorectal Melanoma ◽  
Stage Iiic ◽  
Poorly Differentiated Adenocarcinoma ◽  
Poorly Differentiated ◽  
Tumor Node Metastasis Classification

We report two cases of rectal malignant melanomas. The patients were an 84-year-old male and a 66-year-old female who had blood in their stools. They were preoperatively diagnosed with poorly differentiated adenocarcinoma of the rectum. The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. Pathological examination of the resected specimens revealed a malignant melanoma. Immunohistochemical analysis results were positive for HMB-45 and negative for cytokeratin AE1/AE3, CD45, and synaptophysin. Primary anorectal melanoma is an uncommon and aggressive disease that carries a poor prognosis. Therefore, it is necessary to provide systemic treatment. To improve prognosis, it is important to detect anorectal melanoma at an early stage.

METASTASIS OF AN ADENOCARCINOMA OF THE STOMACH TO THE 4TH METACARPAL BONE

Hand Surgery ◽  
2001 ◽  
Vol 06 (02) ◽  
pp. 239-242 ◽  
Author(s):  
H. C. Chang ◽  
K. H. Lew ◽  
C. O. Low
Keyword(s):  
Metastatic Lesion ◽  
Metacarpal Bone ◽  
Review Of The Literature ◽  
Poorly Differentiated Adenocarcinoma ◽  
Poorly Differentiated ◽  
The Right

Metastatic tumours of the hand are uncommon. The majority of these tumours affect the phalanges and the primary tumours are usually bronchogenic in origin, with breast and kidney tumours next in frequency. Metastatic gastrointestinal to the hand is rare and usually from the colon. We report a case of poorly differentiated adenocarcinoma of the stomach antrum presenting with a metastatic lesion to the right 4th metacarpal bone. A review of the literature is included.

Salivary Duct Carcinoma With Rhabdoid Features—No or Aberrant Expression of E-cadherin and Genetic Changes in CDH1

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Kimihide Kusafuka ◽  
Hidetaka Yamada ◽  
Keiko Ishino ◽  
Matsuyoshi Maeda ◽  
Koji Yamanegi ◽  
...  
Keyword(s):  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Aberrant Expression ◽  
Duct Carcinoma ◽  
Genetic Changes ◽  
Rhabdoid Features ◽  
E Cadherin

Acute Herpetic Nasopharyngitis in an Adult Patient: A Case Report and Literature Review

2022 ◽  
pp. 000348942110701
Author(s):  
Cathleen C. Kuo ◽  
Ellen M. Piccillo ◽  
Jason C. DeGiovanni ◽  
Matt Kabalan ◽  
Gregg Zimmer ◽  
...  
Keyword(s):  
Literature Review ◽  
Adult Patient ◽  
Soft Palate ◽  
Case Reports ◽  
Nasal Congestion ◽  
English Literature ◽  
Immunohistochemical Analysis ◽  
Anatomical Location ◽  
Posterior Aspect ◽  
Mesh Terms

Objective: To report a case of herpes virus-associated nasopharyngitis in an adult patient. Methods: The patient’s medical record was reviewed for demographic and clinical data. For literature review, all case reports or other publications published in English literature were identified using Pubmed with the MeSH terms “herpes,” “nasopharyngitis,” and “upper respiratory infection.” Results: A 40-year-old male presented for nasal congestion and a suspected nasal mass. Computed tomography of the sinuses revealed edematous changes in the nasopharynx which exerted a downward mass effect at the right aspect of the soft palate. Flexible fiberoptic laryngoscopy (FFL) revealed a lesion arising from the posterior aspect of the soft palate with extension into the posterior nasal cavity as well as copious mucopurulent secretions consistent with a superimposed acute sinusitis. Rigid nasal endoscopy demonstrated a friable and ulcerated lesion arising from the aforementioned anatomical location. Biopsy of this lesion and subsequent immunohistochemical analysis revealed a diagnosis of herpetic nasopharyngitis. Conclusions: Herpetic infection should be in the differential diagnosis of patients presenting with atypical symptoms of nasopharyngitis. Early accurate diagnosis and appropriate specific management can limit the duration of disease course and prevent further complications.

scholarly journals A clinicopathological analysis of the poorly differentiated adenocarcinoma of the stomach with special reference to their stroma.

1987 ◽  
Vol 20 (4) ◽  
pp. 849-855
Author(s):  
Kazuo HIROSE ◽  
Jinichi MUKAI ◽  
Toshihiko MATSUMOTO ◽  
Toshinari MURA ◽  
Yoshinori KUSAJIMA ◽  
...  
Keyword(s):  
Special Reference ◽  
Poorly Differentiated Adenocarcinoma ◽  
Clinicopathological Analysis ◽  
Poorly Differentiated

scholarly journals Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocarcinoma

2020 ◽  
Author(s):  
Zhenyang Shen ◽  
Jingbo Xiao ◽  
Junjun Wang ◽  
Lungen Lu ◽  
Xinjian Wan ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Intrahepatic Cholangiocarcinoma ◽  
Smooth Muscle Actin ◽  
Disease Free Survival ◽  
Immunohistochemical Analysis ◽  
Nuclear Antigen ◽  
Cytokeratin 19 ◽  
High Recurrence Rate ◽  
Local Inflammation ◽  
Ductular Reaction

Abstract Background: Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocarcinoma (ICC) which may be derived from small bile duct cells or liver progenitor cells (LPCs) was known to us. However, whether peritumoral DR is also related to non-mucin-producing ICCs remains to be investigated. Methods: Forty-seven patients with non-mucin-producing ICC were eventually included in the study and clinicopathological variables were collected. Immunohistochemical analysis and immunofluorescence staining for cytokeratin 19, proliferating cell nuclear antigen, and α-smooth muscle actin were performed in tumor and peritumor liver tissues.Results: A significant correlation existed between peritumoral DR and local inflammation and fibrosis. (r = 0.357, 95% CI, 0.037-0.557; P = 0.008 and r = 0.742, 95% CI, 0.580-0.849; P < 0.001, respectively). Patients with obvious peritumoral DR had high recurrence rate (81.8% vs 56.0%, P = 0.058) and poor overall and disease-free survival time (P = 0.01 and P = 0.03, respectively) comparing with mild peritumoral DR. Compared with the mild peritumoral DR group, the proliferation activity of LPCs/ cholangiocytes was higher in obvious peritumoral DR, which, however, was not statistically significant. (0.43±0.29 vs 0.28±0.31, P = 0.172). Furthermore, the correlation analysis showed that the DR grade was positively related to the portal/septalα-SMA level (r = 0.359, P = 0.001).Conclusions: Peritumoral DR was associated with local inflammation and fibrosis. Patients with non-mucin-producing ICC having obvious peritumoral DR had a poor prognosis. Peritumoral DR could be a prognostic factor for ICC. However, the mechanism should be further investigated.

scholarly journals A gastric stump cancer with unusual appearance

2015 ◽  
Vol 5 (3) ◽  
pp. 104-106
Author(s):  
Ferdane Sapmaz ◽  
Sebahat Basyigit ◽  
Metin Uzman ◽  
Gulcin Guler Simsek ◽  
Tolga Akkan ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Abdominal Pain ◽  
Classification System ◽  
Distal Gastrectomy ◽  
Gastric Stump ◽  
Billroth Ii ◽  
Poorly Differentiated Adenocarcinoma ◽  
Chief Complaints ◽  
Poorly Differentiated ◽  
Unusual Appearance

A 60 year old man was referred to our hospital with the chief complaints of abdominal pain and vomiting. He underwent a distal gastrectomy with a Billroth II gastrojejunostomy for a peptic ulcer 13 years ago. Esophagogastroduodenoscopy (EGD) did not reveal any gross lesion in the stomach but depigmented areas were seen in the anastomosis line. The histopathology of the anastomotic area revealed poorly differentiated adenocarcinoma. Gastric stump cancers can be polypoid, fungating, ulcerated and diffusely infiltrating tumors respectively. In our case, the appearance of adenocarcinoma was quite different from that described in the classification system.

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