scholarly journals Midterm Fate of the Contralateral Foot in Charcot Arthropathy

2020 ◽  
Vol 41 (10) ◽  
pp. 1181-1189
Author(s):  
Felix W. A. Waibel ◽  
Martin C. Berli ◽  
Viviane Gratwohl ◽  
Kati Sairanen ◽  
Dominik Kaiser ◽  
...  
Keyword(s):  
Diabetes Type 2 ◽  
Female Gender ◽  
Major Amputation ◽  
Diabetes Type ◽  
Diabetes Type 1 ◽  
Charcot Arthropathy ◽  
Level Of Evidence ◽  
Patients With Diabetes

Background: The contralateral foot in Charcot arthropathy or neuroarthropathy (CN) is subject to increased plantar pressure. To date, the clinical consequences of this pressure elevation are yet to be determined. The aim of this study was to evaluate ulcer and amputation rates of the contralateral foot in CN. Methods: We abstracted the medical records of 130 consecutive subjects with unilateral CN. Rates of contralateral CN development and recurrence, contralateral ulcer development, and contralateral amputations were recorded. Statistical analysis was performed to identify possible risk factors for contralateral CN and ulcer development, and contralateral amputation. Mean follow-up was 6.2 (SD 4) years. Results: After a mean of 2.5 years, 19.2% patients developed contralateral CN. Female gender was associated with contralateral CN development (odds ratio 3.13, 95% confidence interval 1.27, 7.7). Overall, 46.2% patients developed a contralateral ulcer. Among the patients who developed contralateral CN, 60% developed an ulcer. Sanders type 2 at the index foot (midfoot CN) was significantly associated with contralateral ulcer development. Ulcer-free survival (UFS) differed significantly between patients with diabetes type 1 (median UFS 5131 days) and patients with diabetes type 2 (median UFS 2158 days). A total of 25 amputations had to be performed in 22 (16.9%) patients. Three of those 22 patients (2.3%) needed major amputation. Conclusion: Almost 20% of patients developed contralateral CN. Nearly half of people with CN developed a contralateral foot ulceration. Patients with type 2 diabetes had significantly shorter UFS than patients with diabetes type 1. Every sixth patient needed an amputation, with the majority being minor amputations. The contralateral foot should be monitored closely and included in the treatment in patients with CN. Level of Evidence: Level IV, retrospective study.

scholarly journals Nonspecific body reactivity in patients with diabetes mellitus depending on its type

2014 ◽  
Vol 18 (2 (70)) ◽  
Author(s):  
O. A. Olenovych
Keyword(s):  
Diabetes Mellitus ◽  
Immune System ◽  
Functional Activity ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Immune Defense ◽  
Diabetes Type 1 ◽  
Patients With Diabetes

According to the results of complex assessment of integral haematological coefficients the development of endogenous intoxication was revealed in case of diabetes mellitus, whose intensity depends on the type of the disease and causes immune system disorganization. The decrease of functional activity of specific immunity as well as nonspecific one in case of diabetes mellitus leads to deregulation of cellular and humoral reactions and depends on diabetes type: in diabetes type 1 the reduction of nonspecific immunoresistance is contributed by microphages, in diabetes type 2 – by macrophages, accompanied by the deficiency of specific immune defense, reliably more significant in diabetes type 2.

Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes – What We Know so Far and the Missing Links

2017 ◽  
Vol 127 (08) ◽  
pp. 497-504 ◽  
Author(s):  
Jan Benedikt Groener ◽  
Dimitrios Oikonomou ◽  
Ruan Cheko ◽  
Zoltan Kender ◽  
Johanna Zemva ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Absolute Risk ◽  
Diabetes Type ◽  
Diabetes Type 1 ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Patients With Diabetes

AbstractHyperglycemia explains the development of late diabetic complications in patients with diabetes type 1 and type 2 only partially. Most therapeutic efforts relying on intensive glucose control failed to decrease the absolute risk for complications by more than 10%, especially in patients with diabetes type 2. Therefore, alternative pathophysiological pathways have to be examined, in order to develop more individualized treatment options for patients with diabetes in the future. One such pathway might be the metabolism of dicarbonyls, among them methylglyoxal and the accumulation of advanced glycation end products. Here we review currently available epidemiological data on dicarbonyls and AGEs in association with human diabetes type 1 and type 2.

P612: Small and large fibre neuropathy in patients with diabetes type 1 compared with type 2: a follow-up study

2014 ◽  
Vol 125 ◽  
pp. S215
Author(s):  
S. Løseth ◽  
E. Stålberg ◽  
S. Lindal ◽  
R. Jorde ◽  
S.I. Mellgren
Keyword(s):  
Diabetes Type ◽  
Diabetes Type 1 ◽  
Follow Up Study ◽  
Patients With Diabetes ◽  
Large Fibre

scholarly journals URINARY TRACT INFECTION

2011 ◽  
Vol 18 (03) ◽  
pp. 466-469
Author(s):  
GHULAM HUSSAIN BALOCH ◽  
MUKHTIAR HUSSAIN JAFFERY ◽  
CHANDRA MADHUDAS ◽  
Bikha Ram Devrajani ◽  
Syed Zulfiquar Ali Shah
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Patients With Diabetes ◽  
The Mean

Objective: To determine the frequency and pattern of urinary tract infection in patients with diabetes mellitus. Design: Descriptive case series study. Period: February 2009 to July 2009. Setting: Department of medicine at Liaquat University Hospital). Patients and methods: All patients ≥18 years of age, of either gender were known diabetes for ≥ 2 years duration. The infection was labeled when >5/hpf leukocyte in urine and growth of organism on urine for C/S. The blood sugar and hemoglobin A1C (HbA1C) was also advised to evaluate the status of their diabetes i.e. control or poorly control. Result: During study period total 150 diabetic patients were evaluated for urinary tract infection, of which 92(61%) had UTI. Out of ninety two 80(87%) had diabetes type 2 and 12(13%) were diabetes type 1. The female gender was predominant. The mean ± SD for age of patients with type 2 and type 1 diabetes mellitus was 53.52±10.74 and 20.77±1.65 whereas the mean random blood sugar level in patients with type 2 and 1 diabetes was 232.85±5.87 and 288.99 ± 7.87. The mean ± SD for duration of diabetes type 2 and 1 was 4.77±2.31 and 2.56±1.42. The isolated microorganism were Staphylococcus aureus, Escherichia coli, Proteus, Pseudomonas aeruginosa, Klebsiella, Enterobacteriaceae and C.albicans. Conclusions: The urinary tract infection is more prevalent in patients with diabetes mellitus.

Risk Factors Associated With Hyperuricemia in Patients with Diabetes Type 2: About 190 Cases

2020 ◽  
Vol 2 (1) ◽  
pp. 12-16
Author(s):  
Fennoun H ◽  
Haraj NE ◽  
El Aziz S ◽  
Bensbaa S ◽  
Chadli A
Keyword(s):  
Type 2 Diabetes ◽  
Heart Disease ◽  
Glycemic Control ◽  
Ischemic Heart Disease ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Ischemic Heart ◽  
Factors Associated ◽  
Patients With Diabetes

Introduction: Hyperuricemia is common Type 2 diabetes at very high cardiovascular risk. Objective: Evaluate the relationship between hyperuricemia and diabetes type 2, and determine its predictive factors in this population. Patients and Methods: Retrospective study cross including 190 patients with diabetes type 2 hospitalized Service of Endocrinology of CHU Ibn Rushd Casablanca from January 2015 to December 2017. Hyperuricemia was defined as a serum uric acid concentration> 70 mg/L (men) and> 60 mg/L (women). The variables studied were the anthropometric measurements), cardiovascular factors (tobacco, hypertension, dyslipidemia), and degenerative complications (retinopathy, neuropathy, kidney failure, ischemic heart disease). The analyzes were performed by SPSS software. Results: Hyperuricemia was found in 26.5% of patients with a female predominance (76%), an average age of 55.9 years, and an average age of 12.4ans diabetes. The glycemic control was found in 84.6% of cases with mean glycated hemoglobin 8.6%. Factors associated al hyperuricemia were the blood pressure in 86% (p <0.05), dyslipidemia in 76.3% of cases (p <0.001) with hypertriglyceridemia in 48.3% of cases (p <0.02), and a hypoHDLémie 28% (p <0.001). The age, obesity, smoking, and glycemic control were associated significantly n al hyperuricemia. The research of degenerative complications of hyperuricemia has objectified renal impairment (GFR between 15 and 60ml / min) chez47% (p <0.001), it was kind of moderate in 35.8% (p <0.01) and severe in 5.1% (p <0.02), ischemic heart disease was found in 34% of cases (p <0.01). Conclusion: In our study, hyperuricemia in type 2 diabetes is common in female patients, especially with hypertension, dyslipidemia, and renal failure. Other factors such as age, obesity, smoking is not associated with hyperuricemia in type 2 diabetics.

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