Precancerous Cervical Lesion Among HIV-Positive Women in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

In sub-Saharan Africa, cervical cancer is an intersecting epidemic with HIV and it is the second most common cause of cancer-related deaths in women. Therefore, this study was aimed to estimate the current status of the prevalence and associated factors of precancerous cervical lesions among HIV-positive women in sub-Saharan Africa. A systematic literature search was conducted from legitimate electronic databases, including MEDLINE (Ovid), PubMed, EMBASE (Ovid), Emcare (Ovid), CINAHL (EBSCOhost), Web of Science, Scopus, and PopLine and other gray literature including Google, Google Scholar, World Cat, ResearchGate, and Mednar. Data were extracted with a structured format prepared in Microsoft Excel. Each study was evaluated using the Joanna Briggs Institute critical appraisal tool for cross-sectional and cohort studies checklists. Accordingly, medium and high-quality studies were included in the review. Data synthesis and statistical analysis was conducted using OpenMeta and comprehensive meta-analysis version 2 software. The study protocol is registered on PROSPERO with ID: CRD42018114266. The pooled prevalence of precancerous cervical lesion among HIV-positive women in sub-Saharan Africa was 25.6% (95% confidence interval [CI]: 19.4%-31.8%). Having more than 2 lifetime sexual partners (odds ratio [OR]: 4.77; 95% CI: 1.35-16.93), having had a history of sexually transmitted infections (STIs; OR: 1.92; 95% CI: 1.03-3.57), having more than 2 births (OR: 1.84; 95% CI: 1.33-2.53), and CD4 count <200 cells/mm3 (OR: 1.765; 95% CI: 1.23-2.535) were significantly associated with precancerous cervical lesions. The prevalence of precancerous cervical lesion among HIV-positive women was high. One in 4 HIV-infected women suffers from precancerous cervical lesion. Lower CD4 cell count, STIs, multiple sexual partnering, and histories of multiple births and abortions were the foremost contributing factors for this burden. Precancerous cervical lesion could be reduced significantly if preventive and promotive measures are done on the associated factors.

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Prevalence and Associated Factors of Precancerous Cervical Lesions among Women in Ethiopia: A Systematic Review and Meta-Analysis

Ethiopian Journal of Health Sciences ◽

10.4314/ejhs.v31i1.20 ◽

2021 ◽

Vol 31 (1) ◽

Author(s):

Dereje Zena ◽

Berhanu Elfu ◽

Kebadnew Mulatu

Keyword(s):

Associated Factors ◽

Meta Analysis ◽

Life Time ◽

Hiv Positive ◽

Cervical Lesions ◽

Common Cancer ◽

Hiv Positive Women ◽

Pooled Prevalence ◽

History Of ◽

Precancerous Cervical Lesions

BACKGROUND፡ Cervical cancer remains the most common cancer of women worldwide. Its burden is more serious in developing countries. It is also the second common cancer deaths of women in Ethiopia followed by breast cancer. The aim of this study was to determine the pooled prevalence and associated factors of precancerous cervical lesions among women in Ethiopia.METHODS: We systematically searched published and unpublished articles reported from 2010 to 2019 using a comprehensive search of electronic databases including PubMed and Google scholar for grey literature from August 1 to September 1, 2019. The methodological qualities of included studies were evaluated using Joanna Briggs Institute meta-analysis of Statistics Assessment. The pooled prevalence estimate was calculated using MedCalc software-version 19.0.7, and the pooled odd ratios for predictors was calculated using RevMan software version 5.3.RESULTS: The pooled prevalence of precancerous cervical lesions among women in Ethiopia was 13.4% (95% CI:10.63% 16.37%). Statistically significant heterogeneity between studies was detected (I2=83.1%, P < 0.001). Among all measured associated factors: numbers of women life time sexual partners > 1, OR=2.5 (95% CI:3.70,4.76), being HIV positive women, OR=2.4 (95% CI:1.33,4.61) and women having history of STI, OR=2.0 (95% CI:1.02,3.87) had statistically significant association with precancerous cervical lesions among women in EthiopiaCONCLUSION: The pooled prevalence of precancerous cervical lesions among women in Ethiopia was high as compared to the 5- year worldwide cervical cancer prevalence. Women having more than one life time sexual partners, being HIV positive women and women having history of STI had a statistically significant association with precancerous cervical lesions.

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Intimate Partner Violence (IPV) Against HIV-Positive Women in Sub-Saharan Africa: A Mixed-Method Systematic Review and Meta-Analysis

Trauma Violence & Abuse ◽

10.1177/1524838020906560 ◽

2020 ◽

pp. 152483802090656 ◽

Cited By ~ 2

Author(s):

Eric Y. Tenkorang ◽

Michael Asamoah-Boaheng ◽

Adobea Y. Owusu

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Intimate Partner Violence ◽

Partner Violence ◽

Meta Analysis ◽

Intimate Partner ◽

Sub Saharan Africa ◽

Hiv Positive ◽

Hiv Positive Women ◽

Sub Saharan

Objectives: To systematically analyze and summarize the literature on intimate partner violence (IPV) against HIV-positive women in sub-Saharan Africa (SSA) and to identify their risk factors for IPV. Method: A comprehensive review of the literature using the Preferred Reporting Item for Systematic Review and Meta-Analysis (PRISMA) and Meta-Analyses of Observational Studies in Epidemiology (MOOSE) yielded 1,879 articles (PubMed = 1,251, Embase = 491, Web of Science = 132, and identified additional records = 5). Twenty were selected for quantitative and qualitative assessment and synthesis. We employed a random effects model with generic inverse variance method and estimated the odds ratios. Findings: Results indicated a high prevalence of physical, sexual, and emotional violence against women living with HIV/AIDS in SSA. Educational background, alcohol use, marital status, previous experiences with IPV, and employment status were identified as significant risk factors. We also assessed the methodological quality of the articles by examining publication bias and some heterogeneity statistics. Conclusion: There is limited research on IPV against HIV-positive women in SSA. However, the few existing studies agree on the importance of targeting HIV-positive women with specific interventions given their vulnerability to IPV and to address factors exacerbating these risks and vulnerabilities.

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Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis

Systematic Reviews ◽

10.1186/s13643-021-01840-0 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Ayele Semachew Kasa ◽

Tadesse Dagget ◽

Yeshiwork Beyene ◽

Getnet Dessie ◽

Aklilu Endalamaw ◽

...

Keyword(s):

Systematic Review ◽

Random Effects ◽

Addis Ababa ◽

Meta Analysis ◽

Cervical Lesion ◽

Random Effects Model ◽

Cervical Lesions ◽

Precancerous Cervical Lesion ◽

Pooled Prevalence ◽

Precancerous Cervical Lesions

Abstract Background Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to study the burden of the disease in Ethiopia, primary studies examining the prevalence of precancerous cervical lesions are fragmented. Hence, this systematic review and meta-analysis is aimed at estimating the pooled prevalence of precancerous cervical lesion and its trends in Ethiopia. Methods This systematic review and meta-analysis was conducted using the following electronic databases. PubMed, Web of Science, SCOPUS, Science Direct, Google Scholar, African Index Medicus (AIM), African Journals Online databases, and Addis Ababa and Bahir Dar Universities research repositories were searched following the Preferred Items for Systematic Review and Meta-analysis (PRISMA) Guideline. STATA 15 statistical software was used to analyze the data. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) quality appraisal tool for meta-analysis. Heterogeneity between studies was assessed using the Cochrane Q test and I2 test statistics based on the random effects model. A random effects model was computed to estimate the pooled prevalence of precancerous cervical lesion in Ethiopia. Finally, the trend of precancerous cervical lesion in the country was presented. Result Seventeen studies with a total of 26,112 participants were included in the analysis. The pooled prevalence of precancerous cervical lesion was 15.16 (95% CI 10.16–19.70). The subgroup analysis by region showed the highest prevalence of precancerous cervical lesion at the Southern Nations and Nationalities Peoples Region (19.65%; 95% CI 15.51–23.80). The trend of precancerous cervical lesion prevalence showed an increased pattern over time. Conclusion Approximately one among six of the study participants had precancerous cervical lesion. The trend also showed that there is still an increasing precancerous cervical lesion in Ethiopia. Best practices in achieving high vaccination coverage shall be informed by practices in other successful countries.

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The impact of approaches in improving male partner involvement in the prevention of mother-to-child transmission of HIV on the uptake of safe infant feeding practices by HIV positive women in sub-Saharan Africa. A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0207060 ◽

2018 ◽

Vol 13 (12) ◽

pp. e0207060 ◽

Cited By ~ 3

Author(s):

Noah F. Takah ◽

Jeannine A. Atem ◽

Leopold N. Aminde ◽

Moffat Malisheni ◽

Grant Murewenhema

Keyword(s):

Meta Analysis ◽

Male Partner ◽

Sub Saharan Africa ◽

Hiv Positive ◽

Male Partner Involvement ◽

Hiv Positive Women ◽

Sub Saharan ◽

Partner Involvement ◽

The Impact ◽

Mother To Child

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Challenges faced by health-care providers offering infant-feeding counseling to HIV-positive women in sub-Saharan Africa: a review of current research

AIDS Care ◽

10.1080/09540121.2014.951310 ◽

2014 ◽

Vol 27 (1) ◽

pp. 17-24 ◽

Cited By ~ 14

Author(s):

Emily L. Tuthill ◽

Jessica Chan ◽

Lisa M. Butler

Keyword(s):

Health Care ◽

Infant Feeding ◽

Health Care Providers ◽

Sub Saharan Africa ◽

Hiv Positive ◽

Care Providers ◽

Hiv Positive Women ◽

Sub Saharan

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Cisplatin and radiation therapy in HIV-positive women with locally advanced cervical cancer in sub-Saharan Africa: A phase II study of the AIDS malignancy consortium

Gynecologic Oncology ◽

10.1016/j.ygyno.2019.01.023 ◽

2019 ◽

Vol 153 (1) ◽

pp. 20-25 ◽

Cited By ~ 4

Author(s):

Mark H. Einstein ◽

Ntokozo Ndlovu ◽

Jeannette Lee ◽

Elizabeth A. Stier ◽

Jeffrey Kotzen ◽

...

Keyword(s):

Cervical Cancer ◽

Radiation Therapy ◽

Phase Ii Study ◽

Locally Advanced ◽

Sub Saharan Africa ◽

Hiv Positive ◽

Advanced Cervical Cancer ◽

Locally Advanced Cervical Cancer ◽

Hiv Positive Women ◽

Sub Saharan

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All-cause mortality after antiretroviral therapy initiation in HIV-positive women from Europe, Sub-Saharan Africa and the Americas

AIDS ◽

10.1097/qad.0000000000002399 ◽

2020 ◽

Vol 34 (2) ◽

pp. 277-289

Author(s):

Keyword(s):

Antiretroviral Therapy ◽

Sub Saharan Africa ◽

Hiv Positive ◽

Therapy Initiation ◽

Hiv Positive Women ◽

All Cause Mortality ◽

Sub Saharan

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Alcohol consumption and its associated factors among pregnant women in Sub-Saharan Africa: a systematic review and meta-analysis' as given in the submission system

Substance Abuse Treatment Prevention and Policy ◽

10.1186/s13011-020-00269-3 ◽

2020 ◽

Vol 15 (1) ◽

Cited By ~ 1

Author(s):

Alemu Earsido Addila ◽

Telake Azale Bisetegn ◽

Yigzaw Kebede Gete ◽

Mezgebu Yitayal Mengistu ◽

Getnet Mihretie Beyene

Keyword(s):

Systematic Review ◽

Alcohol Consumption ◽

Alcohol Use ◽

Pregnant Women ◽

Associated Factors ◽

Unplanned Pregnancy ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Pooled Prevalence ◽

Sub Saharan

Abstract Background Alcohol consumption during pregnancy represents a significant public health concern. It has several adverse health effects for both the mother and the developing fetus. This study aimed to estimate the pooled prevalence and the effect size of associated factors of alcohol consumption during pregnancy in Sub-Saharan Africa countries. Methods The results of the review were reported based on the Preferred Reporting Items for Systematic Review and Meta-Analysis statement (PRISMA) guideline and, it was registered in the Prospero database, number CRD42019127103. The available primary studies were collated from different databases: PubMed, CINAHL, Cochrane Library, PsycINFO, Google Scholar, African Journals Online and Centre for Addiction and Mental Health Library. The main search terms were [((alcohol consumption) OR (alcohol drinking) OR (alcohol use) OR (ethanol use) OR (alcohol exposure)) AND ((pregnant women) OR (pregnant mother) OR (during pregnancy)) AND (Sub-Saharan Africa)]. We used the Joanna Briggs Institute (JBI) for critical appraisal of studies. The random-effects model was computed to estimate the pooled prevalence. Heterogeneity between studies was checked using the I2 statistic and the Cochrane Q test. Results The review resulted in 963 original studies after searching various databases, and finally 37 studies in qualitative synthesis and 30 articles in the systematic review and meta-analysis were included. The overall summary estimate of the prevalence of alcohol consumption during pregnancy was found to be 20.83% (95% CI: 18.21, 23.46). The pooled estimate of meta-analysis showed that depression (OR: 1.572; 95% CI: 1.34, 1.845), partners’ alcohol use (OR: 1.32, 95% CI: 1.11, 1.57), knowledge on harmful effect of alcohol consumption (OR: 0.36, 95% CI: 0.29, 0.45) and, unplanned pregnancy (OR: 2.33, 95% CI: 1.17, 4.63) were statistically significant factors with alcohol consumption during pregnancy. Conclusions The result showed that there was high alcohol consumption during pregnancy in Sub- Saharan Africa. Alcohol consumption during pregnancy was associated with depression, partners’ alcohol use, unplanned pregnancy and knowledge of the harmful effects of alcohol consumption. Therefore, this will be a basis for public policy and resource allocation for prevention initiatives.

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