scholarly journals A Model Shows Utility in Predicting Postoperative Recurrence and Distant Metastasis in Curatively Resected Esophageal Squamous Cell Cancer

2019 ◽  
Vol 26 (1) ◽  
pp. 107327481985296
Author(s):  
Weidong Wang ◽  
Yongqiang Chen ◽  
Xuewen Zhang ◽  
Kexing Xi ◽  
Xiaoli Feng ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sensitivity And Specificity ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Tnm Classification ◽  
Cell Cancer ◽  
Disease Free Survival ◽  
Esophageal Squamous Cell Cancer ◽  
Validation Group ◽  
Cutoff Value

After curative treatment of esophageal squamous cell cancer (ESCC), patients are at high risk for recurrence. The objective of this study was to develop an index with a high sensitivity and specificity to predict ESCC patients’ recurrence and prognosis. A retrospective analysis was conducted on consecutive patients with EC who underwent esophagectomy. In total, 1417 patients were included in the current investigation. In total, 770 patients were included in the current study’s exploratory group. Alcohol consumption, TNM classification, number of lymph node station metastases, and number of lymph node metastases were significantly correlated with recurrence. Multivariate logistical regression analysis resulted in the development of an equation for predicting recurrence and prognosis (REEC). When using the REEC value to predict recurrence, the cutoff value was 1.095, the area under the curve (AUC) values of the REEC were 0.68 ( p < 0.001) in the Exploratory Group and 0.65 ( p < 0.001) in the Validation Group, and the sensitivity and specificity were 76.68% and 51.18%, respectively. When using the REEC value to predict prognosis, the cutoff value was 1.215, the AUC values of the REEC were 0.65 ( p < 0.001) in the Exploratory Group and 0.64 ( p < 0.001) in the Validation Group, and the sensitivity and specificity were 73.12% and 50.67%, respectively. In the Exploratory Group, when the REEC value was >1.095, patients had a longer median overall survival (OS) and median disease-free survival (DFS) than those whose REEC value was < 1.095 (70.01±2.01 months versus 50.92±2.85 months and 75.66±1.35 months versus 53.68±2.81 months, respectively, p < 0.001). The differences were confirmed to still exist in the Validation Group (48.12±1.47 vs 32.68±2.53 months and 55.61±1.32 vs 35.68±2.73 months respectively, p < 0.001).This study reported an index that can predict esophageal cancer recurrence and prognosis, and its use can benefit patients.

CRP Genetic Polymorphism Is Associated with Lymph Node Metastasis in Thoracic Esophageal Squamous Cell Cancer

2009 ◽  
Vol 16 (9) ◽  
pp. 2479-2485 ◽  
Author(s):  
Satoru Motoyama ◽  
Masatomo Miura ◽  
Yudai Hinai ◽  
Kiyotomi Maruyama ◽  
Shuetsu Usami ◽  
...  
Keyword(s):  
Lymph Node ◽  
Genetic Polymorphism ◽  
Lymph Node Metastasis ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer ◽  
Node Metastasis

scholarly journals Postoperative chemoradiotherapy improves survival in esophageal squamous cell cancer with extracapsular lymph node extension

Neoplasma ◽  
2014 ◽  
Vol 61 (06) ◽  
pp. 732-738 ◽  
Author(s):  
Z. W. WANG ◽  
Z. P. LUAN ◽  
W. ZHANG ◽  
W. DONG ◽  
C. R. FU ◽  
...  
Keyword(s):  
Lymph Node ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer

Appraisal of a Revised Lymph Node Classification System for Esophageal Squamous Cell Cancer

2007 ◽  
Vol 83 (4) ◽  
pp. 1265-1272 ◽  
Author(s):  
Dipok Kumar Dhar ◽  
Shinji Hattori ◽  
Yasuhito Tonomoto ◽  
Tadakazu Shimoda ◽  
Hoichi Kato ◽  
...  
Keyword(s):  
Lymph Node ◽  
Squamous Cell ◽  
Classification System ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer ◽  
Node Classification

Impact of body mass index on postoperative complications and long-term survival in patients with esophageal squamous cell carcinoma.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 37-37
Author(s):  
Kenichi Kamachi ◽  
Soji Ozawa ◽  
Tsutomu Hayashi ◽  
Akihito Kazuno ◽  
Eisuke Ito ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Disease Free Survival ◽  
Pulmonary Complications ◽  
Esophageal Squamous Cell Cancer ◽  
Free Survival ◽  
Disease Free

37 Background: Chachexia and undernutrition have been suggested to be risk factors for postoperative complications and survival in cancer patients. The aim of this study was to investigate whether body mass index (BMI) is related to the short-term and long-term outcomes in patients who undergo an esophagectomy for the resection of esophageal squamous cell cancer. Methods: Three hundred forty patients who underwent an esophagectomy for the resection of esophageal squamous cell cancer between 2003 and 2008 were retrospectively reviewed. The patients were divided into two groups: an L-BMI group characterized by a BMI < 18.5 kg/m2, and an N-BMI group characterized by a BMI ≥ 18.5 kg/m2. The overall and disease-free survival curves of the two BMI groups were determined using the Kaplan-Meier method and were compared using a log-rank test. A Cox proportional hazards regression analysis was used for the univariate and multivariate analyses. Results: The study included 40 patients in the L-BMI group and 300 patients in the N-BMI group. Pulmonary complications seemed to occur more frequently in the L-BMI group (P = 0.006). A histopathological assessment showed that nodal involvement was seen more frequently in the L-BMI group (P = 0.016). The 5-year overall survival rate was higher in the N-BMI group (63.6%) than in the L-BMI group (32.3%) (P < 0.001). The 5-year disease-free survival rate was also higher in the N-BMI group (64.2%) than in the L-BMI group (32.3%) (P = 0.014). In a multivariate analysis, a lower BMI, an upper tumor location, an advanced pathological T stage, and a larger number of metastatic lymph nodes were independent prognostic factors for overall survival (P < 0.05). Conclusions: Our data suggested that a lower BMI not only increased pulmonary complications but also impaired overall and disease-free survival after an esophagectomy for the resection of esophageal squamous cell cancer.

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