Vincristine induced fever in a child with embryonal rhadbomyosarcoma

2022 ◽  
pp. 107815522210740
Author(s):  
Dr. Arul Janani ◽  
Dr. Anandkumar Shruthilaya ◽  
Dr. Jayaraman Dhaarani ◽  
Dr. Scott X Julius
Keyword(s):  
Case Report ◽  
Embryonal Rhabdomyosarcoma ◽  
High Grade ◽  
High Grade Fever ◽  
Drug Induced ◽  
Set Up ◽  
Febrile Episodes ◽  
Work Up ◽  
Infective Etiology ◽  
Infectious Etiology

Introduction: Febrile episodes in oncology is common are mostly of infectious etiology requiring repeated investigations and escalation of antibiotics. But, drug induced fever occur more often than we think in oncological set-up. Case Report: A 5 year old male child with rhabdomyosarcoma, developed high grade fever spikes following Vincristine monotherapy. Infective etiology work up was negative and the fever responded to corticosteroids. Management and Outcome: He was treated with corticosteroids as premedication considering vincristine induced fever. The further courses of VCR- monotherapy were uneventful with steroids as premedication. Discussion: We present the case of vincristine induced fever in a child with embryonal rhabdomyosarcoma. Clinician’s should consider drug induced fever at appropriate conditions, to avoid leading to antibiotic resistance.

scholarly journals Sepsis after uterine artery embolization-assisted termination of pregnancy with complete placenta previa: A case report

2017 ◽  
Vol 46 (1) ◽  
pp. 546-550 ◽  
Author(s):  
Yinfeng Wang ◽  
Xiufeng Huang
Keyword(s):  
Severe Sepsis ◽  
Case Report ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Placenta Previa ◽  
Termination Of Pregnancy ◽  
High Grade ◽  
Artery Embolization ◽  
High Grade Fever ◽  
Emergency Cesarean

Uterine artery embolization (UAE)-assisted induction of labor is an alternative method of managing pregnant women with complete placenta previa (CPP). Sepsis secondary to UAE, although rare, is a serious complication. We herein present a case of severe sepsis following UAE-assisted termination of a pregnancy at 27 gestational weeks in a woman with CPP. The woman developed a high-grade fever and elevated inflammatory indices following UAE. She did not recover until the infected tissue was removed by emergency cesarean section. This case suggests that the increasing use of UAE for termination of pregnancy in women with CPP requires awareness regarding the possibility of serious sepsis associated with this procedure.

scholarly journals Torsades de pointes episode in a woman with high-grade fever and inflammatory activation: A case report

2021 ◽  
Vol 9 (12) ◽  
pp. 2899-2907
Author(s):  
Hui Qiu ◽  
Hong-Wei Li ◽  
Shu-Hong Zhang ◽  
Xiao-Ge Zhou ◽  
Wei-Ping Li
Keyword(s):  
Case Report ◽  
Torsades De Pointes ◽  
High Grade ◽  
High Grade Fever ◽  
Inflammatory Activation

scholarly journals Isolated Tuberculous Liver Abscess in an Immunocompromised Adult: A case report

2018 ◽  
Vol 17 (1) ◽  
pp. 155-157
Author(s):  
ASM Rizwan ◽  
Md Rakibul Islam ◽  
Md Ghulam Yusuf
Keyword(s):  
Case Report ◽  
Liver Abscess ◽  
Medical Science ◽  
Diagnostic Delay ◽  
Amoebic Liver Abscess ◽  
High Grade ◽  
High Grade Fever

In Bangladesh tuberculosis (TB) cases are fairly common but isolated hepatobilliary TB cases are extremely rare. Liver abscess due to TB without involvement of any other site causes diagnostic delay and can easily confuse with pyogenic or amoebic liver abscess or haepatocellular carcinoma. We present a case of a 44-years-old diabetic,normotensive male who presented with prolonged high grade fever with chill and rigor with tender hepatomegally. He was put on treatment for liver abscess but was not responding. Later on, histopathology was done and it turned out to be a case of tuberculous liver abscess.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.155-157

scholarly journals Oxaliplatin-related interstitial pneumonia with high-grade fever and relative bradycardia as the presenting signs: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Yasuyuki Taooka ◽  
Hiroki Yoke ◽  
Junya Inata
Keyword(s):  
Interstitial Pneumonia ◽  
Fiberoptic Bronchoscopy ◽  
Japanese Woman ◽  
Ct Scans ◽  
Adverse Side Effect ◽  
High Grade ◽  
Productive Cough ◽  
High Grade Fever ◽  
Drug Induced ◽  
Thoracic Ct

Abstract Background Although drug-induced interstitial pneumonia is a well-known adverse side-effect of cancer chemotherapy, the disease is difficult to detect in the early phase. We report a case of oxaliplatin-induced interstitial pneumonia in which eosinophilia and high-grade fever with relative bradycardia were useful presenting signs for the early diagnosis. Case presentation A 76-year-old Japanese woman with postoperative recurrent rectal cancer (peritoneal dissemination and liver metastasis) was admitted to our hospital because of productive cough and consolidation on thoracic computed tomography (CT) images. Two months prior to the consultation, she had started chemotherapy (fluorouracil, oxaliplatin, and bevacizumab). After finishing three courses of chemotherapy, she developed fever and was noted to have relative bradycardia. After another two courses of chemotherapy, she developed productive cough, chest discomfort, and high-grade fever. At this time, thoracic CT revealed patchy areas of consolidation distributed predominantly in the periphery. Despite the administration of tazobacterium/piperacillin, the consolidation seen on CT scans gradually worsened. Fiberoptic bronchoscopy was performed, and bronchoalveolar lavage fluid analysis showed increased lymphocytes, eosinophils, and total cell count but a low CD4/ CD8 ratio. No specific pathogen was identified. With a diagnosis of interstitial pneumonia, prednisolone was started and chemotherapy was temporarily discontinued. Her productive cough gradually decreased, and the infiltrative shadows on the thoracic CT scans improved. Conclusion Although cases of oxaliplatin-related pneumonia with complicating relative bradycardia are not uncommon, drug-induced interstitial pneumonia should be taken into account in the differential diagnosis. In this case, an increased circulating eosinophil count and high-grade fever with relative bradycardia were the first signs of drug-induced interstitial pneumonia.

scholarly journals Lenalidomide-Induced High Grade Fever in a Patient with Multiple Myeloma: A Case Report

2019 ◽  
Vol 1 (2) ◽  
pp. 23-26
Author(s):  
Ghada ElGohary ◽  
Ghada ElGohary ◽  
Mohammad Al Nahedh ◽  
Riad ElFakih
Keyword(s):  
Multiple Myeloma ◽  
Adverse Event ◽  
Case Report ◽  
Immune System ◽  
Immune Activation ◽  
Stevens Johnson Syndrome ◽  
High Grade ◽  
High Grade Fever ◽  
Johnson Syndrome ◽  
5Q Deletion

Lenalidomide is a second generation immunomodulatory agent and a potent analogue of thalidomide that is FDA approved mainly for the treatment of multiple myeloma (MM) and transfusion-dependent anemia due to low or intermediate-1- risk myelodysplastic syndromes (MDS) associated with 5q deletion among other indications. Through its action on the immune system, lenalidomide alters the production of different cytokines ultimately resulting in immune activation against tumors. This immune activation may lead to collateral immune toxicities like fever, angioedema, Stevens-Johnson syndrome, tumor flare and others. Here we report a case of lenalidomide-induced high grade fever in a patient with MM and we summarize the literature about the physiology of such reaction and how to mitigate this adverse event.

scholarly journals Salmonella gastroenteritis outbreak in a family: a case report

2019 ◽  
Vol 6 (2) ◽  
pp. 51-55
Author(s):  
Sunil Adhikari ◽  
Suraj Rijal ◽  
Ashish Shrestha
Keyword(s):  
Case Report ◽  
Hypovolemic Shock ◽  
Stool Culture ◽  
Stool Examination ◽  
High Grade ◽  
Gastroenteritis Outbreak ◽  
High Grade Fever ◽  
Pain Abdomen

Five members of a family were brought to emergency with complaints of high grade fever, pain abdomen, diarrhoea and vomiting. The symptoms started after five hours of food, the vegetable curry by this family. Four of them were in hypovolemic shock and two had significant pus cells in stool examination. All of them were discharged by seven days. Stool culture of three of these patients showed salmonella.

scholarly journals A case report of life threatening Dapsone Hypersensitivity Syndrome

2017 ◽  
Vol 6 (2) ◽  
pp. 471
Author(s):  
Santoshkumar R. Jeevangi ◽  
Amreen Saba
Keyword(s):  
Case Report ◽  
Adverse Effects ◽  
Hypersensitivity Syndrome ◽  
Organ Damage ◽  
Successful Outcome ◽  
High Grade ◽  
High Grade Fever ◽  
Prompt Treatment ◽  
Life Threatening ◽  
Generalized Lymphadenopathy

Dapsone is widely used for a variety of infections, immune and hypersensitivity disorders. However, the use of Dapsone may be associated with a plethora of adverse effects, the most serious being Dapsone Hypersensitivity Syndrome (DHS) wherein the patient typically presents with a triad of fever, skin eruption and internal organ involvement, that occurs during first 2 to 8 weeks of initiating the treatment. The incidence of DHS ranges from 0.5% to 3%.  Here we report a case of severe life threatening Dapsone induced hypersensitivity reaction in a 21year old female who presented with high grade fever, generalized lymphadenopathy, skin rash and hepato-splenomegaly. This condition is best approached with immediate discontinuation of offending drug and prompt administration of oral or IV glucocorticoids. The case is being reported to emphasize the need for timely diagnosis and prompt treatment for successful outcome as it can cause irreversible organ damage or death if untreated early.

scholarly journals ADVANCED COLLATERAL PHYSIOTHERAPEUTIC APPROACH IN PNEUMONIA

2021 ◽  
Vol 10 (4) ◽  
pp. 3259-3261
Author(s):  
Waqar M. Naqvi
Keyword(s):  
Case Report ◽  
Acute Inflammation ◽  
Treatment Plan ◽  
Age Groups ◽  
Functional Independence ◽  
High Grade ◽  
High Grade Fever ◽  
Airway Clearance ◽  
Lung Expansion ◽  
The World

An acute inflammation associated with lung tissues, alveoli and neighbouring airways caused by streptococcus pneumoniae is referred to as pneumonia. One of the most commonly affecting health problem at all age groups in the world is pneumonia. Antibiotics are the main treatment plan for management of pneumonia, while other treatments are mainly used as supportive care. The purpose of this case report is to evaluate the effect of physiotherapy as an adjuvant for pneumonia management. The patient was a 50 year old male with complaints of dry cough, high grade fever which was associated with chills and breathlessness. He was then diagnosed with pneumonia. Medical management with antibiotics was started along with physiotherapy as an adjuvant. The aim of physiotherapy was to return the patient to his best possible functional recovery. After completion of physiotherapy the patient gained maximum re-expansion of the thorax, had no breathing difficulties, the lungs were clear of sputum and patient was functionally independent. This case report shows how physiotherapy can be used as an adjuvant to rehabilitate a patient diagnosed with pneumonia. This has been demonstrated by increasing the lung expansion, airway clearance and gaining functional independence

scholarly journals KAWASAKI DISEASE: A CASE REPORT

2020 ◽  
pp. 203-208
Author(s):  
Shiv Dinesh Dyarapogu ◽  
Abdul Mustaq Mohammed ◽  
Safi Ur-Rahman Mohammed ◽  
Muneb Ahmed ◽  
Dr. S P Srinivas Nayak
Keyword(s):  
Case Report ◽  
Kawasaki Disease ◽  
Physical Examination ◽  
General Condition ◽  
Systemic Vasculitis ◽  
Cervical Lymphadenopathy ◽  
Symptomatic Treatment ◽  
Acute Onset ◽  
High Grade ◽  
High Grade Fever

Kawasaki disease (KD) is a systemic vasculitis mostly affecting medium-sized arteries. Main symptoms include fever, conjunctivitis, skin and mucous membrane affection, and cervical lymphadenopahty. KD begins with acute-onset high fever, reduced general condition and frequently reduced cooperativity of children which can complicate physical examination. Further symptoms include generalized polymorphic exanthema (>90%), palmoplantar erythema (80%), symmetric non purulent conjunctivitis (80–90%), usually unilateral cervical lymphadenopathy (>1.5 cm; 50%), and mucosal enanthema with red and/or chapped lips (80–90%). A female patient of 8 months and weight 10.2kg was bought to the hospital on 17/1/2020 with the complaints of prolonged high grade fever since last 10 days, previously the baby was treated with antibiotics but the fever was not subsided. On further evaluation the child was diagnosed with KD and symptomatic treatment given along with standard immunoglobulin and aspirin. Patient was treated well and discharged. Keywords: Kawasaki ,medium sized articles, chapped lips, fever

Sign in / Sign up

Export Citation Format

Share Document