A 10-Month-Old Infant Presenting With Signs of Precocious Puberty Secondary to a Sclerosing Stromal Tumor of the Ovary in the Absence of Hormonal Elevation

Precocious puberty in an infant is an alarming and infrequent finding, making the differential diagnosis difficult for practitioners. Precocious puberty secondary to a sclerosing stromal tumor (SST) of the ovary is rare. We present a case of a child that began precocious puberty at 3 months of age including development of breast buds, pubic hair, growth spurt, and menarche 5 days prior to presenting to pediatric endocrinology at 10 months. She underwent right salpingo-oophorectomy which demonstrated a soft tissue mass occupying almost the entire ovary with a tan-pink fleshy cut surface. Histological examination confirmed a variant of SST. This case represents an extremely young onset of precocious puberty secondary to a variant of SST without hormonal elevation.

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Precocious Puberty

US Endocrinology ◽

10.17925/use.2006.00.02.1x ◽

2006 ◽

Vol 00 (02) ◽

Author(s):

Paul B Kaplowitz

Keyword(s):

Precocious Puberty ◽

Linear Growth ◽

Pubertal Development ◽

Black Girls ◽

Pubic Hair ◽

Growth Spurt ◽

Tall Stature ◽

Early Puberty ◽

Bone Maturation ◽

Early Appearance

Precocious puberty refers to the appearance of physical and hormonal signs of pubertal development at an earlier age than is considered normal.Although traditionally, any signs of puberty in girls prior to age eight years have been considered abnormal, recent studies indicate that signs of early puberty (breasts and pubic hair) are often present in girls (particularly black girls) between ages 6–8 years.The early growth spurt initially can cause tall stature, but rapid bone maturation can cause linear growth to cease too early and result in short adult stature.The early appearance of breasts or menses in girls and increased libido in boys can cause emotional distress for some children.

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Sclerosing stromal tumor of the ovary presenting as precocious puberty: Unusual presentation of the rare neoplasm

International Journal of Medicine and Public Health ◽

10.4103/2230-8598.137724 ◽

2014 ◽

Vol 4 (3) ◽

pp. 307 ◽

Cited By ~ 1

Author(s):

JaiKumar Chaurasia ◽

Nishat Afroz ◽

Veena Maheshwari ◽

Mohammed Naim

Keyword(s):

Precocious Puberty ◽

Stromal Tumor ◽

Unusual Presentation ◽

Rare Neoplasm ◽

Sclerosing Stromal Tumor

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Study of an Ovarian Sclerosing Stromal Tumor Presenting as Vaginal Bleeding in a 7-Month-Old

Pediatric and Developmental Pathology ◽

10.2350/07-05-0281 ◽

2006 ◽

Vol preprint (2007) ◽

pp. 1

Author(s):

Odette Hall ◽

Judy Pascasio ◽

Jennifer Morrissette ◽

Christopher Newton ◽

Marshall Schwartz ◽

...

Keyword(s):

Vaginal Bleeding ◽

Stromal Tumor ◽

Sclerosing Stromal Tumor

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Thymoma in an aged backyard Leghorn chicken, with reviews of a database and literature

Journal of Veterinary Diagnostic Investigation ◽

10.1177/1040638721990896 ◽

2021 ◽

Vol 33 (2) ◽

pp. 336-339

Author(s):

Julia Blakey ◽

Carmen Jerry ◽

Ana da Silva ◽

Simone Stoute

Keyword(s):

Soft Tissue Mass ◽

Animal Health ◽

Postmortem Examination ◽

Cervical Region ◽

Laboratory System ◽

Unexpected Death ◽

Tissue Mass ◽

Microscopic Features ◽

History Of ◽

Backyard Chickens

A 7-y-old backyard Leghorn chicken ( Gallus domesticus) was submitted to the California Animal Health and Food Safety Laboratory System (CAHFS)–Turlock branch for postmortem examination, with a history of unexpected death. At postmortem examination, a hemorrhagic soft tissue mass was observed in the cervical region. Microscopically, a densely cellular neoplasm of polygonal epithelial cells and small lymphocytes was observed. The microscopic features of the neoplasm in combination with positive immunohistochemistry for pancytokeratin and CD3 were used to classify the lesion as a thymoma. Thymoma was diagnosed in only 5 birds submitted to CAHFS from 1990 to 2019. Thymoma has been described only rarely in birds, and is an unusual diagnosis in backyard chickens.

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Extradural Peripheral Nerve Sheath Tumour at T7 Level in a 2-Year-Old Dog

VCOT Open ◽

10.1055/s-0041-1731438 ◽

2021 ◽

Vol 04 (01) ◽

pp. e41-e46

Author(s):

Federica Aragosa ◽

Chiara Caterino ◽

Giovanni Della Valle ◽

Ilaria D'Aquino ◽

Dario Costanza ◽

...

Keyword(s):

Clinical Presentation ◽

Soft Tissue Mass ◽

Resonance Imaging ◽

Tissue Mass ◽

Nerve Sheath Tumour ◽

Free Interval ◽

Nerve Sheath ◽

Dorsal Laminectomy ◽

Intervertebral Foramina ◽

Peripheral Nerve Sheath Tumour

AbstractThe aim of this report is to describe an unusual localization of nerve sheath tumour (NST), clinical presentation, imaging, surgical management, and outcome in a 2-year-old dog. A 2-year-old female American Staffordshire Terrier presented with nonambulatory paraparesis, thoracolumbar hyperaesthesia, hindlimb hyperreflexia, and mild muscle atrophy. Computed tomography and magnetic resonance imaging revealed an extradural mass at T7-T8, without vertebral lesions. Surgical treatment consisted in resection of the soft tissue mass through dorsal laminectomy. The dog was ambulatory within 24 hours and free of recurrence at 18 months postoperatively. Histopathologic and features of immunohistochemistry were consistent with NST. The NST of this report was similar to those described before, but exhibited unusual characteristics, such as being extradural, without extension into intervertebral foramina, and being located in an atypical region (T7-T8). Moreover, survival time and relapse-free interval are greater than previously reported for similar cases.

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Primary renal synovial sarcoma presenting with a retroperitoneal bleed

BMJ Case Reports ◽

10.1136/bcr-2020-237099 ◽

2021 ◽

Vol 14 (3) ◽

pp. e237099

Author(s):

Daanesh Huned ◽

Juinn Huar Kam ◽

Lui Shiong Lee ◽

Raj Vikesh Tiwari

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Synovial Sarcoma ◽

Soft Tissue Mass ◽

Renal Angiomyolipoma ◽

Right Hepatectomy ◽

Tissue Mass ◽

Biopsy Confirmation ◽

Synovial Sarcomas ◽

Neo Adjuvant Chemotherapy

Synovial sarcomas are most commonly localised in extremities, especially in the lower thigh and knee areas. Comprising less than 1% of all malignancies, retroperitoneal synovial sarcoma is very rare with primary synovial sarcoma of the kidney being even more infrequent and difficult to diagnose. We describe a case report of a renal synovial sarcoma in a young adult who was initially managed as a case of Wunderlich’s syndrome secondary to what was believed to be a ruptured renal angiomyolipoma. After biopsy confirmation, the patient was eventually managed with neo-adjuvant chemotherapy followed by a right radical nephrectomy and right hepatectomy. Despite its rarity, synovial sarcoma should be considered as differential diagnosis of a bleeding retroperitoneal soft tissue mass detected in young adults.

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