scholarly journals Thymoma in an aged backyard Leghorn chicken, with reviews of a database and literature

2021 ◽  
Vol 33 (2) ◽  
pp. 336-339
Author(s):  
Julia Blakey ◽  
Carmen Jerry ◽  
Ana da Silva ◽  
Simone Stoute
Keyword(s):  
Soft Tissue Mass ◽  
Animal Health ◽  
Postmortem Examination ◽  
Cervical Region ◽  
Laboratory System ◽  
Unexpected Death ◽  
Tissue Mass ◽  
Microscopic Features ◽  
History Of ◽  
Backyard Chickens

A 7-y-old backyard Leghorn chicken ( Gallus domesticus) was submitted to the California Animal Health and Food Safety Laboratory System (CAHFS)–Turlock branch for postmortem examination, with a history of unexpected death. At postmortem examination, a hemorrhagic soft tissue mass was observed in the cervical region. Microscopically, a densely cellular neoplasm of polygonal epithelial cells and small lymphocytes was observed. The microscopic features of the neoplasm in combination with positive immunohistochemistry for pancytokeratin and CD3 were used to classify the lesion as a thymoma. Thymoma was diagnosed in only 5 birds submitted to CAHFS from 1990 to 2019. Thymoma has been described only rarely in birds, and is an unusual diagnosis in backyard chickens.

Sudden, Unexpected Death Associated with Meningioangiomatosis: Case Report

2005 ◽  
Vol 8 (2) ◽  
pp. 240-244 ◽  
Author(s):  
Chris Wixom ◽  
Amy E. Chadwick ◽  
Henry F. Krous
Keyword(s):  
Case Report ◽  
Family History ◽  
Postmortem Examination ◽  
Sudden Unexpected Death ◽  
Healthy Male ◽  
Orbital Frontal Cortex ◽  
Unexpected Death ◽  
Microscopic Features ◽  
History Of ◽  
The Right

We report a case of sudden, unexpected death associated with meningioangiomatosis in a 13-year-old, previously healthy male without a history of seizures, neurologic deficits, or clinical stigmata of neurofibromatosis. There was no family history of neurofibromatosis. The postmortem examination showed a 5-cm mass involving the right posterior frontal and orbital frontal cortex that had microscopic features diagnostic of meningioangiomatosis. Because no other cause of death was found, we postulate that he likely died as a result of a seizure secondary to meningioangiomatosis.

Two concurrent embryonal rhabdomyosarcomas of the oesophageal and perilaryngeal tissue in an adult dog: imaging, cytological and histological features

2020 ◽  
Vol 8 (3) ◽  
pp. e001119
Author(s):  
Alexis Gombert ◽  
Deborah Culang ◽  
Isabelle Lanthier ◽  
Edouard Martin ◽  
Cyrielle Finck
Keyword(s):  
Poor Prognosis ◽  
Ultrasound Guidance ◽  
Soft Tissue Mass ◽  
Final Diagnosis ◽  
Postmortem Examination ◽  
Tissue Mass ◽  
Cervical Oesophagus ◽  
Tissue Histology ◽  
The Right ◽  
Histology And Immunohistochemistry

A five-year-old neutered male Labrador Retriever was presented for recurring severe dyspnoeic episodes. Oral examination performed under sedation revealed a mass originating from the left arytenoid. CT highlighted a large perilaryngeal soft-tissue mass abutting the oesophagus, with a small intralaryngeal component. The mass created a narrowing of the laryngeal lumen and displaced the cranial cervical oesophagus dorsally and to the right. CT also highlighted a second smaller mass rostrally at the level of an oesophageal outpouching, narrowing the caudal aspect of the nasopharynx. The perilaryngeal mass was aspirated under ultrasound guidance. Cytology was suggestive of a tumour arising from skeletal muscle and a rhabdomyosarcoma was suspected. Due to poor prognosis, the patient was euthanased. Postmortem examination confirmed two masses affecting the cranial cervical oesophagus, one of which also invaded the perilaryngeal tissue. Histology and immunohistochemistry provided a final diagnosis of two concurrent oesophageal and perilaryngeal embryonal rhabdomyosarcomas.

Poorly Differentiated Chordomas Showing Loss of INI1/SMARCB1: A Report of 2 Rare Cases With Diagnostic Implications

2018 ◽  
Vol 26 (7) ◽  
pp. 637-643 ◽  
Author(s):  
Bharat Rekhi ◽  
Kemal Kosemehmetoglu ◽  
Swapnil Rane ◽  
Figen Soylemezoglu ◽  
Elif Bulut
Keyword(s):  
Soft Tissue ◽  
Tumor Cells ◽  
Soft Tissue Mass ◽  
Head Movements ◽  
Cervical Region ◽  
Tissue Mass ◽  
First Case ◽  
Radiologic Imaging ◽  
Poorly Differentiated ◽  
Mitotic Figures

Poorly differentiated chordomas are rare musculoskeletal tumors. Case 1. A 42-year-old lady presented with quadriparesis of 2 months’ duration. Radiologic imaging disclosed a soft tissue mass in her left prevertebral- and paravertebral cervical region. Case 2. A 4-year-old male child presented with neck pain and restricted head movements of 1-year duration. Radiologic imaging revealed a contrast enhancing, paraspinal soft tissue mass in his cervical region. Microscopic examination in both the cases revealed a cellular malignant tumor composed of moderate to markedly pleomorphic cells with interspersed mitotic figures, along with focal myxoid change and necrosis. By immunohistochemistry, tumor cells in both cases were diffusely positive for pan cytokeratin (AE1/AE3) and brachyury, whereas these were negative for INI1/SMARCB1. Tumor cells in the second case were also positive for glypican3. The first case developed pulmonary metastasis, while the second case developed recurrence. Poorly differentiated chordomas are uncommon tumors, invariably characterized by loss of INI1. These tumors can be rarely seen in adults and need to be differentiated from their diagnostic mimics, in view of treatment implications and their relatively aggressive clinical outcomes.

Vulval myxoid liposarcoma

2001 ◽  
Vol 11 (4) ◽  
pp. 321-322 ◽  
Author(s):  
R. Donnellan ◽  
M. Moodley
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Lymph Nodes ◽  
Soft Tissue Mass ◽  
Myxoid Liposarcoma ◽  
Complete Resection ◽  
Tissue Mass ◽  
History Of ◽  
Labium Majus ◽  
Draining Lymph Nodes

Abstract.Donnellan R, Moodley M. Vulval myxoid liposarcoma.A 26 year old woman presented with a 4-year history of a gradually enlarging fluctuant mass on the left labium majus. Histologic examination following excision revealed myxoid liposarcoma. Following the diagnosis, further surgery was performed to ensure complete resection. Routine excision of draining lymph nodes is not advocated. Although rare, myxoid liposarcoma should be considered in the differential diagnosis of a vulval soft tissue mass.

Unusual cause of a painless soft tissue mass of the scalp: a rare presentation of primary intracranial neuroendocrine neoplasm

2021 ◽  
Vol 14 (2) ◽  
pp. e236856
Author(s):  
Susruta Manivannan ◽  
Feras Sharouf ◽  
George Lammie ◽  
Paul Leach
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Neuroendocrine Tumour ◽  
Clinical Findings ◽  
Neuroendocrine Neoplasm ◽  
Tumour Resection ◽  
Rare Presentation ◽  
Tissue Mass ◽  
Left Hand ◽  
History Of

Incidental soft tissue lumps in the scalp are a common presenting complaint in clinical practice. However, they may signify more sinister underlying pathologies. Our report examines a 63-year-old man presenting with impaired co-ordination in his left hand following a 3-month history of a painless left retroauricular scalp lump. MRI revealed a large left occipital soft tissue mass eroding through the underlying skull with infiltration into the underlying cerebellum and temporal lobe. Open biopsy confirmed a diagnosis of high-grade intracranial neuroendocrine tumour (NET). At approximately 5 months following successful tumour resection and adjuvant chemotherapy, he developed tumour recurrence and was subsequently palliated, and died at 1 year post diagnosis. Herein, we review other cases of primary intracranial NET, clinical findings, histopathological features and prognosis.

scholarly journals Ossifying Fibroma in a Llama

2000 ◽  
Vol 12 (5) ◽  
pp. 473-476 ◽  
Author(s):  
Charles T. McCauley ◽  
Gregory A. Campbell ◽  
Connie A. Cummings ◽  
Wm. Tod Drost
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Postmortem Examination ◽  
Ossifying Fibroma ◽  
Nasal Discharge ◽  
Left Nostril ◽  
Medial Canthus ◽  
Tissue Mass ◽  
Second Molar ◽  
Firm Mass

A 4.5-year-old llama was admitted for evaluation of a firm mass rostral and ventral to the medial canthus of the left eye. Mucopurulent nasal discharge and absence of airflow through the left nostril were noted. Radiographs of the skull revealed a sharply demarcated soft tissue mass with faint mineralization. Endoscopy of the nasal passages revealed a mucosa-covered mass originating in the area of the second premolar, extending to the edge of the soft palate, and obstructing the airway. Examination of the oral cavity revealed a missing second molar and a mass protruding 2-cm from the empty alveolus. An ossifying fibroma, a previously unre-ported tumor in llamas, was diagnosed at postmortem examination.

Olfactory ganglioneuroblastoma in a dog: case report and literature review

2021 ◽  
pp. 104063872110228
Author(s):  
Ashley M. Romano ◽  
Chad B. Frank
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Ganglion Cells ◽  
Soft Tissue Mass ◽  
Neoplastic Cell ◽  
Cell Populations ◽  
Intact Male ◽  
Tissue Mass ◽  
Immunohistochemical Markers ◽  
History Of

A 7-y-old, intact male Alaskan Malamute was presented with a 3-mo history of stertor and epistaxis. Computed tomography of the skull revealed generalized loss of gas throughout both nasal passages with replacement by a soft tissue mass that traversed the cribriform plate. Histopathology revealed neoplastic neuroblast cells arranged in anastomosing cords, as well as separately located aggregates of ganglion cells. Both neoplastic cell populations demonstrated immunoreactivity to MAP-2, TuJ-1, and synaptophysin. Neuroblastic cells additionally exhibited punctate immunoreactivity to MCK and CK8/18. We document here both the positive neural immunohistochemical markers for this neoplasm, as well as propose possible histomorphologic variants.

Schwannoma with Psammoma Body

2021 ◽  
Vol 111 (1) ◽  
Author(s):  
Lindsay M. Hummel ◽  
Susan Gamble ◽  
Robert Krouse ◽  
Darshana Jhala ◽  
Sharvari Dalal ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Carney Complex ◽  
Psammoma Body ◽  
Psammoma Bodies ◽  
Tissue Mass ◽  
Pathologic Evaluation ◽  
History Of ◽  
Male Veteran

We present a case of a 59-year-old male veteran with a chronic history of right foot soft-tissue mass that was causing pain in his shoes, but not functional or neurologic symptoms. Excision of the mass and pathologic evaluation resulted in multidisciplinary involvement and evaluation. In this example, the mass was found to be either an unusual schwannoma that happens to be psammoma body–rich or an unusual psammomatous melanocytic schwannoma that deviates from conventional examples, as a diagnostic consensus was unable to be reached. Schwannomas are an uncommon finding in the foot, and even more uncommon are those that contain psammoma bodies. Although rare, these tumors can be concerning for more systemic, life-altering diseases such as Carney complex, for which our patient refused genetic testing.

Extraskeletal mesenchymal chondrosarcoma mimicking a thrombosed venous aneurysm with femoral vein involvement: A case report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S25-S25
Author(s):  
J Muldoon ◽  
L Warmke
Keyword(s):  
Case Report ◽  
Gene Fusion ◽  
Soft Tissue Mass ◽  
Femoral Vein ◽  
Mesenchymal Chondrosarcoma ◽  
Venous Aneurysm ◽  
Tissue Mass ◽  
Common Femoral Vein ◽  
Extraskeletal Mesenchymal Chondrosarcoma ◽  
History Of

Abstract Introduction/Objective Mesenchymal chondrosarcoma is a high-grade primitive mesenchymal tumor, which accounts for <5% of all chondrosarcomas and commonly affects young adults (peak incidence in second to third decade of life). The tumor has a widespread anatomic distribution, frequently involving the craniofacial bones as well as extraskeletal sites. The clinical presentation of an inguinal mass mimicking a thrombosed venous aneurysm is unusual and represents a potential diagnostic pitfall. Methods/Case Report A 42-year-old female with hypertension and obesity initially presented with a two-week history of left lower leg swelling. Venous doppler revealed presumed venous thrombosis, and she was prescribed apixaban while no history of coagulopathy, immobility, or recent surgery was noted. Two months later, she had residual swelling. Follow-up CT scan favored a large, peripherally thrombosed venous aneurysm arising from the left common femoral vein, while MRI showed a lobulated, inguinal soft tissue mass abutting the vein. Biopsy of the mass demonstrated a spindle cell mesenchymal neoplasm; subsequent resection revealed a pink-to-tan, well-circumscribed, and encapsulated mass (5.2 cm) with focal left common femoral vein invasion. Microscopically, the lesion demonstrated poorly-differentiated, oval-to-spindle cells with prominent staghorn vasculature interspersed were focal areas of well-differentiated hyaline cartilage. Immunohistochemical stains showed that the lesional cells were negative for cytokeratin cocktail, EMA, SMA, desmin, S100 protein, SOX10, STAT6, MUC4, MDM2, and ER. Next-generation sequencing (NGS) revealed a HEY1-NCOA2 gene fusion, confirming the diagnosis of extraskeletal mesenchymal chondrosarcoma. Results (if a Case Study enter NA) N/A Conclusion Extraskeletal mesenchymal chondrosarcoma can rarely present as an inguinal soft tissue mass with vascular invasion, mimicking a thrombosed venous aneurysm. Molecular confirmation of HEY1-NCOA2 gene fusion can help confirm the diagnosis in unusual clinical presentations.

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