scholarly journals Conditional Reasoning: A Review and Suggestions for Future Test Development and Validation

2019 ◽  
Vol 23 (1) ◽  
pp. 65-95 ◽  
Author(s):  
James M. LeBreton ◽  
Elizabeth M. Grimaldi ◽  
Jeremy L. Schoen
Keyword(s):  
Final Section ◽  
Test Development ◽  
Conditional Reasoning ◽  
The Past ◽  
Conference Presentations ◽  
Development And Validation ◽  
Future Test ◽  
Made In

Lawrence R. James spent the last 20 years of his 35-year career developing and validating a new theory of personality that he called conditional reasoning. This theory was focused on mapping and measuring core aspects of the implicit (i.e., unconscious) personality. In this article, we (a) review James’s seminal contributions to the theory and measurement of conditional reasoning, (b) discuss subsequent contributions made in the area of conditional reasoning, and (c) provide a brief “look under the hood” at James’s approach to test development and validation. This final section of our paper is designed to familiarize other researchers with the protocols that James and his colleagues have used over the past 20 years. Many of these protocols have gone unmentioned or only briefly acknowledged (e.g., in conference presentations or informal meetings); indeed, many of these validation protocols were “implicit” in the thinking of James and his approach to the study of personality. Having benefited from working closely with James, we were privy to many of these implicit assumptions and protocols that privately guided James’s early work on conditional reasoning.

Design of clinical trials in rheumatology

2016 ◽  
Author(s):  
Vibeke Strand ◽  
Jeremy Sokolove ◽  
Alvina D. Chu
Keyword(s):  
Lupus Erythematosus ◽  
Trial Design ◽  
Phase 1 ◽  
Proof Of Concept ◽  
Phase 3 ◽  
Treatment Allocation ◽  
Randomized Controlled ◽  
The Past ◽  
Development And Validation ◽  
Made In

Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, ’first-in-human’ to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the past 15 years, significant progress has been made in the design of RCTs in rheumatoid arthritis (RA). Similarly, development and validation of composite outcome measures in psoriatic arthritis, ankylosing spondylitis, gout, and osteoarthritis have furthered trial design and treatment approvals. RCTs in systemic lupus erythematosus and other multisystem, heterogeneous diseases pose more challenges. Trial design will continue to evolve as promising therapies are introduced into the clinic.

Design of clinical trials in rheumatology

2013 ◽  
Author(s):  
Vibeke Strand ◽  
Jeremy Sokolove ◽  
Alvina D. Chu
Keyword(s):  
Lupus Erythematosus ◽  
Trial Design ◽  
Phase 1 ◽  
Proof Of Concept ◽  
Phase 3 ◽  
Treatment Allocation ◽  
Randomized Controlled ◽  
The Past ◽  
Development And Validation ◽  
Made In

Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, 'first-in-human' to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the past 15 years, significant progress has been made in the design of RCTs in rheumatoid arthritis (RA). Similarly, development and validation of composite outcome measures in psoriatic arthritis, ankylosing spondylitis, gout, and osteoarthritis have furthered trial design and treatment approvals. RCTs in systemic lupus erythematosus and other multisystem, heterogeneous diseases pose more challenges. Trial design will continue to evolve as promising therapies are introduced into the clinic.

scholarly journals Observed Interprofessional Collaboration (OIPC) During Interdisciplinary Team Meetings: Development and Validation of a Tool in a Rehabilitation Setting

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Emmanuelle Careau ◽  
Claude Vincent ◽  
Bonnie R. Swaine
Keyword(s):  
Interrater Reliability ◽  
Interprofessional Collaboration ◽  
Interdisciplinary Team ◽  
Clinical Settings ◽  
Team Meetings ◽  
The Past ◽  
Video Recordings ◽  
Development And Validation ◽  
Made In

Background: Despite all the efforts made in the past few years, interprofessional collaboration (IPC) in clinical settings is not always optimal. In addition, there are only a few instruments that healthcare managers and practitioners can use to evaluate the quality of IPC practice. Therefore, we developed an observationbased tool to evaluate IPC interactional factors occurring during interdisciplinary team meetings, and we examined the initial validation of the tool in a rehabilitation setting.Methods and Findings: The items were developed and pre-tested iteratively by construct experts (N = 7) and non-experts (N = 4). Interrater reliability was determined between two observers, following the analysis of 30 video recordings of meetings in two rehabilitation centres involving a total of 152 participants. An observation grid (OIPC) consisting of 20 items that can be answered on a threepoint scale and demonstrating acceptable interrater reliability was developed.Conclusions: The OIPC is a tool aimed at evaluating IPC interactional factors during interdisciplinary meetings based on team performance rather than individual behaviours. It can be useful for healthcare managers and practitioners who want to evaluate the quality of IPC practices.

scholarly journals Moving the field of vocabulary assessment forward: The need for more rigorous test development and validation

2019 ◽  
Vol 53 (1) ◽  
pp. 109-120 ◽  
Author(s):  
Norbert Schmitt ◽  
Paul Nation ◽  
Benjamin Kremmel
Keyword(s):  
Test Development ◽  
Vocabulary Knowledge ◽  
Language Teachers ◽  
Assessment Literacy ◽  
Vocabulary Test ◽  
The Past ◽  
Minimum Requirements ◽  
Rigorous Test ◽  
Vocabulary Assessment ◽  
Development And Validation

AbstractRecently, a large number of vocabulary tests have been made available to language teachers, testers, and researchers. Unfortunately, most of them have been launched with inadequate validation evidence. The field of language testing has become increasingly more rigorous in the area of test validation, but developers of vocabulary tests have generally not given validation sufficient attention in the past. This paper argues for more rigorous and systematic procedures for test development, starting from a more precise specification of the test's purpose, intended testees and educational context, the particular aspects of vocabulary knowledge which are being measured, and the way in which the test scores should be interpreted. It also calls for greater assessment literacy among vocabulary test developers, and greater support for the end users of the tests, for instance, with the provision of detailed users' manuals. Overall, the authors present what they feel are the minimum requirements for vocabulary test development and validation. They argue that the field should self-police itself more rigorously to ensure that these requirements are met or exceeded, and made explicit for those using vocabulary tests.

Design of clinical trials in rheumatology

2018 ◽  
Author(s):  
Vibeke Strand ◽  
Jeremy Sokolove ◽  
Alvina D. Chu
Keyword(s):  
Lupus Erythematosus ◽  
Trial Design ◽  
Phase 1 ◽  
Proof Of Concept ◽  
Phase 3 ◽  
Treatment Allocation ◽  
Randomized Controlled ◽  
The Past ◽  
Development And Validation ◽  
Made In

Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, ’first-in-human’ to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the past 15 years, significant progress has been made in the design of RCTs in rheumatoid arthritis (RA). Similarly, development and validation of composite outcome measures in psoriatic arthritis, ankylosing spondylitis, gout, and osteoarthritis have furthered trial design and treatment approvals. RCTs in systemic lupus erythematosus and other multisystem, heterogeneous diseases pose more challenges. Trial design will continue to evolve as promising therapies are introduced into the clinic.

The Team Role Test: Development and validation of a team role knowledge situational judgment test.

2008 ◽  
Vol 93 (2) ◽  
pp. 250-267 ◽  
Author(s):  
Troy V. Mumford ◽  
Chad H. Van Iddekinge ◽  
Frederick P. Morgeson ◽  
Michael A. Campion
Keyword(s):  
Test Development ◽  
Situational Judgment Test ◽  
Situational Judgment ◽  
Development And Validation

Same Address, Different Doors: Post-Heritage Deconstruction of the Heritage Household in Upstairs Downstairs in the 1970s and 2010s

2020 ◽  
Author(s):  
William Abbiss
Keyword(s):  
Final Section ◽  
Social Structures ◽  
The Third ◽  
The Past ◽  
War Narrative ◽  
Critical History ◽  
The Social ◽  
Fourth Series ◽  
History Of ◽  
Multiple Episodes

This article offers a ‘post-heritage’ reading of both iterations of Upstairs Downstairs: the LondonWeekend Television (LWT) series (1971–5) and its shortlived BBC revival (2010–12). Identifying elements of subversion and subjectivity allows scholarship on the LWT series to be reassessed, recognising occasions where it challenges rather than supports the social structures of the depicted Edwardian past. The BBC series also incorporates the post-heritage element of self-consciousness, acknowledging the parallel between its narrative and the production’s attempts to recreate the success of its 1970s predecessor. The article’s first section assesses the critical history of the LWT series, identifying areas that are open to further study or revised readings. The second section analyses the serialised war narrative of the fourth series of LWT’s Upstairs, Downstairs (1974), revealing its exploration of female identity across multiple episodes and challenging the notion that the series became more male and upstairs dominated as it progressed. The third section considers the BBC series’ revised concept, identifying the shifts in its main characters’ positions in society that allow the series’ narrative to question the past it evokes. This will be briefly contrasted with the heritage stability of Downton Abbey (ITV, 2010–15). The final section considers the household of 165 Eaton Place’s function as a studio space, which the BBC series self-consciously adopts in order to evoke the aesthetics of prior period dramas. The article concludes by suggesting that the barriers to recreating the past established in the BBC series’ narrative also contributed to its failure to match the success of its earlier iteration.

Same Address, Different Doors: Post-Heritage Deconstruction of the Heritage Household in Upstairs Downstairs in the 1970s and 2010s

2020 ◽  
Author(s):  
William Abbiss
Keyword(s):  
Final Section ◽  
Social Structures ◽  
The Third ◽  
The Past ◽  
War Narrative ◽  
Critical History ◽  
The Social ◽  
Fourth Series ◽  
History Of ◽  
Multiple Episodes

This article offers a ‘post-heritage’ reading of both iterations of Upstairs Downstairs: the LondonWeekend Television (LWT) series (1971–5) and its shortlived BBC revival (2010–12). Identifying elements of subversion and subjectivity allows scholarship on the LWT series to be reassessed, recognising occasions where it challenges rather than supports the social structures of the depicted Edwardian past. The BBC series also incorporates the post-heritage element of self-consciousness, acknowledging the parallel between its narrative and the production’s attempts to recreate the success of its 1970s predecessor. The article’s first section assesses the critical history of the LWT series, identifying areas that are open to further study or revised readings. The second section analyses the serialised war narrative of the fourth series of LWT’s Upstairs, Downstairs (1974), revealing its exploration of female identity across multiple episodes and challenging the notion that the series became more male and upstairs dominated as it progressed. The third section considers the BBC series’ revised concept, identifying the shifts in its main characters’ positions in society that allow the series’ narrative to question the past it evokes. This will be briefly contrasted with the heritage stability of Downton Abbey (ITV, 2010–15). The final section considers the household of 165 Eaton Place’s function as a studio space, which the BBC series self-consciously adopts in order to evoke the aesthetics of prior period dramas. The article concludes by suggesting that the barriers to recreating the past established in the BBC series’ narrative also contributed to its failure to match the success of its earlier iteration.

South Asian Developmental Crisis (Review Article)

1973 ◽  
Vol 12 (2) ◽  
pp. 181-188
Author(s):  
Rafiq Ahmad
Keyword(s):  
Second World War ◽  
World War ◽  
The Past ◽  
The Great Depression ◽  
Political Independence ◽  
Integrated Theory ◽  
Pass Through ◽  
Developed World ◽  
Second World ◽  
Made In

Like nations and civilizations, sciences also pass through period of crises when established theories are overthrown by the unpredictable behaviour of events. Economics is passing through such a crisis. The challenge thrown by the Great Depression of early 1930s took a decade before Keynes re-established the supremacy of economics. But this supremacy has again been upset by the crisis of poverty in the vast under-developed world which attained political independence after the Second World War. Poverty had always existed but never before had it been of such concern to economists as during the past twenty five years or so. Economic literature dealing with this problem has piled up but so have the agonies of poverty. No plausible and well-integrated theory of economic development or under-development has emerged so far, though brilliant advances have been made in isolated directions.

Mass Spectrometry Techniques: Principles and Practices for Quantitative Proteomics

2020 ◽  
Vol 21 ◽  
Author(s):  
Rocco J. Rotello ◽  
Timothy D. Veenstra
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Proteomics ◽  
Protein Identification ◽  
Dynamic Nature ◽  
Complete Coverage ◽  
The Past ◽  
Proteome Level ◽  
A Cell ◽  
Quantitative Changes ◽  
Made In

: In the current omics-age of research, major developments have been made in technologies that attempt to survey the entire repertoire of genes, transcripts, proteins, and metabolites present within a cell. While genomics has led to a dramatic increase in our understanding of such things as disease morphology and how organisms respond to medications, it is critical to obtain information at the proteome level since proteins carry out most of the functions within the cell. The primary tool for obtaining proteome-wide information on proteins within the cell is mass spectrometry (MS). While it has historically been associated with the protein identification, developments over the past couple of decades have made MS a robust technology for protein quantitation as well. Identifying quantitative changes in proteomes is complicated by its dynamic nature and the inability of any technique to guarantee complete coverage of every protein within a proteome sample. Fortunately, the combined development of sample preparation and MS methods have made it capable to quantitatively compare many thousands of proteins obtained from cells and organisms.

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