Intestinal dehiscence and mortality in cats undergoing gastrointestinal surgery

2021 ◽  
pp. 1098612X2110484
Author(s):  
Elizabeth C Hiebert ◽  
Sabrina L Barry ◽  
Dominique M Sawyere ◽  
Stefanie M DeMonaco ◽  
Noelle M Muro
Keyword(s):  
Recovery Period ◽  
Gastrointestinal Surgery ◽  
Clinical Signs ◽  
Postoperative Mortality ◽  
Final Diagnosis ◽  
Serum Biochemistry ◽  
Common Finding ◽  
Septic Peritonitis ◽  
Surgical History ◽  
Complete Blood Counts

Objectives The aim of this study was to determine the incidence of and risk factors for both gastrointestinal (GI) incisional dehiscence and mortality in a large cohort of cats undergoing GI surgery. We hypothesized that cats with preoperative septic peritonitis (PSP), systemic inflammatory response syndrome (SIRS) or sepsis would have higher GI dehiscence and mortality rates than unaffected cats. Methods A medical records search identified cats with surgically created, full-thickness incisions into their stomach, small intestines or large intestines. Preoperative data, including signalment, clinical signs, comorbidities, surgical history, current medications, presenting physical examination findings, complete blood counts and serum biochemistry values, were collected. It was determined whether or not cats had PSP, SIRS or sepsis at admission. Intraoperative data, final diagnosis and postoperative variables such as vital parameters, bloodwork and (if applicable) the development of GI dehiscence or mortality were noted. Postoperative follow-up of at least 10 days was obtained in survivors. Results In total, 126 cats were included. One cat developed GI dehiscence following complete resection of a jejunal adenocarcinoma. Twenty-three cats (18.2%) died within 10 days of surgery. Cats with PSP ( P = 0.0462) or that developed hypothermia 25–72 h postoperatively ( P = 0.0055) had higher odds of mortality in multivariate analysis. Cats with PSP had 6.7-times higher odds of mortality than cats not diagnosed with PSP. Conclusions and relevance In cats receiving GI surgery, the incidence of GI incisional dehiscence was <1%. Cats with PSP had a higher likelihood of mortality. SIRS was a common finding in cats with septic peritonitis, but was not associated with mortality. Postoperative mortality during the home recovery period might be significant in cats. Future studies evaluating postoperative mortality in cats should consider extending the research period beyond the date of discharge.

Spontaneous gastric rupture presenting as severe pneumoperitoneum in a cat with presumed idiopathic gastric ulceration

2020 ◽  
Vol 8 (1) ◽  
pp. e001049 ◽  
Author(s):  
Luis Mate de Haro ◽  
Beatriz Moreno-Aguado ◽  
Juan Martí ◽  
Darren Kelly
Keyword(s):  
Histological Analysis ◽  
Clinical Signs ◽  
Final Diagnosis ◽  
Acute Onset ◽  
Gastric Ulceration ◽  
Neoplastic Disease ◽  
Perforated Gastric Ulcer ◽  
Gastric Rupture ◽  
Septic Peritonitis ◽  
Diagnostic Investigations

An 11-year-old female British blue cat was referred for investigation of acute onset vomiting and marked abdominal enlargement. Diagnostic investigations confirmed a large volume of free gas within the abdomen and changes highly suspicious of an ulcerative gastric lesion. Exploratory surgery confirmed the presence of a perforated gastric ulcer and histological analysis showed only associated inflammatory change. The ulcerated lesions were resected, and the cat recovered rapidly with complete resolution of clinical signs. Spontaneous gastric rupture due complete perforation of an ulcer is rarely reported in cats. The vast majority of reported cases present with septic peritonitis, and the majority are subsequently diagnosed with neoplastic disease or a chronic inflammatory aetiology. The cat reported here had no evidence of septic peritonitis, and the authors feel a final diagnosis of idiopathic gastric ulceration is most likely.

scholarly journals Feline hyperaesthesia syndrome with self-trauma to the tail: retrospective study of seven cases and proposal for an integrated multidisciplinary diagnostic approach

2018 ◽  
Vol 21 (2) ◽  
pp. 178-185 ◽  
Author(s):  
Pablo Amengual Batle ◽  
Clare Rusbridge ◽  
Tim Nuttall ◽  
Sarah Heath ◽  
Katia Marioni-Henry
Keyword(s):  
Retrospective Study ◽  
Cauda Equina ◽  
Clinical Signs ◽  
Case Series ◽  
Final Diagnosis ◽  
Serum Biochemistry ◽  
Response To Treatment ◽  
Leukaemia Virus ◽  
Fluid Analysis ◽  
Mri Scans

Case series summary This was a retrospective study on the clinical features and response to treatment in seven cats with feline hyperaesthesia syndrome (FHS) and tail mutilation. FHS is a poorly understood disorder characterised by skin rippling over the dorsal lumbar area, episodes of jumping and running, excessive vocalisation, and tail chasing and self-trauma. The majority of the cats were young, with a median age of 1 year at the onset of clinical signs, male (n = 6) and with access to the outdoors (n = 5). Multiple daily episodes of tail chasing and self-trauma were reported in five cats, with tail mutilation in four cats. Vocalisation during the episodes (n = 5) and rippling of lumbar skin (n = 5) were also reported. Haematology, serum biochemistry, Toxoplasma gondii and feline immunodeficiency virus/feline leukaemia virus serology, MRI scans of brain, spinal cord and cauda equina, cerebrospinal fluid analysis and electrodiagnostic tests did not reveal any clinically significant abnormalities. A definitive final diagnosis was not reached in any of the cats, but hypersensitivity dermatitis was suspected in two cases. A variety of medications was used alone or in combination, including gabapentin (n = 6), meloxicam (n = 4), antibiotics (n = 4), phenobarbital (n = 2), prednisolone (n = 2) and topiramate (n = 2); ciclosporin, clomipramine, fluoxetine, amitriptyline and tramadol were used in one cat each. Clinical improvement was achieved in six cases; in five cats complete remission of clinical signs was achieved with gabapentin alone (n = 2), a combination of gabapentin/ciclosporin/amitriptyline (n = 1), gabapentin/prednisolone/phenobarbital (n = 1) or gabapentin/topiramate/meloxicam (n = 1). Relevance and novel information This is the first retrospective study on a series of cats with FHS. The diagnostic work-up did not reveal any significant abnormalities of the central or peripheral nervous system; dermatological and behavioural problems could not be ruled out. We propose an integrated multidisciplinary diagnostic pathway to be used for the management of clinical cases and for future prospective studies.

Four-Week Repeated Intravenous Dose Toxicity of Self-Assembled-Micelle Inhibitory RNA-Targeting Amphiregulin in Mice

2021 ◽  
pp. 109158182110312
Author(s):  
Hyeon-Young Kim ◽  
Tae Rim Kim ◽  
Sung-Hwan Kim ◽  
In-Hyeon Kim ◽  
Je-Oh Lim ◽  
...  
Keyword(s):  
Recovery Period ◽  
Clinical Signs ◽  
Serum Biochemistry ◽  
High Dose ◽  
Target Organs ◽  
Rna Targeting ◽  
Adverse Effect Level ◽  
Effect Level ◽  
Self Assembled ◽  
Dose Levels

The present study investigated the potential subchronic toxicity of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG) in mice. The test reagent was administered once-daily by intravenous injection for 4 weeks at 0, 100, 200, or 300 mg/kg/day doses. Additional recovery groups (vehicle control and high dose groups) were observed for a 2-week recovery period. During the test period, mortality, clinical signs, body weight, food consumption, ophthalmology, urinalysis, hematology, serum biochemistry, gross pathology, organ weight, and histopathology were examined. An increase in the percentages of basophil and large unstained cells was observed in the 200 and 300 mg/kg/day groups of both sexes. In addition, the absolute and relative weights of the spleen were higher in males given 300 mg/kg/day relative to the concurrent controls. However, these findings were considered of no toxicological significance because the changes were minimal, were not accompanied by other relevant results (eg, correlating microscopic changes), and were not observed at the end of the 2-week recovery period indicating recovery of the findings. Based on the results, SAMiRNA-AREG did not cause treatment-related adverse effects at dose levels of up to 300 mg/kg/day in mice after 4-week repeated intravenous doses. Under these conditions, the no-observed-adverse-effect level of the SAMiRNA-AREG was ≥300 mg/kg/day in both sexes and no target organs were identified.

scholarly journals Spontaneous poisoning by Prosopis juliflora (Leguminosae) in sheep

2017 ◽  
Vol 37 (2) ◽  
pp. 110-114 ◽  
Author(s):  
Valdir M. Almeida ◽  
Brena P. Rocha ◽  
James A. Pfister ◽  
Rosane M.T. Medeiros ◽  
Franklin Riet-Correa ◽  
...  
Keyword(s):  
Creatine Phosphokinase ◽  
Clinical Signs ◽  
Specific Treatment ◽  
Serum Biochemistry ◽  
Prosopis Juliflora ◽  
Neurologic Examination ◽  
Tongue Protrusion ◽  
Cranial Nerve Function ◽  
Complete Blood Counts ◽  
Male Sheep

ABSTRACT: The aim of this paper is to describe the first report of spontaneous poisoning by Prosopis juliflora in sheep. From flock of 500 sheep at risk, four adult male sheep were affected. One died spontaneously and three other were examined, euthanized and necropsied. Neurologic examination focused particularly on motor and sensory-cranial nerve function, complete blood counts, serum biochemistry and urinalysis were done. The evolution of the disease was chronic and to present signs of poisoning, sheep had to ingest a diet containing at least 80% of P. juliflora pods during 21 months. The biochemistry revealed a substantial increase in creatine phosphokinase levels. Clinical signs included drooling of saliva, dropped jaw, tongue protrusion and loss of food from the mouth. Gross and histological lesions were similar to those previously reported in cattle and goats. Sheep are more resistant to poisoning by P. juliflora considering that it took 21 months of pod consumption to show clinical signs. There is no specific treatment for P. juliflora poisoning in ruminants.

Retrospective Diagnosis of Pontocerebellar Hypoplasia Type 1B in a Family with Two Deceased Newborn Children

2020 ◽  
Author(s):  
Irena Bradinova ◽  
Silvia Andonova ◽  
Alexey Savov
Keyword(s):  
Clinical Signs ◽  
Final Diagnosis ◽  
Population Based ◽  
Neuromuscular Disorder ◽  
Population Characteristics ◽  
High Risk Population ◽  
Pontocerebellar Hypoplasia ◽  
Clinical Genetic ◽  
Retrospective Diagnosis ◽  
Newborn Children

AbstractPontocerebellar hypoplasia type 1B is a severe autosomal recessive neurologic disorder characterized by a combination of cerebellar and spinal motor neuron degeneration beginning at birth. Pontocerebellar hypoplasia type 1B is caused by mutations in EXOSC3 gene. High prevalence of the p.Gly31Ala mutation was found recently, especially in the Roma ethnic minority. We present a young Bulgarian Roma family with two deceased newborn children manifesting severe neuromuscular disorder including severe muscle weakness, respiratory distress, and multiple joint contractures. Based on the clinical signs and family's population characteristics, DNA testing for the previously described EXOSC3 in Bulgarian Roma mutation c.92G > C; p.Gly31Ala was performed on blood samples of both parents and they were found to be heterozygous carriers. This finding indirectly confirmed the diagnosis of pontocerebellar hypoplasia type B in the deceased offspring. Knowledge of population-specific molecular bases of genetic conditions was the key to final diagnosis in the presented family. Designing of population-based clinical-genetic panels may be a powerful diagnostic tool for patients with such origin. Preconception carrier screening in high-risk population groups is a feasible option to discuss.

Porcine teschovirus, sapelovirus, and enterovirus in Swiss pigs: multiplex RT-PCR investigation of viral frequencies and disease association

2021 ◽  
pp. 104063872110258
Author(s):  
Tamara Stäubli ◽  
Charlotte I. Rickli ◽  
Paul R. Torgerson ◽  
Cornel Fraefel ◽  
Julia Lechmann
Keyword(s):  
Clinical Signs ◽  
Virus Detection ◽  
Common Finding ◽  
Fecal Samples ◽  
High Frequencies ◽  
Reverse Transcription Pcr ◽  
Suckling Piglets ◽  
Porcine Teschovirus ◽  
Fattening Pigs ◽  
Pathology Data

Porcine teschovirus (PTV), sapelovirus (PSV-A), and enterovirus (EV-G) are enteric viruses that can infect pigs and wild boars worldwide. The viruses have been associated with several diseases, primarily gastrointestinal, neurologic, reproductive, and respiratory disorders, but also with subclinical infections. However, for most serotypes, proof of a causal relationship between viral infection and clinical signs is still lacking. In Switzerland, there has been limited investigation of the occurrence of the 3 viruses. We used a modified multiplex reverse-transcription PCR protocol to study the distribution of the viruses in Swiss pigs by testing 363 fecal, brain, and placental or abortion samples from 282 healthy and diseased animals. We did not detect the 3 viruses in 94 placental or abortion samples or in 31 brain samples from healthy pigs. In brain tissue of 81 diseased pigs, we detected 5 PSV-A and 4 EV-G positive samples. In contrast, all 3 viruses were detected at high frequencies in fecal samples of both healthy and diseased pigs. In healthy animals, PTV was detected in 47%, PSV-A in 51%, and EV-G in 70% of the 76 samples; in diseased animals, frequencies in the 81 samples were 54%, 64%, and 68%, respectively. The viruses were detected more frequently in fecal samples from weaned and fattening pigs compared to suckling piglets and sows. Co-detections of all 3 viruses were the most common finding. Based on clinical and pathology data, statistical analysis yielded no evidence for an association of virus detection and disease. Further research is required to determine if pathogenicity is linked to specific serotypes of these viruses.

Hematologic and serum biochemistry reference intervals using defined ASCVP methodology for laboratory natal multimammate mice (Mastomys natalensis)

2021 ◽  
pp. 002367722110185
Author(s):  
Brian J Smith ◽  
Patrick W Hanley ◽  
Ousmane Maiga ◽  
Maarit N Culbert ◽  
Marissa J Woods ◽  
...  
Keyword(s):  
Complete Blood Count ◽  
Age Groups ◽  
Serum Biochemistry ◽  
Reference Intervals ◽  
Laboratory Research ◽  
Data Sets ◽  
Mastomys Natalensis ◽  
Complete Blood Counts ◽  
Multimammate Mice ◽  
Female Laboratory

Complete blood count, serum chemistry values, and biological reference intervals were compared between two age groups (34–49 and 84–120 days old) of healthy male and female laboratory raised natal multimammate mice ( Mastomys natalensis). Blood was collected via cardiocentesis under isoflurane anesthesia. Data sets of machine automated complete blood counts and clinical chemistries were analyzed. Significant differences between sex and age groups of the data sets were defined. The baseline hematologic and serum biochemistry values described here can improve interpretation of laboratory research using natal multimammate mice.

scholarly journals Establishing Background Pathologic Changes of Valve Replacement Surgery in Sheep

2021 ◽  
Author(s):  
Jill T. Schappa Faustich ◽  
John P. Carney ◽  
Matthew T. Lahti ◽  
Benjamin L. Zhang ◽  
Richard W. Bianco
Keyword(s):  
Invasive Surgery ◽  
Heart Valves ◽  
Serum Biochemistry ◽  
Preclinical Model ◽  
Sheep Model ◽  
Safety Issues ◽  
Replacement Surgery ◽  
Aortic Replacement ◽  
Complete Blood Counts ◽  
Future Evaluation

Abstract Purpose Sheep are the standard preclinical model for assessing safety of novel replacement heart valves, yet the anatomic and pathologic effects of invasive surgery, including those involving cardiopulmonary bypass (CPB), are unknown. Thus, we aimed to determine the gross, hematologic and biochemical effects of sham mitral and aortic replacement valve procedures in sheep to establish a useful control for evaluation of novel replacement valves. Methods Six control sheep were examined without any surgical intervention. Six sham mitral valve replacements (MVR) and six sham aortic valve replacements (AVR) were performed on 12 sheep. Complete blood counts and serum biochemistry were performed throughout the study. Sheep were sacrificed with a necropsy performed at 90 days. Results Renal infarcts (RIs) were the most frequently observed lesion, averaging 4.7 in control sheep, 2.5 with MVR and 5.8 with AVR. The number of infarcts strongly correlated with total estimated area of infarcted kidney (r = .84, p < .01). Additional cardiac interventions were significantly correlated with increased numbers of RIs (r = .85, p < .01). There was no correlation between number of RIs and time on CPB, or between AVR and MVR procedures. Conclusion The sheep model for AVR and MVR requires invasive surgery and CPB, which are associated with background anatomic and pathologic changes, especially in cases with additional surgical cardiac interventions. These findings serve as a critical control for future evaluation and development of novel replacement valves in order to distinguish device-related safety issues from expected outcomes of the surgical procedure and normal background changes in sheep.

Toxicity of a Novel HMG-CoA Reductase Inhibitor in the Common Marmoset (Callithrix jacchus)

1994 ◽  
Vol 13 (5) ◽  
pp. 357-368 ◽  
Author(s):  
K. Owen ◽  
C.R. Pick ◽  
S.E. Libretto ◽  
M.J. Adams
Keyword(s):  
Recovery Period ◽  
Clinical Signs ◽  
Common Marmoset ◽  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Chronic Study ◽  
Hmg Coa Reductase Inhibitor ◽  
Alveolar Proteinosis ◽  
Coa Reductase

1 GR95030X, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, was administered daily to marmosets by gavage. In a Maximum Repeatable Dose (MRD) study, doses of up to 30 mg kg-1 day-1 were administered for 49 days. In a chronic study, animals received dosages equivalent to 0, 1, 2.5, 7,5 and 20 mg kg-1 day-1 for 204 or 205 days. Some animals were maintained without treatment for a recovery period of 29 or 30 days, 2 Clinical signs included poor coat condition, weakness with impaired coordination, lethargy and other behavioural changes, There was also alimentary disturbance, and some deaths occurred at doses of 20 mg kg-1 day-1 and above. 3 Adverse effects upon body weight were seen although some recovery was apparent after the cessation of treatment. 4 Serum cholesterol concentrations were reduced. Very large increases in serum ALT, AST and CK activities were recorded with CK-MM isoenzymes accounting for 80% or more of the total CK enzyme activity. 5 Treatment was associated with muscle fibre atrophy and a sarcolemmal response with little evidence of regeneration. Histological examination revealed vascular changes, glial proliferation and cell death in the brain, with no consistent distribution. Alveolar capillary congestion and alveolar proteinosis indicated that there may have been a reduction in cardiac function. 6 HMG-CoA reductase inhibitors have evident potential to cause myopathy in marmosets. This is believed to be the first report of such an effect.

scholarly journals Acute Toxicity of the Recombinant and Native Phα1β Toxin: New Analgesic from Phoneutria nigriventer Spider Venom

Toxins ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 531 ◽  
Author(s):  
Eliane Dallegrave ◽  
Eliane Taschetto ◽  
Mirna Bainy Leal ◽  
Flavia Techera Antunes ◽  
Marcus Gomez ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Relative Weight ◽  
Serum Biochemistry ◽  
Renal Tissue ◽  
Organ Weight ◽  
Female Rats ◽  
Mild Degree ◽  
Physiological Limits ◽  
Voltage Dependent ◽  
Phoneutria Nigriventer

Phα1β, a purified peptide from the venom of the spider Phoneutria nigriventer, and its recombinant form CTK 01512-2 are voltage-dependent calcium channel (CaV) blockers of types N, R, P/Q, and L with a preference for type N. These peptides show analgesic action in different pain models in rats. The aim of this study was to evaluate the acute intrathecal toxicity of the native and recombinant Phα1β toxin in Wistar rats. Clinical signs, serum biochemistry, organ weight, and histopathological alterations were evaluated in male and/or female rats. Dyspnea was observed in males, hyporesponsiveness in females, and Straub tail and tremors in both genders. There were no significant differences in male organ weight, although significant differences in the female relative weight of the adrenal glands and spleen have been observed; these values are within the normal range. Serum biochemical data revealed a significant reduction within the physiological limits of species related to urea, ALT, AST, and FA. Hepatic and renal congestion were observed for toxin groups. In renal tissue, glomerular infiltrates were observed with increased glomerular space. These histological alterations were presented in focal areas and in mild degree. Therefore, Phα1β and CTK 01512-2 presented a good safety profile with transient toxicity clinical signals in doses higher than used to obtain the analgesic effect.

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