Heart Rate Variability in Breast Cancer Survivors After the First Year of Treatments

2015 ◽  
Vol 18 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Elena Caro-Morán ◽  
Carolina Fernández-Lao ◽  
Noelia Galiano-Castillo ◽  
Irene Cantarero-Villanueva ◽  
Manuel Arroyo-Morales ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Early Stage ◽  
Analysis Of Covariance ◽  
Controlled Study ◽  
First Year ◽  
Autonomic Balance

The same aggressive treatments that have led to a reduction in the breast cancer may also have adverse effects on cardiac autonomic balance. The objective of this study was to compare heart rate variability (HRV) between breast cancer survivors in the first year posttreatment and healthy women, controlling for known confounders. This descriptive case-controlled study included 22 breast cancer survivors and 22 healthy age- and sex-matched controls. Short-term HRV was measured using an accepted methodology to assess the cardiac autonomic balance. One-way analysis of covariance results revealed that heart rate was significantly higher ( F = 15.86, p < .001) and the standard deviation of normal-to-normal (NN) interval ( F = 19.93, p = .001), square root of mean squared differences of successive NN intervals ( F = 18.72, p = .001), HRV index ( F = 5.44, p = .025), and high-frequency ( F = 5.77, p = .03) values were significantly lower in the breast cancer survivors than in the matched controls. The principal finding of the presence of a cardiovascular imbalance in breast cancer survivors in comparison to healthy age-matched controls suggests that HRV study could be a clinically useful tool to detect cardiovascular disease in early-stage breast cancer survivors.

scholarly journals Features of heart rate variability in breast cancer survivors with various types of attitude to the disease

2018 ◽  
Vol 32 (3) ◽  
pp. 5-9
Author(s):  
Evgen Prystupa ◽  
Tetiana Odynets ◽  
Yuriy Briskin ◽  
Iryna Svistelnyk
Keyword(s):  
Breast Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cancer Survivors ◽  
Breast Cancer Survivors

Mammography use in breast cancer survivors: An administrative claims study.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 6531-6531 ◽  
Author(s):  
Kathryn Jean Ruddy ◽  
Lindsey R. Sangaralingham ◽  
Heather B. Neuman ◽  
Caprice Christian Greenberg ◽  
Rachel A. Freedman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Breast Cancer Survivors ◽  
Breast Tissue ◽  
Early Stage ◽  
Breast Cancer Diagnosis ◽  
First Year ◽  
Administrative Claims ◽  
Mammography Use

6531 Background: Annual mammography is recommended to screen residual breast tissue for new cancers and recurrent disease after treatment for early stage breast cancer. This study aimed to assess mammography rates over time in breast cancer survivors. Methods: We used administrative claims data from a large U.S. commercial insurance database, OptumLabs, to retrospectively identify privately- and Medicare Advantage-insured women with operable breast cancer who had residual breast tissue after definitive breast surgery between 2006 and 2015. We required coverage for at least 13 months following surgery. For each subsequent 13-month time period, we only included women without a loss of coverage, bilateral mastectomy, metastatic breast cancer diagnosis, or non-breast cancer diagnosis. We calculated the proportion of patients who had a mammogram during each 13-month period following breast surgery. We used multivariable logistic regression to test for factors associated with mammography in the first 13 months. Results: The cohort included 26,011 women followed for a median of 2.9 years (IQR 1.9-4.6) after surgery; 63.1% were less than 65 years of age, and 74.4% were white. In their first year of follow-up, 86% underwent mammography, but by year 7, this decreased to 73%. Fewer than 1% underwent MRI instead of mammography. In multivariable analysis, mammograms were less likely during the first year after surgery among women aged < 50 years (odds ratio [OR], 0.7; 95% confidence interval [CI], 0.6 to 0.8), African Americans (OR, 0.7; 95% CI, 0.7 to 0.8), patients who underwent mastectomy (OR, 0.7; 95% CI, 0.6 to 0.7), and patients residing in the Western part of the country (OR, 0.9; 95% CI, 0.7 to 0.9). Those with 1-2 comorbidities were more likely (OR, 1.1; 95% CI 1.1-1.2) than those with none to have a mammogram during that period. Mammography use did not differ significantly by year of diagnosis (2006-2015). Conclusions: Even in an insured cohort, a substantial proportion of breast cancer survivors do not undergo annual surveillance mammography. Mammography use falls as the time from the early stage breast cancer diagnosis increases. Understanding factors associated with lack of mammographic screening may help improve survivorship care.

scholarly journals Differences in Heart Rate Variability and Body Composition in Breast Cancer Survivors and Women Without Cancer

2021 ◽  
Author(s):  
Daniel Escutia-Reyes ◽  
José Garduño-García ◽  
Gerardo López-Chávez ◽  
Ángel Gómez-Villanueva ◽  
Adriana Pliego-Carrillo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Body Composition ◽  
Cancer Survivors ◽  
Visceral Fat ◽  
Breast Cancer Survivors ◽  
Cardiac Activity ◽  
Poincaré Plot ◽  
Linear And Nonlinear

Abstract Purpose: To explore cardiac autonomic changes assessed by linear and nonlinear indexes of heart rate variability (HRV) and body composition modifications in breast cancer survivors and cancer-free control women. Methods: Women who were breast cancer survivors (BCS, n=27) and cancer-free control participants with similar characteristics (Control, n=31) were enrolled in the Regional General Hospital No. 251 of the Mexican Institute of Social Security (Metepec, Mexico). We processed five minutes of R-R interval time series, and we calculated relevant linear and nonlinear parameters of HRV such as mean RR interval (RRave), the Root Mean Square of the Successive Differences (RMSSD), the Poincaré plot measures SD1, SD2, SD1/SD2, and the sample entropy (SampEn). Additionally, we indirectly assessed body composition measures such as body weight, fat mass, visceral fat rating (VFR), normalized VRF (nVFR), muscle mass, metabolic age, and total body water.Results: We found that diverse HRV indexes and only one body composition measure showed statistical differences (p<0.05) between the BCS and Control groups: RRave: 729 (648–802) vs. 795 (713–852) ms; RMSSD: 16.5 (8.9–27.0) vs. 19.7 (14.2–28.5) ms; SD1: 11.6 (6.3–19.0) vs. 13.9 (10.0–20.1) ms; SD1/SD2: 2.5 (2.1–3.3) vs. 2.2 (1.9–2.7), SampEn: 1.5 (1.3–1.8) vs. 1.7 (1.5–1.8), and nVFR 0.12 (0.11–0.13) vs.0.10 (0.08–0.12) points/kg, respectively. The nVFR was significantly correlated to several indexes of HRV.Conclusions: BCS exhibit a lower parasympathetic cardiac activity and changes in HRV patterns than controls, likely because of the concomitant increase of visceral fat.

Exercise Effects on Symptom Cluster, Cortisol, Heart Rate Variability and QOL in Breast Cancer Survivors

2017 ◽  
Vol 49 (5S) ◽  
pp. 898-899
Author(s):  
Kenneth C. Banting ◽  
Linda B. Piacentine ◽  
Aidan Flannagan ◽  
Toni Uhrich ◽  
Judy A. Tjoe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Symptom Cluster

scholarly journals Low heart rate variability and cancer-related fatigue in breast cancer survivors

2014 ◽  
Vol 45 ◽  
pp. 58-66 ◽  
Author(s):  
Alexandra D. Crosswell ◽  
Kimberly G. Lockwood ◽  
Patricia A. Ganz ◽  
Julienne E. Bower
Keyword(s):  
Breast Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Cancer Related Fatigue

Abstract 16348: Comparison of Heart Rate Variability, Physical Activity, and Fitness Parameters Between Healthy Women and Breast Cancer Survivors

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Elena Martínez-Rosales ◽  
Alba Hernández-Martínez ◽  
Manuel Alcaraz-Ibáñez ◽  
Laura López-Sánchez ◽  
David Manuel Díez-Fernández ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Handgrip Strength ◽  
Vigorous Physical Activity ◽  
Low Frequency ◽  
Healthy Women

Introduction: Breast cancer remains the most commonly type of cancer. Heart rate variability (HRV), a clinical indicator of autonomic dysfunction and premature mortality, has been found to be impaired in breast cancer survivors immediately after treatment and in the last stages of metastasis. Physical activity and fitness represent relevant health markers that might prevent some of the side effects following breast cancer treatment, so it would be of clinical interest assessing potential differences with healthy controls. Hypothesis: Compared to healthy women, breast cancer survivors are expected to show impaired HRV-derived parameters, as well as lower physical activity and fitness. Methods: This cross-sectional study included 20 women that survived breast cancer (post-operative period >2 years) and 20 healthy women controls, matched by age and BMI. Fitness evaluations included the modified Ruffier-Dixon test and handgrip strength. Moderate-to-vigorous physical activity (MVPA) was assessed through a self-reported questionnaire. Short-term HRV was measured using 5-minutes recording and were analyzed with Kubios Premium. Sample size was determined for two-tailed tests, statistical power of 0.8, effect size >0.7, and significance level of p<0.05. Between-groups differences were examined using Mann–Whitney U test and Student’s t-test, for normally and not-normally distributed variables, respectively. Results: Concerning HRV parameters, breast cancer survivors presented lower Very Low Frequency and Low Frequency, and higher Low Frequency/High Frequency ratio (all p <0.001), compared to controls. No statistically significant differences were observed in MVPA time ( p =0.48) or estimated VO 2max ( p =0.24), although handgrip strength was decreased in cancer survivors ( p =0.02). Conclusions: A cardiovascular imbalance in breast cancer survivors may be suggested in comparison to healthy age- and BMI-matched controls, as evidenced by reduced HRV after >2 years of post-operative treatment. In contrast, there were no differences in weekly MVPA or VO 2max between groups, although muscular strength could still be affected. These results need to be contrasted by future long-term prospective research.

scholarly journals Differences in heart rate variability and body composition in breast cancer survivors and women without cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniel Escutia-Reyes ◽  
José de Jesús Garduño-García ◽  
Gerardo Emilio-López-Chávez ◽  
Ángel Gómez-Villanueva ◽  
Adriana Cristina Pliego-Carrillo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Body Composition ◽  
Cancer Survivors ◽  
Visceral Fat ◽  
Breast Cancer Survivors ◽  
Scaling Exponent ◽  
Rr Interval ◽  
Linear And Nonlinear

AbstractThe aim of this study was to explore cardiac autonomic changes assessed by linear and nonlinear indexes of heart rate variability (HRV) and body composition modifications in breast cancer survivors and cancer-free control women. Women who were breast cancer survivors (BCS, n = 27) and without cancer with similar characteristics (Control, n = 31) were recruited for this study. We calculated some relevant linear and nonlinear parameters of 5 min of RR interval time series such as mean RR interval (RRave), the corrected Poincaré index (cSD1/SD2), the sample entropy (SampEn), the long-term fractal scaling exponent (α2) and 2UV from symbolic dynamics. Additionally, we indirectly assessed body composition measures such as body weight, fat mass, visceral fat rating (VFR), normalized VRF (nVFR), muscle mass, metabolic age, and total body water. We found that diverse HRV indexes and only one body composition measure showed statistical differences (p < 0.05) between the BCS and Control groups. RRave: 729 (648–802) vs. 795 (713–852) ms; cSD2/SD1: 3.4 (2.7–5.0) vs. 2.9 (2.3–3.5); SampEn: 1.5 (1.3–1.8) vs. 1.7 (1.5–1.8); α2: 0.6 (0.3–0.6) vs. 0.5 (0.4–0.5); 2UV: 7.1 (4.3–11.5) vs. 10.8 (6.4–15.7) and nVFR 0.12 (0.11–0.13) vs. 0.10 (0.08–0.12) points/kg, respectively. The nVFR was strongly significantly correlated with several indexes of HRV only in the BCS group.Our findings suggest that BCS exhibit lower parasympathetic cardiac activity and changes in HRV patterns compared to Controls. A concomitant increase of visceral fat, among other factors, may contribute to cardiac autonomic disturbances and changes in HRV patterns in BCS.

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