Diagnosis and long-term monitoring of adenomas of the ciliary body epithelium by ultrasound biomicroscopy

2020 ◽  
pp. 112067212095264
Author(s):  
Silvia Méndez-Martínez ◽  
María Santiago Varela ◽  
María José Blanco-Teijeiro ◽  
Antonio Piñeiro-Ces
Keyword(s):  
Differential Diagnosis ◽  
Ciliary Body ◽  
Spherical Shape ◽  
Ultrasound Biomicroscopy ◽  
Tertiary Hospital ◽  
Amelanotic Melanoma ◽  
Ciliary Epithelium ◽  
Hospital Patients ◽  
Initial Attitude ◽  
Ciliary Body Epithelium

Introduction: The natural course of adenomas of the ciliary-body epithelium (ACE) is uncertain, due to their low incidence and their frequent initial surgical management. Their differential diagnosis with amelanotic melanoma or metastasis is challenging and diagnostic biopsies require sufficient tissue and highly specialized pathologists. Ultrasound biomicroscopy offers high resolution images and clear sonographic signs suggestive of ACE allowing a more precise differential diagnosis and therefore, a more conservative initial attitude. Methods: Descriptive, retrospective, non-comparative study of consecutive cases of ACE observed between October 2003 and December 2019 in a reference unit in ocular oncology of a tertiary hospital. Patients were studied on a quarterly basis the first year and, subsequently, every 6 months with a complete ophthalmological exam and ultrasound biomicroscopy with the platform Aviso linear scanning 50 MHz probe (Quantel Medical, Clermont-Ferrand, France). Results: Three ACE were analysed for a median of 3 years (interquartile range: 2.5–5.5 years). Clinical features include a whitish-to-brown spherical mass, with engorged superficial vessels. Ultrasound biomicroscopy shows an oval-spherical shape, medium-to-high echogenicity, low acoustic attenuation, regular internal structure, and respect for the neighboring structures. By their clinical-ultrasonographic characteristics, one was considered an adenoma of the pigmented ciliary-body epithelium (browner and hyperechogenic) and two were classified as adenomas of the non-pigmented ciliary epithelium (whitish appearance and medium-echogenicity). Conclusion: Ultrasound biomicroscopy allows a reasonable clinicalsonographic suspicion of ACE. An initial conservative management is proposed as a safer option for stable, mildly symptomatic patients, avoiding aggressive sight threatening treatments.

scholarly journals Differential diagnosis of anterior chamber cysts with ultrasound biomicroscopy: ciliary body medulloepithelioma

2005 ◽  
Vol 84 (1) ◽  
pp. 137-139 ◽  
Author(s):  
Min Zhou ◽  
Gezhi Xu ◽  
Christine M. Bojanowski ◽  
Yuelian Song ◽  
Rongjia Chen ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Anterior Chamber ◽  
Ciliary Body ◽  
Ultrasound Biomicroscopy

scholarly journals Pigmented free floating vitreous cyst in a 10 years old child

2018 ◽  
Vol 9 (2) ◽  
pp. 190-193
Author(s):  
Parthopratim Dutta Majumder ◽  
Nagalekshmi Ganesh ◽  
Vijay Pratap Singh Tomar ◽  
Ranju Kharel ◽  
Parveen Sen
Keyword(s):  
Ciliary Body ◽  
Ultrasound Biomicroscopy ◽  
Class A ◽  
Congenital Origin ◽  
Associated Conditions ◽  
Vitreous Cyst ◽  
Eye Examination ◽  
Rule Out ◽  
Ciliary Body Epithelium

Pigmented free-floating vitreous cyst in retrolental space is rare. It can represent its congenital origin after spontaneous detachment from the ciliary body epithelium or after trivial injury. We report a case of pigmented, free floating non-infective vitreous cyst in a 10 year old child who presented with compliant of transient blurring of vision three days after she joined swimming class. A thorough eye examination with ultrasound B scan and ultrasound biomicroscopy was done to rule out any other associated conditions.

scholarly journals The nationwide retrospective cohort study by Health Insurance Review and Assessment Service proves that asthma management decreases the exacerbation risk of asthma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nam-Eun Kim ◽  
Sanghun Lee ◽  
Bo Yeon Kim ◽  
Ae Gi Hwang ◽  
Ji Hyeon Shin ◽  
...  
Keyword(s):  
Health Insurance ◽  
South Korea ◽  
Asthma Management ◽  
Estimating Equation ◽  
Tertiary Hospital ◽  
Asthma Exacerbations ◽  
Hospital Patients ◽  
Insurance Claims Data ◽  
Health Insurance Claims Data ◽  
Exacerbation Risk

AbstractMedical costs have recently increased in South Korea due to the rising rate of asthma. Primary clinics serve an important role in asthma management, as they are the first stop for patients presenting with symptoms. The Health Insurance Review and Assessment Service (HIRA) in South Korea has assessed asthma-management quality since 2013, but studies are lacking on whether these assessments have been performed properly and contribute toward reducing asthma exacerbations. Therefore, we investigated whether the HIRA’s quality assessments have decreased asthma exacerbations using national health insurance claims data from 2013 to 2017 of 83,375 primary-clinic and 15,931 tertiary-hospital patients with asthma. These patients were classified into four groups based on disease severity according to the monthly prescribed amount of asthma medication using K-means clustering. The associations between HIRA assessments and asthma exacerbation were analyzed using a generalized estimating equation. Our results showed that exacerbation odds gradually decreased as the HIRA assessments progressed, especially in the mild-severity group, and that exacerbation risk among patients with asthma decreased in the order of assessment grades: “Unsatisfactory,” “Satisfactory,” and “Tertiary.” Therefore, we may conclude that asthma exacerbations may decrease with high quality asthma management; appropriate quality assessment could be helpful in reducing asthma exacerbations.

Causes of nasoenteral tube obstruction in tertiary hospital patients

2019 ◽  
Vol 74 (2) ◽  
pp. 261-267
Author(s):  
José L. A. Borges ◽  
Ivens A. O. De Souza ◽  
Michele C. V. Costa ◽  
Fabiana Ruotolo ◽  
Livia M. G. Barbosa ◽  
...  
Keyword(s):  
Tertiary Hospital ◽  
Tube Obstruction ◽  
Hospital Patients

scholarly journals A case report of ultrasonographic findings in bilateral diffuse Uveal melanocytic proliferation

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jingli Guo ◽  
Wenyi Tang ◽  
Wei Liu ◽  
Min Zhou ◽  
Qing Chang ◽  
...  
Keyword(s):  
Case Report ◽  
Retinal Detachment ◽  
High Frequency ◽  
Ciliary Body ◽  
Case Series ◽  
Ultrasound Biomicroscopy ◽  
The Other ◽  
Exudative Retinal Detachment ◽  
Case Presentation ◽  
Choroidal Nevi

Abstract Background To report undescribed characteristics of patients with bilateral diffuse uveal melanocytic proliferation (BDUMP) on ultrasound biomicroscopy (UBM) and high-frequency B-scan ultrasonography. Case presentation Two of four participants presented with worsening bilateral vision after previously diagnosed primary pulmonary or ovarian carcinoma. The other two patients were diagnosed with lung carcinoma after presentation with BDUMP. All patients had ciliary body nevi-like lesion in combination with iris or ciliary body cysts, and uveal thickening on UBM. Focally elevated choroidal nevi-like lesion and exudative retinal detachment with choroidal thickening were detected with B-scan ultrasonography. Conclusions Our case series demonstrates the uveal characteristics of patients with BDUMP based on high-frequency B-scan ultrasonography and UBM. Ultrasonographic findings are crucial in the diagnosis of BDUMP because it is occult in nature.

Morphometric assessment of normal human ciliary body using ultrasound biomicroscopy

2017 ◽  
Vol 255 (12) ◽  
pp. 2437-2442 ◽  
Author(s):  
Yoshifumi Okamoto ◽  
Fumiki Okamoto ◽  
Shinichiro Nakano ◽  
Tetsuro Oshika
Keyword(s):  
Ciliary Body ◽  
Ultrasound Biomicroscopy ◽  
Normal Human ◽  
Morphometric Assessment

scholarly journals DARPP-32 in the ciliary epithelium of the eye: a neurotransmitter-regulated phosphoprotein of brain localizes to secretory cells.

1986 ◽  
Vol 34 (11) ◽  
pp. 1465-1468 ◽  
Author(s):  
R A Stone ◽  
A M Laties ◽  
H C Hemmings ◽  
C C Ouimet ◽  
P Greengard
Keyword(s):  
Ciliary Body ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
Secretory Cells ◽  
Ciliary Epithelium ◽  
Receptor Subtype ◽  
Physiological Effects ◽  
Body Extract ◽  
Innermost Layer ◽  
Pigmented Epithelium

DARPP-32, a phosphoprotein enriched in dopaminoceptive brain neurons containing the D-1 receptor subtype, probably functions as an intracellular third messenger to mediate some of the physiological effects of dopamine at the D-1 receptor. By immunohistochemistry in rat, cat, Rhesus monkey, and human, we have localized DARPP-32 to the non-pigmented epithelium of the ciliary body, the innermost layer of the bi-layered epithelium responsible for secretion of aqueous humor into the eye. The immunoreactive protein in rat ciliary body, identified by immunolabeling of a ciliary body extract separated by sodium dodecyl sulfate/polyacrylamide gel electrophoresis, is indistinguishable from DARPP-32 derived from rat caudatoputamen. By analogy with brain, we propose that DARPP-32 may act as a third messenger in the ciliary epithelium, probably through a dopaminergic mechanism.

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