scholarly journals Breast Cancer Metastasis to the Axillary Lymph Nodes: Are Changes to the Lymph Node “Soil” Localized or Systemic?

2017 ◽  
Vol 11 ◽  
pp. 117822341769124 ◽  
Author(s):  
Heather L Blackburn ◽  
Darrell L Ellsworth ◽  
Craig D Shriver ◽  
Rachel E Ellsworth
Keyword(s):  
Gene Expression ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Metastasis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Breast Cancer Metastasis ◽  
Multiple Hypothesis Testing ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph

Metastasis is a multistep process that is not well understood. Colonization of a secondary organ requires specific molecular alterations of the host microenvironment. To determine the temporal and spatial changes associated with metastatic dissemination to the axillary lymph nodes, gene expression profiles were compared between histologically normal lymph nodes from node-positive patients and tumor-free nodes from node-negative patients. Using a stringent false discovery rate correction (<0.05) for multiple hypothesis testing, we did not detect any differentially expressed genes between the lymph node groups. Thus, the presence of metastatic cells within the lymphatic system does not elicit widespread changes in gene expression through the axillary basin; rather, lymph nodes independently respond to disseminated tumor cells.

scholarly journals Axillary lymph nodes and breast cancer metastasis.

2021 ◽  
Vol 28 (7) ◽  
pp. 978-982
Author(s):  
Shahid Hussain Soomro ◽  
◽  
Abdul Sattar Abro ◽  
Vaqar-e-Sahar Shah ◽  
Saima Ather Shaikh ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Axillary Dissection ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Axillary Lymph Nodes ◽  
Lymph Node Status ◽  
Axillary Lymph ◽  
Carcinoma Breast ◽  
Female Patients

Objectives: The purpose of current study is to evaluate the correlation of axillary lymph node status with metastases in patients presented with carcinoma breast. Study Design: Prospective study. Setting: Surgical Unit 1, CMC Hospital Larkana. Period: March 2019 to January 2020. Material & Methods: Female patients presented with carcinoma breast were assessed clinically and by investigation then underwent a mastectomy and axillary dissection (sampling or clearance). Data was entered into pre-designed proforma. After proper staging, surgery was done in all patients accordingly. Lymph node involvement was confirmed histopathology. Then it was correlated with clinical findings. Results: Fifty-five female patients of proven carcinoma breast underwent a mastectomy and axillary dissection. The majority of the patients (76%) were between 30-60 years, the median age being 45 years. The left breast contained the tumor in 30 (55.5%) patients while the rest of the patients had the right breast involved. The size of the tumor varied from 2cm to 12cm. 33 (61%) patients were in the pre-menopausal state while 21 (38.88%) were in postmenopausal state. In 07 patients (13%) the axillary lymph nodes were not palpable while in the rest of the 47 patients (87%), the axillary lymph nodes were palpable to a variable extent. Most of the patients were in an advanced stages. Among seven patients (N0), histopathology revealed positive lymph nodes in 3/7 (42.85%) patients. Conclusion: Breast carcinoma is a serious type of carcinoma affecting the younger generation in our community, usually diagnosed at a late stage. Clinical examination is not an effective way for proper staging. Further investigations should be performed for accurate staging and management.

scholarly journals Detection of Circulating Tumor Cells in Early-Stage Breast Cancer Metastasis to Axillary Lymph Nodes

2007 ◽  
Vol 13 (14) ◽  
pp. 4105-4110 ◽  
Author(s):  
Taku Nakagawa ◽  
Steve R. Martinez ◽  
Yasufumi Goto ◽  
Kazuo Koyanagi ◽  
Minoru Kitago ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Metastasis ◽  
Early Stage ◽  
Breast Cancer Metastasis ◽  
Early Stage Breast Cancer ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph

scholarly journals CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
David Hiller ◽  
Quyen D. Chu
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Metastasis ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Metastasis ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Peripheral Lymph ◽  
Potential Biomarker ◽  
Node Metastases

CXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. CXCL12 is the ligand for CXCR4 and is highly expressed in areas common for breast cancer metastasis, including the axillary lymph nodes. Axillary lymph nodes positive for breast carcinoma have been an important component of breast cancer diagnosis, treatment, and subsequent research. The goal of this paper is to analyze the literature that has explained the pathways from CXCR4 expression to breast cancer metastasis of the lymph nodes and the prognostic and/or predictive implications of lymph node metastases in the presence of elevated CXCR4.

scholarly journals Gene expression profiles of breast cancer metastasis according to organ site

2021 ◽  
Author(s):  
Fara Brasó‐Maristany ◽  
Laia Paré ◽  
Nuria Chic ◽  
Olga Martínez‐Sáez ◽  
Tomás Pascual ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Metastasis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Breast Cancer Metastasis ◽  
Organ Site

Breast Cancer Metastasis Alters Acetylcholinesterase Activity and the Composition of Enzyme Forms in Axillary Lymph Nodes

2003 ◽  
Vol 80 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Francisco Ruiz-Espejo ◽  
Juan Cabezas-Herrera ◽  
Julián Illana ◽  
Francisco J. Campoy ◽  
Encarnación Muñoz-Delgado ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Metastasis ◽  
Acetylcholinesterase Activity ◽  
Breast Cancer Metastasis ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph

scholarly journals Computed tomography Hounsfield units can predict breast cancer metastasis to axillary lymph nodes

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Masakazu Urata ◽  
Yuko Kijima ◽  
Munetsugu Hirata ◽  
Yoshiaki Shinden ◽  
Hideo Arima ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Computed Tomography ◽  
Lymph Nodes ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Hounsfield Units
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