Factors associated with the effectiveness of plasma exchange for the treatment of NMO-IgG-positive neuromyelitis optica spectrum disorders

2012 ◽  
Vol 19 (9) ◽  
pp. 1216-1218 ◽  
Author(s):  
Young-Min Lim ◽  
So Young Pyun ◽  
Bong-Hui Kang ◽  
Jimin Kim ◽  
Kwang-Kuk Kim
Keyword(s):  
Plasma Exchange ◽  
Neuromyelitis Optica ◽  
Functional Improvement ◽  
Factors Associated ◽  
Mri Features ◽  
Lower Baseline ◽  
Before And After ◽  
Primary Determinant ◽  
Spectrum Disorders ◽  
Magnetic Resonance Imaging Mri

To identify factors associated with plasma exchange response in neuromyelitis optica (NMO) spectrum disorders, the clinical and magnetic resonance imaging (MRI) features of 31 NMO-IgG-positive patients receiving plasma exchange for steroid-resistant exacerbations were analyzed. Functional improvement was observed in 65% of the patients. A lower baseline Expanded Disability Status Scale score was associated with favorable response ( p = 0.040). Patients without cord atrophy had a higher success rate than patients with atrophy ( p = 0.016). Levels of NMO-IgG did not differ between responders and non-responders before and after plasma exchange. In conclusion, a minimal pre-existing disability is the primary determinant of the effectiveness of plasma exchange.

Beneficial effect of plasma exchange in acute attack of neuromyelitis optica spectrum disorders

2018 ◽  
Vol 20 ◽  
pp. 115-121 ◽  
Author(s):  
Tayanan Srisupa - Olan ◽  
Sasitorn Siritho ◽  
Kulvara Kittisares ◽  
Jiraporn Jitprapaikulsan ◽  
Chanjira Sathukitchai ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Plasma Exchange ◽  
Neuromyelitis Optica ◽  
Acute Attack ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spectrum Disorders

scholarly journals Circulating Memory T Follicular Helper Cells in Patients with Neuromyelitis Optica/Neuromyelitis Optica Spectrum Disorders

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Xueli Fan ◽  
Yanfang Jiang ◽  
Jinming Han ◽  
Jingyao Liu ◽  
Yafen Wei ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Potential Role ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Tfh Cells ◽  
Follicular Helper ◽  
Cell Counts ◽  
Before And After ◽  
Spectrum Disorders ◽  
White Blood Cell Counts

Objective. This study aimed to examine the potential role of memory T follicular helper (Tfh) cells in patients with neuromyelitis optica/neuromyelitis optica spectrum disorders (NMO/NMOSD).Methods. The percentages of different subsets of circulating memory Tfh cells in 25 NMO/NMOSD patients before and after treatment as well as in 17 healthy controls were examined by flow cytometry. The levels of IL-21 and AQP4 Ab in plasma and CSF were measured by ELISA.Results. The percentages and numbers of circulating memory Tfh cells, ICOS+, CCR7−, CCR7−ICOS+, CCR7+, CCR7+ICOS+memory Tfh cells, and the levels of IL-21 in plasma and CSF were significantly increased in NMO/NMOSD patients. The percentages of CCR7−and CCR7−ICOS+memory Tfh cells were positively correlated with ARR, plasma IL-21, and AQP4 Ab levels. The percentages of CCR7+and CCR7+ICOS+memory Tfh cells were positively correlated with CSF white blood cell counts, proteins, and IL-21 levels. Treatment with corticosteroids significantly reduced the numbers of CCR7−ICOS+and CCR7+ICOS+memory Tfh cells as well as plasma IL-21 levels in patients with partial remission.Conclusions. Our findings indicate that circulating memory Tfh cells may participate in the relapse and development of NMO/NMOSD and may serve as a new therapeutic target.

scholarly journals NMO-DBr: the Brazilian Neuromyelitis Optica Database System

2011 ◽  
Vol 69 (4) ◽  
pp. 687-692 ◽  
Author(s):  
Marco A. Lana-Peixoto ◽  
Lívia Edwiges Talim ◽  
Alessandra C. Faria-Campos ◽  
Sérgio V.A. Campos ◽  
Cristiane F. Rocha ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Brain Magnetic Resonance Imaging ◽  
Database System ◽  
Optic Coherence Tomography ◽  
History Record ◽  
Information Management Systems ◽  
Associated Conditions ◽  
Laboratory Information Management Systems ◽  
Spectrum Disorders ◽  
Magnetic Resonance Imaging Mri

OBJECTIVE: To present the Brazilian Neuromyelitis Optica Database System (NMO-DBr), a database system which collects, stores, retrieves, and analyzes information from patients with NMO and NMO-related disorders. METHOD: NMO-DBr uses Flux, a LIMS (Laboratory Information Management Systems) for data management. We used information from medical records of patients with NMO spectrum disorders, and NMO variants, the latter defined by the presence of neurological symptoms associated with typical lesions on brain magnetic resonance imaging (MRI) or aquaporin-4 antibody seropositivity. RESULTS: NMO-DBr contains data related to patient's identification, symptoms, associated conditions, index events, recurrences, family history, visual and spinal cord evaluation, disability, cerebrospinal fluid and blood tests, MRI, optic coherence tomography, diagnosis and treatment. It guarantees confidentiality, performs cross-checking and statistical analysis. CONCLUSION: NMO-DBr is a tool which guides professionals to take the history, record and analyze information making medical practice more consistent and improving research in the area.

Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis

2008 ◽  
Vol 14 (9) ◽  
pp. 1181-1190 ◽  
Author(s):  
T Matsuoka ◽  
T Matsushita ◽  
M Osoegawa ◽  
Y Kawano ◽  
M Minohara ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Lesion ◽  
Japanese Patients ◽  
Brain Lesions ◽  
Oligoclonal Bands ◽  
Factors Associated ◽  
Logistic Analysis ◽  
Asian Patients ◽  
Mri Features ◽  
Magnetic Resonance Imaging Mri

Background In Asian patients with multiple sclerosis (MS), a paucity of brain lesions and longitudinally extensive spinal cord lesions (LESCLs) extending three or more vertebral segments are characteristic findings on magnetic resonance imaging (MRI). We aimed to disclose possible factors contributing to the development of such MRI features. Method Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser criteria and 125 healthy controls. Possible factors associated with MRI features were determined by multiple logistic analysis. Patients with MS were classified based on the presence or absence of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) and LESCLs. Barkhof brain lesion–negative (−) patients had a markedly lower frequency of HLA-DRB1*0901 than controls ( Pcorr < 0.05), whereas the frequency of DRB1*1501 was increased in the Barkhof brain lesion–positive (+) group, although this increase was not significant after correction. No Barkhof(−)LESCL(+) patients carried DRB1*0901 ( Pcorr < 0.05), despite this being the most common allele in Japanese. The Barkhof(−)LESCL(−) group showed a significant increase in the frequency of DRB1*0405 compared with controls ( Pcorr < 0.05). None of the DPB1 alleles were significantly different among the groups. Using multiple logistic analysis, the absence of oligoclonal bands was positively associated with an absence of Barkhof brain lesions, whereas a higher EDSS score was positively associated with the presence of LESCLs; however, the presence of anti-aquaporin-4 antibodies was not associated with either feature. Conclusion The characteristic MRI features in Asians are partly related to distinct HLA-DRB1 gene alleles and an absence of oligoclonal bands.

Diagnostic Challenges in Pediatric Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

2017 ◽  
Vol 16 (03) ◽  
pp. 185-191
Author(s):  
Brenda Banwell ◽  
Anusha Yeshokumar
Keyword(s):  
Multiple Sclerosis ◽  
Neuromyelitis Optica ◽  
Spectrum Disorder ◽  
First Episode ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Pediatric Multiple Sclerosis ◽  
Mri Features ◽  
The Central Nervous System ◽  
Mog Antibodies ◽  
Magnetic Resonance Imaging Mri

AbstractThis review highlights the most common presentations of demyelination of the central nervous system (CNS, termed acquired demyelinating syndrome) in children, the difficulty in determining whether the first episode represents a monophasic/transient illness or relapsing disease, and the potential underlying etiologies that must be considered, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and disorders associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) antibodies. The initial clinical and magnetic resonance imaging (MRI) features, as well as those observed over time, are highlighted, emphasizing the distinct and overlapping features of each of these disorders.

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