Comment on extensive white matter lesions after 2 years of fingolimod: Progressive multifocal leukoencephalopathy or MS relapse?

2016 ◽  
Vol 23 (4) ◽  
pp. 617-618
Author(s):  
María Inés Gaitán ◽  
Jorge Correale
2016 ◽  
Vol 23 (4) ◽  
pp. 614-616 ◽  
Author(s):  
Marine Boudot de la Motte ◽  
Céline Louapre ◽  
Anne Bertrand ◽  
Pauline Reach ◽  
Catherine Lubetzki ◽  
...  

Background: Fingolimod is a widely used treatment for highly active relapsing–remitting multiple sclerosis. Objectives: To describe the case of a 27-year-old patient treated for more than 2 years by Fingolimod, who presented hemiplegia and speech disturbances associated with extensive white matter lesions on brain magnetic resonance imaging (MRI). Methods: Case study. Results: Although initial presentation questioned the possibility of progressive multifocal leukoencephalopathy, final diagnosis was multiple sclerosis (MS) relapse. Appropriate treatment resulted in clinical and radiological improvement. Conclusion: Severe MS relapses under Fingolimod have been reported, but late onset after treatment initiation and extensive subcortical topography is unusual and represents a diagnostic challenge.


Author(s):  
Cheng‐Chih Hsiao ◽  
Nina L. Fransen ◽  
Aletta M.R. den Bosch ◽  
Kim I.M. Brandwijk ◽  
Inge Huitinga ◽  
...  

1994 ◽  
Vol 35 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Pernille Christiansen ◽  
H. B. W. Larsson ◽  
C. Thomsen ◽  
S. B. Wieslander ◽  
O. Henriksen

Sign in / Sign up

Export Citation Format

Share Document