Nonpyramidal Motor Systems and Functional Recovery After Damage to the Central Nervous System

1988 ◽  
Vol 2 (1) ◽  
pp. 1-6 ◽  
Author(s):  
S. G. Waxman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional Recovery ◽  
Motor Systems ◽  
The Central Nervous System

scholarly journals Experience-Associated Structural Events, Subependymal Cellular Proliferative Activity, and Functional Recovery After Injury to the Central Nervous System

2000 ◽  
Vol 20 (11) ◽  
pp. 1513-1528 ◽  
Author(s):  
Timothy Schallert ◽  
J. Leigh Leasure ◽  
Bryan Kolb
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional Recovery ◽  
Proliferative Activity ◽  
Structural Changes ◽  
Direct Interaction ◽  
Recovery Process ◽  
Intervention Strategies ◽  
Brain Areas ◽  
The Central Nervous System

Considerable structural plasticity is possible in the damaged neocortex and connected brain areas, and the potential for significant functional recovery remains even during the chronic phases of the recovery process. In this article, the authors review the literature on use-dependent morphologic events, focusing on the direct interaction of behavioral experience and structural changes associated with plasticity and degeneration. Experience-associated neural changes have the potential to either hinder or enhance functional recovery; therefore, issues concerning the nature, timing, and intensity of behavior-based intervention strategies are addressed.

scholarly journals Central nervous system lesions leading to disability

2008 ◽  
Vol 18 (2) ◽  
pp. 11-23 ◽  
Author(s):  
Dejan Popovic ◽  
Thomas Sinkjær
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Electrical Stimulation ◽  
Special Issue ◽  
Motor Systems ◽  
Surface Electrodes ◽  
Sensory Motor ◽  
The Central Nervous System ◽  
High Level ◽  
Artificial Control

The introductory tutorial to this special issue was written for readers with engineering background with the aim to provide the basis for comprehending better the natural motor control and the terminology used in description of impairments and disability caused by to CNS injuries and diseases. The tutorial aims to emphasize the differences between natural and artificial control, complexity of sensory-motor systems in humans, the high level of articulation redundancy, and the fact that all of the said systems are modified after the central nervous system lesion. We hope that the tutorial will simplify the following of the subsequent papers in this special issue dedicated to the use of electrical stimulation with surface electrodes for assisting motor functions.

scholarly journals Functional Recovery of a Locomotor Network after Injury: Plasticity beyond the Central Nervous System

eNeuro ◽  
2018 ◽  
Vol 5 (4) ◽  
pp. ENEURO.0195-18.2018 ◽  
Author(s):  
Joshua G. Puhl ◽  
Anthony W. Bigelow ◽  
Mara C. P. Rue ◽  
Karen A. Mesce
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional Recovery ◽  
The Central Nervous System

scholarly journals Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System

2020 ◽  
Vol 32 (5) ◽  
pp. 767-785.e7 ◽  
Author(s):  
Feng Li ◽  
Armin Sami ◽  
Harun N. Noristani ◽  
Kieran Slattery ◽  
Jingyun Qiu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional Recovery ◽  
Axon Regeneration ◽  
The Central Nervous System

Extrinsic and intrinsic factors controlling axonal regeneration after spinal cord injury

2009 ◽  
Vol 11 ◽  
Author(s):  
Fardad T. Afshari ◽  
Sunil Kappagantula ◽  
James W. Fawcett
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Spinal Cord Injury ◽  
Nervous System ◽  
Functional Recovery ◽  
Extrinsic Factors ◽  
Permanent Disability ◽  
Intrinsic Factors ◽  
Cord Injury ◽  
The Central Nervous System

Spinal cord injury is one of the most devastating conditions that affects the central nervous system. It can lead to permanent disability and there are around two million people affected worldwide. After injury, accumulation of myelin debris and formation of an inhibitory glial scar at the site of injury leads to a physical and chemical barrier that blocks axonal growth and regeneration. The mammalian central nervous system thus has a limited intrinsic ability to repair itself after injury. To improve axonal outgrowth and promote functional recovery, it is essential to identify the various intrinsic and extrinsic factors controlling regeneration and navigation of axons within the inhibitory environment of the central nervous system. Recent advances in spinal cord research have opened new avenues for the exploration of potential targets for repairing the cord and improving functional recovery after trauma. Here, we discuss some of the important key molecules that could be harnessed for repairing spinal cord injury.

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