A cross-cultural exploration of the everyday social participation of individuals with autism spectrum disorders in Australia and Taiwan: An experience sampling study

Autism ◽  
2016 ◽  
Vol 21 (2) ◽  
pp. 231-241 ◽  
Author(s):  
Yu-Wei Chen ◽  
Anita C Bundy ◽  
Reinie Cordier ◽  
Yi-Ling Chien ◽  
Stewart L Einfeld

Individuals with an autism spectrum disorder commonly have limited social participation. This study aimed to examine the similarities and differences of everyday participation among males and females with autism spectrum disorder in Australia and Taiwan, using an experience sampling methodology. A total of 14 Australians (4 males, aged 16–43 years) and 16 Taiwanese (12 males, aged 19–45 years) with autism spectrum disorder who are cognitively able were asked to carry a device which prompted them seven times per day for 7 days, to record everyday participation: where they were, what they were doing, and who they were with. Multilevel analyses were used to identify the relationships between everyday participation and associated factors including gender, country of residence, clinical severity of autism spectrum disorder, and social anxiety. The results showed that Taiwanese participants were more likely to stay at home than Australian participants. However, female participants were more likely to engage in social situations than males. Furthermore, participants with fewer autism spectrum disorder symptoms and those with higher levels of social anxiety were less likely to engage in social interactions. This study sheds light on ways that culture and gender affect social participation and highlights the relationship of social anxiety to social participation. The findings have implications for interventions for social participation.

Author(s):  
Maria Gevezova ◽  
Danail Minchev ◽  
Iliana Pacheva ◽  
Yordan Sbirkov ◽  
Ralitsa Yordanova ◽  
...  

Background: Although Autism Spectrum Disorder (ASD) is considered a heterogeneous neurological disease in childhood, a growing body of evidence associates it with mitochondrial dysfunction explaining the observed comorbidities. Introduction: The aim of this study is to identify variations in cellular bioenergetics and metabolism dependent on mitochondrial function in ASD patients and healthy controls using peripheral blood mononuclear cells (PBMCs). We hypothesized that PBMCs may reveal the cellular pathology and provide evidence of bioenergetic and metabolic changes accompanying the disease. Method: PBMC from children with ASD and a control group of the same age and gender were isolated. All patients underwent an in-depth clinical evaluation. A well-characterized cohort of Bulgarian children was selected. Bioenergetic and metabolic studies of isolated PBMCs were performed with a Seahorse XFp analyzer. Result: Our data show that PBMCs from patients with ASD have increased respiratory reserve capacity (by 27.5%), increased maximal respiration (by 67%) and altered adaptive response to oxidative stress induced by DMNQ. In addition, we demonstrate а strong dependence on fatty acids and impaired ability to reprogram cell metabolism. The listed characteristics are not observed in the control group. These results can contribute to a better understanding of the underlying causes of ASD, which is crucial for selecting a successful treatment. Conclusion: The current study, for the first time, provides a functional analysis of cell bioenergetics and metabolic changes in a group of Bulgarian patients with ASD. It reveals physiological abnormalities that do not allow mitochondria to adapt and meet the increased energetic requirements of the cell. The link between mitochondria and ASD is not yet fully understood, but this may lead to the discovery of new approaches for nutrition and therapy.


2015 ◽  
Vol 9 (3) ◽  
pp. 382-392 ◽  
Author(s):  
Eugenia Conti ◽  
Sara Calderoni ◽  
Anna Gaglianese ◽  
Kerstin Pannek ◽  
Sara Mazzotti ◽  
...  

2019 ◽  
Vol 205 ◽  
pp. 202-209 ◽  
Author(s):  
Susan E. Levy ◽  
Jennifer A. Pinto-Martin ◽  
Chyrise B. Bradley ◽  
Jesse Chittams ◽  
Susan L. Johnson ◽  
...  

2018 ◽  
Vol 48 (6) ◽  
pp. 2023-2037 ◽  
Author(s):  
Catherine A. Burrows ◽  
Lauren V. Usher ◽  
Emily M. Becker-Haimes ◽  
Camilla M. McMahon ◽  
Peter C. Mundy ◽  
...  

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